YDR021W / FAL1

Nucleolar protein required for maturation of 18S rRNA, member of the eIF4A subfamily of DEAD-box ATP-dependent RNA helicases

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDR021W / FAL1

Click on Significant Values for Screen Details ID:SGTC_116|Compound:0155-0182|FD-Score:-4.38|P-value:2.60E-7 ID:SGTC_182|Compound:3448-4371|FD-Score:2.69|P-value:9.40E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:4.57|P-value:6.78E-8 ID:SGTC_264|Compound:promethazine|FD-Score:-2.82|P-value:6.30E-4 ID:SGTC_561|Compound:1550-0330|FD-Score:2.79|P-value:6.44E-4 ID:SGTC_740|Compound:k014-0057|FD-Score:2.86|P-value:4.76E-4 ID:SGTC_764|Compound:1951-2361|FD-Score:3.95|P-value:2.61E-6 ID:SGTC_766|Compound:1391-0721|FD-Score:2.71|P-value:8.96E-4 ID:SGTC_842|Compound:0271-0008|FD-Score:2.71|P-value:8.93E-4 ID:SGTC_885|Compound:0865-0106|FD-Score:-2.90|P-value:4.39E-4 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:-2.99|P-value:3.05E-4 ID:SGTC_1171|Compound:0368-0077|FD-Score:2.88|P-value:4.48E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:4.23|P-value:5.29E-7 ID:SGTC_1435|Compound:4092-0789|FD-Score:2.78|P-value:6.71E-4 ID:SGTC_1494|Compound:4358-1428|FD-Score:3.50|P-value:2.70E-5 ID:SGTC_1545|Compound:lovastatin|FD-Score:2.68|P-value:9.87E-4 ID:SGTC_1579|Compound:chlormadinone acetate|FD-Score:3.14|P-value:1.45E-4 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:2.73|P-value:8.14E-4 ID:SGTC_1587|Compound:estradiol valerate|FD-Score:-4.12|P-value:1.16E-6 ID:SGTC_1690|Compound:st023502|FD-Score:-3.34|P-value:6.59E-5 ID:SGTC_1724|Compound:st037281|FD-Score:-3.13|P-value:1.68E-4 ID:SGTC_1727|Compound:st034309|FD-Score:4.39|P-value:2.08E-7 ID:SGTC_1731|Compound:st035964|FD-Score:-2.82|P-value:6.28E-4 ID:SGTC_1732|Compound:st034308|FD-Score:5.71|P-value:2.45E-11 ID:SGTC_1736|Compound:st036774|FD-Score:3.03|P-value:2.35E-4 ID:SGTC_2285|Compound:7945142|FD-Score:2.74|P-value:7.87E-4 ID:SGTC_2381|Compound:9035592|FD-Score:4.17|P-value:7.81E-7 ID:SGTC_2387|Compound:9077560|FD-Score:3.27|P-value:7.97E-5 ID:SGTC_2456|Compound:5770359|FD-Score:3.58|P-value:1.79E-5 ID:SGTC_2462|Compound:5162487|FD-Score:3.60|P-value:1.61E-5 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:2.82|P-value:5.79E-4 ID:SGTC_2958|Compound:9077254|FD-Score:3.00|P-value:2.66E-4 ID:SGTC_2960|Compound:9079389|FD-Score:4.30|P-value:3.50E-7 ID:SGTC_2965|Compound:9082772|FD-Score:-5.45|P-value:2.00E-10 ID:SGTC_2966|Compound:9084041|FD-Score:-3.02|P-value:2.66E-4 ID:SGTC_3006|Compound:9075424|FD-Score:-2.77|P-value:7.67E-4 ID:SGTC_3150|Compound:9097574|FD-Score:3.07|P-value:2.00E-4 ID:SGTC_3158|Compound:9100007|FD-Score:-2.93|P-value:3.87E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:-4.38|P-value:2.60E-7 ID:SGTC_182|Compound:3448-4371|FD-Score:2.69|P-value:9.40E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:4.57|P-value:6.78E-8 ID:SGTC_264|Compound:promethazine|FD-Score:-2.82|P-value:6.30E-4 ID:SGTC_561|Compound:1550-0330|FD-Score:2.79|P-value:6.44E-4 ID:SGTC_740|Compound:k014-0057|FD-Score:2.86|P-value:4.76E-4 ID:SGTC_764|Compound:1951-2361|FD-Score:3.95|P-value:2.61E-6 ID:SGTC_766|Compound:1391-0721|FD-Score:2.71|P-value:8.96E-4 ID:SGTC_842|Compound:0271-0008|FD-Score:2.71|P-value:8.93E-4 ID:SGTC_885|Compound:0865-0106|FD-Score:-2.90|P-value:4.39E-4 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:-2.99|P-value:3.05E-4 ID:SGTC_1171|Compound:0368-0077|FD-Score:2.88|P-value:4.48E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:4.23|P-value:5.29E-7 ID:SGTC_1435|Compound:4092-0789|FD-Score:2.78|P-value:6.71E-4 ID:SGTC_1494|Compound:4358-1428|FD-Score:3.50|P-value:2.70E-5 ID:SGTC_1545|Compound:lovastatin|FD-Score:2.68|P-value:9.87E-4 ID:SGTC_1579|Compound:chlormadinone acetate|FD-Score:3.14|P-value:1.45E-4 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:2.73|P-value:8.14E-4 ID:SGTC_1587|Compound:estradiol valerate|FD-Score:-4.12|P-value:1.16E-6 ID:SGTC_1690|Compound:st023502|FD-Score:-3.34|P-value:6.59E-5 ID:SGTC_1724|Compound:st037281|FD-Score:-3.13|P-value:1.68E-4 ID:SGTC_1727|Compound:st034309|FD-Score:4.39|P-value:2.08E-7 ID:SGTC_1731|Compound:st035964|FD-Score:-2.82|P-value:6.28E-4 ID:SGTC_1732|Compound:st034308|FD-Score:5.71|P-value:2.45E-11 ID:SGTC_1736|Compound:st036774|FD-Score:3.03|P-value:2.35E-4 ID:SGTC_2285|Compound:7945142|FD-Score:2.74|P-value:7.87E-4 ID:SGTC_2381|Compound:9035592|FD-Score:4.17|P-value:7.81E-7 ID:SGTC_2387|Compound:9077560|FD-Score:3.27|P-value:7.97E-5 ID:SGTC_2456|Compound:5770359|FD-Score:3.58|P-value:1.79E-5 ID:SGTC_2462|Compound:5162487|FD-Score:3.60|P-value:1.61E-5 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:2.82|P-value:5.79E-4 ID:SGTC_2958|Compound:9077254|FD-Score:3.00|P-value:2.66E-4 ID:SGTC_2960|Compound:9079389|FD-Score:4.30|P-value:3.50E-7 ID:SGTC_2965|Compound:9082772|FD-Score:-5.45|P-value:2.00E-10 ID:SGTC_2966|Compound:9084041|FD-Score:-3.02|P-value:2.66E-4 ID:SGTC_3006|Compound:9075424|FD-Score:-2.77|P-value:7.67E-4 ID:SGTC_3150|Compound:9097574|FD-Score:3.07|P-value:2.00E-4 ID:SGTC_3158|Compound:9100007|FD-Score:-2.93|P-value:3.87E-4

