YDR010C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR010C / YDR010C

Click on Significant Values for Screen Details ID:SGTC_2|Compound:0422-0095|FD-Score:4.78|P-value:6.43E-6 ID:SGTC_3|Compound:0833-0587|FD-Score:10.60|P-value:1.26E-22 ID:SGTC_43|Compound:0570-0105|FD-Score:9.38|P-value:5.19E-18 ID:SGTC_55|Compound:0767-0285|FD-Score:9.21|P-value:1.89E-17 ID:SGTC_90|Compound:0870-0863|FD-Score:4.95|P-value:3.13E-6 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:3.49|P-value:7.18E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:3.84|P-value:2.30E-4 ID:SGTC_156|Compound:3474-0145|FD-Score:4.45|P-value:2.40E-5 ID:SGTC_157|Compound:1348-1695|FD-Score:29.50|P-value:3.89E-160 ID:SGTC_315|Compound:k915-0449|FD-Score:5.74|P-value:7.97E-8 ID:SGTC_352|Compound:k048-0007|FD-Score:9.00|P-value:9.55E-17 ID:SGTC_660|Compound:4031-1742|FD-Score:17.10|P-value:1.54E-55 ID:SGTC_667|Compound:1498-1044|FD-Score:-3.49|P-value:6.72E-4 ID:SGTC_761|Compound:k216-0224|FD-Score:5.53|P-value:2.14E-7 ID:SGTC_762|Compound:1165-0429|FD-Score:-3.90|P-value:1.76E-4 ID:SGTC_764|Compound:1951-2361|FD-Score:9.44|P-value:3.02E-18 ID:SGTC_773|Compound:4358-1457|FD-Score:7.68|P-value:1.13E-12 ID:SGTC_788|Compound:1182-0090|FD-Score:3.80|P-value:2.65E-4 ID:SGTC_1057|Compound:3448-5381|FD-Score:4.84|P-value:4.88E-6 ID:SGTC_1174|Compound:0739-0097|FD-Score:3.85|P-value:2.24E-4 ID:SGTC_1179|Compound:1021-1431|FD-Score:3.68|P-value:3.92E-4 ID:SGTC_1206|Compound:3978-0017|FD-Score:4.64|P-value:1.14E-5 ID:SGTC_1401|Compound:3807-4679|FD-Score:-4.67|P-value:9.43E-6 ID:SGTC_1404|Compound:3909-7820|FD-Score:3.54|P-value:6.12E-4 ID:SGTC_1457|Compound:k015-0032|FD-Score:3.46|P-value:7.96E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-5.01|P-value:2.21E-6 ID:SGTC_1463|Compound:k081-0032|FD-Score:-4.44|P-value:2.31E-5 ID:SGTC_1556|Compound:plumbagin|FD-Score:4.37|P-value:3.30E-5 ID:SGTC_1609|Compound:st001574|FD-Score:-3.60|P-value:4.83E-4 ID:SGTC_1612|Compound:st002233|FD-Score:3.88|P-value:2.00E-4 ID:SGTC_1635|Compound:st007035|FD-Score:3.76|P-value:3.00E-4 ID:SGTC_1659|Compound:st012954|FD-Score:-4.22|P-value:5.39E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:3.89|P-value:1.91E-4 ID:SGTC_1875|Compound:nocodazole|FD-Score:6.22|P-value:6.58E-9 ID:SGTC_1984|Compound:st072354|FD-Score:-3.76|P-value:2.79E-4 ID:SGTC_1995|Compound:st072814|FD-Score:3.62|P-value:4.76E-4 ID:SGTC_1999|Compound:st074831|FD-Score:4.01|P-value:1.24E-4 ID:SGTC_2124|Compound:5246320|FD-Score:3.45|P-value:8.30E-4 ID:SGTC_2248|Compound:tofa|FD-Score:7.01|P-value:7.33E-11 ID:SGTC_2274|Compound:7947094|FD-Score:4.38|P-value:3.22E-5 ID:SGTC_2315|Compound:7733312|FD-Score:4.38|P-value:3.24E-5 ID:SGTC_2322|Compound:7413319|FD-Score:3.77|P-value:2.92E-4 ID:SGTC_2416|Compound:tofa|FD-Score:4.92|P-value:3.58E-6 ID:SGTC_2623|Compound:humulene|FD-Score:-4.05|P-value:1.00E-4 ID:SGTC_2701|Compound:st077767|FD-Score:3.77|P-value:2.88E-4 ID:SGTC_2735|Compound:sertaconazole|FD-Score:-3.45|P-value:7.65E-4 ID:SGTC_2744|Compound:captopril|FD-Score:3.81|P-value:2.57E-4 ID:SGTC_2810|Compound:7959871|FD-Score:7.91|P-value:2.43E-13 ID:SGTC_2830|Compound:7992007|FD-Score:4.18|P-value:6.69E-5 