YDR034C / LYS14

Transcriptional activator involved in regulation of genes of the lysine biosynthesis pathway; requires 2-aminoadipate semialdehyde as co-inducer

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR034C / LYS14

Click on Significant Values for Screen Details ID:SGTC_11|Compound:0438-0307|FD-Score:3.39|P-value:3.00E-4 ID:SGTC_22|Compound:0964-0034|FD-Score:3.20|P-value:5.93E-4 ID:SGTC_25|Compound:0118-0223|FD-Score:3.46|P-value:2.26E-4 ID:SGTC_34|Compound:0469-0683|FD-Score:3.46|P-value:2.32E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.84|P-value:3.88E-5 ID:SGTC_65|Compound:0798-0905|FD-Score:5.36|P-value:2.62E-8 ID:SGTC_96|Compound:0929-0093|FD-Score:4.26|P-value:7.68E-6 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:5.21|P-value:6.19E-8 ID:SGTC_175|Compound:3793-3120|FD-Score:3.26|P-value:4.90E-4 ID:SGTC_644|Compound:1498-1197|FD-Score:3.11|P-value:8.35E-4 ID:SGTC_1028|Compound:k015-0029|FD-Score:4.79|P-value:5.88E-7 ID:SGTC_1285|Compound:0929-0069|FD-Score:3.38|P-value:3.11E-4 ID:SGTC_1295|Compound:1013-0063|FD-Score:3.30|P-value:4.23E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:3.51|P-value:1.91E-4 ID:SGTC_1410|Compound:3909-8106|FD-Score:3.18|P-value:6.34E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.36|P-value:2.73E-4 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:5.30|P-value:3.61E-8 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:3.41|P-value:2.78E-4 ID:SGTC_1731|Compound:st035964|FD-Score:4.54|P-value:2.04E-6 ID:SGTC_2001|Compound:4023502|FD-Score:3.83|P-value:5.16E-5 ID:SGTC_2004|Compound:4023728|FD-Score:3.79|P-value:6.19E-5 ID:SGTC_2058|Compound:5236698|FD-Score:4.02|P-value:2.33E-5 ID:SGTC_2078|Compound:5212016|FD-Score:3.41|P-value:2.74E-4 ID:SGTC_2156|Compound:5649887|FD-Score:-3.16|P-value:5.57E-4 ID:SGTC_2316|Compound:5844804|FD-Score:-3.22|P-value:4.51E-4 ID:SGTC_2342|Compound:7990637|FD-Score:3.93|P-value:3.32E-5 ID:SGTC_2343|Compound:7990716|FD-Score:3.22|P-value:5.52E-4 ID:SGTC_2467|Compound:5474540|FD-Score:3.26|P-value:4.81E-4 ID:SGTC_2468|Compound:5987765|FD-Score:-3.40|P-value:2.31E-4 ID:SGTC_2474|Compound:5321570|FD-Score:-3.59|P-value:1.09E-4 ID:SGTC_2555|Compound:cholic acid|FD-Score:-3.03|P-value:8.90E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:3.34|P-value:3.62E-4 ID:SGTC_2784|Compound:7567673|FD-Score:3.13|P-value:7.62E-4 ID:SGTC_2793|Compound:7325131|FD-Score:3.12|P-value:7.98E-4 ID:SGTC_2799|Compound:7812892|FD-Score:-3.07|P-value:7.84E-4 ID:SGTC_2851|Compound:9015922|FD-Score:-4.57|P-value:1.29E-6 ID:SGTC_2865|Compound:9030313|FD-Score:3.09|P-value:8.93E-4 ID:SGTC_2868|Compound:9035608|FD-Score:-3.21|P-value:4.62E-4 ID:SGTC_2878|Compound:9043973|FD-Score:4.31|P-value:6.03E-6 ID:SGTC_2888|Compound:9058547|FD-Score:-3.06|P-value:8.00E-4 ID:SGTC_2971|Compound:9092186|FD-Score:3.62|P-value:1.24E-4 ID:SGTC_3091|Compound:9116372|FD-Score:3.14|P-value:7.31E-4 ID:SGTC_11|Compound:0438-0307|FD-Score:3.39|P-value:3.00E-4 ID:SGTC_22|Compound:0964-0034|FD-Score:3.20|P-value:5.93E-4 ID:SGTC_25|Compound:0118-0223|FD-Score:3.46|P-value:2.26E-4 ID:SGTC_34|Compound:0469-0683|FD-Score:3.46|P-value:2.32E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.84|P-value:3.88E-5 