YDR037W / KRS1

Lysyl-tRNA synthetase

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDR037W / KRS1

Click on Significant Values for Screen Details ID:SGTC_55|Compound:0767-0285|FD-Score:-3.16|P-value:3.91E-5 ID:SGTC_182|Compound:3448-4371|FD-Score:2.65|P-value:3.80E-4 ID:SGTC_375|Compound:3970-0961|FD-Score:-2.66|P-value:4.43E-4 ID:SGTC_433|Compound:pimozide|FD-Score:2.58|P-value:5.11E-4 ID:SGTC_438|Compound:sphingosine|FD-Score:-2.93|P-value:1.22E-4 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:3.99|P-value:2.08E-7 ID:SGTC_516|Compound:3992-2719|FD-Score:7.31|P-value:1.15E-20 ID:SGTC_727|Compound:3032-0951|FD-Score:3.06|P-value:5.20E-5 ID:SGTC_750|Compound:4073-0104|FD-Score:-4.95|P-value:2.62E-10 ID:SGTC_756|Compound:0508-1999|FD-Score:2.70|P-value:2.92E-4 ID:SGTC_784|Compound:4579-0127|FD-Score:2.61|P-value:4.45E-4 ID:SGTC_874|Compound:0599-0792|FD-Score:3.53|P-value:3.77E-6 ID:SGTC_948|Compound:3448-0295|FD-Score:-2.55|P-value:7.29E-4 ID:SGTC_967|Compound:1306-0166|FD-Score:3.09|P-value:4.45E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.97|P-value:3.32E-7 ID:SGTC_1170|Compound:0310-0127|FD-Score:2.56|P-value:5.56E-4 ID:SGTC_1268|Compound:0828-0275|FD-Score:5.43|P-value:3.07E-12 ID:SGTC_1270|Compound:0831-1170|FD-Score:6.50|P-value:9.42E-17 ID:SGTC_1276|Compound:0871-0068|FD-Score:3.80|P-value:7.17E-7 ID:SGTC_1281|Compound:0884-0031|FD-Score:-4.74|P-value:1.31E-9 ID:SGTC_1287|Compound:0971-0001|FD-Score:-5.68|P-value:4.98E-13 ID:SGTC_1288|Compound:0973-0013|FD-Score:3.02|P-value:6.12E-5 ID:SGTC_1290|Compound:0986-0249|FD-Score:-2.71|P-value:3.51E-4 ID:SGTC_1383|Compound:3049-0032|FD-Score:2.83|P-value:1.60E-4 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:2.43|P-value:9.91E-4 ID:SGTC_1676|Compound:st018489|FD-Score:-2.83|P-value:2.00E-4 ID:SGTC_1682|Compound:st012968|FD-Score:-3.55|P-value:4.30E-6 ID:SGTC_1693|Compound:xanthone|FD-Score:2.92|P-value:1.01E-4 ID:SGTC_1710|Compound:st031758|FD-Score:2.89|P-value:1.19E-4 ID:SGTC_1989|Compound:st071868|FD-Score:2.47|P-value:8.45E-4 ID:SGTC_2051|Compound:5263410|FD-Score:-3.73|P-value:1.52E-6 ID:SGTC_2053|Compound:5265679|FD-Score:-3.31|P-value:1.72E-5 ID:SGTC_2054|Compound:5233173|FD-Score:-8.39|P-value:2.54E-26 ID:SGTC_2130|Compound:NSC 7|FD-Score:2.67|P-value:3.42E-4 ID:SGTC_2163|Compound:5671233|FD-Score:-2.74|P-value:3.00E-4 ID:SGTC_2210|Compound:7115885|FD-Score:-2.85|P-value:1.83E-4 ID:SGTC_2283|Compound:7944793|FD-Score:-2.60|P-value:5.69E-4 ID:SGTC_2292|Compound:7671323|FD-Score:3.63|P-value:2.02E-6 ID:SGTC_2297|Compound:7971671|FD-Score:5.80|P-value:1.08E-13 ID:SGTC_2302|Compound:7771753|FD-Score:-3.71|P-value:1.69E-6 ID:SGTC_2398|Compound:5228213|FD-Score:2.55|P-value:6.00E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:2.63|P-value:4.07E-4 ID:SGTC_2557|Compound:derrustone|FD-Score:2.48|P-value:7.95E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:2.80|P-value:1.87E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:2.53|P-value:6.30E-4 