YDR034W-B_p

Predicted tail-anchored plasma membrane protein containing a conserved CYSTM module; related proteins in other organisms may be involved in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR034W-B / YDR034W-B

Click on Significant Values for Screen Details ID:SGTC_35|Compound:0133-0054|FD-Score:-3.62|P-value:1.28E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:-3.46|P-value:2.36E-4 ID:SGTC_97|Compound:0535-0701|FD-Score:4.48|P-value:3.83E-6 ID:SGTC_115|Compound:0527-0192|FD-Score:-3.53|P-value:1.81E-4 ID:SGTC_129|Compound:0088-0017|FD-Score:-3.22|P-value:5.56E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:5.07|P-value:2.07E-7 ID:SGTC_389|Compound:tpck|FD-Score:-3.25|P-value:5.10E-4 ID:SGTC_516|Compound:3992-2719|FD-Score:3.69|P-value:1.20E-4 ID:SGTC_522|Compound:1273-0010|FD-Score:3.67|P-value:1.25E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:3.56|P-value:1.96E-4 ID:SGTC_771|Compound:0250-0039|FD-Score:-4.59|P-value:1.87E-6 ID:SGTC_815|Compound:1582-0027|FD-Score:3.87|P-value:5.80E-5 ID:SGTC_976|Compound:1348-1067|FD-Score:3.37|P-value:3.92E-4 ID:SGTC_1121|Compound:fusaric acid|FD-Score:-3.09|P-value:8.99E-4 ID:SGTC_1125|Compound:tnp00248|FD-Score:-3.75|P-value:7.46E-5 ID:SGTC_1141|Compound:3253-0389|FD-Score:4.09|P-value:2.23E-5 ID:SGTC_1154|Compound:4088-0362|FD-Score:3.96|P-value:3.90E-5 ID:SGTC_1232|Compound:0279-0259|FD-Score:3.51|P-value:2.35E-4 ID:SGTC_1236|Compound:0330-0013|FD-Score:3.73|P-value:9.87E-5 ID:SGTC_1384|Compound:3089-0840|FD-Score:-3.29|P-value:4.37E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:3.37|P-value:3.99E-4 ID:SGTC_1607|Compound:st000305|FD-Score:4.59|P-value:2.29E-6 ID:SGTC_1621|Compound:st003705|FD-Score:3.26|P-value:5.94E-4 ID:SGTC_1635|Compound:st007035|FD-Score:3.25|P-value:6.08E-4 ID:SGTC_1749|Compound:st037932|FD-Score:4.33|P-value:7.87E-6 ID:SGTC_1955|Compound:wogonin|FD-Score:-3.24|P-value:5.27E-4 ID:SGTC_1963|Compound:st076565|FD-Score:3.84|P-value:6.42E-5 ID:SGTC_2026|Compound:5148700|FD-Score:-3.62|P-value:1.27E-4 ID:SGTC_2038|Compound:4100038|FD-Score:4.46|P-value:4.31E-6 ID:SGTC_2057|Compound:5236571|FD-Score:-3.17|P-value:6.72E-4 ID:SGTC_2065|Compound:5221596|FD-Score:-3.29|P-value:4.35E-4 ID:SGTC_2080|Compound:5212524|FD-Score:-4.82|P-value:5.72E-7 ID:SGTC_2247|Compound:cerulenin|FD-Score:3.38|P-value:3.86E-4 ID:SGTC_2348|Compound:9022543|FD-Score:3.16|P-value:8.31E-4 ID:SGTC_2385|Compound:9074692|FD-Score:4.11|P-value:2.03E-5 ID:SGTC_2414|Compound:st077232|FD-Score:5.23|P-value:9.04E-8 ID:SGTC_2691|Compound:st077356|FD-Score:5.69|P-value:6.49E-9 ID:SGTC_2752|Compound:diclazuril|FD-Score:6.81|P-value:4.85E-12 ID:SGTC_3101|Compound:9120531|FD-Score:3.33|P-value:4.53E-4 ID:SGTC_3106|Compound:9121286|FD-Score:3.47|P-value:2.78E-4 ID:SGTC_3153|Compound:9100258|FD-Score:3.23|P-value:6.60E-4 ID:SGTC_3254|Compound:9136651|FD-Score:-3.10|P-value:8.64E-4 ID:SGTC_3263|Compound:9137018|FD-Score:3.74|P-value:9.61E-5 ID:SGTC_3265|Compound:9137266|FD-Score:3.41|P-value:3.35E-4 