YDR023W / SES1

Cytosolic seryl-tRNA synthetase, class II aminoacyl-tRNA synthetase that aminoacylates tRNA(Ser), displays tRNA-dependent amino acid recognition which enhances discrimination of the serine substrate, interacts with peroxin Pex21p

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDR023W / SES1

Click on Significant Values for Screen Details ID:SGTC_21|Compound:0849-0113|FD-Score:3.27|P-value:5.03E-5 ID:SGTC_116|Compound:0155-0182|FD-Score:-5.19|P-value:2.62E-10 ID:SGTC_190|Compound:3970-0790|FD-Score:2.67|P-value:7.57E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:-4.39|P-value:7.29E-8 ID:SGTC_383|Compound:2324-0395|FD-Score:-2.80|P-value:3.93E-4 ID:SGTC_403|Compound:arphamenine a|FD-Score:2.92|P-value:2.56E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:2.74|P-value:5.72E-4 ID:SGTC_530|Compound:4358-1714|FD-Score:2.77|P-value:4.97E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:2.82|P-value:4.12E-4 ID:SGTC_969|Compound:1313-0238|FD-Score:-2.71|P-value:5.66E-4 ID:SGTC_1098|Compound:clofazimine|FD-Score:2.80|P-value:4.38E-4 ID:SGTC_1169|Compound:aniline yellow|FD-Score:2.73|P-value:6.04E-4 ID:SGTC_1176|Compound:0848-0131|FD-Score:2.72|P-value:6.31E-4 ID:SGTC_1278|Compound:0874-0585|FD-Score:2.83|P-value:3.86E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:-3.18|P-value:6.97E-5 ID:SGTC_1404|Compound:3909-7820|FD-Score:2.66|P-value:7.94E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.26|P-value:4.52E-5 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.22|P-value:5.48E-5 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:2.70|P-value:6.73E-4 ID:SGTC_1833|Compound:st055984|FD-Score:-3.42|P-value:2.04E-5 ID:SGTC_1841|Compound:st054148|FD-Score:2.83|P-value:3.96E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:4.99|P-value:1.42E-9 ID:SGTC_1958|Compound:st076513|FD-Score:2.62|P-value:9.44E-4 ID:SGTC_1963|Compound:st076565|FD-Score:-3.60|P-value:7.89E-6 ID:SGTC_1970|Compound:st070122|FD-Score:-2.73|P-value:5.22E-4 ID:SGTC_1972|Compound:st070201|FD-Score:2.76|P-value:5.18E-4 ID:SGTC_2012|Compound:4023501|FD-Score:3.93|P-value:1.46E-6 ID:SGTC_2054|Compound:5233173|FD-Score:-4.72|P-value:7.92E-9 ID:SGTC_2171|Compound:5739187|FD-Score:5.83|P-value:1.90E-12 ID:SGTC_2339|Compound:9000433|FD-Score:-2.88|P-value:2.76E-4 ID:SGTC_2358|Compound:9037157|FD-Score:2.80|P-value:4.38E-4 ID:SGTC_2373|Compound:9071805|FD-Score:-2.93|P-value:2.20E-4 ID:SGTC_2456|Compound:5770359|FD-Score:-4.91|P-value:2.05E-9 ID:SGTC_2466|Compound:5983409|FD-Score:2.80|P-value:4.44E-4 ID:SGTC_2467|Compound:5474540|FD-Score:-2.89|P-value:2.59E-4 ID:SGTC_2469|Compound:5655019|FD-Score:4.51|P-value:4.11E-8 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:-3.49|P-value:1.41E-5 ID:SGTC_2679|Compound:rapamycin|FD-Score:9.62|P-value:9.61E-31 ID:SGTC_2731|Compound:amoxapine|FD-Score:-2.62|P-value:8.16E-4 ID:SGTC_2820|Compound:7989630|FD-Score:4.27|P-value:1.85E-7 ID:SGTC_2925|Compound:9010536|FD-Score:-2.86|P-value:3.02E-4 ID:SGTC_2965|Compound:9082772|FD-Score:-4.22|P-value:2.11E-7 ID:SGTC_3062|Compound:9077494|FD-Score:-4.05|P-value:6.14E-7 ID:SGTC_3080|Compound:9117754|FD-Score:-3.63|P-value:6.62E-6 ID:SGTC_3094|Compound:9117742|FD-Score:-3.18|P-value:6.97E-5 ID:SGTC_3319|Compound:9138450|FD-Score:2.71|P-value:6.36E-4 ID:SGTC_3331|Compound:9141060|FD-Score:-6.87|P-value:9.88E-17 ID:SGTC_21|Compound:0849-0113|FD-Score:3.27|P-value:5.03E-5 ID:SGTC_116|Compound:0155-0182|FD-Score:-5.19|P-value:2.62E-10 ID:SGTC_190|Compound:3970-0790|FD-Score:2.67|P-value:7.57E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:-4.39|P-value:7.29E-8 ID:SGTC_383|Compound:2324-0395|FD-Score:-2.80|P-value:3.93E-4 ID:SGTC_403|Compound:arphamenine a|FD-Score:2.92|P-value:2.56E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:2.74|P-value:5.72E-4 ID:SGTC_530|Compound:4358-1714|FD-Score:2.77|P-value:4.97E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:2.82|P-value:4.12E-4 ID:SGTC_969|Compound:1313-0238|FD-Score:-2.71|P-value:5.66E-4 ID:SGTC_1098|Compound:clofazimine|FD-Score:2.80|P-value:4.38E-4 ID:SGTC_1169|Compound:aniline yellow|FD-Score:2.73|P-value:6.04E-4 ID:SGTC_1176|Compound:0848-0131|FD-Score:2.72|P-value:6.31E-4 ID:SGTC_1278|Compound:0874-0585|FD-Score:2.83|P-value:3.86E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:-3.18|P-value:6.97E-5 ID:SGTC_1404|Compound:3909-7820|FD-Score:2.66|P-value:7.94E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.26|P-value:4.52E-5 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.22|P-value:5.48E-5 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:2.70|P-value:6.73E-4 ID:SGTC_1833|Compound:st055984|FD-Score:-3.42|P-value:2.04E-5 ID:SGTC_1841|Compound:st054148|FD-Score:2.83|P-value:3.96E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:4.99|P-value:1.42E-9 ID:SGTC_1958|Compound:st076513|FD-Score:2.62|P-value:9.44E-4 ID:SGTC_1963|Compound:st076565|FD-Score:-3.60|P-value:7.89E-6 ID:SGTC_1970|Compound:st070122|FD-Score:-2.73|P-value:5.22E-4 ID:SGTC_1972|Compound:st070201|FD-Score:2.76|P-value:5.18E-4 ID:SGTC_2012|Compound:4023501|FD-Score:3.93|P-value:1.46E-6 ID:SGTC_2054|Compound:5233173|FD-Score:-4.72|P-value:7.92E-9 ID:SGTC_2171|Compound:5739187|FD-Score:5.83|P-value:1.90E-12 ID:SGTC_2339|Compound:9000433|FD-Score:-2.88|P-value:2.76E-4 ID:SGTC_2358|Compound:9037157|FD-Score:2.80|P-value:4.38E-4 ID:SGTC_2373|Compound:9071805|FD-Score:-2.93|P-value:2.20E-4 ID:SGTC_2456|Compound:5770359|FD-Score:-4.91|P-value:2.05E-9 ID:SGTC_2466|Compound:5983409|FD-Score:2.80|P-value:4.44E-4 ID:SGTC_2467|Compound:5474540|FD-Score:-2.89|P-value:2.59E-4 ID:SGTC_2469|Compound:5655019|FD-Score:4.51|P-value:4.11E-8 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:-3.49|P-value:1.41E-5 ID:SGTC_2679|Compound:rapamycin|FD-Score:9.62|P-value:9.61E-31 ID:SGTC_2731|Compound:amoxapine|FD-Score:-2.62|P-value:8.16E-4 ID:SGTC_2820|Compound:7989630|FD-Score:4.27|P-value:1.85E-7 ID:SGTC_2925|Compound:9010536|FD-Score:-2.86|P-value:3.02E-4 ID:SGTC_2965|Compound:9082772|FD-Score:-4.22|P-value:2.11E-7 ID:SGTC_3062|Compound:9077494|FD-Score:-4.05|P-value:6.14E-7 ID:SGTC_3080|Compound:9117754|FD-Score:-3.63|P-value:6.62E-6 ID:SGTC_3094|Compound:9117742|FD-Score:-3.18|P-value:6.97E-5 ID:SGTC_3319|Compound:9138450|FD-Score:2.71|P-value:6.36E-4 ID:SGTC_3331|Compound:9141060|FD-Score:-6.87|P-value:9.88E-17