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:3.83|P-value:6.05E-7 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:2.79|P-value:1.91E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:-2.60|P-value:5.71E-4 ID:SGTC_2797|Compound:7859098|FD-Score:-3.38|P-value:1.17E-5 ID:SGTC_2798|Compound:7813637|FD-Score:-3.21|P-value:2.87E-5 ID:SGTC_2801|Compound:7907800|FD-Score:-5.70|P-value:4.10E-13 ID:SGTC_2803|Compound:7707263|FD-Score:2.93|P-value:9.96E-5 ID:SGTC_2806|Compound:7952793|FD-Score:2.61|P-value:4.60E-4 ID:SGTC_2811|Compound:7967822|FD-Score:-4.49|P-value:9.01E-9 ID:SGTC_2839|Compound:9003951|FD-Score:4.79|P-value:6.29E-10 ID:SGTC_2847|Compound:9005661|FD-Score:2.83|P-value:1.57E-4 ID:SGTC_2857|Compound:9024691|FD-Score:2.44|P-value:9.71E-4 ID:SGTC_2942|Compound:9052777|FD-Score:7.60|P-value:3.54E-22 ID:SGTC_55|Compound:0767-0285|FD-Score:-3.16|P-value:3.91E-5 ID:SGTC_182|Compound:3448-4371|FD-Score:2.65|P-value:3.80E-4 ID:SGTC_375|Compound:3970-0961|FD-Score:-2.66|P-value:4.43E-4 ID:SGTC_433|Compound:pimozide|FD-Score:2.58|P-value:5.11E-4 ID:SGTC_438|Compound:sphingosine|FD-Score:-2.93|P-value:1.22E-4 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:3.99|P-value:2.08E-7 ID:SGTC_516|Compound:3992-2719|FD-Score:7.31|P-value:1.15E-20 ID:SGTC_727|Compound:3032-0951|FD-Score:3.06|P-value:5.20E-5 ID:SGTC_750|Compound:4073-0104|FD-Score:-4.95|P-value:2.62E-10 ID:SGTC_756|Compound:0508-1999|FD-Score:2.70|P-value:2.92E-4 ID:SGTC_784|Compound:4579-0127|FD-Score:2.61|P-value:4.45E-4 ID:SGTC_874|Compound:0599-0792|FD-Score:3.53|P-value:3.77E-6 ID:SGTC_948|Compound:3448-0295|FD-Score:-2.55|P-value:7.29E-4 ID:SGTC_967|Compound:1306-0166|FD-Score:3.09|P-value:4.45E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.97|P-value:3.32E-7 ID:SGTC_1170|Compound:0310-0127|FD-Score:2.56|P-value:5.56E-4 ID:SGTC_1268|Compound:0828-0275|FD-Score:5.43|P-value:3.07E-12 ID:SGTC_1270|Compound:0831-1170|FD-Score:6.50|P-value:9.42E-17 ID:SGTC_1276|Compound:0871-0068|FD-Score:3.80|P-value:7.17E-7 ID:SGTC_1281|Compound:0884-0031|FD-Score:-4.74|P-value:1.31E-9 ID:SGTC_1287|Compound:0971-0001|FD-Score:-5.68|P-value:4.98E-13 ID:SGTC_1288|Compound:0973-0013|FD-Score:3.02|P-value:6.12E-5 ID:SGTC_1290|Compound:0986-0249|FD-Score:-2.71|P-value:3.51E-4 ID:SGTC_1383|Compound:3049-0032|FD-Score:2.83|P-value:1.60E-4 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:2.43|P-value:9.91E-4 ID:SGTC_1676|Compound:st018489|FD-Score:-2.83|P-value:2.00E-4 ID:SGTC_1682|Compound:st012968|FD-Score:-3.55|P-value:4.30E-6 ID:SGTC_1693|Compound:xanthone|FD-Score:2.92|P-value:1.01E-4 ID:SGTC_1710|Compound:st031758|FD-Score:2.89|P-value:1.19E-4 ID:SGTC_1989|Compound:st071868|FD-Score:2.47|P-value:8.45E-4 ID:SGTC_2051|Compound:5263410|FD-Score:-3.73|P-value:1.52E-6 ID:SGTC_2053|Compound:5265679|FD-Score:-3.31|P-value:1.72E-5 