Top fitness defect scores for YDR021W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1732 st034308 5.71 51.8 µM 2.45E-11 1 5.75E-9 0.44
2 SGTC_184 1494-0393 4.57 24.7 µM 6.78E-8 22 2.39E-6 0.02
3 SGTC_1727 st034309 4.39 9.9 µM 2.08E-7 11 5.63E-6 0.13
4 SGTC_2960 9079389 4.30 6.0 µM 3.50E-7 2 8.37E-6 0.21
5 SGTC_1246 0422-0085 4.23 105.0 µM 5.29E-7 7 1.15E-5 0.03
6 SGTC_2381 9035592 4.17 200.0 µM 7.81E-7 6 1.55E-5 0.32
7 SGTC_764 1951-2361 3.95 146.0 µM 2.61E-6 11 3.88E-5 0.01
8 SGTC_2462 5162487 3.60 171.8 µM 1.61E-5 7 1.56E-4 0.26
9 SGTC_2456 5770359 3.58 74.5 µM 1.79E-5 6 1.69E-4 0.19
10 SGTC_1494 4358-1428 3.50 177.0 µM 2.70E-5 8 2.32E-4 0.04
11 SGTC_2387 9077560 3.27 195.1 µM 7.97E-5 17 5.31E-4 0.01
12 SGTC_1579 chlormadinone acetate 3.14 49.4 µM 1.45E-4 11 8.39E-4 0.03
13 SGTC_3150 9097574 3.07 49.5 µM 2.00E-4 11 0.00108 0.24
14 SGTC_1736 st036774 3.03 51.0 µM 2.35E-4 10 0.00122 0.10
15 SGTC_2958 9077254 3.00 16.7 µM 2.66E-4 16 0.00134 0.14
16 SGTC_1171 0368-0077 2.88 21.4 µM 4.48E-4 33 0.00200 0.00
17 SGTC_740 k014-0057 2.86 261.0 µM 4.76E-4 22 0.00210 0.08
18 SGTC_2574 2',4'-dihydroxychalcone 2.82 14.6 µM 5.79E-4 29 0.00244 0.09
19 SGTC_561 1550-0330 2.79 72.9 µM 6.44E-4 16 0.00265 0.12
20 SGTC_1435 4092-0789 2.78 56.7 µM 6.71E-4 plasma membrane duress 22 0.00273 0.09

