YDR016C / DAD1

Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDR016C / DAD1

Click on Significant Values for Screen Details ID:SGTC_1|Compound:0258-0098|FD-Score:5.70|P-value:3.86E-8 ID:SGTC_22|Compound:0964-0034|FD-Score:6.21|P-value:2.37E-9 ID:SGTC_68|Compound:0986-0284|FD-Score:-3.96|P-value:1.15E-4 ID:SGTC_93|Compound:0109-0045|FD-Score:3.57|P-value:3.65E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:15.20|P-value:7.79E-47 ID:SGTC_144|Compound:4161-2749|FD-Score:-3.36|P-value:8.90E-4 ID:SGTC_288|Compound:1315-0019|FD-Score:10.40|P-value:7.70E-23 ID:SGTC_319|Compound:1348-1596|FD-Score:3.85|P-value:1.36E-4 ID:SGTC_324|Compound:1315-0088|FD-Score:5.58|P-value:7.02E-8 ID:SGTC_327|Compound:1273-0057|FD-Score:4.30|P-value:2.40E-5 ID:SGTC_329|Compound:k048-0121|FD-Score:8.86|P-value:3.85E-17 ID:SGTC_331|Compound:k048-0133|FD-Score:4.78|P-value:3.17E-6 ID:SGTC_407|Compound:eburnamonine|FD-Score:-3.42|P-value:7.39E-4 ID:SGTC_586|Compound:0957-0265|FD-Score:3.80|P-value:1.62E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:4.78|P-value:3.20E-6 ID:SGTC_673|Compound:1082-0474|FD-Score:5.17|P-value:5.45E-7 ID:SGTC_778|Compound:3456-2434|FD-Score:-4.65|P-value:7.37E-6 ID:SGTC_829|Compound:1635-0120|FD-Score:7.12|P-value:1.01E-11 ID:SGTC_959|Compound:1222-0044|FD-Score:4.37|P-value:1.82E-5 ID:SGTC_966|Compound:1300-0360|FD-Score:9.41|P-value:4.07E-19 ID:SGTC_1044|Compound:1222-0021|FD-Score:4.74|P-value:3.84E-6 ID:SGTC_1050|Compound:3232-1156|FD-Score:4.54|P-value:8.88E-6 ID:SGTC_1098|Compound:clofazimine|FD-Score:3.33|P-value:8.03E-4 ID:SGTC_1113|Compound:artemisinin|FD-Score:3.50|P-value:4.60E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:3.88|P-value:1.23E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:3.52|P-value:4.39E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:3.36|P-value:7.42E-4 ID:SGTC_1556|Compound:plumbagin|FD-Score:4.25|P-value:2.98E-5 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:-3.60|P-value:4.05E-4 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:-3.39|P-value:8.16E-4 ID:SGTC_1652|Compound:st011932|FD-Score:3.33|P-value:8.23E-4 ID:SGTC_1702|Compound:st027038|FD-Score:3.31|P-value:8.59E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:4.06|P-value:6.21E-5 ID:SGTC_1915|Compound:st067105|FD-Score:4.33|P-value:2.14E-5 ID:SGTC_1945|Compound:st075991|FD-Score:3.34|P-value:7.89E-4 ID:SGTC_1959|Compound:st077091|FD-Score:5.06|P-value:9.08E-7 ID:SGTC_2000|Compound:st075254|FD-Score:3.71|P-value:2.25E-4 ID:SGTC_2066|Compound:5222451|FD-Score:3.92|P-value:1.05E-4 ID:SGTC_2139|Compound:5578692|FD-Score:4.68|P-value:5.04E-6 ID:SGTC_2174|Compound:5790901|FD-Score:-3.36|P-value:8.95E-4 ID:SGTC_2225|Compound:6654152|FD-Score:5.82|P-value:2.04E-8 ID:SGTC_2233|Compound:sulbentine|FD-Score:10.00|P-value:2.21E-21 ID:SGTC_2295|Compound:7971645|FD-Score:3.60|P-value:3.34E-4 ID:SGTC_2344|Compound:7990960|FD-Score:6.02|P-value:6.93E-9 ID:SGTC_2348|Compound:9022543|FD-Score:3.91|P-value:1.11E-4 ID:SGTC_2396|Compound:5342950|FD-Score:4.80|P-value:2.97E-6 ID:SGTC_2408|Compound:sulbentine|FD-Score:6.19|P-value:2.73E-9 ID:SGTC_2759|Compound:disulfiram|FD-Score:3.70|P-value:2.37E-4 