YDR011W / SNQ2

Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter involved in multidrug resistance and resistance to singlet oxygen species

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR011W / SNQ2

Click on Significant Values for Screen Details ID:SGTC_2|Compound:0422-0095|FD-Score:29.60|P-value:5.44E-138 ID:SGTC_3|Compound:0833-0587|FD-Score:12.50|P-value:2.25E-26 ID:SGTC_12|Compound:0849-0099|FD-Score:4.22|P-value:1.86E-4 ID:SGTC_21|Compound:0849-0113|FD-Score:7.93|P-value:1.15E-11 ID:SGTC_31|Compound:0508-1974|FD-Score:-4.14|P-value:2.41E-4 ID:SGTC_32|Compound:0928-0142|FD-Score:4.85|P-value:2.14E-5 ID:SGTC_43|Compound:0570-0105|FD-Score:8.91|P-value:2.74E-14 ID:SGTC_55|Compound:0767-0285|FD-Score:16.00|P-value:9.22E-42 ID:SGTC_58|Compound:0957-0393|FD-Score:4.99|P-value:1.29E-5 ID:SGTC_62|Compound:0180-0423|FD-Score:7.55|P-value:9.36E-11 ID:SGTC_90|Compound:0870-0863|FD-Score:16.00|P-value:6.71E-42 ID:SGTC_96|Compound:0929-0093|FD-Score:4.03|P-value:3.40E-4 ID:SGTC_97|Compound:0535-0701|FD-Score:9.79|P-value:7.62E-17 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:5.77|P-value:5.75E-7 ID:SGTC_156|Compound:3474-0145|FD-Score:20.50|P-value:2.05E-67 ID:SGTC_157|Compound:1348-1695|FD-Score:20.80|P-value:5.28E-69 ID:SGTC_164|Compound:4100-3994|FD-Score:5.28|P-value:4.28E-6 ID:SGTC_196|Compound:k015-0023|FD-Score:3.94|P-value:4.39E-4 ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide  (4-NQO)|FD-Score:4.16|P-value:2.26E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:7.07|P-value:1.25E-9 ID:SGTC_315|Compound:k915-0449|FD-Score:18.90|P-value:1.54E-57 ID:SGTC_318|Compound:1488-0629|FD-Score:3.73|P-value:8.22E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:5.86|P-value:3.80E-7 ID:SGTC_352|Compound:k048-0007|FD-Score:15.20|P-value:1.02E-37 ID:SGTC_382|Compound:3229-0966|FD-Score:3.75|P-value:7.77E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:18.00|P-value:1.47E-52 ID:SGTC_551|Compound:k048-0028|FD-Score:3.69|P-value:9.20E-4 ID:SGTC_599|Compound:1935-0052|FD-Score:-4.70|P-value:3.71E-5 ID:SGTC_621|Compound:3584-0052|FD-Score:5.38|P-value:2.88E-6 ID:SGTC_660|Compound:4031-1742|FD-Score:13.40|P-value:4.52E-30 ID:SGTC_740|Compound:k014-0057|FD-Score:4.13|P-value:2.49E-4 ID:SGTC_754|Compound:3474-0146|FD-Score:4.71|P-value:3.48E-5 ID:SGTC_761|Compound:k216-0224|FD-Score:6.56|P-value:1.54E-8 ID:SGTC_764|Compound:1951-2361|FD-Score:5.04|P-value:1.07E-5 ID:SGTC_783|Compound:0848-0141|FD-Score:-3.94|P-value:4.39E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:14.60|P-value:4.04E-35 ID:SGTC_789|Compound:1309-1135|FD-Score:3.72|P-value:8.57E-4 ID:SGTC_843|Compound:0310-0051|FD-Score:4.82|P-value:2.37E-5 ID:SGTC_859|Compound:0439-0102|FD-Score:28.20|P-value:1.39E-125 ID:SGTC_866|Compound:0495-0101|FD-Score:6.17|P-value:9.74E-8 ID:SGTC_908|Compound:3448-7491|FD-Score:13.60|P-value:7.04E-31 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:-5.28|P-value:4.26E-6 