YDR044W / HEM13

Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; transcription is repressed by oxygen and heme (via Rox1p and Hap1p)

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDR044W / HEM13

Click on Significant Values for Screen Details ID:SGTC_186|Compound:3455-3465|FD-Score:2.83|P-value:5.41E-4 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:2.70|P-value:9.41E-4 ID:SGTC_406|Compound:estrone|FD-Score:3.25|P-value:9.05E-5 ID:SGTC_408|Compound:cantharidin|FD-Score:4.13|P-value:1.01E-6 ID:SGTC_614|Compound:0462-0418|FD-Score:-2.93|P-value:4.12E-4 ID:SGTC_744|Compound:1594-0068|FD-Score:-3.01|P-value:2.94E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.26|P-value:9.79E-5 ID:SGTC_851|Compound:0394-0702|FD-Score:4.54|P-value:8.92E-8 ID:SGTC_861|Compound:0443-0273|FD-Score:2.98|P-value:3.02E-4 ID:SGTC_969|Compound:1313-0238|FD-Score:3.00|P-value:2.76E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.50|P-value:1.31E-7 ID:SGTC_1166|Compound:k206-0078|FD-Score:-3.42|P-value:4.58E-5 ID:SGTC_1190|Compound:1486-1332|FD-Score:-3.28|P-value:8.79E-5 ID:SGTC_1216|Compound:1165-0504|FD-Score:4.02|P-value:1.83E-6 ID:SGTC_1249|Compound:0481-0015|FD-Score:-4.09|P-value:1.42E-6 ID:SGTC_1251|Compound:0490-5699|FD-Score:6.00|P-value:2.51E-12 ID:SGTC_1291|Compound:0993-0025|FD-Score:2.94|P-value:3.44E-4 ID:SGTC_1363|Compound:1636-0063|FD-Score:-2.83|P-value:6.16E-4 ID:SGTC_1602|Compound:st001878|FD-Score:3.09|P-value:1.85E-4 ID:SGTC_1716|Compound:st033144|FD-Score:3.81|P-value:5.74E-6 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.38|P-value:2.67E-7 ID:SGTC_1720|Compound:st037298|FD-Score:4.49|P-value:1.19E-7 ID:SGTC_1721|Compound:st082152|FD-Score:-3.57|P-value:2.24E-5 ID:SGTC_1725|Compound:st036284|FD-Score:2.73|P-value:8.11E-4 ID:SGTC_1898|Compound:st060199|FD-Score:2.86|P-value:4.83E-4 ID:SGTC_1907|Compound:st060210|FD-Score:2.70|P-value:9.40E-4 ID:SGTC_2054|Compound:5233173|FD-Score:-3.81|P-value:6.46E-6 ID:SGTC_2145|Compound:5634607|FD-Score:-2.71|P-value:9.89E-4 ID:SGTC_2184|Compound:6075246|FD-Score:2.86|P-value:4.90E-4 ID:SGTC_2243|Compound:6634756|FD-Score:3.29|P-value:7.46E-5 ID:SGTC_2261|Compound:9010538|FD-Score:3.26|P-value:8.65E-5 ID:SGTC_2299|Compound:7976368|FD-Score:3.02|P-value:2.51E-4 ID:SGTC_2303|Compound:7774051|FD-Score:3.16|P-value:1.38E-4 ID:SGTC_2342|Compound:7990637|FD-Score:2.89|P-value:4.37E-4 ID:SGTC_2350|Compound:9023895|FD-Score:3.11|P-value:1.72E-4 ID:SGTC_2353|Compound:9059630|FD-Score:-2.89|P-value:4.84E-4 ID:SGTC_2357|Compound:9067248|FD-Score:-3.62|P-value:1.75E-5 ID:SGTC_2408|Compound:sulbentine|FD-Score:3.91|P-value:3.28E-6 ID:SGTC_2418|Compound:pentamidine|FD-Score:-3.78|P-value:7.55E-6 ID:SGTC_2458|Compound:5808907|FD-Score:2.81|P-value:6.05E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:-5.72|P-value:2.97E-11 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:2.95|P-value:3.36E-4 ID:SGTC_2714|Compound:st079313|FD-Score:-2.79|P-value:7.17E-4 ID:SGTC_2849|Compound:9019321|FD-Score:2.93|P-value:3.67E-4 ID:SGTC_2850|Compound:9015429|FD-Score:3.23|P-value:9.86E-5 