YDR025W / RPS11A

Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S11 and bacterial S17; RPS11A has a paralog, RPS11B, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR025W / RPS11A

Click on Significant Values for Screen Details ID:SGTC_115|Compound:0527-0192|FD-Score:3.26|P-value:7.31E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:3.63|P-value:1.94E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:4.48|P-value:5.87E-6 ID:SGTC_428|Compound:3448-4153|FD-Score:3.19|P-value:9.35E-4 ID:SGTC_462|Compound:ag-879|FD-Score:-4.14|P-value:2.38E-5 ID:SGTC_470|Compound:aa-861|FD-Score:3.66|P-value:1.77E-4 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:4.43|P-value:7.43E-6 ID:SGTC_512|Compound:prima-1|FD-Score:3.85|P-value:8.48E-5 ID:SGTC_625|Compound:k213-0058|FD-Score:4.36|P-value:1.03E-5 ID:SGTC_627|Compound:1391-0720|FD-Score:5.06|P-value:3.73E-7 ID:SGTC_631|Compound:k072-0230|FD-Score:3.80|P-value:1.01E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:3.94|P-value:5.92E-5 ID:SGTC_728|Compound:3030-5151|FD-Score:3.34|P-value:5.59E-4 ID:SGTC_819|Compound:1013-0258|FD-Score:-4.78|P-value:1.31E-6 ID:SGTC_822|Compound:1487-0950|FD-Score:-3.39|P-value:4.28E-4 ID:SGTC_828|Compound:2074-0507|FD-Score:-3.25|P-value:7.01E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:-4.51|P-value:4.69E-6 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:3.82|P-value:9.59E-5 ID:SGTC_948|Compound:3448-0295|FD-Score:3.37|P-value:5.03E-4 ID:SGTC_1006|Compound:4099-6547|FD-Score:3.88|P-value:7.67E-5 ID:SGTC_1170|Compound:0310-0127|FD-Score:-3.28|P-value:6.30E-4 ID:SGTC_1181|Compound:1222-0449|FD-Score:3.35|P-value:5.43E-4 ID:SGTC_1209|Compound:2323-2347|FD-Score:-3.38|P-value:4.47E-4 ID:SGTC_1280|Compound:0880-0253|FD-Score:-3.33|P-value:5.26E-4 ID:SGTC_1320|Compound:1313-0481|FD-Score:-3.80|P-value:9.41E-5 ID:SGTC_1425|Compound:4048-4433|FD-Score:6.03|P-value:1.85E-9 ID:SGTC_1493|Compound:4348-0038|FD-Score:3.56|P-value:2.54E-4 ID:SGTC_1715|Compound:st032160|FD-Score:-4.20|P-value:1.85E-5 ID:SGTC_1721|Compound:st082152|FD-Score:4.15|P-value:2.52E-5 ID:SGTC_1740|Compound:st038286|FD-Score:3.52|P-value:2.95E-4 ID:SGTC_1826|Compound:st055655|FD-Score:4.02|P-value:4.32E-5 ID:SGTC_1839|Compound:st053978|FD-Score:3.57|P-value:2.47E-4 ID:SGTC_1961|Compound:st076550|FD-Score:-3.84|P-value:7.97E-5 ID:SGTC_2109|Compound:5483026|FD-Score:3.79|P-value:1.08E-4 ID:SGTC_2117|Compound:5521686|FD-Score:-3.32|P-value:5.48E-4 ID:SGTC_2128|Compound:5255449|FD-Score:3.70|P-value:1.53E-4 ID:SGTC_2308|Compound:7584454|FD-Score:-5.09|P-value:2.89E-7 ID:SGTC_2437|Compound:5741531|FD-Score:-3.17|P-value:9.25E-4 ID:SGTC_2444|Compound:5485484|FD-Score:5.01|P-value:4.89E-7 ID:SGTC_2450|Compound:5739737|FD-Score:-4.40|P-value:7.59E-6 ID:SGTC_2457|Compound:5731572|FD-Score:-3.68|P-value:1.47E-4 ID:SGTC_2459|Compound:5811157|FD-Score:3.26|P-value:7.23E-4 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:3.42|P-value:4.21E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.67|P-value:1.58E-4 