ID:SGTC_955|Compound:1216-0110|FD-Score:6.47|P-value:2.38E-8 ID:SGTC_1057|Compound:3448-5381|FD-Score:16.10|P-value:3.70E-42 ID:SGTC_1081|Compound:sertraline|FD-Score:4.90|P-value:1.81E-5 ID:SGTC_1097|Compound:itavastatin|FD-Score:19.60|P-value:7.19E-62 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:3.81|P-value:6.48E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:6.67|P-value:9.28E-9 ID:SGTC_1164|Compound:k060-0068|FD-Score:-4.11|P-value:2.62E-4 ID:SGTC_1174|Compound:0739-0097|FD-Score:4.67|P-value:4.07E-5 ID:SGTC_1187|Compound:1391-0724|FD-Score:4.36|P-value:1.19E-4 ID:SGTC_1198|Compound:1612-1005|FD-Score:4.11|P-value:2.59E-4 ID:SGTC_1206|Compound:3978-0017|FD-Score:5.58|P-value:1.23E-6 ID:SGTC_1208|Compound:2323-2347|FD-Score:5.04|P-value:1.07E-5 ID:SGTC_1334|Compound:1486-0610|FD-Score:4.33|P-value:1.30E-4 ID:SGTC_1338|Compound:1486-1223|FD-Score:3.95|P-value:4.36E-4 ID:SGTC_1404|Compound:3909-7820|FD-Score:8.64|P-value:1.58E-13 ID:SGTC_1425|Compound:4048-4433|FD-Score:5.14|P-value:7.31E-6 ID:SGTC_1450|Compound:4112-4260|FD-Score:6.40|P-value:3.31E-8 ID:SGTC_1457|Compound:k015-0032|FD-Score:5.89|P-value:3.41E-7 ID:SGTC_1462|Compound:k081-0014|FD-Score:-5.25|P-value:4.76E-6 ID:SGTC_1495|Compound:4469-0029|FD-Score:3.89|P-value:5.16E-4 ID:SGTC_1522|Compound:st012842|FD-Score:8.52|P-value:3.23E-13 ID:SGTC_1556|Compound:plumbagin|FD-Score:8.24|P-value:1.79E-12 ID:SGTC_1612|Compound:st002233|FD-Score:4.01|P-value:3.57E-4 ID:SGTC_1615|Compound:st002656|FD-Score:9.17|P-value:5.00E-15 ID:SGTC_1619|Compound:st003326|FD-Score:5.09|P-value:8.86E-6 ID:SGTC_1635|Compound:st007035|FD-Score:8.41|P-value:6.46E-13 ID:SGTC_1664|Compound:st014217|FD-Score:3.78|P-value:7.15E-4 ID:SGTC_1687|Compound:st020778|FD-Score:4.00|P-value:3.66E-4 ID:SGTC_1707|Compound:st032323|FD-Score:6.51|P-value:1.96E-8 ID:SGTC_1718|Compound:roemerine|FD-Score:8.18|P-value:2.55E-12 ID:SGTC_1766|Compound:st045414|FD-Score:6.61|P-value:1.25E-8 ID:SGTC_1780|Compound:st038448|FD-Score:5.60|P-value:1.17E-6 ID:SGTC_1875|Compound:nocodazole|FD-Score:23.90|P-value:7.67E-91 ID:SGTC_1885|Compound:st057546|FD-Score:3.90|P-value:4.95E-4 ID:SGTC_1917|Compound:st066507|FD-Score:9.29|P-value:2.35E-15 ID:SGTC_1987|Compound:st072290|FD-Score:4.26|P-value:1.63E-4 ID:SGTC_1991|Compound:st073000|FD-Score:7.19|P-value:6.67E-10 ID:SGTC_2248|Compound:tofa|FD-Score:13.70|P-value:2.38E-31 ID:SGTC_2322|Compound:7413319|FD-Score:5.90|P-value:3.26E-7 ID:SGTC_2348|Compound:9022543|FD-Score:4.34|P-value:1.26E-4 ID:SGTC_2399|Compound:5884133|FD-Score:6.85|P-value:3.68E-9 ID:SGTC_2416|Compound:tofa|FD-Score:18.00|P-value:1.86E-52 ID:SGTC_2548|Compound:3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin|FD-Score:4.03|P-value:3.38E-4 ID:SGTC_2557|Compound:derrustone|FD-Score:4.59|P-value:5.36E-5 ID:SGTC_2575|Compound:plumbagin|FD-Score:4.58|P-value:5.60E-5 ID:SGTC_2701|Compound:st077767|FD-Score:6.89|P-value:3.06E-9 ID:SGTC_2740|Compound:felodipine|FD-Score:5.47|P-value:1.95E-6 