YDR045C / RPC11

RNA polymerase III subunit C11; mediates pol III RNA cleavage activity and is important for termination of transcription; homologous to TFIIS

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDR045C / RPC11

Click on Significant Values for Screen Details ID:SGTC_11|Compound:0438-0307|FD-Score:3.61|P-value:2.79E-4 ID:SGTC_17|Compound:0960-0276|FD-Score:3.46|P-value:4.79E-4 ID:SGTC_35|Compound:0133-0054|FD-Score:5.37|P-value:1.32E-7 ID:SGTC_69|Compound:0096-0274|FD-Score:5.82|P-value:1.20E-8 ID:SGTC_111|Compound:0083-0039|FD-Score:-4.24|P-value:1.96E-5 ID:SGTC_141|Compound:0443-0274|FD-Score:-3.24|P-value:8.16E-4 ID:SGTC_323|Compound:4013-0906|FD-Score:-3.68|P-value:1.75E-4 ID:SGTC_336|Compound:4111-0029|FD-Score:3.73|P-value:1.84E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:-3.34|P-value:5.87E-4 ID:SGTC_370|Compound:0180-0345|FD-Score:4.06|P-value:5.21E-5 ID:SGTC_378|Compound:3970-0959|FD-Score:3.92|P-value:8.86E-5 ID:SGTC_488|Compound:nitrendipine|FD-Score:3.46|P-value:4.80E-4 ID:SGTC_527|Compound:4476-4215|FD-Score:4.01|P-value:6.23E-5 ID:SGTC_591|Compound:4299-0174|FD-Score:-3.59|P-value:2.47E-4 ID:SGTC_654|Compound:1124-0271|FD-Score:3.26|P-value:9.31E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:3.77|P-value:1.56E-4 ID:SGTC_853|Compound:0419-0306|FD-Score:3.25|P-value:9.54E-4 ID:SGTC_1108|Compound:betulinic acid|FD-Score:3.74|P-value:1.75E-4 ID:SGTC_1196|Compound:1588-0294|FD-Score:3.35|P-value:6.99E-4 ID:SGTC_1214|Compound:0358-0031|FD-Score:-3.29|P-value:7.10E-4 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:3.40|P-value:5.90E-4 ID:SGTC_1843|Compound:st055809|FD-Score:4.17|P-value:3.34E-5 ID:SGTC_1916|Compound:st067606|FD-Score:3.85|P-value:1.16E-4 ID:SGTC_1919|Compound:st067113|FD-Score:4.06|P-value:5.20E-5 ID:SGTC_2146|Compound:5545642|FD-Score:-3.27|P-value:7.52E-4 ID:SGTC_2164|Compound:5685496|FD-Score:6.71|P-value:6.05E-11 ID:SGTC_2313|Compound:7726885|FD-Score:-4.59|P-value:4.30E-6 ID:SGTC_2337|Compound:9009472|FD-Score:4.15|P-value:3.64E-5 ID:SGTC_2481|Compound:5478948|FD-Score:3.64|P-value:2.50E-4 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:4.08|P-value:4.73E-5 ID:SGTC_2700|Compound:st077718|FD-Score:4.14|P-value:3.76E-5 ID:SGTC_2702|Compound:st077768|FD-Score:4.05|P-value:5.29E-5 ID:SGTC_2713|Compound:st079149|FD-Score:4.24|P-value:2.49E-5 ID:SGTC_2921|Compound:7974240|FD-Score:-5.25|P-value:1.82E-7 ID:SGTC_2923|Compound:7992654|FD-Score:7.48|P-value:3.55E-13 ID:SGTC_2924|Compound:9010168|FD-Score:3.34|P-value:7.16E-4 ID:SGTC_2927|Compound:9011802|FD-Score:-5.30|P-value:1.48E-7 ID:SGTC_2980|Compound:9014342|FD-Score:-3.98|P-value:5.64E-5 ID:SGTC_3043|Compound:9092303|FD-Score:-3.63|P-value:2.14E-4 ID:SGTC_3050|Compound:9093513|FD-Score:5.03|P-value:7.43E-7 ID:SGTC_3051|Compound:9093778|FD-Score:3.40|P-value:5.84E-4 ID:SGTC_3140|Compound:9094243|FD-Score:3.69|P-value:2.14E-4 ID:SGTC_3154|Compound:9100113|FD-Score:-3.53|P-value:3.09E-4 ID:SGTC_3159|Compound:9100096|FD-Score:3.49|P-value:4.33E-4 ID:SGTC_3308|Compound:9128332|FD-Score:3.43|P-value:5.28E-4 ID:SGTC_3317|Compound:9138495|FD-Score:4.05|P-value:5.29E-5 