ID:SGTC_2799|Compound:7812892|FD-Score:6.68|P-value:1.59E-10 ID:SGTC_2830|Compound:7992007|FD-Score:4.11|P-value:5.24E-5 ID:SGTC_2867|Compound:9039098|FD-Score:-3.36|P-value:8.93E-4 ID:SGTC_2930|Compound:9013230|FD-Score:4.17|P-value:4.01E-5 ID:SGTC_2971|Compound:9092186|FD-Score:3.51|P-value:4.50E-4 ID:SGTC_3037|Compound:9091026|FD-Score:3.55|P-value:3.86E-4 ID:SGTC_3050|Compound:9093513|FD-Score:3.28|P-value:9.65E-4 ID:SGTC_3094|Compound:9117742|FD-Score:-3.46|P-value:6.46E-4 ID:SGTC_3155|Compound:9099265|FD-Score:-3.35|P-value:9.38E-4 ID:SGTC_3215|Compound:9129942|FD-Score:-3.49|P-value:5.79E-4 ID:SGTC_3247|Compound:9135149|FD-Score:3.34|P-value:7.83E-4 ID:SGTC_3264|Compound:9137442|FD-Score:-4.38|P-value:2.24E-5 ID:SGTC_3284|Compound:9108171|FD-Score:-5.94|P-value:1.50E-8 ID:SGTC_3285|Compound:9112818|FD-Score:3.86|P-value:1.32E-4 ID:SGTC_3293|Compound:9120939|FD-Score:3.55|P-value:3.95E-4 ID:SGTC_3348|Compound:9149464|FD-Score:-3.49|P-value:5.87E-4 ID:SGTC_1|Compound:0258-0098|FD-Score:5.70|P-value:3.86E-8 ID:SGTC_22|Compound:0964-0034|FD-Score:6.21|P-value:2.37E-9 ID:SGTC_68|Compound:0986-0284|FD-Score:-3.96|P-value:1.15E-4 ID:SGTC_93|Compound:0109-0045|FD-Score:3.57|P-value:3.65E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:15.20|P-value:7.79E-47 ID:SGTC_144|Compound:4161-2749|FD-Score:-3.36|P-value:8.90E-4 ID:SGTC_288|Compound:1315-0019|FD-Score:10.40|P-value:7.70E-23 ID:SGTC_319|Compound:1348-1596|FD-Score:3.85|P-value:1.36E-4 ID:SGTC_324|Compound:1315-0088|FD-Score:5.58|P-value:7.02E-8 ID:SGTC_327|Compound:1273-0057|FD-Score:4.30|P-value:2.40E-5 ID:SGTC_329|Compound:k048-0121|FD-Score:8.86|P-value:3.85E-17 ID:SGTC_331|Compound:k048-0133|FD-Score:4.78|P-value:3.17E-6 ID:SGTC_407|Compound:eburnamonine|FD-Score:-3.42|P-value:7.39E-4 ID:SGTC_586|Compound:0957-0265|FD-Score:3.80|P-value:1.62E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:4.78|P-value:3.20E-6 ID:SGTC_673|Compound:1082-0474|FD-Score:5.17|P-value:5.45E-7 ID:SGTC_778|Compound:3456-2434|FD-Score:-4.65|P-value:7.37E-6 ID:SGTC_829|Compound:1635-0120|FD-Score:7.12|P-value:1.01E-11 ID:SGTC_959|Compound:1222-0044|FD-Score:4.37|P-value:1.82E-5 ID:SGTC_966|Compound:1300-0360|FD-Score:9.41|P-value:4.07E-19 ID:SGTC_1044|Compound:1222-0021|FD-Score:4.74|P-value:3.84E-6 ID:SGTC_1050|Compound:3232-1156|FD-Score:4.54|P-value:8.88E-6 ID:SGTC_1098|Compound:clofazimine|FD-Score:3.33|P-value:8.03E-4 ID:SGTC_1113|Compound:artemisinin|FD-Score:3.50|P-value:4.60E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:3.88|P-value:1.23E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:3.52|P-value:4.39E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:3.36|P-value:7.42E-4 ID:SGTC_1556|Compound:plumbagin|FD-Score:4.25|P-value:2.98E-5 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:-3.60|P-value:4.05E-4 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:-3.39|P-value:8.16E-4 ID:SGTC_1652|Compound:st011932|FD-Score:3.33|P-value:8.23E-4 ID:SGTC_1702|Compound:st027038|FD-Score:3.31|P-value:8.59E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:4.06|P-value:6.21E-5 