ID:SGTC_2744|Compound:captopril|FD-Score:4.60|P-value:5.29E-5 ID:SGTC_2753|Compound:fluvastatin|FD-Score:11.10|P-value:2.75E-21 ID:SGTC_2810|Compound:7959871|FD-Score:15.20|P-value:9.54E-38 ID:SGTC_2811|Compound:7967822|FD-Score:-3.69|P-value:9.36E-4 ID:SGTC_2872|Compound:9044037|FD-Score:-3.74|P-value:8.05E-4 ID:SGTC_2937|Compound:9044753|FD-Score:4.93|P-value:1.58E-5 ID:SGTC_3000|Compound:9075062|FD-Score:3.67|P-value:9.73E-4 ID:SGTC_3027|Compound:9089541|FD-Score:5.77|P-value:5.76E-7 ID:SGTC_3032|Compound:9089427|FD-Score:6.28|P-value:5.98E-8 ID:SGTC_3185|Compound:9108267|FD-Score:3.93|P-value:4.52E-4 ID:SGTC_3222|Compound:9128301|FD-Score:3.76|P-value:7.47E-4 ID:SGTC_3280|Compound:9140961|FD-Score:4.86|P-value:2.08E-5 ID:SGTC_3303|Compound:9125618|FD-Score:11.40|P-value:4.91E-22 ID:SGTC_3339|Compound:9145883|FD-Score:3.88|P-value:5.33E-4 ID:SGTC_2|Compound:0422-0095|FD-Score:29.60|P-value:5.44E-138 ID:SGTC_3|Compound:0833-0587|FD-Score:12.50|P-value:2.25E-26 ID:SGTC_12|Compound:0849-0099|FD-Score:4.22|P-value:1.86E-4 ID:SGTC_21|Compound:0849-0113|FD-Score:7.93|P-value:1.15E-11 ID:SGTC_31|Compound:0508-1974|FD-Score:-4.14|P-value:2.41E-4 ID:SGTC_32|Compound:0928-0142|FD-Score:4.85|P-value:2.14E-5 ID:SGTC_43|Compound:0570-0105|FD-Score:8.91|P-value:2.74E-14 ID:SGTC_55|Compound:0767-0285|FD-Score:16.00|P-value:9.22E-42 ID:SGTC_58|Compound:0957-0393|FD-Score:4.99|P-value:1.29E-5 ID:SGTC_62|Compound:0180-0423|FD-Score:7.55|P-value:9.36E-11 ID:SGTC_90|Compound:0870-0863|FD-Score:16.00|P-value:6.71E-42 ID:SGTC_96|Compound:0929-0093|FD-Score:4.03|P-value:3.40E-4 ID:SGTC_97|Compound:0535-0701|FD-Score:9.79|P-value:7.62E-17 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:5.77|P-value:5.75E-7 ID:SGTC_156|Compound:3474-0145|FD-Score:20.50|P-value:2.05E-67 ID:SGTC_157|Compound:1348-1695|FD-Score:20.80|P-value:5.28E-69 ID:SGTC_164|Compound:4100-3994|FD-Score:5.28|P-value:4.28E-6 ID:SGTC_196|Compound:k015-0023|FD-Score:3.94|P-value:4.39E-4 ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide  (4-NQO)|FD-Score:4.16|P-value:2.26E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:7.07|P-value:1.25E-9 ID:SGTC_315|Compound:k915-0449|FD-Score:18.90|P-value:1.54E-57 ID:SGTC_318|Compound:1488-0629|FD-Score:3.73|P-value:8.22E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:5.86|P-value:3.80E-7 ID:SGTC_352|Compound:k048-0007|FD-Score:15.20|P-value:1.02E-37 ID:SGTC_382|Compound:3229-0966|FD-Score:3.75|P-value:7.77E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:18.00|P-value:1.47E-52 ID:SGTC_551|Compound:k048-0028|FD-Score:3.69|P-value:9.20E-4 ID:SGTC_599|Compound:1935-0052|FD-Score:-4.70|P-value:3.71E-5 ID:SGTC_621|Compound:3584-0052|FD-Score:5.38|P-value:2.88E-6 ID:SGTC_660|Compound:4031-1742|FD-Score:13.40|P-value:4.52E-30 ID:SGTC_740|Compound:k014-0057|FD-Score:4.13|P-value:2.49E-4 ID:SGTC_754|Compound:3474-0146|FD-Score:4.71|P-value:3.48E-5 ID:SGTC_761|Compound:k216-0224|FD-Score:6.56|P-value:1.54E-8 ID:SGTC_764|Compound:1951-2361|FD-Score:5.04|P-value:1.07E-5 