ID:SGTC_3280|Compound:9140961|FD-Score:-3.36|P-value:3.43E-4 ID:SGTC_3305|Compound:9127027|FD-Score:3.34|P-value:4.39E-4 ID:SGTC_3314|Compound:9135860|FD-Score:-3.97|P-value:3.08E-5 ID:SGTC_3339|Compound:9145883|FD-Score:3.41|P-value:3.45E-4 ID:SGTC_35|Compound:0133-0054|FD-Score:-3.62|P-value:1.28E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:-3.46|P-value:2.36E-4 ID:SGTC_97|Compound:0535-0701|FD-Score:4.48|P-value:3.83E-6 ID:SGTC_115|Compound:0527-0192|FD-Score:-3.53|P-value:1.81E-4 ID:SGTC_129|Compound:0088-0017|FD-Score:-3.22|P-value:5.56E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:5.07|P-value:2.07E-7 ID:SGTC_389|Compound:tpck|FD-Score:-3.25|P-value:5.10E-4 ID:SGTC_516|Compound:3992-2719|FD-Score:3.69|P-value:1.20E-4 ID:SGTC_522|Compound:1273-0010|FD-Score:3.67|P-value:1.25E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:3.56|P-value:1.96E-4 ID:SGTC_771|Compound:0250-0039|FD-Score:-4.59|P-value:1.87E-6 ID:SGTC_815|Compound:1582-0027|FD-Score:3.87|P-value:5.80E-5 ID:SGTC_976|Compound:1348-1067|FD-Score:3.37|P-value:3.92E-4 ID:SGTC_1121|Compound:fusaric acid|FD-Score:-3.09|P-value:8.99E-4 ID:SGTC_1125|Compound:tnp00248|FD-Score:-3.75|P-value:7.46E-5 ID:SGTC_1141|Compound:3253-0389|FD-Score:4.09|P-value:2.23E-5 ID:SGTC_1154|Compound:4088-0362|FD-Score:3.96|P-value:3.90E-5 ID:SGTC_1232|Compound:0279-0259|FD-Score:3.51|P-value:2.35E-4 ID:SGTC_1236|Compound:0330-0013|FD-Score:3.73|P-value:9.87E-5 ID:SGTC_1384|Compound:3089-0840|FD-Score:-3.29|P-value:4.37E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:3.37|P-value:3.99E-4 ID:SGTC_1607|Compound:st000305|FD-Score:4.59|P-value:2.29E-6 ID:SGTC_1621|Compound:st003705|FD-Score:3.26|P-value:5.94E-4 ID:SGTC_1635|Compound:st007035|FD-Score:3.25|P-value:6.08E-4 ID:SGTC_1749|Compound:st037932|FD-Score:4.33|P-value:7.87E-6 ID:SGTC_1955|Compound:wogonin|FD-Score:-3.24|P-value:5.27E-4 ID:SGTC_1963|Compound:st076565|FD-Score:3.84|P-value:6.42E-5 ID:SGTC_2026|Compound:5148700|FD-Score:-3.62|P-value:1.27E-4 ID:SGTC_2038|Compound:4100038|FD-Score:4.46|P-value:4.31E-6 ID:SGTC_2057|Compound:5236571|FD-Score:-3.17|P-value:6.72E-4 ID:SGTC_2065|Compound:5221596|FD-Score:-3.29|P-value:4.35E-4 ID:SGTC_2080|Compound:5212524|FD-Score:-4.82|P-value:5.72E-7 ID:SGTC_2247|Compound:cerulenin|FD-Score:3.38|P-value:3.86E-4 ID:SGTC_2348|Compound:9022543|FD-Score:3.16|P-value:8.31E-4 ID:SGTC_2385|Compound:9074692|FD-Score:4.11|P-value:2.03E-5 ID:SGTC_2414|Compound:st077232|FD-Score:5.23|P-value:9.04E-8 ID:SGTC_2691|Compound:st077356|FD-Score:5.69|P-value:6.49E-9 ID:SGTC_2752|Compound:diclazuril|FD-Score:6.81|P-value:4.85E-12 ID:SGTC_3101|Compound:9120531|FD-Score:3.33|P-value:4.53E-4 ID:SGTC_3106|Compound:9121286|FD-Score:3.47|P-value:2.78E-4 ID:SGTC_3153|Compound:9100258|FD-Score:3.23|P-value:6.60E-4 ID:SGTC_3254|Compound:9136651|FD-Score:-3.10|P-value:8.64E-4 ID:SGTC_3263|Compound:9137018|FD-Score:3.74|P-value:9.61E-5 ID:SGTC_3265|Compound:9137266|FD-Score:3.41|P-value:3.35E-4 ID:SGTC_3280|Compound:9140961|FD-Score:-3.36|P-value:3.43E-4 ID:SGTC_3305|Compound:9127027|FD-Score:3.34|P-value:4.39E-4 ID:SGTC_3314|Compound:9135860|FD-Score:-3.97|P-value:3.08E-5 ID:SGTC_3339|Compound:9145883|FD-Score:3.41|P-value:3.45E-4