ID:SGTC_1915|Compound:st067105|FD-Score:4.33|P-value:2.14E-5 ID:SGTC_1945|Compound:st075991|FD-Score:3.34|P-value:7.89E-4 ID:SGTC_1959|Compound:st077091|FD-Score:5.06|P-value:9.08E-7 ID:SGTC_2000|Compound:st075254|FD-Score:3.71|P-value:2.25E-4 ID:SGTC_2066|Compound:5222451|FD-Score:3.92|P-value:1.05E-4 ID:SGTC_2139|Compound:5578692|FD-Score:4.68|P-value:5.04E-6 ID:SGTC_2174|Compound:5790901|FD-Score:-3.36|P-value:8.95E-4 ID:SGTC_2225|Compound:6654152|FD-Score:5.82|P-value:2.04E-8 ID:SGTC_2233|Compound:sulbentine|FD-Score:10.00|P-value:2.21E-21 ID:SGTC_2295|Compound:7971645|FD-Score:3.60|P-value:3.34E-4 ID:SGTC_2344|Compound:7990960|FD-Score:6.02|P-value:6.93E-9 ID:SGTC_2348|Compound:9022543|FD-Score:3.91|P-value:1.11E-4 ID:SGTC_2396|Compound:5342950|FD-Score:4.80|P-value:2.97E-6 ID:SGTC_2408|Compound:sulbentine|FD-Score:6.19|P-value:2.73E-9 ID:SGTC_2759|Compound:disulfiram|FD-Score:3.70|P-value:2.37E-4 ID:SGTC_2799|Compound:7812892|FD-Score:6.68|P-value:1.59E-10 ID:SGTC_2830|Compound:7992007|FD-Score:4.11|P-value:5.24E-5 ID:SGTC_2867|Compound:9039098|FD-Score:-3.36|P-value:8.93E-4 ID:SGTC_2930|Compound:9013230|FD-Score:4.17|P-value:4.01E-5 ID:SGTC_2971|Compound:9092186|FD-Score:3.51|P-value:4.50E-4 ID:SGTC_3037|Compound:9091026|FD-Score:3.55|P-value:3.86E-4 ID:SGTC_3050|Compound:9093513|FD-Score:3.28|P-value:9.65E-4 ID:SGTC_3094|Compound:9117742|FD-Score:-3.46|P-value:6.46E-4 ID:SGTC_3155|Compound:9099265|FD-Score:-3.35|P-value:9.38E-4 ID:SGTC_3215|Compound:9129942|FD-Score:-3.49|P-value:5.79E-4 ID:SGTC_3247|Compound:9135149|FD-Score:3.34|P-value:7.83E-4 ID:SGTC_3264|Compound:9137442|FD-Score:-4.38|P-value:2.24E-5 ID:SGTC_3284|Compound:9108171|FD-Score:-5.94|P-value:1.50E-8 ID:SGTC_3285|Compound:9112818|FD-Score:3.86|P-value:1.32E-4 ID:SGTC_3293|Compound:9120939|FD-Score:3.55|P-value:3.95E-4 ID:SGTC_3348|Compound:9149464|FD-Score:-3.49|P-value:5.87E-4

Top fitness defect scores for YDR016C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_138 0850-0259 15.20 40.9 µM 7.79E-47 cell wall 4 9.47E-53 1.97
2 SGTC_288 1315-0019 10.40 35.1 µM 7.70E-23 RSC & ERG11 1 1.47E-25 1.79
3 SGTC_2233 sulbentine 10.00 40.4 µM 2.21E-21 9 6.56E-24 0.60
4 SGTC_966 1300-0360 9.41 30.2 µM 4.07E-19 heme requiring 2 2.39E-21 2.11
5 SGTC_329 k048-0121 8.86 21.3 µM 3.85E-17 RSC & ERG11 2 4.12E-19 1.34
6 SGTC_829 1635-0120 7.12 117.0 µM 1.01E-11 DNA damage response 21 5.49E-13 0.21
7 SGTC_2799 7812892 6.68 81.8 µM 1.59E-10 superoxide 5 1.23E-11 0.38
8 SGTC_22 0964-0034 6.21 14.5 µM 2.37E-9 unfolded protein response 15 2.60E-10 0.11
9 SGTC_2408 sulbentine 6.19 18.4 µM 2.73E-9 19 3.05E-10 0.85
10 SGTC_2344 7990960 6.02 77.0 µM 6.93E-9 18 8.72E-10 0.18
11 SGTC_2225 6654152 5.82 15.4 µM 2.04E-8 16 2.95E-9 0.11
12 SGTC_1 0258-0098 5.70 57.4 µM 3.86E-8 heme biosynthesis & mitochondrial translocase 8 6.05E-9 0.03
13 SGTC_324 1315-0088 5.58 19.6 µM 7.02E-8 RSC & ERG11 5 1.19E-8 0.49
14 SGTC_673 1082-0474 5.17 110.0 µM 5.45E-7 RSC complex & mRNA processing 33 1.19E-7 0.07
15 SGTC_1959 st077091 5.06 55.8 µM 9.08E-7 RPP1 & pyrimidine depletion 17 2.12E-7 0.24
16 SGTC_2396 5342950 4.80 42.8 µM 2.97E-6 RSC complex & mRNA processing 20 8.02E-7 0.01