ID:SGTC_783|Compound:0848-0141|FD-Score:-3.94|P-value:4.39E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:14.60|P-value:4.04E-35 ID:SGTC_789|Compound:1309-1135|FD-Score:3.72|P-value:8.57E-4 ID:SGTC_843|Compound:0310-0051|FD-Score:4.82|P-value:2.37E-5 ID:SGTC_859|Compound:0439-0102|FD-Score:28.20|P-value:1.39E-125 ID:SGTC_866|Compound:0495-0101|FD-Score:6.17|P-value:9.74E-8 ID:SGTC_908|Compound:3448-7491|FD-Score:13.60|P-value:7.04E-31 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:-5.28|P-value:4.26E-6 ID:SGTC_955|Compound:1216-0110|FD-Score:6.47|P-value:2.38E-8 ID:SGTC_1057|Compound:3448-5381|FD-Score:16.10|P-value:3.70E-42 ID:SGTC_1081|Compound:sertraline|FD-Score:4.90|P-value:1.81E-5 ID:SGTC_1097|Compound:itavastatin|FD-Score:19.60|P-value:7.19E-62 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:3.81|P-value:6.48E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:6.67|P-value:9.28E-9 ID:SGTC_1164|Compound:k060-0068|FD-Score:-4.11|P-value:2.62E-4 ID:SGTC_1174|Compound:0739-0097|FD-Score:4.67|P-value:4.07E-5 ID:SGTC_1187|Compound:1391-0724|FD-Score:4.36|P-value:1.19E-4 ID:SGTC_1198|Compound:1612-1005|FD-Score:4.11|P-value:2.59E-4 ID:SGTC_1206|Compound:3978-0017|FD-Score:5.58|P-value:1.23E-6 ID:SGTC_1208|Compound:2323-2347|FD-Score:5.04|P-value:1.07E-5 ID:SGTC_1334|Compound:1486-0610|FD-Score:4.33|P-value:1.30E-4 ID:SGTC_1338|Compound:1486-1223|FD-Score:3.95|P-value:4.36E-4 ID:SGTC_1404|Compound:3909-7820|FD-Score:8.64|P-value:1.58E-13 ID:SGTC_1425|Compound:4048-4433|FD-Score:5.14|P-value:7.31E-6 ID:SGTC_1450|Compound:4112-4260|FD-Score:6.40|P-value:3.31E-8 ID:SGTC_1457|Compound:k015-0032|FD-Score:5.89|P-value:3.41E-7 ID:SGTC_1462|Compound:k081-0014|FD-Score:-5.25|P-value:4.76E-6 ID:SGTC_1495|Compound:4469-0029|FD-Score:3.89|P-value:5.16E-4 ID:SGTC_1522|Compound:st012842|FD-Score:8.52|P-value:3.23E-13 ID:SGTC_1556|Compound:plumbagin|FD-Score:8.24|P-value:1.79E-12 ID:SGTC_1612|Compound:st002233|FD-Score:4.01|P-value:3.57E-4 ID:SGTC_1615|Compound:st002656|FD-Score:9.17|P-value:5.00E-15 ID:SGTC_1619|Compound:st003326|FD-Score:5.09|P-value:8.86E-6 ID:SGTC_1635|Compound:st007035|FD-Score:8.41|P-value:6.46E-13 ID:SGTC_1664|Compound:st014217|FD-Score:3.78|P-value:7.15E-4 ID:SGTC_1687|Compound:st020778|FD-Score:4.00|P-value:3.66E-4 ID:SGTC_1707|Compound:st032323|FD-Score:6.51|P-value:1.96E-8 ID:SGTC_1718|Compound:roemerine|FD-Score:8.18|P-value:2.55E-12 ID:SGTC_1766|Compound:st045414|FD-Score:6.61|P-value:1.25E-8 ID:SGTC_1780|Compound:st038448|FD-Score:5.60|P-value:1.17E-6 ID:SGTC_1875|Compound:nocodazole|FD-Score:23.90|P-value:7.67E-91 ID:SGTC_1885|Compound:st057546|FD-Score:3.90|P-value:4.95E-4 ID:SGTC_1917|Compound:st066507|FD-Score:9.29|P-value:2.35E-15 ID:SGTC_1987|Compound:st072290|FD-Score:4.26|P-value:1.63E-4 ID:SGTC_1991|Compound:st073000|FD-Score:7.19|P-value:6.67E-10 ID:SGTC_2248|Compound:tofa|FD-Score:13.70|P-value:2.38E-31 ID:SGTC_2322|Compound:7413319|FD-Score:5.90|P-value:3.26E-7 