Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; transcription is repressed by oxygen and heme (via Rox1p and Hap1p)
Zygosity: Heterozygous strain
fixedexpanded
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Top fitness defect scores for YDR044W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.194 | 6.87E-30 | YDR210W_p | YDR210W_p | hom | Predicted tail-anchored plasma membrane protein containing a conserved CYSTM module; related proteins in other organisms may be involved in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery |
0.193 | 1.82E-29 | YER023W | PRO3 | het | Delta 1-pyrroline-5-carboxylate reductase, catalyzes the last step in proline biosynthesis |
0.174 | 3.14E-24 | YAL060W | BDH1 | hom | NAD-dependent (R,R)-butanediol dehydrogenase, catalyzes oxidation of (R,R)-2,3-butanediol to (3R)-acetoin, oxidation of meso-butanediol to (3S)-acetoin, and reduction of acetoin; enhances use of 2,3-butanediol as an aerobic carbon source |
0.168 | 1.07E-22 | YBR118W | TEF2 | hom | Translational elongation factor EF-1 alpha; also encoded by TEF1; functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes; may also have a role in tRNA re-export from the nucleus; TEF2 has a paralog, TEF1, that arose from the whole genome duplication |
0.168 | 1.17E-22 | YKL122C | SRP21 | het | Subunit of the signal recognition particle (SRP), which functions in protein targeting to the endoplasmic reticulum membrane; not found in mammalian SRP; forms a pre-SRP structure in the nucleolus that is translocated to the cytoplasm |
0.168 | 1.31E-22 | YLR401C | DUS3 | hom | Dihydrouridine synthase; member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p; contains a consensus oleate response element (ORE) in its promoter region; forms nuclear foci upon DNA replication stress |
0.157 | 5.94E-20 | YOR012W_p | YOR012W_p | hom | Putative protein of unknown function |
0.155 | 1.39E-19 | YAL068C | PAU8 | hom | Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions |
0.151 | 1.75E-18 | YDL174C | DLD1 | hom | D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane |
0.150 | 2.28E-18 | YGR025W_d | YGR025W_d | hom | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
0.149 | 3.88E-18 | YAL034W-A | MTW1 | het | Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; critical to kinetochore assembly |
0.149 | 5.26E-18 | YBR299W | MAL32 | hom | Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL3 complex locus; functional in genomic reference strain S288C; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose |
0.148 | 7.54E-18 | YKL179C | COY1 | hom | Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function |
0.146 | 2.10E-17 | YOR298C-A | MBF1 | hom | Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress |
0.144 | 5.98E-17 | YHR003C | YHR003C | hom | Protein of unknown function, localized to the mitochondrial outer membrane |