ID:SGTC_2602|Compound:kawain|FD-Score:-3.28|P-value:6.41E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.30|P-value:1.07E-7 ID:SGTC_2797|Compound:7859098|FD-Score:-3.84|P-value:7.95E-5 ID:SGTC_2800|Compound:7887935|FD-Score:-4.15|P-value:2.31E-5 ID:SGTC_2844|Compound:9010103|FD-Score:-3.25|P-value:6.98E-4 ID:SGTC_2913|Compound:7966556|FD-Score:-3.25|P-value:7.07E-4 ID:SGTC_2993|Compound:9054257|FD-Score:3.56|P-value:2.53E-4 ID:SGTC_2996|Compound:9066192|FD-Score:3.54|P-value:2.70E-4 ID:SGTC_3004|Compound:9076122|FD-Score:-3.31|P-value:5.61E-4 ID:SGTC_3080|Compound:9117754|FD-Score:3.21|P-value:8.77E-4 ID:SGTC_3178|Compound:9107506|FD-Score:3.75|P-value:1.26E-4 ID:SGTC_3249|Compound:9135183|FD-Score:-3.64|P-value:1.72E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:3.26|P-value:7.31E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:3.63|P-value:1.94E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:4.48|P-value:5.87E-6 ID:SGTC_428|Compound:3448-4153|FD-Score:3.19|P-value:9.35E-4 ID:SGTC_462|Compound:ag-879|FD-Score:-4.14|P-value:2.38E-5 ID:SGTC_470|Compound:aa-861|FD-Score:3.66|P-value:1.77E-4 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:4.43|P-value:7.43E-6 ID:SGTC_512|Compound:prima-1|FD-Score:3.85|P-value:8.48E-5 ID:SGTC_625|Compound:k213-0058|FD-Score:4.36|P-value:1.03E-5 ID:SGTC_627|Compound:1391-0720|FD-Score:5.06|P-value:3.73E-7 ID:SGTC_631|Compound:k072-0230|FD-Score:3.80|P-value:1.01E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:3.94|P-value:5.92E-5 ID:SGTC_728|Compound:3030-5151|FD-Score:3.34|P-value:5.59E-4 ID:SGTC_819|Compound:1013-0258|FD-Score:-4.78|P-value:1.31E-6 ID:SGTC_822|Compound:1487-0950|FD-Score:-3.39|P-value:4.28E-4 ID:SGTC_828|Compound:2074-0507|FD-Score:-3.25|P-value:7.01E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:-4.51|P-value:4.69E-6 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:3.82|P-value:9.59E-5 ID:SGTC_948|Compound:3448-0295|FD-Score:3.37|P-value:5.03E-4 ID:SGTC_1006|Compound:4099-6547|FD-Score:3.88|P-value:7.67E-5 ID:SGTC_1170|Compound:0310-0127|FD-Score:-3.28|P-value:6.30E-4 ID:SGTC_1181|Compound:1222-0449|FD-Score:3.35|P-value:5.43E-4 ID:SGTC_1209|Compound:2323-2347|FD-Score:-3.38|P-value:4.47E-4 ID:SGTC_1280|Compound:0880-0253|FD-Score:-3.33|P-value:5.26E-4 ID:SGTC_1320|Compound:1313-0481|FD-Score:-3.80|P-value:9.41E-5 ID:SGTC_1425|Compound:4048-4433|FD-Score:6.03|P-value:1.85E-9 ID:SGTC_1493|Compound:4348-0038|FD-Score:3.56|P-value:2.54E-4 ID:SGTC_1715|Compound:st032160|FD-Score:-4.20|P-value:1.85E-5 ID:SGTC_1721|Compound:st082152|FD-Score:4.15|P-value:2.52E-5 ID:SGTC_1740|Compound:st038286|FD-Score:3.52|P-value:2.95E-4 ID:SGTC_1826|Compound:st055655|FD-Score:4.02|P-value:4.32E-5 ID:SGTC_1839|Compound:st053978|FD-Score:3.57|P-value:2.47E-4 ID:SGTC_1961|Compound:st076550|FD-Score:-3.84|P-value:7.97E-5 ID:SGTC_2109|Compound:5483026|FD-Score:3.79|P-value:1.08E-4 