ID:SGTC_3319|Compound:9138450|FD-Score:3.46|P-value:4.68E-4 ID:SGTC_3332|Compound:9141069|FD-Score:4.88|P-value:1.46E-6 ID:SGTC_11|Compound:0438-0307|FD-Score:3.61|P-value:2.79E-4 ID:SGTC_17|Compound:0960-0276|FD-Score:3.46|P-value:4.79E-4 ID:SGTC_35|Compound:0133-0054|FD-Score:5.37|P-value:1.32E-7 ID:SGTC_69|Compound:0096-0274|FD-Score:5.82|P-value:1.20E-8 ID:SGTC_111|Compound:0083-0039|FD-Score:-4.24|P-value:1.96E-5 ID:SGTC_141|Compound:0443-0274|FD-Score:-3.24|P-value:8.16E-4 ID:SGTC_323|Compound:4013-0906|FD-Score:-3.68|P-value:1.75E-4 ID:SGTC_336|Compound:4111-0029|FD-Score:3.73|P-value:1.84E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:-3.34|P-value:5.87E-4 ID:SGTC_370|Compound:0180-0345|FD-Score:4.06|P-value:5.21E-5 ID:SGTC_378|Compound:3970-0959|FD-Score:3.92|P-value:8.86E-5 ID:SGTC_488|Compound:nitrendipine|FD-Score:3.46|P-value:4.80E-4 ID:SGTC_527|Compound:4476-4215|FD-Score:4.01|P-value:6.23E-5 ID:SGTC_591|Compound:4299-0174|FD-Score:-3.59|P-value:2.47E-4 ID:SGTC_654|Compound:1124-0271|FD-Score:3.26|P-value:9.31E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:3.77|P-value:1.56E-4 ID:SGTC_853|Compound:0419-0306|FD-Score:3.25|P-value:9.54E-4 ID:SGTC_1108|Compound:betulinic acid|FD-Score:3.74|P-value:1.75E-4 ID:SGTC_1196|Compound:1588-0294|FD-Score:3.35|P-value:6.99E-4 ID:SGTC_1214|Compound:0358-0031|FD-Score:-3.29|P-value:7.10E-4 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:3.40|P-value:5.90E-4 ID:SGTC_1843|Compound:st055809|FD-Score:4.17|P-value:3.34E-5 ID:SGTC_1916|Compound:st067606|FD-Score:3.85|P-value:1.16E-4 ID:SGTC_1919|Compound:st067113|FD-Score:4.06|P-value:5.20E-5 ID:SGTC_2146|Compound:5545642|FD-Score:-3.27|P-value:7.52E-4 ID:SGTC_2164|Compound:5685496|FD-Score:6.71|P-value:6.05E-11 ID:SGTC_2313|Compound:7726885|FD-Score:-4.59|P-value:4.30E-6 ID:SGTC_2337|Compound:9009472|FD-Score:4.15|P-value:3.64E-5 ID:SGTC_2481|Compound:5478948|FD-Score:3.64|P-value:2.50E-4 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:4.08|P-value:4.73E-5 ID:SGTC_2700|Compound:st077718|FD-Score:4.14|P-value:3.76E-5 ID:SGTC_2702|Compound:st077768|FD-Score:4.05|P-value:5.29E-5 ID:SGTC_2713|Compound:st079149|FD-Score:4.24|P-value:2.49E-5 ID:SGTC_2921|Compound:7974240|FD-Score:-5.25|P-value:1.82E-7 ID:SGTC_2923|Compound:7992654|FD-Score:7.48|P-value:3.55E-13 ID:SGTC_2924|Compound:9010168|FD-Score:3.34|P-value:7.16E-4 ID:SGTC_2927|Compound:9011802|FD-Score:-5.30|P-value:1.48E-7 ID:SGTC_2980|Compound:9014342|FD-Score:-3.98|P-value:5.64E-5 ID:SGTC_3043|Compound:9092303|FD-Score:-3.63|P-value:2.14E-4 ID:SGTC_3050|Compound:9093513|FD-Score:5.03|P-value:7.43E-7 ID:SGTC_3051|Compound:9093778|FD-Score:3.40|P-value:5.84E-4 ID:SGTC_3140|Compound:9094243|FD-Score:3.69|P-value:2.14E-4 ID:SGTC_3154|Compound:9100113|FD-Score:-3.53|P-value:3.09E-4 ID:SGTC_3159|Compound:9100096|FD-Score:3.49|P-value:4.33E-4 ID:SGTC_3308|Compound:9128332|FD-Score:3.43|P-value:5.28E-4 ID:SGTC_3317|Compound:9138495|FD-Score:4.05|P-value:5.29E-5 ID:SGTC_3319|Compound:9138450|FD-Score:3.46|P-value:4.68E-4 ID:SGTC_3332|Compound:9141069|FD-Score:4.88|P-value:1.46E-6