Top fitness defect scores for YDR023W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2679 rapamycin 9.62 1.0 nM 9.61E-31 9 3.28E-22 0.16
2 SGTC_2171 5739187 5.83 198.1 µM 1.90E-12 copper-dependent oxidative stress 1 2.74E-9 1.21
3 SGTC_1844 rapamycin 4.99 4.0 nM 1.42E-9 33 3.00E-7 0.01
4 SGTC_2469 5655019 4.51 90.8 µM 4.11E-8 1 3.29E-6 0.63
5 SGTC_2820 7989630 4.27 71.4 µM 1.85E-7 ERG2 2 9.65E-6 0.29
6 SGTC_2012 4023501 3.93 200.0 µM 1.46E-6 11 4.21E-5 0.07
7 SGTC_21 0849-0113 3.27 23.0 µM 5.03E-5 12 5.33E-4 0.09
8 SGTC_403 arphamenine a 2.92 50.0 µM 2.56E-4 60S ribosome export 17 0.00172 0.04
9 SGTC_1278 0874-0585 2.83 172.0 µM 3.86E-4 21 0.00232 0.04
10 SGTC_1841 st054148 2.83 70.0 µM 3.96E-4 16 0.00236 0.05
11 SGTC_635 k038-0028 2.82 24.7 µM 4.12E-4 ubiquinone biosynthesis & proteasome 34 0.00243 0.00
12 SGTC_2358 9037157 2.80 4.0 µM 4.38E-4 36 0.00254 0.06
13 SGTC_1098 clofazimine 2.80 15.1 µM 4.38E-4 heme biosynthesis & mitochondrial translocase 49 0.00254 0.01
14 SGTC_2466 5983409 2.80 37.1 µM 4.44E-4 26 0.00256 0.07
15 SGTC_530 4358-1714 2.77 28.0 µM 4.97E-4 25 0.00278 0.02
16 SGTC_1972 st070201 2.76 17.4 µM 5.18E-4 14 0.00287 0.05
17 SGTC_518 1021-0119 2.74 62.6 µM 5.72E-4 ERG2 25 0.00308 0.02
18 SGTC_1169 aniline yellow 2.73 25.8 µM 6.04E-4 13 0.00320 0.05
19 SGTC_1176 0848-0131 2.72 83.3 µM 6.31E-4 Golgi 18 0.00331 0.12
20 SGTC_3319 9138450 2.71 16.8 µM 6.36E-4 16 0.00332 0.07