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.175 1.66E-24 YBR155W CNS1 het TPR-containing co-chaperone; binds both Hsp82p (Hsp90) and Ssa1p (Hsp70) and stimulates the ATPase activity of SSA1, ts mutants reduce Hsp82p function while over expression suppresses the phenotypes of an HSP82 ts allele and a cpr7 deletion
0.170 3.69E-23 YPL035C_d YPL035C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YPL034W; YPL035C is not an essential gene
0.135 4.40E-15 YDR478W SNM1 het Subunit of RNase MRP, which cleaves pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; binds to the NME1 RNA subunit of RNase MRP
0.124 5.11E-13 YOR335C ALA1 het Cytoplasmic and mitochondrial alanyl-tRNA synthetase, required for protein synthesis; point mutation (cdc64-1 allele) causes cell cycle arrest at G1; lethality of null mutation is functionally complemented by human homolog
0.122 1.54E-12 YDL102W POL3 het Catalytic subunit of DNA polymerase delta; required for chromosomal DNA replication during mitosis and meiosis, intragenic recombination, repair of double strand DNA breaks, and DNA replication during nucleotide excision repair (NER)
0.121 1.91E-12 YOR063W RPL3 het Ribosomal 60S subunit protein L3; homologous to mammalian ribosomal protein L3 and bacterial L3; involved in the replication and maintenance of killer double stranded RNA virus
0.121 2.25E-12 YHR019C DED81 het Cytosolic asparaginyl-tRNA synthetase, required for protein synthesis, catalyzes the specific attachment of asparagine to its cognate tRNA
0.119 4.75E-12 YMR308C PSE1 het Karyopherin/importin that interacts with the nuclear pore complex; acts as the nuclear import receptor for specific proteins, including Pdr1p, Yap1p, Ste12p, and Aft1p
0.115 2.64E-11 YOR056C NOB1 het Protein involved in proteasomal and 40S ribosomal subunit biogenesis; required for cleavage of the 20S pre-rRNA to generate the mature 18S rRNA; cleavage is activated by Fun12p, a GTPase and translation initiation factor; relocalizes from nucleus to nucleolus upon DNA replication stress
0.115 3.11E-11 YPL262W FUM1 hom Fumarase, converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial distribution determined by the N-terminal targeting sequence, protein conformation, and status of glyoxylate shunt; phosphorylated in mitochondria
0.111 1.28E-10 YKL196C YKT6 het Vesicle membrane protein (v-SNARE) with acyltransferase activity; involved in trafficking to and within the Golgi, endocytic trafficking to the vacuole, and vacuolar fusion; membrane localization due to prenylation at the carboxy-terminus
0.111 1.32E-10 YLR195C NMT1 het N-myristoyl transferase, catalyzes the cotranslational, covalent attachment of myristic acid to the N-terminal glycine residue of several proteins involved in cellular growth and signal transduction
0.107 4.99E-10 YDR416W SYF1 het Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; null mutant has splicing defect and arrests in G2/M; homologs in human and C. elegans
0.105 1.09E-9 YDL153C SAS10 het Essential subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit; disrupts silencing when overproduced; mutant has increased aneuploidy tolerance
0.104 1.47E-9 YDR235W PRP42 het U1 snRNP protein involved in splicing, required for U1 snRNP biogenesis; contains multiple tetriatricopeptide repeats