ID:SGTC_2348|Compound:9022543|FD-Score:4.34|P-value:1.26E-4 ID:SGTC_2399|Compound:5884133|FD-Score:6.85|P-value:3.68E-9 ID:SGTC_2416|Compound:tofa|FD-Score:18.00|P-value:1.86E-52 ID:SGTC_2548|Compound:3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin|FD-Score:4.03|P-value:3.38E-4 ID:SGTC_2557|Compound:derrustone|FD-Score:4.59|P-value:5.36E-5 ID:SGTC_2575|Compound:plumbagin|FD-Score:4.58|P-value:5.60E-5 ID:SGTC_2701|Compound:st077767|FD-Score:6.89|P-value:3.06E-9 ID:SGTC_2740|Compound:felodipine|FD-Score:5.47|P-value:1.95E-6 ID:SGTC_2744|Compound:captopril|FD-Score:4.60|P-value:5.29E-5 ID:SGTC_2753|Compound:fluvastatin|FD-Score:11.10|P-value:2.75E-21 ID:SGTC_2810|Compound:7959871|FD-Score:15.20|P-value:9.54E-38 ID:SGTC_2811|Compound:7967822|FD-Score:-3.69|P-value:9.36E-4 ID:SGTC_2872|Compound:9044037|FD-Score:-3.74|P-value:8.05E-4 ID:SGTC_2937|Compound:9044753|FD-Score:4.93|P-value:1.58E-5 ID:SGTC_3000|Compound:9075062|FD-Score:3.67|P-value:9.73E-4 ID:SGTC_3027|Compound:9089541|FD-Score:5.77|P-value:5.76E-7 ID:SGTC_3032|Compound:9089427|FD-Score:6.28|P-value:5.98E-8 ID:SGTC_3185|Compound:9108267|FD-Score:3.93|P-value:4.52E-4 ID:SGTC_3222|Compound:9128301|FD-Score:3.76|P-value:7.47E-4 ID:SGTC_3280|Compound:9140961|FD-Score:4.86|P-value:2.08E-5 ID:SGTC_3303|Compound:9125618|FD-Score:11.40|P-value:4.91E-22 ID:SGTC_3339|Compound:9145883|FD-Score:3.88|P-value:5.33E-4

Top fitness defect scores for YDR011W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2 0422-0095 29.60 29.0 µM 5.44E-138 redox potentiating 1 5.75E-193
2 SGTC_859 0439-0102 28.20 54.6 µM 1.39E-125 redox potentiating 1 1.54E-175
3 SGTC_1875 nocodazole 23.90 6.0 µM 7.67E-91 tubulin folding & SWR complex 3 9.59E-127
4 SGTC_157 1348-1695 20.80 65.8 µM 5.28E-69 iron homeostasis 5 4.42E-96
5 SGTC_156 3474-0145 20.50 5.6 µM 2.05E-67 endomembrane recycling 2 7.51E-94
6 SGTC_1097 itavastatin 19.60 7.2 µM 7.19E-62 azole & statin 2 4.59E-86
7 SGTC_315 k915-0449 18.90 187.0 µM 1.54E-57 1 5.52E-80
8 SGTC_518 1021-0119 18.00 62.6 µM 1.47E-52 ERG2 1 5.36E-73
9 SGTC_2416 tofa 18.00 880.0 nM 1.86E-52 sphingolipid biosynthesis & PDR1 5 7.45E-73
10 SGTC_1057 3448-5381 16.10 134.0 µM 3.70E-42 calcium & mitochondrial duress 2 2.12E-58
11 SGTC_90 0870-0863 16.00 4.6 µM 6.71E-42 3 4.89E-58
12 SGTC_55 0767-0285 16.00 6.6 µM 9.22E-42 1 7.64E-58
13 SGTC_2810 7959871 15.20 45.5 µM 9.54E-38 copper-dependent oxidative stress 1 3.28E-52
14 SGTC_352 k048-0007 15.20 5.1 µM 1.02E-37 ERAD & cell cycle 4 3.61E-52
15 SGTC_788 1182-0090 14.60 188.0 µM 4.04E-35 endomembrane recycling 7 1.59E-48
16 SGTC_2248 tofa 13.70 1.1 µM 2.38E-31 sphingolipid biosynthesis & PDR1 6 3.08E-43
17 SGTC_908 3448-7491 13.60 47.7 µM 7.04E-31 mitochondrial stress 2 1.41E-42
18 SGTC_660 4031-1742 13.40 102.0 µM 4.52E-30 redox potentiating 3 1.91E-41
19 SGTC_3 0833-0587 12.50 95.6 µM 2.25E-26 redox potentiating 1 2.92E-36
20 SGTC_3303 9125618 11.40 40.6 µM 4.91E-22 3 3.51E-30

