YDR013W / PSF1

Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDR013W / PSF1

Click on Significant Values for Screen Details ID:SGTC_79|Compound:0052-0007|FD-Score:3.19|P-value:3.95E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-3.89|P-value:2.30E-5 ID:SGTC_166|Compound:k072-0058|FD-Score:-2.99|P-value:8.76E-4 ID:SGTC_504|Compound:lovastatin|FD-Score:3.11|P-value:5.21E-4 ID:SGTC_505|Compound:gw-5074|FD-Score:3.21|P-value:3.56E-4 ID:SGTC_511|Compound:blebbistatin|FD-Score:3.14|P-value:4.76E-4 ID:SGTC_531|Compound:3788-1495|FD-Score:-3.53|P-value:1.10E-4 ID:SGTC_631|Compound:k072-0230|FD-Score:3.84|P-value:2.66E-5 ID:SGTC_633|Compound:0437-0093|FD-Score:-3.53|P-value:1.08E-4 ID:SGTC_636|Compound:0kpi-0074|FD-Score:-3.47|P-value:1.43E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:-3.41|P-value:1.81E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:3.74|P-value:4.09E-5 ID:SGTC_932|Compound:2857-0803|FD-Score:3.26|P-value:2.91E-4 ID:SGTC_1034|Compound:k072-0165|FD-Score:-3.07|P-value:6.65E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-5.09|P-value:4.87E-8 ID:SGTC_1107|Compound:amlodipine|FD-Score:-5.01|P-value:7.49E-8 ID:SGTC_1383|Compound:3049-0032|FD-Score:3.31|P-value:2.47E-4 ID:SGTC_1401|Compound:3807-4679|FD-Score:-3.19|P-value:4.21E-4 ID:SGTC_1506|Compound:4226-2149|FD-Score:3.07|P-value:6.15E-4 ID:SGTC_1526|Compound:st051518|FD-Score:-3.39|P-value:1.92E-4 ID:SGTC_1542|Compound:7-hydroxy-3'-methoxyflavone|FD-Score:-3.04|P-value:7.27E-4 ID:SGTC_1553|Compound:gossypol|FD-Score:3.53|P-value:1.01E-4 ID:SGTC_1733|Compound:st037357|FD-Score:3.18|P-value:4.09E-4 ID:SGTC_1838|Compound:st055369|FD-Score:2.98|P-value:8.49E-4 ID:SGTC_1916|Compound:st067606|FD-Score:-4.19|P-value:5.71E-6 ID:SGTC_1970|Compound:st070122|FD-Score:3.45|P-value:1.37E-4 ID:SGTC_1982|Compound:st072467|FD-Score:3.31|P-value:2.40E-4 ID:SGTC_1996|Compound:st072960|FD-Score:4.47|P-value:1.24E-6 ID:SGTC_2002|Compound:4023503|FD-Score:-3.97|P-value:1.63E-5 ID:SGTC_2011|Compound:4012611|FD-Score:4.89|P-value:1.31E-7 ID:SGTC_2053|Compound:5265679|FD-Score:-5.39|P-value:7.95E-9 ID:SGTC_2054|Compound:5233173|FD-Score:-7.83|P-value:1.08E-16 ID:SGTC_2059|Compound:5238311|FD-Score:4.20|P-value:4.95E-6 ID:SGTC_2079|Compound:5212404|FD-Score:3.61|P-value:7.17E-5 ID:SGTC_2081|Compound:5214970|FD-Score:3.47|P-value:1.27E-4 ID:SGTC_2160|Compound:5660466|FD-Score:3.64|P-value:6.42E-5 ID:SGTC_2253|Compound:7938677|FD-Score:4.66|P-value:4.73E-7 ID:SGTC_2282|Compound:7944268|FD-Score:-5.46|P-value:5.20E-9 ID:SGTC_2284|Compound:7945075|FD-Score:-9.19|P-value:2.87E-22 ID:SGTC_2285|Compound:7945142|FD-Score:10.10|P-value:1.40E-26 ID:SGTC_2287|Compound:7945887|FD-Score:-7.49|P-value:2.00E-15 ID:SGTC_2302|Compound:7771753|FD-Score:-5.14|P-value:3.57E-8 ID:SGTC_2308|Compound:7584454|FD-Score:5.07|P-value:4.67E-8 ID:SGTC_2310|Compound:7668677|FD-Score:3.03|P-value:7.03E-4 ID:SGTC_2344|Compound:7990960|FD-Score:-3.05|P-value:7.01E-4 ID:SGTC_2349|Compound:9023730|FD-Score:3.52|P-value:1.04E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:-4.53|P-value:1.06E-6 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:3.19|P-value:3.95E-4 