Top fitness defect scores for YDR034W-B deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2752 diclazuril 6.81 33.1 µM 4.85E-12 51 4.78E-12
2 SGTC_2691 st077356 5.69 60.2 µM 6.49E-9 10 6.28E-9
3 SGTC_2414 st077232 5.23 92.9 µM 9.04E-8 7 8.69E-8
4 SGTC_236 1509-0011 5.07 5.3 µM 2.07E-7 324 1.99E-7
5 SGTC_1607 st000305 4.59 50.6 µM 2.29E-6 5 2.18E-6
6 SGTC_97 0535-0701 4.48 19.1 µM 3.83E-6 60S ribosome export 10 3.66E-6
7 SGTC_2038 4100038 4.46 31.0 µM 4.31E-6 plasma membrane duress 33 4.12E-6
8 SGTC_1749 st037932 4.33 54.2 µM 7.87E-6 22 7.51E-6
9 SGTC_2385 9074692 4.11 200.0 µM 2.03E-5 38 1.94E-5
10 SGTC_1141 3253-0389 4.09 52.6 µM 2.23E-5 5 2.13E-5
11 SGTC_1154 4088-0362 3.96 150.0 µM 3.90E-5 20 3.72E-5
12 SGTC_815 1582-0027 3.87 36.9 µM 5.80E-5 30 5.53E-5
13 SGTC_1963 st076565 3.84 50.3 µM 6.42E-5 13 6.11E-5
14 SGTC_3263 9137018 3.74 49.5 µM 9.61E-5 22 9.15E-5
15 SGTC_1236 0330-0013 3.73 258.0 µM 9.87E-5 14 9.40E-5
16 SGTC_516 3992-2719 3.69 87.3 µM 1.20E-4 19 1.14E-4
17 SGTC_522 1273-0010 3.67 11.6 µM 1.25E-4 60S ribosome export 28 1.19E-4
18 SGTC_769 0302-0231 3.56 76.0 µM 1.96E-4 60 1.87E-4
19 SGTC_1232 0279-0259 3.51 161.0 µM 2.35E-4 36 2.24E-4
20 SGTC_3106 9121286 3.47 49.5 µM 2.78E-4 27 2.65E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.190 1.55E-28 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.188 4.44E-28 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.185 3.25E-27 YGL237C HAP2 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.175 1.98E-24 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.174 3.72E-24 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.172 1.50E-23 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.171 1.60E-23 YGR183C QCR9 hom Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex
0.171 1.86E-23 YEL059C-A SOM1 hom Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.171 2.75E-23 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.169 5.15E-23 YPL132W COX11 hom Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p
0.167 2.17E-22 YGR028W MSP1 hom Mitochondrial protein involved in sorting of proteins in the mitochondria; putative membrane-spanning ATPase
0.165 5.16E-22 YPL215W CBP3 hom Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.164 1.47E-21 YBL021C HAP3 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences contributing to both complex assembly and DNA binding
0.163 2.20E-21 YER058W PET117 hom Protein required for assembly of cytochrome c oxidase
0.162 3.11E-21 YJL209W CBP1 hom Mitochondrial protein, regulator of COB mRNA stability and translation; interacts with the 5'-untranslated region of the COB mRNA; found in a complex at the inner membrane along with Pet309p; localizes to mitochondrial foci upon DNA replication stress