YDR022C / ATG31

Autophagy-specific protein required for autophagosome formation; may form a complex with Atg17p and Atg29p that localizes other proteins to the pre-autophagosomal structure; high-copy suppressor of CIK1 deletion

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR022C / ATG31

Click on Significant Values for Screen Details ID:SGTC_50|Compound:0929-0078|FD-Score:4.05|P-value:1.32E-5 ID:SGTC_72|Compound:0744-0168|FD-Score:3.71|P-value:5.79E-5 ID:SGTC_86|Compound:0417-1630|FD-Score:-3.70|P-value:6.57E-5 ID:SGTC_159|Compound:3970-0959|FD-Score:6.75|P-value:1.27E-12 ID:SGTC_169|Compound:k015-0017|FD-Score:3.61|P-value:8.95E-5 ID:SGTC_171|Compound:k064-0041|FD-Score:-3.08|P-value:7.33E-4 ID:SGTC_230|Compound:MPP+|FD-Score:3.04|P-value:7.78E-4 ID:SGTC_379|Compound:3970-0972|FD-Score:-4.65|P-value:7.47E-7 ID:SGTC_407|Compound:eburnamonine|FD-Score:-3.19|P-value:4.95E-4 ID:SGTC_651|Compound:3253-0966|FD-Score:3.15|P-value:5.35E-4 ID:SGTC_807|Compound:1315-0151|FD-Score:3.15|P-value:5.39E-4 ID:SGTC_867|Compound:0518-0118|FD-Score:-3.33|P-value:2.94E-4 ID:SGTC_924|Compound:2046-0044|FD-Score:-3.11|P-value:6.47E-4 ID:SGTC_925|Compound:2064-1272|FD-Score:3.49|P-value:1.45E-4 ID:SGTC_935|Compound:2996-0153|FD-Score:4.01|P-value:1.59E-5 ID:SGTC_1075|Compound:aripiprazole|FD-Score:2.98|P-value:9.81E-4 ID:SGTC_1096|Compound:rimcazole|FD-Score:3.10|P-value:6.39E-4 ID:SGTC_1148|Compound:3909-7663|FD-Score:3.07|P-value:7.21E-4 ID:SGTC_1185|Compound:1319-0113|FD-Score:-3.09|P-value:7.09E-4 ID:SGTC_1258|Compound:0671-0043|FD-Score:4.62|P-value:7.95E-7 ID:SGTC_1284|Compound:0929-0043|FD-Score:3.27|P-value:3.43E-4 ID:SGTC_1400|Compound:3771-8998|FD-Score:3.78|P-value:4.24E-5 ID:SGTC_1435|Compound:4092-0789|FD-Score:3.52|P-value:1.28E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.24|P-value:4.05E-4 ID:SGTC_1466|Compound:k213-0079|FD-Score:-3.46|P-value:1.74E-4 ID:SGTC_1475|Compound:4092-1048|FD-Score:-3.21|P-value:4.63E-4 ID:SGTC_1477|Compound:0139-0234|FD-Score:-3.43|P-value:1.97E-4 ID:SGTC_1485|Compound:3909-9022|FD-Score:-3.60|P-value:9.82E-5 ID:SGTC_1487|Compound:3970-0795|FD-Score:-5.32|P-value:1.92E-8 ID:SGTC_1494|Compound:4358-1428|FD-Score:-3.73|P-value:5.90E-5 ID:SGTC_1495|Compound:4469-0029|FD-Score:-3.45|P-value:1.79E-4 ID:SGTC_1497|Compound:4476-2978|FD-Score:3.19|P-value:4.60E-4 ID:SGTC_1618|Compound:st003135|FD-Score:3.34|P-value:2.57E-4 ID:SGTC_1619|Compound:st003326|FD-Score:3.94|P-value:2.18E-5 ID:SGTC_1676|Compound:st018489|FD-Score:3.06|P-value:7.45E-4 ID:SGTC_1888|Compound:azatryptophan|FD-Score:-3.21|P-value:4.60E-4 ID:SGTC_1895|Compound:st058434|FD-Score:3.04|P-value:8.03E-4 ID:SGTC_1958|Compound:st076513|FD-Score:3.53|P-value:1.23E-4 ID:SGTC_2132|Compound:5317594|FD-Score:-3.99|P-value:1.90E-5 