ID:SGTC_2934|Compound:9036370|FD-Score:-4.38|P-value:2.95E-5 ID:SGTC_2992|Compound:9074591|FD-Score:-3.56|P-value:5.50E-4 ID:SGTC_2996|Compound:9066192|FD-Score:-5.17|P-value:1.09E-6 ID:SGTC_3047|Compound:9092122|FD-Score:-3.43|P-value:8.29E-4 ID:SGTC_3062|Compound:9077494|FD-Score:3.97|P-value:1.46E-4 ID:SGTC_3078|Compound:9116413|FD-Score:6.53|P-value:1.23E-9 ID:SGTC_3153|Compound:9100258|FD-Score:4.60|P-value:1.33E-5 ID:SGTC_3185|Compound:9108267|FD-Score:5.30|P-value:6.49E-7 ID:SGTC_3204|Compound:9114183|FD-Score:3.57|P-value:5.54E-4 ID:SGTC_3303|Compound:9125618|FD-Score:10.60|P-value:1.90E-22 ID:SGTC_2|Compound:0422-0095|FD-Score:4.78|P-value:6.43E-6 ID:SGTC_3|Compound:0833-0587|FD-Score:10.60|P-value:1.26E-22 ID:SGTC_43|Compound:0570-0105|FD-Score:9.38|P-value:5.19E-18 ID:SGTC_55|Compound:0767-0285|FD-Score:9.21|P-value:1.89E-17 ID:SGTC_90|Compound:0870-0863|FD-Score:4.95|P-value:3.13E-6 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:3.49|P-value:7.18E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:3.84|P-value:2.30E-4 ID:SGTC_156|Compound:3474-0145|FD-Score:4.45|P-value:2.40E-5 ID:SGTC_157|Compound:1348-1695|FD-Score:29.50|P-value:3.89E-160 ID:SGTC_315|Compound:k915-0449|FD-Score:5.74|P-value:7.97E-8 ID:SGTC_352|Compound:k048-0007|FD-Score:9.00|P-value:9.55E-17 ID:SGTC_660|Compound:4031-1742|FD-Score:17.10|P-value:1.54E-55 ID:SGTC_667|Compound:1498-1044|FD-Score:-3.49|P-value:6.72E-4 ID:SGTC_761|Compound:k216-0224|FD-Score:5.53|P-value:2.14E-7 ID:SGTC_762|Compound:1165-0429|FD-Score:-3.90|P-value:1.76E-4 ID:SGTC_764|Compound:1951-2361|FD-Score:9.44|P-value:3.02E-18 ID:SGTC_773|Compound:4358-1457|FD-Score:7.68|P-value:1.13E-12 ID:SGTC_788|Compound:1182-0090|FD-Score:3.80|P-value:2.65E-4 ID:SGTC_1057|Compound:3448-5381|FD-Score:4.84|P-value:4.88E-6 ID:SGTC_1174|Compound:0739-0097|FD-Score:3.85|P-value:2.24E-4 ID:SGTC_1179|Compound:1021-1431|FD-Score:3.68|P-value:3.92E-4 ID:SGTC_1206|Compound:3978-0017|FD-Score:4.64|P-value:1.14E-5 ID:SGTC_1401|Compound:3807-4679|FD-Score:-4.67|P-value:9.43E-6 ID:SGTC_1404|Compound:3909-7820|FD-Score:3.54|P-value:6.12E-4 ID:SGTC_1457|Compound:k015-0032|FD-Score:3.46|P-value:7.96E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-5.01|P-value:2.21E-6 ID:SGTC_1463|Compound:k081-0032|FD-Score:-4.44|P-value:2.31E-5 ID:SGTC_1556|Compound:plumbagin|FD-Score:4.37|P-value:3.30E-5 ID:SGTC_1609|Compound:st001574|FD-Score:-3.60|P-value:4.83E-4 ID:SGTC_1612|Compound:st002233|FD-Score:3.88|P-value:2.00E-4 ID:SGTC_1635|Compound:st007035|FD-Score:3.76|P-value:3.00E-4 ID:SGTC_1659|Compound:st012954|FD-Score:-4.22|P-value:5.39E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:3.89|P-value:1.91E-4 ID:SGTC_1875|Compound:nocodazole|FD-Score:6.22|P-value:6.58E-9 ID:SGTC_1984|Compound:st072354|FD-Score:-3.76|P-value:2.79E-4 ID:SGTC_1995|Compound:st072814|FD-Score:3.62|P-value:4.76E-4 ID:SGTC_1999|Compound:st074831|FD-Score:4.01|P-value:1.24E-4 ID:SGTC_2124|Compound:5246320|FD-Score:3.45|P-value:8.30E-4 ID:SGTC_2248|Compound:tofa|FD-Score:7.01|P-value:7.33E-11 ID:SGTC_2274|Compound:7947094|FD-Score:4.38|P-value:3.22E-5 ID:SGTC_2315|Compound:7733312|FD-Score:4.38|P-value:3.24E-5 