YDR041W / RSM10

Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S10 ribosomal protein; essential for viability, unlike most other mitoribosomal proteins

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDR041W / RSM10

Click on Significant Values for Screen Details ID:SGTC_70|Compound:0141-0289|FD-Score:-3.40|P-value:3.45E-4 ID:SGTC_81|Compound:0411-0046|FD-Score:10.30|P-value:2.11E-25 ID:SGTC_97|Compound:0535-0701|FD-Score:3.11|P-value:7.91E-4 ID:SGTC_214|Compound:4373-3496|FD-Score:4.14|P-value:1.40E-5 ID:SGTC_374|Compound:0880-0231|FD-Score:-3.98|P-value:3.44E-5 ID:SGTC_412|Compound:gemfibrozil|FD-Score:3.19|P-value:5.96E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-7.19|P-value:2.78E-13 ID:SGTC_513|Compound:4245-1575|FD-Score:3.93|P-value:3.44E-5 ID:SGTC_525|Compound:k781-2675|FD-Score:3.53|P-value:1.76E-4 ID:SGTC_584|Compound:0986-0246|FD-Score:3.32|P-value:3.80E-4 ID:SGTC_586|Compound:0957-0265|FD-Score:-3.11|P-value:9.72E-4 ID:SGTC_601|Compound:0986-0029|FD-Score:3.58|P-value:1.44E-4 ID:SGTC_602|Compound:3130-1533|FD-Score:3.14|P-value:7.29E-4 ID:SGTC_611|Compound:3453-1652|FD-Score:5.88|P-value:1.42E-9 ID:SGTC_673|Compound:1082-0474|FD-Score:-3.10|P-value:9.86E-4 ID:SGTC_687|Compound:k029-0044|FD-Score:3.19|P-value:6.04E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:5.95|P-value:9.34E-10 ID:SGTC_743|Compound:1275-0778|FD-Score:4.13|P-value:1.44E-5 ID:SGTC_758|Compound:0868-0029|FD-Score:-3.15|P-value:8.47E-4 ID:SGTC_765|Compound:1319-0117|FD-Score:3.25|P-value:4.88E-4 ID:SGTC_807|Compound:1315-0151|FD-Score:3.16|P-value:6.85E-4 ID:SGTC_907|Compound:3448-6986|FD-Score:3.06|P-value:9.66E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.14|P-value:8.64E-4 ID:SGTC_1167|Compound:k781-0610|FD-Score:5.48|P-value:1.51E-8 ID:SGTC_1200|Compound:1643-0193|FD-Score:3.53|P-value:1.72E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:3.32|P-value:3.74E-4 ID:SGTC_1209|Compound:2323-2347|FD-Score:3.85|P-value:4.91E-5 ID:SGTC_1211|Compound:1056-0033|FD-Score:4.66|P-value:1.23E-6 ID:SGTC_1215|Compound:3852-0577|FD-Score:3.55|P-value:1.62E-4 ID:SGTC_1330|Compound:1469-0054|FD-Score:-3.38|P-value:3.73E-4 ID:SGTC_1343|Compound:1487-0095|FD-Score:3.08|P-value:8.77E-4 ID:SGTC_1351|Compound:1496-0003|FD-Score:3.59|P-value:1.38E-4 ID:SGTC_1422|Compound:4031-0024|FD-Score:3.41|P-value:2.69E-4 ID:SGTC_1455|Compound:4262-0120|FD-Score:-3.26|P-value:5.76E-4 ID:SGTC_1658|Compound:st012944|FD-Score:3.63|P-value:1.19E-4 ID:SGTC_1749|Compound:st037932|FD-Score:3.37|P-value:3.21E-4 ID:SGTC_1814|Compound:st052110|FD-Score:3.39|P-value:2.96E-4 ID:SGTC_1877|Compound:wortmannin|FD-Score:5.72|P-value:3.72E-9 ID:SGTC_1908|Compound:st060353|FD-Score:3.07|P-value:9.06E-4 ID:SGTC_1915|Compound:st067105|FD-Score:-3.20|P-value:7.15E-4 ID:SGTC_1968|Compound:st069590|FD-Score:-3.36|P-value:3.94E-4 ID:SGTC_2004|Compound:4023728|FD-Score:8.44|P-value:8.44E-18 ID:SGTC_2019|Compound:4016004|FD-Score:3.46|P-value:2.22E-4 ID:SGTC_2046|Compound:4110841|FD-Score:4.38|P-value:4.55E-6 ID:SGTC_2246|Compound:7293507|FD-Score:4.98|P-value:2.35E-7 