ID:SGTC_65|Compound:0798-0905|FD-Score:5.36|P-value:2.62E-8 ID:SGTC_96|Compound:0929-0093|FD-Score:4.26|P-value:7.68E-6 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:5.21|P-value:6.19E-8 ID:SGTC_175|Compound:3793-3120|FD-Score:3.26|P-value:4.90E-4 ID:SGTC_644|Compound:1498-1197|FD-Score:3.11|P-value:8.35E-4 ID:SGTC_1028|Compound:k015-0029|FD-Score:4.79|P-value:5.88E-7 ID:SGTC_1285|Compound:0929-0069|FD-Score:3.38|P-value:3.11E-4 ID:SGTC_1295|Compound:1013-0063|FD-Score:3.30|P-value:4.23E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:3.51|P-value:1.91E-4 ID:SGTC_1410|Compound:3909-8106|FD-Score:3.18|P-value:6.34E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.36|P-value:2.73E-4 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:5.30|P-value:3.61E-8 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:3.41|P-value:2.78E-4 ID:SGTC_1731|Compound:st035964|FD-Score:4.54|P-value:2.04E-6 ID:SGTC_2001|Compound:4023502|FD-Score:3.83|P-value:5.16E-5 ID:SGTC_2004|Compound:4023728|FD-Score:3.79|P-value:6.19E-5 ID:SGTC_2058|Compound:5236698|FD-Score:4.02|P-value:2.33E-5 ID:SGTC_2078|Compound:5212016|FD-Score:3.41|P-value:2.74E-4 ID:SGTC_2156|Compound:5649887|FD-Score:-3.16|P-value:5.57E-4 ID:SGTC_2316|Compound:5844804|FD-Score:-3.22|P-value:4.51E-4 ID:SGTC_2342|Compound:7990637|FD-Score:3.93|P-value:3.32E-5 ID:SGTC_2343|Compound:7990716|FD-Score:3.22|P-value:5.52E-4 ID:SGTC_2467|Compound:5474540|FD-Score:3.26|P-value:4.81E-4 ID:SGTC_2468|Compound:5987765|FD-Score:-3.40|P-value:2.31E-4 ID:SGTC_2474|Compound:5321570|FD-Score:-3.59|P-value:1.09E-4 ID:SGTC_2555|Compound:cholic acid|FD-Score:-3.03|P-value:8.90E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:3.34|P-value:3.62E-4 ID:SGTC_2784|Compound:7567673|FD-Score:3.13|P-value:7.62E-4 ID:SGTC_2793|Compound:7325131|FD-Score:3.12|P-value:7.98E-4 ID:SGTC_2799|Compound:7812892|FD-Score:-3.07|P-value:7.84E-4 ID:SGTC_2851|Compound:9015922|FD-Score:-4.57|P-value:1.29E-6 ID:SGTC_2865|Compound:9030313|FD-Score:3.09|P-value:8.93E-4 ID:SGTC_2868|Compound:9035608|FD-Score:-3.21|P-value:4.62E-4 ID:SGTC_2878|Compound:9043973|FD-Score:4.31|P-value:6.03E-6 ID:SGTC_2888|Compound:9058547|FD-Score:-3.06|P-value:8.00E-4 ID:SGTC_2971|Compound:9092186|FD-Score:3.62|P-value:1.24E-4 ID:SGTC_3091|Compound:9116372|FD-Score:3.14|P-value:7.31E-4

Top fitness defect scores for YDR034C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_65 0798-0905 5.36 35.0 µM 2.62E-8 calcium & mitochondrial duress 44 4.22E-8
2 SGTC_1557 sumaresinolic acid 5.30 42.3 µM 3.61E-8 4 5.73E-8
3 SGTC_102 gallobenzophenone 5.21 83.6 µM 6.19E-8 redox potentiating 20 9.66E-8
4 SGTC_1028 k015-0029 4.79 4.8 µM 5.88E-7 10 8.47E-7
5 SGTC_1731 st035964 4.54 63.0 µM 2.04E-6 14 2.82E-6
6 SGTC_2878 9043973 4.31 26.0 µM 6.03E-6 11 8.03E-6
7 SGTC_96 0929-0093 4.26 37.3 µM 7.68E-6 calcium & mitochondrial duress 7 1.01E-5
8 SGTC_2058 5236698 4.02 133.0 µM 2.33E-5 26 2.97E-5
9 SGTC_2342 7990637 3.93 118.9 µM 3.32E-5 RNA processing & uracil transport 36 4.18E-5
10 SGTC_2001 4023502 3.83 57.7 µM 5.16E-5 mitochondrial processes 21 6.39E-5
11 SGTC_2004 4023728 3.79 41.9 µM 6.19E-5 31 7.63E-5