ID:SGTC_2117|Compound:5521686|FD-Score:-3.32|P-value:5.48E-4 ID:SGTC_2128|Compound:5255449|FD-Score:3.70|P-value:1.53E-4 ID:SGTC_2308|Compound:7584454|FD-Score:-5.09|P-value:2.89E-7 ID:SGTC_2437|Compound:5741531|FD-Score:-3.17|P-value:9.25E-4 ID:SGTC_2444|Compound:5485484|FD-Score:5.01|P-value:4.89E-7 ID:SGTC_2450|Compound:5739737|FD-Score:-4.40|P-value:7.59E-6 ID:SGTC_2457|Compound:5731572|FD-Score:-3.68|P-value:1.47E-4 ID:SGTC_2459|Compound:5811157|FD-Score:3.26|P-value:7.23E-4 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:3.42|P-value:4.21E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.67|P-value:1.58E-4 ID:SGTC_2602|Compound:kawain|FD-Score:-3.28|P-value:6.41E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.30|P-value:1.07E-7 ID:SGTC_2797|Compound:7859098|FD-Score:-3.84|P-value:7.95E-5 ID:SGTC_2800|Compound:7887935|FD-Score:-4.15|P-value:2.31E-5 ID:SGTC_2844|Compound:9010103|FD-Score:-3.25|P-value:6.98E-4 ID:SGTC_2913|Compound:7966556|FD-Score:-3.25|P-value:7.07E-4 ID:SGTC_2993|Compound:9054257|FD-Score:3.56|P-value:2.53E-4 ID:SGTC_2996|Compound:9066192|FD-Score:3.54|P-value:2.70E-4 ID:SGTC_3004|Compound:9076122|FD-Score:-3.31|P-value:5.61E-4 ID:SGTC_3080|Compound:9117754|FD-Score:3.21|P-value:8.77E-4 ID:SGTC_3178|Compound:9107506|FD-Score:3.75|P-value:1.26E-4 ID:SGTC_3249|Compound:9135183|FD-Score:-3.64|P-value:1.72E-4

Top fitness defect scores for YDR025W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1425 4048-4433 6.03 7.3 µM 1.85E-9 copper-dependent oxidative stress 11 8.18E-10
2 SGTC_2688 kanamycin b 5.30 96.7 µM 1.07E-7 calcium & mitochondrial duress 220 5.64E-8
3 SGTC_627 1391-0720 5.06 175.0 µM 3.73E-7 2 2.07E-7
4 SGTC_2444 5485484 5.01 36.4 µM 4.89E-7 13 2.74E-7
5 SGTC_184 1494-0393 4.48 24.7 µM 5.87E-6 48 3.65E-6
6 SGTC_471 1-acyl-paf 4.43 4.0 µM 7.43E-6 DNA intercalators 24 4.67E-6
7 SGTC_625 k213-0058 4.36 121.0 µM 1.03E-5 translation 77 6.57E-6
8 SGTC_1721 st082152 4.15 9.3 µM 2.52E-5 60S ribosome export 16 1.67E-5
9 SGTC_1826 st055655 4.02 41.6 µM 4.32E-5 ERG2 38 2.93E-5
10 SGTC_708 3448-5400 3.94 146.0 µM 5.92E-5 43 4.06E-5
11 SGTC_1006 4099-6547 3.88 255.0 µM 7.67E-5 23 5.33E-5
12 SGTC_512 prima-1 3.85 270.0 µM 8.48E-5 DNA intercalators 27 5.91E-5
13 SGTC_920 mycophenolic acid 3.82 780.4 nM 9.59E-5 34 6.72E-5
14 SGTC_631 k072-0230 3.80 41.5 µM 1.01E-4 60S ribosome export 19 7.11E-5
15 SGTC_2109 5483026 3.79 200.0 µM 1.08E-4 RSC complex & mRNA processing 29 7.61E-5
16 SGTC_3178 9107506 3.75 49.5 µM 1.26E-4 19 8.94E-5
17 SGTC_2128 5255449 3.70 168.5 µM 1.53E-4 42 1.09E-4
18 SGTC_470 aa-861 3.66 153.0 µM 1.77E-4 sphingolipid biosynthesis & PDR1 68 1.27E-4
19 SGTC_166 k072-0058 3.63 166.4 µM 1.94E-4 DNA intercalators 51 1.40E-4
20 SGTC_1839 st053978 3.57 48.0 µM 2.47E-4 22 1.80E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.133 1.07E-14 YOR085W OST3 hom Gamma subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; Ost3p is important for N-glycosylation of a subset of proteins
