YDR015C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene HED1/YDR014W-A

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR015C / YDR015C

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:-3.45|P-value:1.29E-4 ID:SGTC_90|Compound:0870-0863|FD-Score:3.38|P-value:1.67E-4 ID:SGTC_143|Compound:4032-1194|FD-Score:3.00|P-value:7.28E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:3.24|P-value:2.89E-4 ID:SGTC_198|Compound:3454-2873|FD-Score:3.04|P-value:6.22E-4 ID:SGTC_349|Compound:k015-0014|FD-Score:3.52|P-value:9.44E-5 ID:SGTC_447|Compound:ml7|FD-Score:-3.47|P-value:1.17E-4 ID:SGTC_448|Compound:monastrol|FD-Score:-3.12|P-value:4.66E-4 ID:SGTC_668|Compound:1682-0499|FD-Score:3.61|P-value:6.34E-5 ID:SGTC_888|Compound:0916-0002|FD-Score:-3.27|P-value:2.67E-4 ID:SGTC_1029|Compound:k015-0030|FD-Score:-3.12|P-value:4.72E-4 ID:SGTC_1141|Compound:3253-0389|FD-Score:-3.50|P-value:1.04E-4 ID:SGTC_1173|Compound:0443-0020|FD-Score:3.36|P-value:1.84E-4 ID:SGTC_1182|Compound:1222-0449|FD-Score:-3.92|P-value:1.62E-5 ID:SGTC_1185|Compound:1319-0113|FD-Score:-2.96|P-value:8.40E-4 ID:SGTC_1218|Compound:1348-1416|FD-Score:-5.74|P-value:5.94E-10 ID:SGTC_1219|Compound:1469-0211|FD-Score:4.70|P-value:3.09E-7 ID:SGTC_1338|Compound:1486-1223|FD-Score:3.84|P-value:2.36E-5 ID:SGTC_1377|Compound:2944-0135|FD-Score:4.06|P-value:8.16E-6 ID:SGTC_1380|Compound:2291-0730|FD-Score:3.20|P-value:3.46E-4 ID:SGTC_1506|Compound:4226-2149|FD-Score:5.25|P-value:1.31E-8 ID:SGTC_1508|Compound:1080-0625|FD-Score:3.76|P-value:3.34E-5 ID:SGTC_1514|Compound:1189-1591|FD-Score:4.07|P-value:7.91E-6 ID:SGTC_1515|Compound:3460-0031|FD-Score:-4.34|P-value:2.12E-6 ID:SGTC_1578|Compound:josamycin|FD-Score:3.71|P-value:4.25E-5 ID:SGTC_1579|Compound:chlormadinone acetate|FD-Score:3.35|P-value:1.93E-4 ID:SGTC_1753|Compound:st043925|FD-Score:-3.51|P-value:9.99E-5 ID:SGTC_1931|Compound:st074438|FD-Score:3.55|P-value:8.25E-5 ID:SGTC_1936|Compound:st074407|FD-Score:3.19|P-value:3.55E-4 ID:SGTC_1980|Compound:st071811|FD-Score:3.33|P-value:2.04E-4 ID:SGTC_2204|Compound:7233102|FD-Score:3.41|P-value:1.49E-4 ID:SGTC_2313|Compound:7726885|FD-Score:2.94|P-value:9.02E-4 ID:SGTC_2316|Compound:5844804|FD-Score:-3.07|P-value:5.68E-4 ID:SGTC_2404|Compound:5161160|FD-Score:-3.22|P-value:3.19E-4 ID:SGTC_2438|Compound:5259590|FD-Score:-2.99|P-value:7.78E-4 ID:SGTC_2475|Compound:5812728|FD-Score:2.97|P-value:8.02E-4 ID:SGTC_2480|Compound:5767542|FD-Score:-3.35|P-value:1.92E-4 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:3.02|P-value:6.89E-4 ID:SGTC_2537|Compound:larixol|FD-Score:-3.39|P-value:1.60E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:3.27|P-value:2.64E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:-3.60|P-value:6.70E-5 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:2.93|P-value:9.47E-4 ID:SGTC_2616|Compound:abietic acid|FD-Score:5.19|P-value:1.90E-8 ID:SGTC_2784|Compound:7567673|FD-Score:4.07|P-value:7.86E-6 ID:SGTC_2865|Compound:9030313|FD-Score:2.92|P-value:9.80E-4 ID:SGTC_3208|Compound:9114115|FD-Score:3.00|P-value:7.25E-4 ID:SGTC_3343|Compound:9148379|FD-Score:6.41|P-value:5.23E-12 ID:SGTC_3346|Compound:9158254|FD-Score:-3.15|P-value:4.27E-4 ID:SGTC_3350|Compound:9150499|FD-Score:-3.24|P-value:2.95E-4 ID:SGTC_3354|Compound:9151612|FD-Score:3.80|P-value:2.75E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.45|P-value:1.29E-4 ID:SGTC_90|Compound:0870-0863|FD-Score:3.38|P-value:1.67E-4 ID:SGTC_143|Compound:4032-1194|FD-Score:3.00|P-value:7.28E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:3.24|P-value:2.89E-4 ID:SGTC_198|Compound:3454-2873|FD-Score:3.04|P-value:6.22E-4 ID:SGTC_349|Compound:k015-0014|FD-Score:3.52|P-value:9.44E-5 ID:SGTC_447|Compound:ml7|FD-Score:-3.47|P-value:1.17E-4 ID:SGTC_448|Compound:monastrol|FD-Score:-3.12|P-value:4.66E-4 ID:SGTC_668|Compound:1682-0499|FD-Score:3.61|P-value:6.34E-5 ID:SGTC_888|Compound:0916-0002|FD-Score:-3.27|P-value:2.67E-4 ID:SGTC_1029|Compound:k015-0030|FD-Score:-3.12|P-value:4.72E-4 ID:SGTC_1141|Compound:3253-0389|FD-Score:-3.50|P-value:1.04E-4 ID:SGTC_1173|Compound:0443-0020|FD-Score:3.36|P-value:1.84E-4 ID:SGTC_1182|Compound:1222-0449|FD-Score:-3.92|P-value:1.62E-5 ID:SGTC_1185|Compound:1319-0113|FD-Score:-2.96|P-value:8.40E-4 ID:SGTC_1218|Compound:1348-1416|FD-Score:-5.74|P-value:5.94E-10 ID:SGTC_1219|Compound:1469-0211|FD-Score:4.70|P-value:3.09E-7 ID:SGTC_1338|Compound:1486-1223|FD-Score:3.84|P-value:2.36E-5 ID:SGTC_1377|Compound:2944-0135|FD-Score:4.06|P-value:8.16E-6 ID:SGTC_1380|Compound:2291-0730|FD-Score:3.20|P-value:3.46E-4 ID:SGTC_1506|Compound:4226-2149|FD-Score:5.25|P-value:1.31E-8 ID:SGTC_1508|Compound:1080-0625|FD-Score:3.76|P-value:3.34E-5 ID:SGTC_1514|Compound:1189-1591|FD-Score:4.07|P-value:7.91E-6 ID:SGTC_1515|Compound:3460-0031|FD-Score:-4.34|P-value:2.12E-6 ID:SGTC_1578|Compound:josamycin|FD-Score:3.71|P-value:4.25E-5 ID:SGTC_1579|Compound:chlormadinone acetate|FD-Score:3.35|P-value:1.93E-4 ID:SGTC_1753|Compound:st043925|FD-Score:-3.51|P-value:9.99E-5 ID:SGTC_1931|Compound:st074438|FD-Score:3.55|P-value:8.25E-5 ID:SGTC_1936|Compound:st074407|FD-Score:3.19|P-value:3.55E-4 ID:SGTC_1980|Compound:st071811|FD-Score:3.33|P-value:2.04E-4 ID:SGTC_2204|Compound:7233102|FD-Score:3.41|P-value:1.49E-4 ID:SGTC_2313|Compound:7726885|FD-Score:2.94|P-value:9.02E-4 ID:SGTC_2316|Compound:5844804|FD-Score:-3.07|P-value:5.68E-4 ID:SGTC_2404|Compound:5161160|FD-Score:-3.22|P-value:3.19E-4 ID:SGTC_2438|Compound:5259590|FD-Score:-2.99|P-value:7.78E-4 ID:SGTC_2475|Compound:5812728|FD-Score:2.97|P-value:8.02E-4 ID:SGTC_2480|Compound:5767542|FD-Score:-3.35|P-value:1.92E-4 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:3.02|P-value:6.89E-4 ID:SGTC_2537|Compound:larixol|FD-Score:-3.39|P-value:1.60E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:3.27|P-value:2.64E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:-3.60|P-value:6.70E-5 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:2.93|P-value:9.47E-4 ID:SGTC_2616|Compound:abietic acid|FD-Score:5.19|P-value:1.90E-8 ID:SGTC_2784|Compound:7567673|FD-Score:4.07|P-value:7.86E-6 ID:SGTC_2865|Compound:9030313|FD-Score:2.92|P-value:9.80E-4 ID:SGTC_3208|Compound:9114115|FD-Score:3.00|P-value:7.25E-4 ID:SGTC_3343|Compound:9148379|FD-Score:6.41|P-value:5.23E-12 ID:SGTC_3346|Compound:9158254|FD-Score:-3.15|P-value:4.27E-4 ID:SGTC_3350|Compound:9150499|FD-Score:-3.24|P-value:2.95E-4 ID:SGTC_3354|Compound:9151612|FD-Score:3.80|P-value:2.75E-5

Top fitness defect scores for YDR015C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3343 9148379 6.41 19.0 µM 5.23E-12 1 7.19E-11
2 SGTC_1506 4226-2149 5.25 212.0 µM 1.31E-8 11 7.70E-8
3 SGTC_2616 abietic acid 5.19 100.0 µM 1.90E-8 15 1.08E-7
4 SGTC_1219 1469-0211 4.70 33.1 µM 3.09E-7 13 1.30E-6
5 SGTC_2784 7567673 4.07 72.7 µM 7.86E-6 iron homeostasis 26 2.34E-5
6 SGTC_1514 1189-1591 4.07 158.0 µM 7.91E-6 32 2.35E-5
7 SGTC_1377 2944-0135 4.06 198.0 µM 8.16E-6 calcium & mitochondrial duress 33 2.42E-5
8 SGTC_1338 1486-1223 3.84 76.0 µM 2.36E-5 29 6.24E-5
9 SGTC_3354 9151612 3.80 71.4 µM 2.75E-5 14 7.17E-5
10 SGTC_1508 1080-0625 3.76 72.9 µM 3.34E-5 24 8.52E-5
11 SGTC_1578 josamycin 3.71 24.2 µM 4.25E-5 16 1.06E-4
12 SGTC_668 1682-0499 3.61 62.6 µM 6.34E-5 31 1.51E-4
13 SGTC_1931 st074438 3.55 57.1 µM 8.25E-5 31 1.91E-4
14 SGTC_349 k015-0014 3.52 24.0 µM 9.44E-5 36 2.16E-4
15 SGTC_2204 7233102 3.41 200.0 µM 1.49E-4 60S ribosome export 10 3.24E-4
16 SGTC_90 0870-0863 3.38 4.6 µM 1.67E-4 71 3.59E-4