ID:SGTC_2322|Compound:7413319|FD-Score:3.77|P-value:2.92E-4 ID:SGTC_2416|Compound:tofa|FD-Score:4.92|P-value:3.58E-6 ID:SGTC_2623|Compound:humulene|FD-Score:-4.05|P-value:1.00E-4 ID:SGTC_2701|Compound:st077767|FD-Score:3.77|P-value:2.88E-4 ID:SGTC_2735|Compound:sertaconazole|FD-Score:-3.45|P-value:7.65E-4 ID:SGTC_2744|Compound:captopril|FD-Score:3.81|P-value:2.57E-4 ID:SGTC_2810|Compound:7959871|FD-Score:7.91|P-value:2.43E-13 ID:SGTC_2830|Compound:7992007|FD-Score:4.18|P-value:6.69E-5 ID:SGTC_2934|Compound:9036370|FD-Score:-4.38|P-value:2.95E-5 ID:SGTC_2992|Compound:9074591|FD-Score:-3.56|P-value:5.50E-4 ID:SGTC_2996|Compound:9066192|FD-Score:-5.17|P-value:1.09E-6 ID:SGTC_3047|Compound:9092122|FD-Score:-3.43|P-value:8.29E-4 ID:SGTC_3062|Compound:9077494|FD-Score:3.97|P-value:1.46E-4 ID:SGTC_3078|Compound:9116413|FD-Score:6.53|P-value:1.23E-9 ID:SGTC_3153|Compound:9100258|FD-Score:4.60|P-value:1.33E-5 ID:SGTC_3185|Compound:9108267|FD-Score:5.30|P-value:6.49E-7 ID:SGTC_3204|Compound:9114183|FD-Score:3.57|P-value:5.54E-4 ID:SGTC_3303|Compound:9125618|FD-Score:10.60|P-value:1.90E-22

Top fitness defect scores for YDR010C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_157 1348-1695 29.50 65.8 µM 3.89E-160 iron homeostasis 1 6.11E-191
2 SGTC_660 4031-1742 17.10 102.0 µM 1.54E-55 redox potentiating 2 5.37E-66
3 SGTC_3 0833-0587 10.60 95.6 µM 1.26E-22 redox potentiating 3 1.07E-26
4 SGTC_3303 9125618 10.60 40.6 µM 1.90E-22 4 1.75E-26
5 SGTC_764 1951-2361 9.44 146.0 µM 3.02E-18 1 1.81E-21
6 SGTC_43 0570-0105 9.38 72.5 µM 5.19E-18 ERG2 13 3.44E-21
7 SGTC_55 0767-0285 9.21 6.6 µM 1.89E-17 6 1.61E-20
8 SGTC_352 k048-0007 9.00 5.1 µM 9.55E-17 ERAD & cell cycle 13 1.11E-19
9 SGTC_2810 7959871 7.91 45.5 µM 2.43E-13 copper-dependent oxidative stress 5 1.28E-15
10 SGTC_773 4358-1457 7.68 44.6 µM 1.13E-12 8 8.00E-15
11 SGTC_2248 tofa 7.01 1.1 µM 7.33E-11 sphingolipid biosynthesis & PDR1 15 1.16E-12
12 SGTC_3078 9116413 6.53 49.5 µM 1.23E-9 unfolded protein response 8 3.35E-11
13 SGTC_1875 nocodazole 6.22 6.0 µM 6.58E-9 tubulin folding & SWR complex 28 2.46E-10
14 SGTC_315 k915-0449 5.74 187.0 µM 7.97E-8 24 4.79E-9
15 SGTC_761 k216-0224 5.53 480.0 µM 2.14E-7 4 1.56E-8
16 SGTC_3185 9108267 5.30 49.5 µM 6.49E-7 60S ribosome export 4 5.81E-8
17 SGTC_90 0870-0863 4.95 4.6 µM 3.13E-6 22 3.77E-7
18 SGTC_2416 tofa 4.92 880.0 nM 3.58E-6 sphingolipid biosynthesis & PDR1 29 4.43E-7
19 SGTC_1057 3448-5381 4.84 134.0 µM 4.88E-6 calcium & mitochondrial duress 14 6.40E-7
20 SGTC_2 0422-0095 4.78 29.0 µM 6.43E-6 redox potentiating 4 8.88E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.545 2.51E-258 YDR011W SNQ2 hom Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter involved in multidrug resistance and resistance to singlet oxygen species
0.315 9.81E-78 YDR269C_d YDR269C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.233 1.94E-42 YDR270W CCC2 hom Cu(+2)-transporting P-type ATPase; required for export of copper from the cytosol into an extracytosolic compartment; has similarity to human proteins involved in Menkes and Wilsons diseases; protein abundance increases in response to DNA replication stress; affects TBSV model (+)RNA virus replication by regulating copper metabolism