ID:SGTC_2134|Compound:5324836|FD-Score:-3.33|P-value:2.86E-4 ID:SGTC_2447|Compound:5741742|FD-Score:3.00|P-value:9.19E-4 ID:SGTC_2448|Compound:5185112|FD-Score:3.95|P-value:2.05E-5 ID:SGTC_2791|Compound:5663188|FD-Score:-3.49|P-value:1.58E-4 ID:SGTC_2797|Compound:7859098|FD-Score:3.48|P-value:1.52E-4 ID:SGTC_3312|Compound:9133330|FD-Score:-3.07|P-value:7.51E-4 ID:SGTC_3321|Compound:9137793|FD-Score:-3.10|P-value:6.79E-4 ID:SGTC_3325|Compound:9138760|FD-Score:-3.31|P-value:3.14E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:4.05|P-value:1.32E-5 ID:SGTC_72|Compound:0744-0168|FD-Score:3.71|P-value:5.79E-5 ID:SGTC_86|Compound:0417-1630|FD-Score:-3.70|P-value:6.57E-5 ID:SGTC_159|Compound:3970-0959|FD-Score:6.75|P-value:1.27E-12 ID:SGTC_169|Compound:k015-0017|FD-Score:3.61|P-value:8.95E-5 ID:SGTC_171|Compound:k064-0041|FD-Score:-3.08|P-value:7.33E-4 ID:SGTC_230|Compound:MPP+|FD-Score:3.04|P-value:7.78E-4 ID:SGTC_379|Compound:3970-0972|FD-Score:-4.65|P-value:7.47E-7 ID:SGTC_407|Compound:eburnamonine|FD-Score:-3.19|P-value:4.95E-4 ID:SGTC_651|Compound:3253-0966|FD-Score:3.15|P-value:5.35E-4 ID:SGTC_807|Compound:1315-0151|FD-Score:3.15|P-value:5.39E-4 ID:SGTC_867|Compound:0518-0118|FD-Score:-3.33|P-value:2.94E-4 ID:SGTC_924|Compound:2046-0044|FD-Score:-3.11|P-value:6.47E-4 ID:SGTC_925|Compound:2064-1272|FD-Score:3.49|P-value:1.45E-4 ID:SGTC_935|Compound:2996-0153|FD-Score:4.01|P-value:1.59E-5 ID:SGTC_1075|Compound:aripiprazole|FD-Score:2.98|P-value:9.81E-4 ID:SGTC_1096|Compound:rimcazole|FD-Score:3.10|P-value:6.39E-4 ID:SGTC_1148|Compound:3909-7663|FD-Score:3.07|P-value:7.21E-4 ID:SGTC_1185|Compound:1319-0113|FD-Score:-3.09|P-value:7.09E-4 ID:SGTC_1258|Compound:0671-0043|FD-Score:4.62|P-value:7.95E-7 ID:SGTC_1284|Compound:0929-0043|FD-Score:3.27|P-value:3.43E-4 ID:SGTC_1400|Compound:3771-8998|FD-Score:3.78|P-value:4.24E-5 ID:SGTC_1435|Compound:4092-0789|FD-Score:3.52|P-value:1.28E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.24|P-value:4.05E-4 ID:SGTC_1466|Compound:k213-0079|FD-Score:-3.46|P-value:1.74E-4 ID:SGTC_1475|Compound:4092-1048|FD-Score:-3.21|P-value:4.63E-4 ID:SGTC_1477|Compound:0139-0234|FD-Score:-3.43|P-value:1.97E-4 ID:SGTC_1485|Compound:3909-9022|FD-Score:-3.60|P-value:9.82E-5 ID:SGTC_1487|Compound:3970-0795|FD-Score:-5.32|P-value:1.92E-8 ID:SGTC_1494|Compound:4358-1428|FD-Score:-3.73|P-value:5.90E-5 ID:SGTC_1495|Compound:4469-0029|FD-Score:-3.45|P-value:1.79E-4 ID:SGTC_1497|Compound:4476-2978|FD-Score:3.19|P-value:4.60E-4 ID:SGTC_1618|Compound:st003135|FD-Score:3.34|P-value:2.57E-4 ID:SGTC_1619|Compound:st003326|FD-Score:3.94|P-value:2.18E-5 ID:SGTC_1676|Compound:st018489|FD-Score:3.06|P-value:7.45E-4 ID:SGTC_1888|Compound:azatryptophan|FD-Score:-3.21|P-value:4.60E-4 