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.545 2.51E-258 YDR010C_d YDR010C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.190 1.44E-28 YGL094C PAN2 hom Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes
0.175 1.82E-24 YKR028W SAP190 hom Protein that forms a complex with the Sit4p protein phosphatase; required for Sit4p function; member of a family of similar proteins including Sap4p, Sap155p, and Sap185p; SAP190 has a paralog, SAP185, that arose from the whole genome duplication
0.146 1.83E-17 YNL149C PGA2 het Essential protein required for maturation of Gas1p and Pho8p; involved in protein trafficking; GFP-fusion protein localizes to the ER and YFP-fusion protein to the nuclear envelope-ER network; null mutants have a cell separation defect
0.144 5.00E-17 YDR269C_d YDR269C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.142 1.12E-16 YGL013C PDR1 hom Transcription factor that regulates the pleiotropic drug response; zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance genes; PDR1 has a paralog, PDR3, that arose from the whole genome duplication
0.123 7.79E-13 YGL025C PGD1 hom Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for basal and activated transcription; direct target of Cyc8p-Tup1p transcriptional corepressor
0.123 1.03E-12 YGL012W ERG4 hom C-24(28) sterol reductase, catalyzes the final step in ergosterol biosynthesis; mutants are viable, but lack ergosterol
0.122 1.55E-12 YER177W BMH1 hom 14-3-3 protein, major isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress
0.113 4.51E-11 YKL025C PAN3 hom Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes
0.111 9.84E-11 YOL051W GAL11 hom Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; affects transcription by acting as target of activators and repressors; forms part of the tail domain of mediator
0.111 1.02E-10 YOR162C YRR1 hom Zn2-Cys6 zinc-finger transcription factor; activates genes involved in multidrug resistance; paralog of Yrm1p, acting on an overlapping set of target genes; YRR1 has a paralog, PDR8, that arose from the whole genome duplication
0.110 1.77E-10 YKR052C MRS4 hom Iron transporter of the mitochondrial carrier family; mediates Fe2+ transport across the inner mitochondrial membrane; active under low-iron conditions; may transport other cations; protein abundance increases in response to DNA replication stress; MRS4 has a paralog, MRS3, that arose from the whole genome duplication
0.109 2.34E-10 YKL216W URA1 hom Dihydroorotate dehydrogenase, catalyzes the fourth enzymatic step in the de novo biosynthesis of pyrimidines, converting dihydroorotic acid into orotic acid
0.107 4.42E-10 YLR135W SLX4 hom Endonuclease involved in processing DNA; acts during recombination and repair; cleaves branched structures in a complex with Slx1p; involved interstrand cross-link repair and in Rad1p/Rad10p-dependent removal of 3'-nonhomologous tails during DSBR via single-strand annealing; relative distribution to nuclear foci increases upon DNA replication stress