0.130 5.07E-14 YLR264W RPS28B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S28, no bacterial homolog; RPS28B has a paralog, RPS28A, that arose from the whole genome duplication
0.123 8.28E-13 YLR367W RPS22B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22B has a paralog, RPS22A, that arose from the whole genome duplication
0.110 1.63E-10 YKR057W RPS21A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21A has a paralog, RPS21B, that arose from the whole genome duplication
0.108 4.06E-10 YDL058W USO1 het Essential protein involved in the vesicle-mediated ER to Golgi transport step of secretion; binds membranes and functions during vesicle docking to the Golgi; required for assembly of the ER-to-Golgi SNARE complex
0.103 2.04E-9 YPR059C_d YPR059C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YMC1/YPR058W
0.099 1.06E-8 YKL139W CTK1 hom Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I); phosphorylates both RNA pol II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and ribosomal protein Rps2p to increase translational fidelity; similar to the Drosophila dCDK12 and human CDK12 and probably CDK13
0.097 1.81E-8 YBL082C ALG3 hom Dolichol-P-Man dependent alpha(1-3) mannosyltransferase, involved in the synthesis of dolichol-linked oligosaccharide donor for N-linked glycosylation of proteins
0.097 2.06E-8 YBL022C PIM1 hom ATP-dependent Lon protease, involved in degradation of misfolded proteins in mitochondria; required for biogenesis and maintenance of mitochondria
0.096 2.87E-8 YDR447C RPS17B hom Ribosomal protein 51 (rp51) of the small (40s) subunit; homologous to mammalian ribosomal protein S17, no bacterial homolog; RPS17B has a paralog, RPS17A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.094 4.86E-8 YMR119W ASI1 hom Putative integral membrane E3 ubiquitin ligase; acts with Asi2p and Asi3p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals; ASI1 has a paralog, ASI3, that arose from the whole genome duplication
0.094 5.82E-8 YJR145C RPS4A hom Protein component of the small (40S) ribosomal subunit; mutation affects 20S pre-rRNA processing; homologous to mammalian ribosomal protein S4, no bacterial homolog; RPS4A has a paralog, RPS4B, that arose from the whole genome duplication
0.093 7.41E-8 YER003C PMI40 het Mannose-6-phosphate isomerase, catalyzes the interconversion of fructose-6-P and mannose-6-P; required for early steps in protein mannosylation
0.093 7.48E-8 YBR078W ECM33 hom GPI-anchored protein of unknown function, has a possible role in apical bud growth; GPI-anchoring on the plasma membrane crucial to function; phosphorylated in mitochondria; similar to Sps2p and Pst1p
0.092 8.48E-8 YGR214W RPS0A hom Ribosomal 40S subunit protein S0A; required for maturation of 18S rRNA along with Rps0Bp; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2; RPS0A has a paralog, RPS0B, that arose from the whole genome duplication;