12 SGTC_2971 9092186 3.62 9.9 µM 1.24E-4 ergosterol biosynthesis 42 1.49E-4
13 SGTC_1310 1188-0297 3.51 994.0 nM 1.91E-4 azole & statin 44 2.26E-4
14 SGTC_25 0118-0223 3.46 35.7 µM 2.26E-4 31 2.67E-4
15 SGTC_34 0469-0683 3.46 81.8 µM 2.32E-4 SWF1 & branched chain AA biosynthesis 42 2.73E-4
16 SGTC_2078 5212016 3.41 200.0 µM 2.74E-4 60S ribosome export 27 3.22E-4
17 SGTC_1580 hydrocortisone 21-hemisuccinate 3.41 43.2 µM 2.78E-4 34 3.26E-4
18 SGTC_11 0438-0307 3.39 1.3 µM 3.00E-4 18 3.51E-4
19 SGTC_1285 0929-0069 3.38 65.5 µM 3.11E-4 39 3.64E-4
20 SGTC_2604 4'-hydroxychalcone 3.34 11.3 µM 3.62E-4 62 4.21E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.120 3.74E-12 YDR312W SSF2 hom Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication
0.116 1.64E-11 YBR139W YBR139W hom Putative serine type carboxypeptidase with a role in phytochelatin synthesis; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner
0.115 2.17E-11 YGL097W SRM1 het Nucleotide exchange factor for Gsp1p, localizes to the nucleus, required for nucleocytoplasmic trafficking of macromolecules; suppressor of the pheromone response pathway; potentially phosphorylated by Cdc28p
0.115 2.80E-11 YIL010W DOT5 hom Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth
0.112 9.13E-11 YDR480W DIG2 hom MAP kinase-responsive inhibitor of the Ste12p transcription factor, involved in the regulation of mating-specific genes and the invasive growth pathway; related regulators Dig1p and Dig2p bind to Ste12p
0.111 1.05E-10 YBR151W APD1 hom Protein of unknown function, required for normal localization of actin patches and for normal tolerance of sodium ions and hydrogen peroxide; localizes to both cytoplasm and nucleus
0.110 1.80E-10 YDR415C_p YDR415C_p hom Putative aminopeptidase
0.102 3.01E-9 YPL027W SMA1 hom Protein of unknown function involved in the assembly of the prospore membrane during sporulation; interacts with Spo14p
0.099 8.60E-9 YMR118C_p SHH3_p hom Putative mitochondrial inner membrane protein of unknown function; although similar to Sdh3p, Shh3p is not a stoichiometric subunit of either succinate dehydrogenase or of the TIM22 translocase
0.097 1.78E-8 YNL326C PFA3 hom Palmitoyltransferase for Vac8p, required for vacuolar membrane fusion; contains an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; autoacylates; required for vacuolar integrity under stress conditions
0.093 5.79E-8 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.093 6.92E-8 YLR213C CRR1 hom Putative glycoside hydrolase of the spore wall envelope; required for normal spore wall assembly, possibly for cross-linking between the glucan and chitosan layers; expressed during sporulation
0.092 8.12E-8 YLR179C YLR179C hom Protein of unknown function with similarity to Tfs1p; transcription is activated by paralogous proteins Yrm1p and Yrr1p along with proteins involved in multidrug resistance; GFP-tagged protein localizes to the cytoplasm and nucleus
0.088 3.34E-7 YGR136W LSB1 hom Protein containing an N-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein increases in abundance and forms nuclear foci in response to DNA replication stress
0.086 6.68E-7 YJL136W-A_p YJL136W-A_p hom Putative protein of unknown function; identified by SAGE