ID:SGTC_2416|Compound:tofa|FD-Score:-3.26|P-value:3.19E-4 ID:SGTC_2433|Compound:5607874|FD-Score:-3.43|P-value:1.66E-4 ID:SGTC_2479|Compound:5617353|FD-Score:4.33|P-value:2.54E-6 ID:SGTC_2568|Compound:diosmetin|FD-Score:3.57|P-value:8.40E-5 ID:SGTC_2569|Compound:tetrandrine|FD-Score:3.83|P-value:2.74E-5 ID:SGTC_2807|Compound:7945238|FD-Score:3.11|P-value:5.27E-4 ID:SGTC_2841|Compound:9004761|FD-Score:-3.74|P-value:4.55E-5 ID:SGTC_2908|Compound:7930301|FD-Score:-3.09|P-value:6.20E-4 ID:SGTC_2922|Compound:7999257|FD-Score:3.31|P-value:2.46E-4 ID:SGTC_2955|Compound:9076254|FD-Score:-3.62|P-value:7.57E-5 ID:SGTC_2957|Compound:9076800|FD-Score:-4.17|P-value:6.32E-6 ID:SGTC_2960|Compound:9079389|FD-Score:-4.27|P-value:3.79E-6 ID:SGTC_2981|Compound:9013952|FD-Score:-5.67|P-value:1.45E-9 ID:SGTC_2985|Compound:9022375|FD-Score:-3.66|P-value:6.45E-5 ID:SGTC_3025|Compound:9087895|FD-Score:-3.21|P-value:3.94E-4 ID:SGTC_3026|Compound:9090633|FD-Score:2.96|P-value:9.14E-4 ID:SGTC_3067|Compound:9117431|FD-Score:3.65|P-value:6.04E-5 ID:SGTC_3076|Compound:9116187|FD-Score:-3.45|P-value:1.50E-4 ID:SGTC_3188|Compound:9110789|FD-Score:3.19|P-value:3.83E-4 ID:SGTC_79|Compound:0052-0007|FD-Score:3.19|P-value:3.95E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-3.89|P-value:2.30E-5 ID:SGTC_166|Compound:k072-0058|FD-Score:-2.99|P-value:8.76E-4 ID:SGTC_504|Compound:lovastatin|FD-Score:3.11|P-value:5.21E-4 ID:SGTC_505|Compound:gw-5074|FD-Score:3.21|P-value:3.56E-4 ID:SGTC_511|Compound:blebbistatin|FD-Score:3.14|P-value:4.76E-4 ID:SGTC_531|Compound:3788-1495|FD-Score:-3.53|P-value:1.10E-4 ID:SGTC_631|Compound:k072-0230|FD-Score:3.84|P-value:2.66E-5 ID:SGTC_633|Compound:0437-0093|FD-Score:-3.53|P-value:1.08E-4 ID:SGTC_636|Compound:0kpi-0074|FD-Score:-3.47|P-value:1.43E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:-3.41|P-value:1.81E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:3.74|P-value:4.09E-5 ID:SGTC_932|Compound:2857-0803|FD-Score:3.26|P-value:2.91E-4 ID:SGTC_1034|Compound:k072-0165|FD-Score:-3.07|P-value:6.65E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-5.09|P-value:4.87E-8 ID:SGTC_1107|Compound:amlodipine|FD-Score:-5.01|P-value:7.49E-8 ID:SGTC_1383|Compound:3049-0032|FD-Score:3.31|P-value:2.47E-4 ID:SGTC_1401|Compound:3807-4679|FD-Score:-3.19|P-value:4.21E-4 ID:SGTC_1506|Compound:4226-2149|FD-Score:3.07|P-value:6.15E-4 ID:SGTC_1526|Compound:st051518|FD-Score:-3.39|P-value:1.92E-4 ID:SGTC_1542|Compound:7-hydroxy-3'-methoxyflavone|FD-Score:-3.04|P-value:7.27E-4 ID:SGTC_1553|Compound:gossypol|FD-Score:3.53|P-value:1.01E-4 ID:SGTC_1733|Compound:st037357|FD-Score:3.18|P-value:4.09E-4 ID:SGTC_1838|Compound:st055369|FD-Score:2.98|P-value:8.49E-4 ID:SGTC_1916|Compound:st067606|FD-Score:-4.19|P-value:5.71E-6 ID:SGTC_1970|Compound:st070122|FD-Score:3.45|P-value:1.37E-4 ID:SGTC_1982|Compound:st072467|FD-Score:3.31|P-value:2.40E-4 ID:SGTC_1996|Compound:st072960|FD-Score:4.47|P-value:1.24E-6 ID:SGTC_2002|Compound:4023503|FD-Score:-3.97|P-value:1.63E-5 ID:SGTC_2011|Compound:4012611|FD-Score:4.89|P-value:1.31E-7 ID:SGTC_2053|Compound:5265679|FD-Score:-5.39|P-value:7.95E-9 ID:SGTC_2054|Compound:5233173|FD-Score:-7.83|P-value:1.08E-16 