HIPHOP chemogenomics database
YDR036C / EHD3 
3-hydroxyisobutyryl-CoA hydrolase, member of a family of enoyl-CoA hydratase/isomerases; non-tagged protein is detected in highly purified mitochondria in high-throughput studies; phosphorylated; mutation affects fluid-phase endocytosis
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YDR036C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.179 | 1.06E-25 | YER067C-A_d | YER067C-A_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER067W |
| 0.170 | 3.41E-23 | YGL017W | ATE1 | hom | Arginyl-tRNA-protein transferase, catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway |
| 0.168 | 1.19E-22 | YBR262C | AIM5 | hom | Mitochondrial inner membrane protein; subunit of the mitochondrial inner membrane organizing system (MitOS, MICOS, or MINOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture |
| 0.153 | 5.03E-19 | YOR300W_d | YOR300W_d | hom | Dubious open reading frame, unlikely to encode a protein; overlaps with verified gene BUD7/YOR299W; mutation affects bipolar budding and bud site selection, though phenotype could be due to the mutation's effects on BUD7 |
| 0.148 | 6.95E-18 | YHL006C | SHU1 | hom | Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function |
| 0.140 | 4.53E-16 | YDL110C | TMA17 | hom | Protein of unknown function that associates with ribosomes; heterozygous deletion demonstrated increases in chromosome instability in a rad9 deletion background; protein abundance is decreased upon intracellular iron depletion |
| 0.140 | 4.63E-16 | YBL086C_p | YBL086C_p | hom | Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery |
| 0.139 | 6.48E-16 | YDR146C | SWI5 | hom | Transcription factor that recruits Mediator and Swi/Snf complexes; activates transcription of genes expressed at the M/G1 phase boundary and in G1 phase; required for expression of the HO gene controlling mating type switching; localization to nucleus occurs during G1 and appears to be regulated by phosphorylation by Cdc28p kinase; SWI5 has a paralog, ACE2, that arose from the whole genome duplication |
| 0.138 | 9.03E-16 | YML053C_p | YML053C_p | hom | Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; overexpression causes a cell cycle delay or arrest; YML053C is not an essential gene |
| 0.134 | 5.45E-15 | YDR046C | BAP3 | hom | Amino acid permease; involved in uptake of cysteine, leucine, isoleucine and valine; BAP3 has a paralog, BAP2, that arose from the whole genome duplication |
| 0.130 | 3.95E-14 | YMR173W | DDR48 | hom | DNA damage-responsive protein; expression is increased in response to heat-shock stress or treatments that produce DNA lesions; contains multiple repeats of the amino acid sequence NNNDSYGS; protein abundance increases in response to DNA replication stress |
| 0.129 | 7.85E-14 | YNL242W | ATG2 | hom | Peripheral membrane protein required for autophagic vesicle formation; also required for vesicle formation during pexophagy and the cytoplasm-to-vaucole targeting (Cvt) pathway; involved in Atg9p cycling between the phagophore assembly site and mitochondria; forms cytoplasmic foci upon DNA replication stress |
| 0.126 | 2.52E-13 | YHL017W_p | YHL017W_p | hom | Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein co-localizes with clathrin-coated vesicles; YHL017W has a paralog, PTM1, that arose from the whole genome duplication |
| 0.124 | 4.85E-13 | YGR251W | NOP19 | het | Ribosome biogenesis factor; nucleolar protein associated with pre-rRNA components of the 90S preribosome, required for cleavage of pre-rRNA at A0, A1 and A2 sites; interacts with RNA helicase Dhr2p and RNA helicase-like protein Utp25p; required for incorporation of Utp25p into preribosomes |
| 0.119 | 3.85E-12 | YNL078W | NIS1 | hom | Protein localized in the bud neck at G2/M phase; physically interacts with septins; possibly involved in a mitotic signaling network |