ID:SGTC_2054|Compound:5233173|FD-Score:-8.39|P-value:2.54E-26 ID:SGTC_2130|Compound:NSC 7|FD-Score:2.67|P-value:3.42E-4 ID:SGTC_2163|Compound:5671233|FD-Score:-2.74|P-value:3.00E-4 ID:SGTC_2210|Compound:7115885|FD-Score:-2.85|P-value:1.83E-4 ID:SGTC_2283|Compound:7944793|FD-Score:-2.60|P-value:5.69E-4 ID:SGTC_2292|Compound:7671323|FD-Score:3.63|P-value:2.02E-6 ID:SGTC_2297|Compound:7971671|FD-Score:5.80|P-value:1.08E-13 ID:SGTC_2302|Compound:7771753|FD-Score:-3.71|P-value:1.69E-6 ID:SGTC_2398|Compound:5228213|FD-Score:2.55|P-value:6.00E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:2.63|P-value:4.07E-4 ID:SGTC_2557|Compound:derrustone|FD-Score:2.48|P-value:7.95E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:2.80|P-value:1.87E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:2.53|P-value:6.30E-4 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:3.83|P-value:6.05E-7 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:2.79|P-value:1.91E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:-2.60|P-value:5.71E-4 ID:SGTC_2797|Compound:7859098|FD-Score:-3.38|P-value:1.17E-5 ID:SGTC_2798|Compound:7813637|FD-Score:-3.21|P-value:2.87E-5 ID:SGTC_2801|Compound:7907800|FD-Score:-5.70|P-value:4.10E-13 ID:SGTC_2803|Compound:7707263|FD-Score:2.93|P-value:9.96E-5 ID:SGTC_2806|Compound:7952793|FD-Score:2.61|P-value:4.60E-4 ID:SGTC_2811|Compound:7967822|FD-Score:-4.49|P-value:9.01E-9 ID:SGTC_2839|Compound:9003951|FD-Score:4.79|P-value:6.29E-10 ID:SGTC_2847|Compound:9005661|FD-Score:2.83|P-value:1.57E-4 ID:SGTC_2857|Compound:9024691|FD-Score:2.44|P-value:9.71E-4 ID:SGTC_2942|Compound:9052777|FD-Score:7.60|P-value:3.54E-22

Top fitness defect scores for YDR037W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2942 9052777 7.60 62.2 µM 3.54E-22 1 1.47E-14 1.66
2 SGTC_516 3992-2719 7.31 87.3 µM 1.15E-20 1 1.32E-13 2.27
3 SGTC_1270 0831-1170 6.50 17.3 µM 9.42E-17 1 3.92E-11 2.02
4 SGTC_2297 7971671 5.80 152.3 µM 1.08E-13 RNA processing & uracil transport 3 3.36E-9 0.56
5 SGTC_1268 0828-0275 5.43 2.5 µM 3.07E-12 3 2.80E-8 0.55
6 SGTC_2839 9003951 4.79 26.0 µM 6.29E-10 1 8.20E-7 0.88
7 SGTC_473 2-arachidonoylglycerol 3.99 10.0 µM 2.08E-7 4 3.28E-5 0.14
8 SGTC_2574 2',4'-dihydroxychalcone 3.83 14.6 µM 6.05E-7 11 6.48E-5 0.00
9 SGTC_1276 0871-0068 3.80 94.2 µM 7.17E-7 8 7.23E-5 0.23
10 SGTC_2292 7671323 3.63 168.1 µM 2.02E-6 RNA processing & uracil transport 14 1.40E-4 0.02
11 SGTC_874 0599-0792 3.53 117.0 µM 3.77E-6 9 2.09E-4 0.08
12 SGTC_967 1306-0166 3.09 352.0 µM 4.45E-5 6 0.00102 0.06
13 SGTC_727 3032-0951 3.06 202.0 µM 5.20E-5 7 0.00112 0.23
14 SGTC_1288 0973-0013 3.02 65.5 µM 6.12E-5 7 0.00125 0.02
15 SGTC_2803 7707263 2.93 71.4 µM 9.96E-5 10 0.00171 0.06
16 SGTC_1693 xanthone 2.92 101.9 µM 1.01E-4 DNA damage response 21 0.00172 0.03
17 SGTC_1710 st031758 2.89 61.5 µM 1.19E-4 14 0.00191 0.09
18 SGTC_2847 9005661 2.83 71.4 µM 1.57E-4 5 0.00229 0.06
19 SGTC_1383 3049-0032 2.83 20.7 µM 1.60E-4 60S ribosome export 28 0.00231 0.05