ID:SGTC_1895|Compound:st058434|FD-Score:3.04|P-value:8.03E-4 ID:SGTC_1958|Compound:st076513|FD-Score:3.53|P-value:1.23E-4 ID:SGTC_2132|Compound:5317594|FD-Score:-3.99|P-value:1.90E-5 ID:SGTC_2134|Compound:5324836|FD-Score:-3.33|P-value:2.86E-4 ID:SGTC_2447|Compound:5741742|FD-Score:3.00|P-value:9.19E-4 ID:SGTC_2448|Compound:5185112|FD-Score:3.95|P-value:2.05E-5 ID:SGTC_2791|Compound:5663188|FD-Score:-3.49|P-value:1.58E-4 ID:SGTC_2797|Compound:7859098|FD-Score:3.48|P-value:1.52E-4 ID:SGTC_3312|Compound:9133330|FD-Score:-3.07|P-value:7.51E-4 ID:SGTC_3321|Compound:9137793|FD-Score:-3.10|P-value:6.79E-4 ID:SGTC_3325|Compound:9138760|FD-Score:-3.31|P-value:3.14E-4

Top fitness defect scores for YDR022C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_159 3970-0959 6.75 50.0 µM 1.27E-12 19 7.49E-12
2 SGTC_1258 0671-0043 4.62 57.1 µM 7.95E-7 12 1.89E-6
3 SGTC_50 0929-0078 4.05 56.4 µM 1.32E-5 43 2.59E-5
4 SGTC_935 2996-0153 4.01 430.0 µM 1.59E-5 PDR1 20 3.09E-5
5 SGTC_2448 5185112 3.95 27.2 µM 2.05E-5 13 3.90E-5
6 SGTC_1619 st003326 3.94 88.7 µM 2.18E-5 60S ribosome export 20 4.14E-5
7 SGTC_1400 3771-8998 3.78 51.5 µM 4.24E-5 11 7.69E-5
8 SGTC_72 0744-0168 3.71 198.4 µM 5.79E-5 RPP1 & pyrimidine depletion 37 1.03E-4
9 SGTC_169 k015-0017 3.61 16.0 µM 8.95E-5 29 1.54E-4
10 SGTC_1958 st076513 3.53 41.9 µM 1.23E-4 60S ribosome export 44 2.07E-4
11 SGTC_1435 4092-0789 3.52 56.7 µM 1.28E-4 plasma membrane duress 22 2.16E-4
12 SGTC_925 2064-1272 3.49 59.6 µM 1.45E-4 37 2.43E-4
13 SGTC_2797 7859098 3.48 81.8 µM 1.52E-4 41 2.53E-4
14 SGTC_1618 st003135 3.34 44.5 µM 2.57E-4 34 4.14E-4
15 SGTC_1284 0929-0043 3.27 16.0 µM 3.43E-4 55 5.41E-4
16 SGTC_1497 4476-2978 3.19 41.3 µM 4.60E-4 45 7.12E-4
17 SGTC_651 3253-0966 3.15 34.4 µM 5.35E-4 calcium & mitochondrial duress 72 8.20E-4
18 SGTC_807 1315-0151 3.15 48.0 µM 5.39E-4 55 8.26E-4
19 SGTC_1096 rimcazole 3.10 32.2 µM 6.39E-4 36 9.69E-4
20 SGTC_1148 3909-7663 3.07 27.7 µM 7.21E-4 49 0.00108

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.153 4.15E-19 YGR209C TRX2 hom Cytoplasmic thioredoxin isoenzyme; part of the thioredoxin system which protects cells against oxidative and reductive stress; forms LMA1 complex with Pbi2p; acts as a cofactor for Tsa1p; required for ER-Golgi transport and vacuole inheritance; protein abundance increases in response to DNA replication stress
0.133 1.09E-14 YDR001C NTH1 hom Neutral trehalase, degrades trehalose; required for thermotolerance and may mediate resistance to other cellular stresses; may be phosphorylated by Cdc28p; NTH1 has a paralog, NTH2, that arose from the whole genome duplication