ID:SGTC_2989|Compound:9073649|FD-Score:2.77|P-value:6.91E-4 ID:SGTC_3132|Compound:9126706|FD-Score:2.91|P-value:3.97E-4 ID:SGTC_186|Compound:3455-3465|FD-Score:2.83|P-value:5.41E-4 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:2.70|P-value:9.41E-4 ID:SGTC_406|Compound:estrone|FD-Score:3.25|P-value:9.05E-5 ID:SGTC_408|Compound:cantharidin|FD-Score:4.13|P-value:1.01E-6 ID:SGTC_614|Compound:0462-0418|FD-Score:-2.93|P-value:4.12E-4 ID:SGTC_744|Compound:1594-0068|FD-Score:-3.01|P-value:2.94E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.26|P-value:9.79E-5 ID:SGTC_851|Compound:0394-0702|FD-Score:4.54|P-value:8.92E-8 ID:SGTC_861|Compound:0443-0273|FD-Score:2.98|P-value:3.02E-4 ID:SGTC_969|Compound:1313-0238|FD-Score:3.00|P-value:2.76E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.50|P-value:1.31E-7 ID:SGTC_1166|Compound:k206-0078|FD-Score:-3.42|P-value:4.58E-5 ID:SGTC_1190|Compound:1486-1332|FD-Score:-3.28|P-value:8.79E-5 ID:SGTC_1216|Compound:1165-0504|FD-Score:4.02|P-value:1.83E-6 ID:SGTC_1249|Compound:0481-0015|FD-Score:-4.09|P-value:1.42E-6 ID:SGTC_1251|Compound:0490-5699|FD-Score:6.00|P-value:2.51E-12 ID:SGTC_1291|Compound:0993-0025|FD-Score:2.94|P-value:3.44E-4 ID:SGTC_1363|Compound:1636-0063|FD-Score:-2.83|P-value:6.16E-4 ID:SGTC_1602|Compound:st001878|FD-Score:3.09|P-value:1.85E-4 ID:SGTC_1716|Compound:st033144|FD-Score:3.81|P-value:5.74E-6 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.38|P-value:2.67E-7 ID:SGTC_1720|Compound:st037298|FD-Score:4.49|P-value:1.19E-7 ID:SGTC_1721|Compound:st082152|FD-Score:-3.57|P-value:2.24E-5 ID:SGTC_1725|Compound:st036284|FD-Score:2.73|P-value:8.11E-4 ID:SGTC_1898|Compound:st060199|FD-Score:2.86|P-value:4.83E-4 ID:SGTC_1907|Compound:st060210|FD-Score:2.70|P-value:9.40E-4 ID:SGTC_2054|Compound:5233173|FD-Score:-3.81|P-value:6.46E-6 ID:SGTC_2145|Compound:5634607|FD-Score:-2.71|P-value:9.89E-4 ID:SGTC_2184|Compound:6075246|FD-Score:2.86|P-value:4.90E-4 ID:SGTC_2243|Compound:6634756|FD-Score:3.29|P-value:7.46E-5 ID:SGTC_2261|Compound:9010538|FD-Score:3.26|P-value:8.65E-5 ID:SGTC_2299|Compound:7976368|FD-Score:3.02|P-value:2.51E-4 ID:SGTC_2303|Compound:7774051|FD-Score:3.16|P-value:1.38E-4 ID:SGTC_2342|Compound:7990637|FD-Score:2.89|P-value:4.37E-4 ID:SGTC_2350|Compound:9023895|FD-Score:3.11|P-value:1.72E-4 ID:SGTC_2353|Compound:9059630|FD-Score:-2.89|P-value:4.84E-4 ID:SGTC_2357|Compound:9067248|FD-Score:-3.62|P-value:1.75E-5 ID:SGTC_2408|Compound:sulbentine|FD-Score:3.91|P-value:3.28E-6 ID:SGTC_2418|Compound:pentamidine|FD-Score:-3.78|P-value:7.55E-6 ID:SGTC_2458|Compound:5808907|FD-Score:2.81|P-value:6.05E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:-5.72|P-value:2.97E-11 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:2.95|P-value:3.36E-4 ID:SGTC_2714|Compound:st079313|FD-Score:-2.79|P-value:7.17E-4 ID:SGTC_2849|Compound:9019321|FD-Score:2.93|P-value:3.67E-4 ID:SGTC_2850|Compound:9015429|FD-Score:3.23|P-value:9.86E-5 ID:SGTC_2989|Compound:9073649|FD-Score:2.77|P-value:6.91E-4 ID:SGTC_3132|Compound:9126706|FD-Score:2.91|P-value:3.97E-4