ID:SGTC_2278|Compound:7948257|FD-Score:3.25|P-value:4.85E-4 ID:SGTC_2430|Compound:5571206|FD-Score:4.20|P-value:1.07E-5 ID:SGTC_2466|Compound:5983409|FD-Score:3.31|P-value:3.98E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:5.55|P-value:9.99E-9 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:-3.53|P-value:2.08E-4 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:3.25|P-value:4.95E-4 ID:SGTC_2864|Compound:9034755|FD-Score:-3.64|P-value:1.39E-4 ID:SGTC_2968|Compound:9090663|FD-Score:3.13|P-value:7.48E-4 ID:SGTC_2969|Compound:9091408|FD-Score:3.32|P-value:3.78E-4 ID:SGTC_3142|Compound:9086498|FD-Score:6.32|P-value:8.52E-11 ID:SGTC_3188|Compound:9110789|FD-Score:3.23|P-value:5.23E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:-3.40|P-value:3.45E-4 ID:SGTC_81|Compound:0411-0046|FD-Score:10.30|P-value:2.11E-25 ID:SGTC_97|Compound:0535-0701|FD-Score:3.11|P-value:7.91E-4 ID:SGTC_214|Compound:4373-3496|FD-Score:4.14|P-value:1.40E-5 ID:SGTC_374|Compound:0880-0231|FD-Score:-3.98|P-value:3.44E-5 ID:SGTC_412|Compound:gemfibrozil|FD-Score:3.19|P-value:5.96E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-7.19|P-value:2.78E-13 ID:SGTC_513|Compound:4245-1575|FD-Score:3.93|P-value:3.44E-5 ID:SGTC_525|Compound:k781-2675|FD-Score:3.53|P-value:1.76E-4 ID:SGTC_584|Compound:0986-0246|FD-Score:3.32|P-value:3.80E-4 ID:SGTC_586|Compound:0957-0265|FD-Score:-3.11|P-value:9.72E-4 ID:SGTC_601|Compound:0986-0029|FD-Score:3.58|P-value:1.44E-4 ID:SGTC_602|Compound:3130-1533|FD-Score:3.14|P-value:7.29E-4 ID:SGTC_611|Compound:3453-1652|FD-Score:5.88|P-value:1.42E-9 ID:SGTC_673|Compound:1082-0474|FD-Score:-3.10|P-value:9.86E-4 ID:SGTC_687|Compound:k029-0044|FD-Score:3.19|P-value:6.04E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:5.95|P-value:9.34E-10 ID:SGTC_743|Compound:1275-0778|FD-Score:4.13|P-value:1.44E-5 ID:SGTC_758|Compound:0868-0029|FD-Score:-3.15|P-value:8.47E-4 ID:SGTC_765|Compound:1319-0117|FD-Score:3.25|P-value:4.88E-4 ID:SGTC_807|Compound:1315-0151|FD-Score:3.16|P-value:6.85E-4 ID:SGTC_907|Compound:3448-6986|FD-Score:3.06|P-value:9.66E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.14|P-value:8.64E-4 ID:SGTC_1167|Compound:k781-0610|FD-Score:5.48|P-value:1.51E-8 ID:SGTC_1200|Compound:1643-0193|FD-Score:3.53|P-value:1.72E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:3.32|P-value:3.74E-4 ID:SGTC_1209|Compound:2323-2347|FD-Score:3.85|P-value:4.91E-5 ID:SGTC_1211|Compound:1056-0033|FD-Score:4.66|P-value:1.23E-6 ID:SGTC_1215|Compound:3852-0577|FD-Score:3.55|P-value:1.62E-4 ID:SGTC_1330|Compound:1469-0054|FD-Score:-3.38|P-value:3.73E-4 ID:SGTC_1343|Compound:1487-0095|FD-Score:3.08|P-value:8.77E-4 ID:SGTC_1351|Compound:1496-0003|FD-Score:3.59|P-value:1.38E-4 ID:SGTC_1422|Compound:4031-0024|FD-Score:3.41|P-value:2.69E-4 ID:SGTC_1455|Compound:4262-0120|FD-Score:-3.26|P-value:5.76E-4 ID:SGTC_1658|Compound:st012944|FD-Score:3.63|P-value:1.19E-4 ID:SGTC_1749|Compound:st037932|FD-Score:3.37|P-value:3.21E-4 ID:SGTC_1814|Compound:st052110|FD-Score:3.39|P-value:2.96E-4 ID:SGTC_1877|Compound:wortmannin|FD-Score:5.72|P-value:3.72E-9 ID:SGTC_1908|Compound:st060353|FD-Score:3.07|P-value:9.06E-4 ID:SGTC_1915|Compound:st067105|FD-Score:-3.20|P-value:7.15E-4 ID:SGTC_1968|Compound:st069590|FD-Score:-3.36|P-value:3.94E-4 ID:SGTC_2004|Compound:4023728|FD-Score:8.44|P-value:8.44E-18 ID:SGTC_2019|Compound:4016004|FD-Score:3.46|P-value:2.22E-4 ID:SGTC_2046|Compound:4110841|FD-Score:4.38|P-value:4.55E-6 ID:SGTC_2246|Compound:7293507|FD-Score:4.98|P-value:2.35E-7 ID:SGTC_2278|Compound:7948257|FD-Score:3.25|P-value:4.85E-4 ID:SGTC_2430|Compound:5571206|FD-Score:4.20|P-value:1.07E-5 ID:SGTC_2466|Compound:5983409|FD-Score:3.31|P-value:3.98E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:5.55|P-value:9.99E-9 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:-3.53|P-value:2.08E-4 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:3.25|P-value:4.95E-4 ID:SGTC_2864|Compound:9034755|FD-Score:-3.64|P-value:1.39E-4 ID:SGTC_2968|Compound:9090663|FD-Score:3.13|P-value:7.48E-4 ID:SGTC_2969|Compound:9091408|FD-Score:3.32|P-value:3.78E-4 ID:SGTC_3142|Compound:9086498|FD-Score:6.32|P-value:8.52E-11 ID:SGTC_3188|Compound:9110789|FD-Score:3.23|P-value:5.23E-4

Top fitness defect scores for YDR041W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_81 0411-0046 10.30 10.0 µM 2.11E-25 7 5.32E-25 1.05
2 SGTC_2004 4023728 8.44 41.9 µM 8.44E-18 10 1.65E-17 0.18
3 SGTC_3142 9086498 6.32 49.5 µM 8.52E-11 iron homeostasis 22 1.30E-10 0.06
4 SGTC_690 glyoxal 5.95 20.3 µM 9.34E-10 10 1.37E-9 0.34
5 SGTC_611 3453-1652 5.88 23.7 µM 1.42E-9 9 2.07E-9 0.17
6 SGTC_1877 wortmannin 5.72 25.0 µM 3.72E-9 3 5.35E-9 0.39
7 SGTC_2573 2',4'-dihydroxychalcone 5.55 15.0 µM 9.99E-9 7 1.41E-8 0.81
8 SGTC_1167 k781-0610 5.48 148.0 µM 1.51E-8 RNA processing & uracil transport 2 2.13E-8 0.66
9 SGTC_2246 7293507 4.98 91.6 µM 2.35E-7 8 3.15E-7 0.64
10 SGTC_1211 1056-0033 4.66 32.3 µM 1.23E-6 2 1.61E-6 0.91
11 SGTC_2046 4110841 4.38 106.0 µM 4.55E-6 iron homeostasis 6 5.81E-6 0.17
12 SGTC_2430 5571206 4.20 200.0 µM 1.07E-5 19 1.34E-5 0.15
13 SGTC_214 4373-3496 4.14 70.0 µM 1.40E-5 17 1.76E-5 0.20
14 SGTC_743 1275-0778 4.13 158.0 µM 1.44E-5 excess fatty acid 13 1.80E-5 0.13
15 SGTC_513 4245-1575 3.93 41.7 µM 3.44E-5 unfolded protein response 30 4.24E-5 0.04
16 SGTC_1209 2323-2347 3.85 50.3 µM 4.91E-5 4 6.03E-5 0.29
17 SGTC_1658 st012944 3.63 20.0 µM 1.19E-4 iron homeostasis 11 1.44E-4 0.26
18 SGTC_1351 1496-0003 3.59 46.5 µM 1.38E-4 6 1.66E-4 0.20
19 SGTC_601 0986-0029 3.58 62.9 µM 1.44E-4 calcium & mitochondrial duress 21 1.74E-4 0.12
20 SGTC_1215 3852-0577 3.55 11.2 µM 1.62E-4 10 1.94E-4 0.08

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.347 8.50E-96 YMR260C TIF11 het Translation initiation factor eIF1A, essential protein that forms a complex with Sui1p (eIF1) and the 40S ribosomal subunit and scans for the start codon; C-terminus associates with Fun12p (eIF5B); N terminus interacts with eIF2 and eIF3
0.289 1.75E-65 YNL112W DBP2 het ATP-dependent RNA helicase of the DEAD-box protein family; has a strong preference for dsRNA; involved mRNA decay and rRNA processing; may be involved in suppression of transcription from cryptic initiation sites