ID:SGTC_2059|Compound:5238311|FD-Score:4.20|P-value:4.95E-6 ID:SGTC_2079|Compound:5212404|FD-Score:3.61|P-value:7.17E-5 ID:SGTC_2081|Compound:5214970|FD-Score:3.47|P-value:1.27E-4 ID:SGTC_2160|Compound:5660466|FD-Score:3.64|P-value:6.42E-5 ID:SGTC_2253|Compound:7938677|FD-Score:4.66|P-value:4.73E-7 ID:SGTC_2282|Compound:7944268|FD-Score:-5.46|P-value:5.20E-9 ID:SGTC_2284|Compound:7945075|FD-Score:-9.19|P-value:2.87E-22 ID:SGTC_2285|Compound:7945142|FD-Score:10.10|P-value:1.40E-26 ID:SGTC_2287|Compound:7945887|FD-Score:-7.49|P-value:2.00E-15 ID:SGTC_2302|Compound:7771753|FD-Score:-5.14|P-value:3.57E-8 ID:SGTC_2308|Compound:7584454|FD-Score:5.07|P-value:4.67E-8 ID:SGTC_2310|Compound:7668677|FD-Score:3.03|P-value:7.03E-4 ID:SGTC_2344|Compound:7990960|FD-Score:-3.05|P-value:7.01E-4 ID:SGTC_2349|Compound:9023730|FD-Score:3.52|P-value:1.04E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:-4.53|P-value:1.06E-6 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:3.19|P-value:3.95E-4 ID:SGTC_2416|Compound:tofa|FD-Score:-3.26|P-value:3.19E-4 ID:SGTC_2433|Compound:5607874|FD-Score:-3.43|P-value:1.66E-4 ID:SGTC_2479|Compound:5617353|FD-Score:4.33|P-value:2.54E-6 ID:SGTC_2568|Compound:diosmetin|FD-Score:3.57|P-value:8.40E-5 ID:SGTC_2569|Compound:tetrandrine|FD-Score:3.83|P-value:2.74E-5 ID:SGTC_2807|Compound:7945238|FD-Score:3.11|P-value:5.27E-4 ID:SGTC_2841|Compound:9004761|FD-Score:-3.74|P-value:4.55E-5 ID:SGTC_2908|Compound:7930301|FD-Score:-3.09|P-value:6.20E-4 ID:SGTC_2922|Compound:7999257|FD-Score:3.31|P-value:2.46E-4 ID:SGTC_2955|Compound:9076254|FD-Score:-3.62|P-value:7.57E-5 ID:SGTC_2957|Compound:9076800|FD-Score:-4.17|P-value:6.32E-6 ID:SGTC_2960|Compound:9079389|FD-Score:-4.27|P-value:3.79E-6 ID:SGTC_2981|Compound:9013952|FD-Score:-5.67|P-value:1.45E-9 ID:SGTC_2985|Compound:9022375|FD-Score:-3.66|P-value:6.45E-5 ID:SGTC_3025|Compound:9087895|FD-Score:-3.21|P-value:3.94E-4 ID:SGTC_3026|Compound:9090633|FD-Score:2.96|P-value:9.14E-4 ID:SGTC_3067|Compound:9117431|FD-Score:3.65|P-value:6.04E-5 ID:SGTC_3076|Compound:9116187|FD-Score:-3.45|P-value:1.50E-4 ID:SGTC_3188|Compound:9110789|FD-Score:3.19|P-value:3.83E-4

Top fitness defect scores for YDR013W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2285 7945142 10.10 200.0 µM 1.40E-26 1 3.11E-24 2.61
2 SGTC_2308 7584454 5.07 197.6 µM 4.67E-8 5 1.96E-7 0.34
3 SGTC_2011 4012611 4.89 177.0 µM 1.31E-7 mitochondrial processes 6 5.00E-7 0.40
4 SGTC_2253 7938677 4.66 135.8 µM 4.73E-7 3 1.60E-6 0.79
5 SGTC_1996 st072960 4.47 66.8 µM 1.24E-6 3 3.83E-6 0.52
6 SGTC_2479 5617353 4.33 43.9 µM 2.54E-6 3 7.37E-6 0.03
7 SGTC_2059 5238311 4.20 157.0 µM 4.95E-6 3 1.35E-5 0.18
8 SGTC_631 k072-0230 3.84 41.5 µM 2.66E-5 60S ribosome export 6 6.21E-5 0.07
9 SGTC_2569 tetrandrine 3.83 100.0 µM 2.74E-5 3 6.39E-5 0.00
10 SGTC_908 3448-7491 3.74 47.7 µM 4.09E-5 mitochondrial stress 10 9.21E-5 0.16
11 SGTC_3067 9117431 3.65 49.5 µM 6.04E-5 11 1.31E-4 0.13
12 SGTC_2160 5660466 3.64 132.9 µM 6.42E-5 60S ribosome export 18 1.39E-4 0.03
13 SGTC_2079 5212404 3.61 121.0 µM 7.17E-5 3 1.53E-4 0.18
14 SGTC_2568 diosmetin 3.57 100.0 µM 8.40E-5 15 1.77E-4 0.07
15 SGTC_1553 gossypol 3.53 38.6 µM 1.01E-4 3 2.09E-4 0.58