17 SGTC_1173 0443-0020 3.36 122.0 µM 1.84E-4 TSC3-RPN4 68 3.92E-4
18 SGTC_1579 chlormadinone acetate 3.35 49.4 µM 1.93E-4 26 4.09E-4
19 SGTC_1980 st071811 3.33 45.7 µM 2.04E-4 RPP1 & pyrimidine depletion 37 4.30E-4
20 SGTC_2538 3',7'-epoxycaryophyllan-6-one 3.27 100.0 µM 2.64E-4 44 5.43E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.101 4.09E-9 YDR406W PDR15 hom Plasma membrane ATP binding cassette (ABC) transporter, multidrug transporter and general stress response factor implicated in cellular detoxification; regulated by Pdr1p, Pdr3p and Pdr8p; promoter contains a PDR responsive element
0.091 1.25E-7 YBR097W VPS15 hom Serine/threonine protein kinase involved in vacuolar protein sorting; functions as a membrane-associated complex with Vps34p; active form recruits Vps34p to the Golgi membrane; interacts with the GDP-bound form of Gpa1p; myristoylated; a fraction is localized, with Vps34p, to nuclear pores at nucleus-vacuole junctions and may facilitate transcription elongation for genes positioned at the nuclear periphery
0.089 2.38E-7 YGR121C MEP1 hom Ammonium permease; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation
0.088 2.95E-7 YER046W SPO73 hom Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensible for both nuclear divisions during meiosis
0.084 1.04E-6 YJL109C UTP10 het Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA; mutant has increased aneuploidy tolerance
0.082 2.18E-6 YML058W SML1 hom Ribonucleotide reductase inhibitor involved in regulating dNTP production; regulated by Mec1p and Rad53p during DNA damage and S phase
0.081 2.94E-6 YDL236W PHO13 hom Alkaline phosphatase specific for p-nitrophenyl phosphate; also has protein phosphatase activity
0.077 7.91E-6 YOR144C ELG1 hom Subunit of an alternative replication factor C complex important for DNA replication and genome integrity; suppresses spontaneous DNA damage; involved in homologous recombination-mediated repair and telomere homeostasis; required for PCNA (Pol30p) unloading during DNA replication
0.076 9.78E-6 YGL047W ALG13 het Catalytic component of UDP-GlcNAc transferase; required for the second step of dolichyl-linked oligosaccharide synthesis; anchored to the ER membrane via interaction with Alg14p; similar to bacterial and human glycosyltransferases; protein abundance increases in response to DNA replication stress
0.076 1.10E-5 YMR147W_p YMR147W_p hom Putative protein of unknown function
0.075 1.41E-5 YLR397C AFG2 het ATPase of the CDC48/PAS1/SEC18 (AAA) family, forms a hexameric complex; is essential for pre-60S maturation and release of several preribosome maturation factors; releases Rlp24p from purified pre-60S particles in vitro; may be involved in degradation of aberrant mRNAs
0.073 2.25E-5 YPL137C GIP3 hom Cytoplasmic protein that regulates protein phosphatase 1 Glc7p; overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; may interact with ribosomes, based on co-purification experiments; GIP3 has a paralog, HER1, that arose from the whole genome duplication
0.070 4.88E-5 YDL201W TRM8 hom Noncatalytic subunit of a tRNA methyltransferase complex; Trm8p and Trm82p comprise an enzyme that catalyzes a methyl-transfer from S-adenosyl-l-methionine to the N(7) atom of guanine at position 46 in tRNA; Trm8 lacks catalytic activity if not bound to Trm82p
0.069 6.12E-5 YOL079W_d YOL079W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.067 1.02E-4 YNL219C ALG9 hom Mannosyltransferase, involved in N-linked glycosylation; catalyzes both the transfer of seventh mannose residue on B-arm and ninth mannose residue on the C-arm from Dol-P-Man to lipid-linked oligosaccharides; mutation of the human ortholog causes type 1 congenital disorders of glycosylation