0.250 6.62E-49 YLR243W GPN3 het Putative GTPase with a role in biogenesis of RNA pol II and polIII; may be involved in assembly of RNA polymerases II and III and in their transport into the nucleus; contains a Gly-Pro-Asn motif in the G domain; similar to Npa3p and Gpn2p
0.200 1.40E-31 YDR527W RBA50 het Protein involved in transcription; interacts with RNA polymerase II subunits Rpb2p, Rpb3, and Rpb11p; has similarity to human RPAP1
0.181 4.87E-26 YNL114C_d YNL114C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RPC19/YNL113W, an RNA polymerase subunit
0.155 1.80E-19 YDR272W GLO2 hom Cytoplasmic glyoxalase II, catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate
0.148 8.39E-18 YNL131W TOM22 het Component of the TOM (translocase of outer mitochondrial membrane) complex responsible for initial import of mitochondrially directed proteins; acts as a receptor for precursor proteins and mediates interaction between TOM and TIM complexes
0.140 3.04E-16 YDR189W SLY1 het Hydrophilic protein involved in vesicle trafficking between the ER and Golgi; SM (Sec1/Munc-18) family protein that binds the tSNARE Sed5p and stimulates its assembly into a trans-SNARE membrane-protein complex
0.136 2.43E-15 YGL252C RTG2 hom Sensor of mitochondrial dysfunction; regulates the subcellular location of Rtg1p and Rtg3p, transcriptional activators of the retrograde (RTG) and TOR pathways; Rtg2p is inhibited by the phosphorylated form of Mks1p
0.135 3.95E-15 YJR139C HOM6 hom Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase), dimeric enzyme that catalyzes the third step in the common pathway for methionine and threonine biosynthesis; enzyme has nucleotide-binding, dimerization and catalytic regions
0.134 6.98E-15 YLR193C UPS1 hom Phosphatidic acid transfer protein; plays a role in phospholipid metabolism by transporting phosphatidic acid from the outer to the inner mitochondrial membrane; localizes to the mitochondrial intermembrane space; null mutant has altered cardiolipin and phosphatidic acid levels; ortholog of human PRELI
0.130 4.82E-14 YML004C GLO1 hom Monomeric glyoxalase I, catalyzes the detoxification of methylglyoxal (a by-product of glycolysis) via condensation with glutathione to produce S-D-lactoylglutathione; expression regulated by methylglyoxal levels and osmotic stress
0.119 5.17E-12 YPR094W RDS3 het Component of the SF3b subcomplex of the U2 snRNP, zinc cluster protein involved in pre-mRNA splicing and cycloheximide resistance
0.118 7.13E-12 YFR052W RPN12 het Subunit of the 19S regulatory particle of the 26S proteasome lid; synthetically lethal with RPT1, which is an ATPase component of the 19S regulatory particle; physically interacts with Nob1p and Rpn3p; protein abundance increases in response to DNA replication stress
0.117 8.57E-12 YBR109C CMD1 het Calmodulin; Ca++ binding protein that regulates Ca++ independent processes (mitosis, bud growth, actin organization, endocytosis, etc.) and Ca++ dependent processes (stress-activated pathways), targets include Nuf1p, Myo2p and calcineurin