0.213 9.43E-36 YJR040W GEF1 hom Voltage-gated chloride channel localized to the golgi, the endosomal system, and plasma membrane, and involved in cation homeostasis; highly homologous to vertebrate voltage-gated chloride channels; modulates TBSV model (+) RNA virus replication by regulating copper metabolism
0.208 4.62E-34 YJL094C KHA1 hom Putative K+/H+ antiporter with a probable role in intracellular cation homeostasis, localized to Golgi vesicles and detected in highly purified mitochondria in high-throughput studies
0.177 7.28E-25 YNL259C ATX1 hom Cytosolic copper metallochaperone that transports copper to the secretory vesicle copper transporter Ccc2p for eventual insertion into Fet3p, which is a multicopper oxidase required for high-affinity iron uptake
0.161 9.00E-21 YNR043W MVD1 het Mevalonate pyrophosphate decarboxylase, essential enzyme involved in the biosynthesis of isoprenoids and sterols, including ergosterol; acts as a homodimer
0.159 2.35E-20 YER145C FTR1 hom High affinity iron permease; involved in the transport of iron across the plasma membrane; forms complex with Fet3p; expression is regulated by iron; protein abundance increases in response to DNA replication stress
0.151 1.31E-18 YGL025C PGD1 hom Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for basal and activated transcription; direct target of Cyc8p-Tup1p transcriptional corepressor
0.148 1.04E-17 YCL026C-A FRM2 hom Type II nitroreductase, using NADH as reductant; mutants are defective in fatty acid mediated repression of genes involved in fatty acid biosynthesis indicative of a role in lipid signaling; involved in the oxidative stress response; transcription induction by cadmium and selenite indicates a possible role in the metal stress response; expression induced in cells treated with the mycotoxin patulin
0.146 2.24E-17 YML051W GAL80 hom Transcriptional regulator involved in the repression of GAL genes in the absence of galactose; inhibits transcriptional activation by Gal4p; inhibition relieved by Gal3p or Gal1p binding
0.144 6.39E-17 YKL048C ELM1 hom Serine/threonine protein kinase that regulates cellular morphogenesis, septin behavior, and cytokinesis; required for the regulation of other kinases, such as Kin4p; forms part of the bud neck ring
0.143 1.10E-16 YIL106W MOB1 het Component of the mitotic exit network; associates with and is required for the activation and Cdc15p-dependent phosphorylation of the Dbf2p kinase; required for cytokinesis and cell separation; component of the CCR4 transcriptional complex; relocalizes from cytoplasm to the nuclear periphery upon DNA replication stress
0.141 2.06E-16 YOR256C TRE2 het Transferrin receptor-like protein; functions with Tre1p to regulate ubiquitylation and vacuolar degradation of the metal transporter Smf1p; inviability of null mutant in systematic studies is due to proximity to CDC31; TRE2 has a paralog, TRE1, that arose from the whole genome duplication
0.141 2.82E-16 YHR058C MED6 het Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; protein abundance increases in response to DNA replication stress