20 SGTC_2564 betulinic acid 2.80 100.0 µM 1.87E-4 24 0.00256 0.05

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.198 4.64E-31 YKL122C SRP21 het Subunit of the signal recognition particle (SRP), which functions in protein targeting to the endoplasmic reticulum membrane; not found in mammalian SRP; forms a pre-SRP structure in the nucleolus that is translocated to the cytoplasm
0.181 4.45E-26 YGR149W_p YGR149W_p hom Putative protein of unknown function; predicted to be an integal membrane protein
0.170 4.14E-23 YMR111C YMR111C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR111C is not an essential gene; forms nuclear foci upon DNA replication stress
0.165 5.79E-22 YLR016C PML1 hom Subunit of the RES complex, which is required for nuclear retention of unspliced pre-mRNAs; acts in the same pathway as Pml39p and Mlp1p
0.159 2.45E-20 YMR210W YMR210W hom Putative acyltransferase with similarity to Eeb1p and Eht1p, has a minor role in medium-chain fatty acid ethyl ester biosynthesis; may be involved in lipid metabolism and detoxification
0.156 1.23E-19 YDL224C WHI4 hom Putative RNA binding protein; regulates the cell size requirement for passage through Start and commitment to cell division; WHI4 has a paralog, WHI3, that arose from the whole genome duplication
0.155 1.91E-19 YGL081W_p YGL081W_p hom Putative protein of unknown function; non-essential gene; interacts genetically with CHS5, a gene involved in chitin biosynthesis
0.147 8.76E-18 YDR013W PSF1 het Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery
0.146 1.45E-17 YLR353W BUD8 hom Protein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the proximal pole
0.146 1.53E-17 YFR042W KEG1 het Integral membrane protein of the ER; physically interacts with Kre6p; has a role in the synthesis of beta-1,6-glucan in the cell wall; required for cell viability
0.146 1.58E-17 YJL122W ALB1 hom Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit; interacts directly with Arx1p; responsible for Tif6p recycling defects in absence of Rei1p
0.144 3.99E-17 YJR051W OSM1 hom Fumarate reductase, catalyzes the reduction of fumarate to succinate; required for the reoxidation of intracellular NADH under anaerobic conditions; mutations cause osmotic sensitivity; OSM1 has a paralog, FRD1, that arose from the whole genome duplication
0.138 1.09E-15 YML011C RAD33 hom Protein involved in nucleotide excision repair; green fluorescent protein (GFP)-fusion protein localizes to the nucleus
0.137 1.51E-15 YDR044W HEM13 het Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; transcription is repressed by oxygen and heme (via Rox1p and Hap1p)
0.137 1.72E-15 YGR032W GSC2 hom Catalytic subunit of 1,3-beta-glucan synthase, involved in formation of the inner layer of the spore wall; activity positively regulated by Rho1p and negatively by Smk1p; has similarity to an alternate catalytic subunit, Fks1p (Gsc1p)