Top fitness defect scores for YDR045C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2923 7992654 7.48 58.1 µM 3.55E-13 Golgi 1 3.65E-14 2.38
2 SGTC_2164 5685496 6.71 200.0 µM 6.05E-11 3 9.45E-12 1.39
3 SGTC_69 0096-0274 5.82 206.7 µM 1.20E-8 mitochondrial processes 23 2.88E-9 0.42
4 SGTC_35 0133-0054 5.37 64.1 µM 1.32E-7 2 3.84E-8 0.72
5 SGTC_3050 9093513 5.03 49.5 µM 7.43E-7 3 2.49E-7 0.13
6 SGTC_3332 9141069 4.88 11.2 µM 1.46E-6 1 5.19E-7 1.32
7 SGTC_2713 st079149 4.24 53.4 µM 2.49E-5 3 1.11E-5 0.49
8 SGTC_1843 st055809 4.17 45.5 µM 3.34E-5 3 1.53E-5 0.00
9 SGTC_2337 9009472 4.15 200.0 µM 3.64E-5 7 1.68E-5 0.30
10 SGTC_2700 st077718 4.14 96.8 µM 3.76E-5 4 1.74E-5 0.12
11 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 4.08 100.0 µM 4.73E-5 5 2.23E-5 0.07
12 SGTC_1919 st067113 4.06 52.3 µM 5.20E-5 TSC3-RPN4 10 2.46E-5 0.11
13 SGTC_370 0180-0345 4.06 38.7 µM 5.21E-5 DNA intercalators 8 2.47E-5 0.16
14 SGTC_2702 st077768 4.05 96.8 µM 5.29E-5 7 2.51E-5 0.25
15 SGTC_3317 9138495 4.05 8.8 µM 5.29E-5 10 2.51E-5 0.18
16 SGTC_527 4476-4215 4.01 268.0 µM 6.23E-5 PDR1 2 3.00E-5 0.28
17 SGTC_378 3970-0959 3.92 8.3 µM 8.86E-5 2 4.39E-5 0.39
18 SGTC_1916 st067606 3.85 49.2 µM 1.16E-4 6 5.89E-5 0.10
19 SGTC_674 0498-0004 3.77 451.0 µM 1.56E-4 heme requiring 24 8.08E-5 0.04
20 SGTC_1108 betulinic acid 3.74 729.1 nM 1.75E-4 5 9.18E-5 0.24

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.119 4.77E-12 YDL188C PPH22 hom Catalytic subunit of protein phosphatase 2A (PP2A); functionally redundant with Pph21p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis; protein abundance increases in response to DNA replication stress; PPH22 has a paralog, PPH21, that arose from the whole genome duplication
0.097 1.60E-8 YBR114W RAD16 hom Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad7p) during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex
0.085 7.13E-7 YDL200C MGT1 hom DNA repair methyltransferase (6-O-methylguanine-DNA methylase) involved in protection against DNA alkylation damage
0.082 1.82E-6 YLR191W PEX13 hom Integral peroxisomal membrane protein required for translocation of peroxisomal matrix proteins, interacts with the PTS1 signal recognition factor Pex5p and the PTS2 signal recognition factor Pex7p, forms a complex with Pex14p and Pex17p
0.081 2.35E-6 YNL172W APC1 het Largest subunit of the Anaphase-Promoting Complex/Cyclosome; APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; localizes to nuclear foci that become diffuse upon DNA replication stress
0.080 3.47E-6 YCL059C KRR1 het Essential nucleolar protein required for the synthesis of 18S rRNA and for the assembly of 40S ribosomal subunit
0.079 4.76E-6 YOR348C PUT4 hom Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells
0.076 1.06E-5 YCL044C MGR1 hom Subunit of the mitochondrial (mt) i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr3p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA
0.075 1.35E-5 YJL033W HCA4 het DEAD box RNA helicase; high-copy number suppression of a U14 snoRNA processing mutant suggests an involvement in 18S rRNA synthesis
0.075 1.36E-5 YMR306W FKS3 hom Protein involved in spore wall assembly, has similarity to 1,3-beta-D-glucan synthase catalytic subunits Fks1p and Gsc2p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.074 1.73E-5 YPR160W GPH1 hom Non-essential glycogen phosphorylase required for the mobilization of glycogen, activity is regulated by cyclic AMP-mediated phosphorylation, expression is regulated by stress-response elements and by the HOG MAP kinase pathway
0.073 2.20E-5 YOR325W_d YOR325W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF FRT1
0.073 2.51E-5 YNR062C_p YNR062C_p hom Putative membrane protein of unknown function
0.072 2.78E-5 YCR036W RBK1 hom Putative ribokinase
0.071 4.08E-5 YPR121W THI22 hom Protein with similarity to hydroxymethylpyrimidine phosphate kinases; member of a gene family with THI20 and THI21; not required for thiamine biosynthesis