0.132 2.03E-14 YDR049W VMS1 hom Component of a Cdc48p-complex involved in protein quality control; exhibits cytosolic and ER-membrane localization, with Cdc48p, during normal growth, and contributes to ER-associated degradation (ERAD) of specific substrates at a step after their ubiquitination; forms a mitochondrially-associated complex with Cdc48p and Npl4p under oxidative stress that is required for ubiquitin-mediated mitochondria-associated protein degradation (MAD); conserved in C. elegans and humans
0.131 2.47E-14 YOL043C NTG2 hom DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair, localizes to the nucleus; sumoylated; NTG2 has a paralog, NTG1, that arose from the whole genome duplication
0.129 5.87E-14 YDR446W ECM11 hom Non-essential protein apparently involved in meiosis, GFP fusion protein is present in discrete clusters in the nucleus throughout mitosis; may be involved in maintaining chromatin structure
0.109 2.28E-10 YGL051W MST27 hom Putative integral membrane protein, involved in vesicle formation; forms complex with Mst28p; member of DUP240 gene family; binds COPI and COPII vesicles
0.109 2.64E-10 YGL042C_d YGL042C_d hom Dubious open reading frame, not conserved in closely related Saccharomyces species; deletion mutation blocks replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene DST1
0.105 9.24E-10 YLR352W_p YLR352W_p hom Putative protein of unknown function with similarity to F-box proteins; interacts with Skp1p and Cdc53p; YLR352W is not an essential gene
0.105 1.00E-9 YKL193C SDS22 het Regulatory subunit of the type 1 protein phosphatase (PP1) Glc7p; whether it functions as a positive or negative regulator of Glc7p is controversial; involved in the regulation of Glc7p nuclear localization and function
0.098 1.10E-8 YDR275W BSC2 hom Protein of unknown function; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; BSC2 has a paralog, IRC23, that arose from the whole genome duplication
0.091 1.30E-7 YFL048C EMP47 hom Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport
0.088 3.26E-7 YLR213C CRR1 hom Putative glycoside hydrolase of the spore wall envelope; required for normal spore wall assembly, possibly for cross-linking between the glucan and chitosan layers; expressed during sporulation
0.086 5.97E-7 YER016W BIM1 hom Microtubule-binding protein that together with Kar9p makes up the cortical microtubule capture site and delays the exit from mitosis when the spindle is oriented abnormally
0.086 6.26E-7 YDR471W RPL27B hom Ribosomal 60S subunit protein L27B; homologous to mammalian ribosomal protein L27, no bacterial homolog; RPL27B has a paralog, RPL27A, that arose from the whole genome duplication
0.085 8.73E-7 YIL083C CAB2 het Probable phosphopantothenoylcysteine synthetase (PPCS), which catalyzes the second step of coenzyme A biosynthesis from pantothenate; null mutant lethality is complemented by E. coli coaBC (encoding a bifunctional enzyme with PPCS activity)