Top fitness defect scores for YDR044W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1251 0490-5699 6.00 265.0 µM 2.51E-12 1 9.68E-10 0.65
2 SGTC_851 0394-0702 4.54 453.0 µM 8.92E-8 mitochondrial processes 16 2.87E-6 0.27
3 SGTC_1720 st037298 4.49 9.5 µM 1.19E-7 7 3.57E-6 0.09
4 SGTC_408 cantharidin 4.13 100.0 µM 1.01E-6 cell wall signaling 8 1.83E-5 0.03
5 SGTC_1216 1165-0504 4.02 9.7 µM 1.83E-6 3 2.89E-5 0.22
6 SGTC_2408 sulbentine 3.91 18.4 µM 3.28E-6 35 4.53E-5 0.06
7 SGTC_1716 st033144 3.81 30.6 µM 5.74E-6 7 6.96E-5 0.07
8 SGTC_2243 6634756 3.29 200.0 µM 7.46E-5 6 4.98E-4 0.17
9 SGTC_2261 9010538 3.26 184.7 µM 8.65E-5 10 5.58E-4 0.08
10 SGTC_406 estrone 3.25 100.0 µM 9.05E-5 5 5.78E-4 0.14
11 SGTC_2850 9015429 3.23 58.4 µM 9.86E-5 15 6.18E-4 0.03
12 SGTC_2303 7774051 3.16 200.0 µM 1.38E-4 18 7.98E-4 0.09
13 SGTC_2350 9023895 3.11 38.9 µM 1.72E-4 ergosterol biosynthesis 13 9.47E-4 0.01
14 SGTC_1602 st001878 3.09 87.6 µM 1.85E-4 21 0.00100 0.07
15 SGTC_2299 7976368 3.02 114.9 µM 2.51E-4 16 0.00127 0.03
16 SGTC_969 1313-0238 3.00 134.0 µM 2.76E-4 mitochondrial processes 44 0.00136 0.05
17 SGTC_861 0443-0273 2.98 110.0 µM 3.02E-4 10 0.00146 0.00
18 SGTC_2567 aureobasidin a 2.95 60.0 nM 3.36E-4 69 0.00159 0.05
19 SGTC_1291 0993-0025 2.94 5.8 µM 3.44E-4 7 0.00162 0.01
20 SGTC_2849 9019321 2.93 13.0 µM 3.67E-4 18 0.00170 0.03

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.194 6.87E-30 YDR210W_p YDR210W_p hom Predicted tail-anchored plasma membrane protein containing a conserved CYSTM module; related proteins in other organisms may be involved in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.193 1.82E-29 YER023W PRO3 het Delta 1-pyrroline-5-carboxylate reductase, catalyzes the last step in proline biosynthesis
0.174 3.14E-24 YAL060W BDH1 hom NAD-dependent (R,R)-butanediol dehydrogenase, catalyzes oxidation of (R,R)-2,3-butanediol to (3R)-acetoin, oxidation of meso-butanediol to (3S)-acetoin, and reduction of acetoin; enhances use of 2,3-butanediol as an aerobic carbon source
0.168 1.07E-22 YBR118W TEF2 hom Translational elongation factor EF-1 alpha; also encoded by TEF1; functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes; may also have a role in tRNA re-export from the nucleus; TEF2 has a paralog, TEF1, that arose from the whole genome duplication
0.168 1.17E-22 YKL122C SRP21 het Subunit of the signal recognition particle (SRP), which functions in protein targeting to the endoplasmic reticulum membrane; not found in mammalian SRP; forms a pre-SRP structure in the nucleolus that is translocated to the cytoplasm
0.168 1.31E-22 YLR401C DUS3 hom Dihydrouridine synthase; member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p; contains a consensus oleate response element (ORE) in its promoter region; forms nuclear foci upon DNA replication stress
0.157 5.94E-20 YOR012W_p YOR012W_p hom Putative protein of unknown function
0.155 1.39E-19 YAL068C PAU8 hom Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions
0.151 1.75E-18 YDL174C DLD1 hom D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane
0.150 2.28E-18 YGR025W_d YGR025W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.149 3.88E-18 YAL034W-A MTW1 het Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; critical to kinetochore assembly
0.149 5.26E-18 YBR299W MAL32 hom Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL3 complex locus; functional in genomic reference strain S288C; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose
0.148 7.54E-18 YKL179C COY1 hom Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function
0.146 2.10E-17 YOR298C-A MBF1 hom Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress
0.144 5.98E-17 YHR003C YHR003C hom Protein of unknown function, localized to the mitochondrial outer membrane