16 SGTC_2349 9023730 3.52 187.1 µM 1.04E-4 6 2.15E-4 0.36
17 SGTC_2081 5214970 3.47 32.3 µM 1.27E-4 3 2.58E-4 0.04
18 SGTC_1970 st070122 3.45 35.8 µM 1.37E-4 TSC3-RPN4 13 2.75E-4 0.06
19 SGTC_1982 st072467 3.31 71.9 µM 2.40E-4 14 4.59E-4 0.14
20 SGTC_2922 7999257 3.31 32.5 µM 2.46E-4 12 4.71E-4 0.23

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.222 1.14E-38 YKL071W_p YKL071W_p hom Putative protein of unknown function; expression induced in cells treated with the mycotoxin patulin, and also the quinone methide triterpene celastrol; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.147 8.76E-18 YDR037W KRS1 het Lysyl-tRNA synthetase
0.144 4.81E-17 YFR042W KEG1 het Integral membrane protein of the ER; physically interacts with Kre6p; has a role in the synthesis of beta-1,6-glucan in the cell wall; required for cell viability
0.136 2.11E-15 YDR201W SPC19 het Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; also localized to nuclear side of spindle pole body
0.133 9.50E-15 YDR434W GPI17 het Transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins; human PIG-S homolog
0.127 1.74E-13 YKL122C SRP21 het Subunit of the signal recognition particle (SRP), which functions in protein targeting to the endoplasmic reticulum membrane; not found in mammalian SRP; forms a pre-SRP structure in the nucleolus that is translocated to the cytoplasm
0.124 4.91E-13 YGR251W NOP19 het Ribosome biogenesis factor; nucleolar protein associated with pre-rRNA components of the 90S preribosome, required for cleavage of pre-rRNA at A0, A1 and A2 sites; interacts with RNA helicase Dhr2p and RNA helicase-like protein Utp25p; required for incorporation of Utp25p into preribosomes
0.118 7.34E-12 YPR026W ATH1 hom Acid trehalase required for utilization of extracellular trehalose
0.116 1.62E-11 YER159C BUR6 het Subunit of a heterodimeric NC2 transcription regulator complex with Ncb2p; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2alpha
0.109 2.12E-10 YLR209C PNP1 hom Purine nucleoside phosphorylase, specifically metabolizes inosine and guanosine nucleosides; involved in the nicotinamide riboside salvage pathway
0.108 3.70E-10 YOR304W ISW2 hom ATP-dependent DNA translocase involved in chromatin remodeling; ATPase component that, with Itc1p, forms a complex required for repression of a-specific genes, INO1, and early meiotic genes during mitotic growth
0.107 5.37E-10 YGL081W_p YGL081W_p hom Putative protein of unknown function; non-essential gene; interacts genetically with CHS5, a gene involved in chitin biosynthesis
0.106 7.43E-10 YER064C VHR2 hom Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.103 1.99E-9 YDL060W TSR1 het Protein required for processing of 20S pre-rRNA in the cytoplasm; associates with pre-40S ribosomal particles; inhibits the premature association of 60S subunits with assembling 40S subunits in the cytoplasm; similar to Bms1p; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.103 2.31E-9 YNL102W POL1 het Catalytic subunit of the DNA polymerase I alpha-primase complex, required for the initiation of DNA replication during mitotic DNA synthesis and premeiotic DNA synthesis