17 SGTC_331 k048-0133 4.78 24.5 µM 3.17E-6 RSC & ERG11 6 8.63E-7 0.07
18 SGTC_632 0781-2353 4.78 4.7 µM 3.20E-6 Golgi 12 8.74E-7 0.37
19 SGTC_1044 1222-0021 4.74 1.8 µM 3.84E-6 heme biosynthesis & mitochondrial translocase 27 1.07E-6 0.03
20 SGTC_2139 5578692 4.68 56.5 µM 5.04E-6 superoxide 8 1.46E-6 0.13

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.435 6.38E-155 YJL039C NUP192 het Essential subunit of the inner ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport; homologous to human NUP205
0.344 3.96E-94 YIL126W STH1 het ATPase component of the RSC chromatin remodeling complex; required for expression of early meiotic genes; essential helicase-related protein homologous to Snf2p
0.294 7.62E-68 YLR321C SFH1 het Component of the RSC chromatin remodeling complex; essential gene required for cell cycle progression and maintenance of proper ploidy; phosphorylated in the G1 phase of the cell cycle; Snf5p paralog
0.291 1.30E-66 YLR033W RSC58 het Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance
0.282 2.13E-62 YFR037C RSC8 het Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters
0.252 7.45E-50 YML127W RSC9 het Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway
0.249 1.34E-48 YMR033W ARP9 het Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation
0.237 4.45E-44 YBR091C TIM12 het Essential protein of the inner mitochondrial membrane, peripherally localized; component of the TIM22 complex, which is a twin-pore translocase that mediates insertion of numerous multispanning inner membrane proteins
0.226 4.69E-40 YDL205C HEM3 het Porphobilinogen deaminase, catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane, the third step in heme biosynthesis; localizes to the cytoplasm and nucleus; expression is regulated by Hap2p-Hap3p, but not by levels of heme
0.215 2.32E-36 YEL034W HYP2 het Translation elongation factor eIF-5A; may function in translation initiation; structural homolog of bacterial EF-P; undergoes an essential hypusination modification; HYP2 has a paralog, ANB1, that arose from the whole genome duplication
0.212 1.48E-35 YKR008W RSC4 het Component of the RSC chromatin remodeling complex; found in close proximity to nucleosomal DNA; displaced from the surface of nucleosomal DNA after chromatin remodeling; acetylated (K25) by Gcn5p, altering replication stress tolerance; contains tandem bromodomains that recognize histone H3 acetylated on K14 (H3K14ac) by Gcn5p
0.211 5.42E-35 YER165W PAB1 het Poly(A) binding protein, part of the 3'-end RNA-processing complex, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G
0.210 7.88E-35 YDR540C IRC4 hom Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
0.204 8.79E-33 YBR192W RIM2 het Mitochondrial pyrimidine nucleotide transporter; imports pyrimidine nucleoside triphosphates and exports pyrimidine nucleoside monophosphates; member of the mitochondrial carrier family
0.201 7.98E-32 YPR033C HTS1 het Cytoplasmic and mitochondrial histidine tRNA synthetase; efficient mitochondrial localization requires both a presequence and an amino-terminal sequence; mutations in human ortholog HARS2 are associated with Perrault syndrome