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.409 7.17E-136 YKL203C TOR2 het PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis; TOR2 has a paralog, TOR1, that arose from the whole genome duplication
0.288 2.55E-65 YJR066W TOR1 hom PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis; TOR1 has a paralog, TOR2, that arose from the whole genome duplication
0.281 4.86E-62 YLR114C AVL9 hom Conserved protein involved in exocytic transport from the Golgi; mutation is synthetically lethal with apl2 vps1 double mutation; member of a protein superfamily with orthologs in diverse organisms; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.271 1.63E-57 YHR186C KOG1 het Subunit of TORC1, a rapamycin-sensitive complex involved in growth control that contains Tor1p or Tor2p, Lst8p and Tco89p; contains four HEAT repeats and seven WD-40 repeats; may act as a scaffold protein to couple TOR and its effectors
0.247 4.97E-48 YHR187W IKI1 hom Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; iki1 mutations confer resistance to the K. lactis toxin zymocin
0.241 2.40E-45 YNL119W NCS2 hom Protein required for thiolation of the uridine at the wobble position of Lys(UUU) and Glu(UUC) tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae
0.239 8.17E-45 YKL110C KTI12 hom Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p
0.230 1.93E-41 YML121W GTR1 hom Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB
0.224 3.91E-39 YFL024C EPL1 het Subunit of NuA4, an essential histone H4/H2A acetyltransferase complex; conserved region at N-terminus is essential for interaction with the NPC (nucleosome core particle); required for autophagy; homologous to Drosophila Enhancer of Polycomb
0.223 4.67E-39 YLR384C IKI3 hom Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD)
0.222 9.96E-39 YDR158W HOM2 hom Aspartic beta semi-aldehyde dehydrogenase, catalyzes the second step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
0.219 1.48E-37 YBR077C SLM4 hom Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; gene exhibits synthetic genetic interaction with MSS4
0.218 3.01E-37 YOR184W SER1 hom 3-phosphoserine aminotransferase; catalyzes the formation of phosphoserine from 3-phosphohydroxypyruvate, required for serine and glycine biosynthesis; regulated by the general control of amino acid biosynthesis mediated by Gcn4p; protein abundance increases in response to DNA replication stress
0.214 4.72E-36 YOR274W MOD5 hom Delta 2-isopentenyl pyrophosphate:tRNA isopentenyl transferase; required for biosynthesis of the modified base isopentenyladenosine in mitochondrial and cytoplasmic tRNAs; gene is nuclear and encodes two isozymic forms; converts to a prion form, and prion conversion contributes to azole antifungal resistance by upregulating ergosterol biosynthesis
0.213 1.40E-35 YER052C HOM3 hom Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis