YDR047W / HEM12

Uroporphyrinogen decarboxylase, catalyzes the fifth step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; a hem12 mutant has phenotypes similar to patients with porphyria cutanea tarda

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDR047W / HEM12

Click on Significant Values for Screen Details ID:SGTC_1|Compound:0258-0098|FD-Score:27.30|P-value:7.76E-174 ID:SGTC_26|Compound:0302-0163|FD-Score:8.66|P-value:1.78E-19 ID:SGTC_44|Compound:0929-0055|FD-Score:-6.44|P-value:2.64E-11 ID:SGTC_46|Compound:0329-0187a|FD-Score:-3.87|P-value:4.30E-5 ID:SGTC_62|Compound:0180-0423|FD-Score:3.46|P-value:1.57E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:3.10|P-value:5.96E-4 ID:SGTC_108|Compound:0509-0257|FD-Score:3.43|P-value:1.76E-4 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:3.45|P-value:1.61E-4 ID:SGTC_177|Compound:1327-0068|FD-Score:3.84|P-value:3.24E-5 ID:SGTC_201|Compound:4262-0159|FD-Score:3.15|P-value:5.09E-4 ID:SGTC_203|Compound:k066-0004|FD-Score:11.50|P-value:1.18E-32 ID:SGTC_208|Compound:k072-0098|FD-Score:12.80|P-value:2.45E-40 ID:SGTC_218|Compound:alverine citrate|FD-Score:8.00|P-value:6.74E-17 ID:SGTC_224|Compound:benfluorex|FD-Score:3.52|P-value:1.20E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:8.31|P-value:4.43E-18 ID:SGTC_254|Compound:nsc-64875|FD-Score:5.07|P-value:7.02E-8 ID:SGTC_258|Compound:haloperidol|FD-Score:8.48|P-value:9.54E-19 ID:SGTC_262|Compound:fenpropimorph|FD-Score:4.39|P-value:2.54E-6 ID:SGTC_273|Compound:hydroxyurea|FD-Score:49.80|P-value:0 ID:SGTC_319|Compound:1348-1596|FD-Score:5.09|P-value:6.39E-8 ID:SGTC_322|Compound:k048-0136|FD-Score:3.73|P-value:5.14E-5 ID:SGTC_331|Compound:k048-0133|FD-Score:4.10|P-value:1.01E-5 ID:SGTC_332|Compound:4112-0506|FD-Score:7.32|P-value:1.87E-14 ID:SGTC_342|Compound:k048-0088|FD-Score:3.02|P-value:7.88E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:4.25|P-value:5.03E-6 ID:SGTC_368|Compound:fentichlor|FD-Score:5.60|P-value:3.10E-9 ID:SGTC_383|Compound:2324-0395|FD-Score:3.21|P-value:3.99E-4 ID:SGTC_396|Compound:dithiazanine|FD-Score:3.15|P-value:5.06E-4 ID:SGTC_459|Compound:nigericin|FD-Score:5.22|P-value:3.10E-8 ID:SGTC_462|Compound:ag-879|FD-Score:4.50|P-value:1.45E-6 ID:SGTC_524|Compound:r073-0010|FD-Score:3.49|P-value:1.37E-4 ID:SGTC_553|Compound:k007-0256|FD-Score:8.27|P-value:6.04E-18 ID:SGTC_623|Compound:k072-0108|FD-Score:10.30|P-value:8.08E-27 ID:SGTC_641|Compound:4092-0595|FD-Score:3.84|P-value:3.22E-5 ID:SGTC_646|Compound:4092-0839|FD-Score:7.01|P-value:1.96E-13 ID:SGTC_674|Compound:0498-0004|FD-Score:8.55|P-value:4.73E-19 ID:SGTC_730|Compound:1436-0052|FD-Score:6.18|P-value:7.74E-11 ID:SGTC_743|Compound:1275-0778|FD-Score:4.35|P-value:3.11E-6 ID:SGTC_745|Compound:0469-0705|FD-Score:3.68|P-value:6.44E-5 ID:SGTC_746|Compound:1095-0025|FD-Score:2.96|P-value:9.73E-4 ID:SGTC_765|Compound:1319-0117|FD-Score:3.04|P-value:7.52E-4 ID:SGTC_790|Compound:1575-0012|FD-Score:3.34|P-value:2.44E-4 ID:SGTC_801|Compound:0866-0028|FD-Score:5.44|P-value:8.48E-9 ID:SGTC_813|Compound:k007-0158|FD-Score:3.32|P-value:2.70E-4 ID:SGTC_816|Compound:0325-0417|FD-Score:3.26|P-value:3.39E-4 ID:SGTC_842|Compound:0271-0008|FD-Score:12.80|P-value:4.25E-40 ID:SGTC_858|Compound:0438-0351|FD-Score:5.68|P-value:1.99E-9 ID:SGTC_875|Compound:0709-0210|FD-Score:5.74|P-value:1.31E-9 ID:SGTC_895|Compound:0964-0006|FD-Score:4.53|P-value:1.26E-6 ID:SGTC_902|Compound:1120-0002|FD-Score:6.14|P-value:1.03E-10 ID:SGTC_921|Compound:1561-0023|FD-Score:3.84|P-value:3.19E-5 ID:SGTC_923|Compound:1900-2434|FD-Score:-3.34|P-value:3.71E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:4.06|P-value:1.17E-5 ID:SGTC_956|Compound:1185-0240|FD-Score:-3.56|P-value:1.55E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:-3.88|P-value:4.25E-5 ID:SGTC_966|Compound:1300-0360|FD-Score:10.20|P-value:1.88E-26 ID:SGTC_1001|Compound:4048-4355|FD-Score:7.70|P-value:8.65E-16 ID:SGTC_1005|Compound:4092-0690|FD-Score:5.51|P-value:5.56E-9 ID:SGTC_1036|Compound:k216-0215|FD-Score:-3.24|P-value:5.19E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:6.61|P-value:3.76E-12 ID:SGTC_1050|Compound:3232-1156|FD-Score:3.17|P-value:4.64E-4 ID:SGTC_1054|Compound:3429-0080|FD-Score:4.69|P-value:5.60E-7 ID:SGTC_1056|Compound:3448-1962|FD-Score:-5.48|P-value:1.24E-8 ID:SGTC_1057|Compound:3448-5381|FD-Score:19.10|P-value:1.49E-86 ID:SGTC_1061|Compound:3448-9325|FD-Score:3.28|P-value:3.11E-4 ID:SGTC_1098|Compound:clofazimine|FD-Score:10.00|P-value:2.44E-25 ID:SGTC_1113|Compound:artemisinin|FD-Score:15.80|P-value:5.04E-60 ID:SGTC_1138|Compound:3761-0006|FD-Score:3.10|P-value:6.01E-4 ID:SGTC_1150|Compound:3909-7983|FD-Score:4.25|P-value:4.93E-6 ID:SGTC_1156|Compound:4092-0367|FD-Score:9.28|P-value:4.62E-22 ID:SGTC_1160|Compound:4092-0570|FD-Score:8.05|P-value:4.40E-17 ID:SGTC_1211|Compound:1056-0033|FD-Score:3.05|P-value:7.10E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:4.44|P-value:2.00E-6 ID:SGTC_1271|Compound:0832-2808|FD-Score:7.61|P-value:1.68E-15 ID:SGTC_1280|Compound:0880-0253|FD-Score:3.03|P-value:7.79E-4 ID:SGTC_1300|Compound:1094-0077|FD-Score:3.91|P-value:2.38E-5 ID:SGTC_1310|Compound:1188-0297|FD-Score:9.52|P-value:3.85E-23 ID:SGTC_1315|Compound:1237-0019|FD-Score:4.07|P-value:1.15E-5 ID:SGTC_1390|Compound:3413-2614|FD-Score:3.76|P-value:4.55E-5 ID:SGTC_1410|Compound:3909-8106|FD-Score:3.03|P-value:7.77E-4 ID:SGTC_1435|Compound:4092-0789|FD-Score:5.97|P-value:3.05E-10 ID:SGTC_1437|Compound:4092-1038|FD-Score:4.46|P-value:1.81E-6 ID:SGTC_1447|Compound:4239-0816|FD-Score:6.02|P-value:2.20E-10 ID:SGTC_1453|Compound:4237-0541|FD-Score:6.42|P-value:1.44E-11 ID:SGTC_1455|Compound:4262-0120|FD-Score:5.25|P-value:2.56E-8 ID:SGTC_1475|Compound:4092-1048|FD-Score:11.30|P-value:1.00E-31 ID:SGTC_1540|Compound:guanosine|FD-Score:4.08|P-value:1.09E-5 ID:SGTC_1552|Compound:6-methylflavone|FD-Score:10.30|P-value:9.49E-27 ID:SGTC_1556|Compound:plumbagin|FD-Score:15.40|P-value:5.34E-57 ID:SGTC_1639|Compound:Lupinine o-methylbenzoicacid ester hydrochloride|FD-Score:3.38|P-value:2.09E-4 ID:SGTC_1735|Compound:st034310|FD-Score:-3.56|P-value:1.54E-4 ID:SGTC_1797|Compound:st048695|FD-Score:3.47|P-value:1.50E-4 ID:SGTC_1807|Compound:st050092|FD-Score:2.96|P-value:9.77E-4 ID:SGTC_1831|Compound:st055328|FD-Score:3.89|P-value:2.59E-5 ID:SGTC_1855|Compound:st056195|FD-Score:3.00|P-value:8.52E-4 ID:SGTC_1886|Compound:st057356|FD-Score:3.84|P-value:3.18E-5 ID:SGTC_1962|Compound:st076595|FD-Score:3.61|P-value:8.46E-5 ID:SGTC_2001|Compound:4023502|FD-Score:3.14|P-value:5.12E-4 ID:SGTC_2037|Compound:5169046|FD-Score:6.96|P-value:2.91E-13 ID:SGTC_2066|Compound:5222451|FD-Score:11.00|P-value:3.35E-30 ID:SGTC_2073|Compound:5212005|FD-Score:3.40|P-value:1.93E-4 ID:SGTC_2124|Compound:5246320|FD-Score:5.36|P-value:1.33E-8 ID:SGTC_2129|Compound:girgensonine|FD-Score:10.40|P-value:2.74E-27 ID:SGTC_2139|Compound:5578692|FD-Score:4.36|P-value:2.98E-6 ID:SGTC_2163|Compound:5671233|FD-Score:-4.53|P-value:2.10E-6 ID:SGTC_2179|Compound:6298986|FD-Score:5.36|P-value:1.33E-8 ID:SGTC_2196|Compound:6573537|FD-Score:3.47|P-value:1.46E-4 ID:SGTC_2223|Compound:6903751|FD-Score:3.35|P-value:2.40E-4 ID:SGTC_2225|Compound:6654152|FD-Score:11.20|P-value:2.10E-31 ID:SGTC_2233|Compound:sulbentine|FD-Score:3.66|P-value:6.71E-5 ID:SGTC_2283|Compound:7944793|FD-Score:-4.02|P-value:2.33E-5 ID:SGTC_2289|Compound:7946404|FD-Score:4.09|P-value:1.03E-5 ID:SGTC_2308|Compound:7584454|FD-Score:3.32|P-value:2.71E-4 ID:SGTC_2319|Compound:6033012|FD-Score:-3.81|P-value:5.54E-5 ID:SGTC_2336|Compound:9001819|FD-Score:20.00|P-value:1.63E-94 ID:SGTC_2344|Compound:7990960|FD-Score:10.50|P-value:1.81E-27 ID:SGTC_2385|Compound:9074692|FD-Score:3.16|P-value:4.76E-4 ID:SGTC_2401|Compound:5128683|FD-Score:3.66|P-value:6.95E-5 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:4.11|P-value:9.51E-6 ID:SGTC_2415|Compound:st077333|FD-Score:3.04|P-value:7.54E-4 ID:SGTC_2430|Compound:5571206|FD-Score:5.34|P-value:1.56E-8 ID:SGTC_2483|Compound:5729050|FD-Score:3.00|P-value:8.54E-4 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:4.73|P-value:4.61E-7 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:13.20|P-value:2.76E-42 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:5.59|P-value:3.32E-9 ID:SGTC_2575|Compound:plumbagin|FD-Score:8.48|P-value:9.45E-19 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:4.60|P-value:8.90E-7 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:20.10|P-value:5.67E-96 ID:SGTC_2686|Compound:alizarin|FD-Score:3.32|P-value:2.62E-4 ID:SGTC_2687|Compound:chenodiol|FD-Score:-4.78|P-value:5.82E-7 ID:SGTC_2694|Compound:st077685|FD-Score:-4.11|P-value:1.55E-5 ID:SGTC_2700|Compound:st077718|FD-Score:3.26|P-value:3.36E-4 ID:SGTC_2721|Compound:ifenprodil|FD-Score:3.93|P-value:2.12E-5 ID:SGTC_2725|Compound:haloperidol|FD-Score:9.43|P-value:1.03E-22 ID:SGTC_2753|Compound:fluvastatin|FD-Score:4.19|P-value:6.54E-6 ID:SGTC_2757|Compound:clomiphene|FD-Score:3.63|P-value:7.72E-5 ID:SGTC_2760|Compound:etidronate|FD-Score:3.63|P-value:7.83E-5 ID:SGTC_2766|Compound:oltipraz|FD-Score:5.85|P-value:6.47E-10 ID:SGTC_2792|Compound:7535235|FD-Score:3.29|P-value:3.02E-4 ID:SGTC_2799|Compound:7812892|FD-Score:3.65|P-value:7.26E-5 ID:SGTC_2825|Compound:7998094|FD-Score:4.55|P-value:1.12E-6 ID:SGTC_2862|Compound:9027634|FD-Score:3.81|P-value:3.65E-5 ID:SGTC_2880|Compound:9042983|FD-Score:3.97|P-value:1.78E-5 ID:SGTC_2887|Compound:9044784|FD-Score:7.00|P-value:2.22E-13 ID:SGTC_2893|Compound:9048488|FD-Score:5.69|P-value:1.79E-9 ID:SGTC_2910|Compound:7948405|FD-Score:4.11|P-value:9.31E-6 ID:SGTC_2928|Compound:9011484|FD-Score:6.65|P-value:2.93E-12 ID:SGTC_2930|Compound:9013230|FD-Score:3.31|P-value:2.81E-4 ID:SGTC_2938|Compound:9059746|FD-Score:3.36|P-value:2.26E-4 ID:SGTC_2954|Compound:9074818|FD-Score:-3.53|P-value:1.73E-4 ID:SGTC_2957|Compound:9076800|FD-Score:-3.49|P-value:2.08E-4 ID:SGTC_2963|Compound:9082507|FD-Score:7.44|P-value:7.10E-15 ID:SGTC_2965|Compound:9082772|FD-Score:3.83|P-value:3.30E-5 ID:SGTC_2988|Compound:9073640|FD-Score:-3.21|P-value:5.83E-4 ID:SGTC_2993|Compound:9054257|FD-Score:4.99|P-value:1.14E-7 ID:SGTC_3027|Compound:9089541|FD-Score:3.69|P-value:5.93E-5 ID:SGTC_3071|Compound:9117417|FD-Score:4.89|P-value:1.87E-7 ID:SGTC_3081|Compound:9117243|FD-Score:8.48|P-value:9.34E-19 ID:SGTC_3214|Compound:9129694|FD-Score:3.18|P-value:4.56E-4 ID:SGTC_3334|Compound:9142812|FD-Score:3.15|P-value:5.10E-4 ID:SGTC_3351|Compound:9150312|FD-Score:3.24|P-value:3.60E-4 ID:SGTC_3355|Compound:9151058|FD-Score:-3.27|P-value:4.76E-4 ID:SGTC_1|Compound:0258-0098|FD-Score:27.30|P-value:7.76E-174 ID:SGTC_26|Compound:0302-0163|FD-Score:8.66|P-value:1.78E-19 ID:SGTC_44|Compound:0929-0055|FD-Score:-6.44|P-value:2.64E-11 ID:SGTC_46|Compound:0329-0187a|FD-Score:-3.87|P-value:4.30E-5 ID:SGTC_62|Compound:0180-0423|FD-Score:3.46|P-value:1.57E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:3.10|P-value:5.96E-4 ID:SGTC_108|Compound:0509-0257|FD-Score:3.43|P-value:1.76E-4 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:3.45|P-value:1.61E-4 ID:SGTC_177|Compound:1327-0068|FD-Score:3.84|P-value:3.24E-5 ID:SGTC_201|Compound:4262-0159|FD-Score:3.15|P-value:5.09E-4 ID:SGTC_203|Compound:k066-0004|FD-Score:11.50|P-value:1.18E-32 ID:SGTC_208|Compound:k072-0098|FD-Score:12.80|P-value:2.45E-40 ID:SGTC_218|Compound:alverine citrate|FD-Score:8.00|P-value:6.74E-17 ID:SGTC_224|Compound:benfluorex|FD-Score:3.52|P-value:1.20E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:8.31|P-value:4.43E-18 ID:SGTC_254|Compound:nsc-64875|FD-Score:5.07|P-value:7.02E-8 ID:SGTC_258|Compound:haloperidol|FD-Score:8.48|P-value:9.54E-19 ID:SGTC_262|Compound:fenpropimorph|FD-Score:4.39|P-value:2.54E-6 ID:SGTC_273|Compound:hydroxyurea|FD-Score:49.80|P-value:0 ID:SGTC_319|Compound:1348-1596|FD-Score:5.09|P-value:6.39E-8 ID:SGTC_322|Compound:k048-0136|FD-Score:3.73|P-value:5.14E-5 ID:SGTC_331|Compound:k048-0133|FD-Score:4.10|P-value:1.01E-5 ID:SGTC_332|Compound:4112-0506|FD-Score:7.32|P-value:1.87E-14 ID:SGTC_342|Compound:k048-0088|FD-Score:3.02|P-value:7.88E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:4.25|P-value:5.03E-6 ID:SGTC_368|Compound:fentichlor|FD-Score:5.60|P-value:3.10E-9 ID:SGTC_383|Compound:2324-0395|FD-Score:3.21|P-value:3.99E-4 ID:SGTC_396|Compound:dithiazanine|FD-Score:3.15|P-value:5.06E-4 ID:SGTC_459|Compound:nigericin|FD-Score:5.22|P-value:3.10E-8 ID:SGTC_462|Compound:ag-879|FD-Score:4.50|P-value:1.45E-6 ID:SGTC_524|Compound:r073-0010|FD-Score:3.49|P-value:1.37E-4 ID:SGTC_553|Compound:k007-0256|FD-Score:8.27|P-value:6.04E-18 ID:SGTC_623|Compound:k072-0108|FD-Score:10.30|P-value:8.08E-27 ID:SGTC_641|Compound:4092-0595|FD-Score:3.84|P-value:3.22E-5 ID:SGTC_646|Compound:4092-0839|FD-Score:7.01|P-value:1.96E-13 ID:SGTC_674|Compound:0498-0004|FD-Score:8.55|P-value:4.73E-19 ID:SGTC_730|Compound:1436-0052|FD-Score:6.18|P-value:7.74E-11 ID:SGTC_743|Compound:1275-0778|FD-Score:4.35|P-value:3.11E-6 ID:SGTC_745|Compound:0469-0705|FD-Score:3.68|P-value:6.44E-5 ID:SGTC_746|Compound:1095-0025|FD-Score:2.96|P-value:9.73E-4 ID:SGTC_765|Compound:1319-0117|FD-Score:3.04|P-value:7.52E-4 ID:SGTC_790|Compound:1575-0012|FD-Score:3.34|P-value:2.44E-4 ID:SGTC_801|Compound:0866-0028|FD-Score:5.44|P-value:8.48E-9 ID:SGTC_813|Compound:k007-0158|FD-Score:3.32|P-value:2.70E-4 ID:SGTC_816|Compound:0325-0417|FD-Score:3.26|P-value:3.39E-4 ID:SGTC_842|Compound:0271-0008|FD-Score:12.80|P-value:4.25E-40 ID:SGTC_858|Compound:0438-0351|FD-Score:5.68|P-value:1.99E-9 ID:SGTC_875|Compound:0709-0210|FD-Score:5.74|P-value:1.31E-9 ID:SGTC_895|Compound:0964-0006|FD-Score:4.53|P-value:1.26E-6 ID:SGTC_902|Compound:1120-0002|FD-Score:6.14|P-value:1.03E-10 ID:SGTC_921|Compound:1561-0023|FD-Score:3.84|P-value:3.19E-5 ID:SGTC_923|Compound:1900-2434|FD-Score:-3.34|P-value:3.71E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:4.06|P-value:1.17E-5 ID:SGTC_956|Compound:1185-0240|FD-Score:-3.56|P-value:1.55E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:-3.88|P-value:4.25E-5 ID:SGTC_966|Compound:1300-0360|FD-Score:10.20|P-value:1.88E-26 ID:SGTC_1001|Compound:4048-4355|FD-Score:7.70|P-value:8.65E-16 ID:SGTC_1005|Compound:4092-0690|FD-Score:5.51|P-value:5.56E-9 ID:SGTC_1036|Compound:k216-0215|FD-Score:-3.24|P-value:5.19E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:6.61|P-value:3.76E-12 ID:SGTC_1050|Compound:3232-1156|FD-Score:3.17|P-value:4.64E-4 ID:SGTC_1054|Compound:3429-0080|FD-Score:4.69|P-value:5.60E-7 ID:SGTC_1056|Compound:3448-1962|FD-Score:-5.48|P-value:1.24E-8 ID:SGTC_1057|Compound:3448-5381|FD-Score:19.10|P-value:1.49E-86 ID:SGTC_1061|Compound:3448-9325|FD-Score:3.28|P-value:3.11E-4 ID:SGTC_1098|Compound:clofazimine|FD-Score:10.00|P-value:2.44E-25 ID:SGTC_1113|Compound:artemisinin|FD-Score:15.80|P-value:5.04E-60 ID:SGTC_1138|Compound:3761-0006|FD-Score:3.10|P-value:6.01E-4 ID:SGTC_1150|Compound:3909-7983|FD-Score:4.25|P-value:4.93E-6 ID:SGTC_1156|Compound:4092-0367|FD-Score:9.28|P-value:4.62E-22 ID:SGTC_1160|Compound:4092-0570|FD-Score:8.05|P-value:4.40E-17 ID:SGTC_1211|Compound:1056-0033|FD-Score:3.05|P-value:7.10E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:4.44|P-value:2.00E-6 ID:SGTC_1271|Compound:0832-2808|FD-Score:7.61|P-value:1.68E-15 ID:SGTC_1280|Compound:0880-0253|FD-Score:3.03|P-value:7.79E-4 ID:SGTC_1300|Compound:1094-0077|FD-Score:3.91|P-value:2.38E-5 ID:SGTC_1310|Compound:1188-0297|FD-Score:9.52|P-value:3.85E-23 ID:SGTC_1315|Compound:1237-0019|FD-Score:4.07|P-value:1.15E-5 ID:SGTC_1390|Compound:3413-2614|FD-Score:3.76|P-value:4.55E-5 ID:SGTC_1410|Compound:3909-8106|FD-Score:3.03|P-value:7.77E-4 ID:SGTC_1435|Compound:4092-0789|FD-Score:5.97|P-value:3.05E-10 ID:SGTC_1437|Compound:4092-1038|FD-Score:4.46|P-value:1.81E-6 ID:SGTC_1447|Compound:4239-0816|FD-Score:6.02|P-value:2.20E-10 ID:SGTC_1453|Compound:4237-0541|FD-Score:6.42|P-value:1.44E-11 ID:SGTC_1455|Compound:4262-0120|FD-Score:5.25|P-value:2.56E-8 ID:SGTC_1475|Compound:4092-1048|FD-Score:11.30|P-value:1.00E-31 ID:SGTC_1540|Compound:guanosine|FD-Score:4.08|P-value:1.09E-5 ID:SGTC_1552|Compound:6-methylflavone|FD-Score:10.30|P-value:9.49E-27 ID:SGTC_1556|Compound:plumbagin|FD-Score:15.40|P-value:5.34E-57 ID:SGTC_1639|Compound:Lupinine o-methylbenzoicacid ester hydrochloride|FD-Score:3.38|P-value:2.09E-4 ID:SGTC_1735|Compound:st034310|FD-Score:-3.56|P-value:1.54E-4 ID:SGTC_1797|Compound:st048695|FD-Score:3.47|P-value:1.50E-4 ID:SGTC_1807|Compound:st050092|FD-Score:2.96|P-value:9.77E-4 ID:SGTC_1831|Compound:st055328|FD-Score:3.89|P-value:2.59E-5 ID:SGTC_1855|Compound:st056195|FD-Score:3.00|P-value:8.52E-4 ID:SGTC_1886|Compound:st057356|FD-Score:3.84|P-value:3.18E-5 ID:SGTC_1962|Compound:st076595|FD-Score:3.61|P-value:8.46E-5 ID:SGTC_2001|Compound:4023502|FD-Score:3.14|P-value:5.12E-4 ID:SGTC_2037|Compound:5169046|FD-Score:6.96|P-value:2.91E-13 ID:SGTC_2066|Compound:5222451|FD-Score:11.00|P-value:3.35E-30 ID:SGTC_2073|Compound:5212005|FD-Score:3.40|P-value:1.93E-4 ID:SGTC_2124|Compound:5246320|FD-Score:5.36|P-value:1.33E-8 ID:SGTC_2129|Compound:girgensonine|FD-Score:10.40|P-value:2.74E-27 ID:SGTC_2139|Compound:5578692|FD-Score:4.36|P-value:2.98E-6 ID:SGTC_2163|Compound:5671233|FD-Score:-4.53|P-value:2.10E-6 ID:SGTC_2179|Compound:6298986|FD-Score:5.36|P-value:1.33E-8 ID:SGTC_2196|Compound:6573537|FD-Score:3.47|P-value:1.46E-4 ID:SGTC_2223|Compound:6903751|FD-Score:3.35|P-value:2.40E-4 ID:SGTC_2225|Compound:6654152|FD-Score:11.20|P-value:2.10E-31 ID:SGTC_2233|Compound:sulbentine|FD-Score:3.66|P-value:6.71E-5 ID:SGTC_2283|Compound:7944793|FD-Score:-4.02|P-value:2.33E-5 ID:SGTC_2289|Compound:7946404|FD-Score:4.09|P-value:1.03E-5 ID:SGTC_2308|Compound:7584454|FD-Score:3.32|P-value:2.71E-4 ID:SGTC_2319|Compound:6033012|FD-Score:-3.81|P-value:5.54E-5 ID:SGTC_2336|Compound:9001819|FD-Score:20.00|P-value:1.63E-94 ID:SGTC_2344|Compound:7990960|FD-Score:10.50|P-value:1.81E-27 ID:SGTC_2385|Compound:9074692|FD-Score:3.16|P-value:4.76E-4 ID:SGTC_2401|Compound:5128683|FD-Score:3.66|P-value:6.95E-5 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:4.11|P-value:9.51E-6 ID:SGTC_2415|Compound:st077333|FD-Score:3.04|P-value:7.54E-4 ID:SGTC_2430|Compound:5571206|FD-Score:5.34|P-value:1.56E-8 ID:SGTC_2483|Compound:5729050|FD-Score:3.00|P-value:8.54E-4 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:4.73|P-value:4.61E-7 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:13.20|P-value:2.76E-42 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:5.59|P-value:3.32E-9 ID:SGTC_2575|Compound:plumbagin|FD-Score:8.48|P-value:9.45E-19 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:4.60|P-value:8.90E-7 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:20.10|P-value:5.67E-96 ID:SGTC_2686|Compound:alizarin|FD-Score:3.32|P-value:2.62E-4 ID:SGTC_2687|Compound:chenodiol|FD-Score:-4.78|P-value:5.82E-7 ID:SGTC_2694|Compound:st077685|FD-Score:-4.11|P-value:1.55E-5 ID:SGTC_2700|Compound:st077718|FD-Score:3.26|P-value:3.36E-4 ID:SGTC_2721|Compound:ifenprodil|FD-Score:3.93|P-value:2.12E-5 ID:SGTC_2725|Compound:haloperidol|FD-Score:9.43|P-value:1.03E-22 ID:SGTC_2753|Compound:fluvastatin|FD-Score:4.19|P-value:6.54E-6 ID:SGTC_2757|Compound:clomiphene|FD-Score:3.63|P-value:7.72E-5 ID:SGTC_2760|Compound:etidronate|FD-Score:3.63|P-value:7.83E-5 ID:SGTC_2766|Compound:oltipraz|FD-Score:5.85|P-value:6.47E-10 ID:SGTC_2792|Compound:7535235|FD-Score:3.29|P-value:3.02E-4 ID:SGTC_2799|Compound:7812892|FD-Score:3.65|P-value:7.26E-5 ID:SGTC_2825|Compound:7998094|FD-Score:4.55|P-value:1.12E-6 ID:SGTC_2862|Compound:9027634|FD-Score:3.81|P-value:3.65E-5 ID:SGTC_2880|Compound:9042983|FD-Score:3.97|P-value:1.78E-5 ID:SGTC_2887|Compound:9044784|FD-Score:7.00|P-value:2.22E-13 ID:SGTC_2893|Compound:9048488|FD-Score:5.69|P-value:1.79E-9 ID:SGTC_2910|Compound:7948405|FD-Score:4.11|P-value:9.31E-6 ID:SGTC_2928|Compound:9011484|FD-Score:6.65|P-value:2.93E-12 ID:SGTC_2930|Compound:9013230|FD-Score:3.31|P-value:2.81E-4 ID:SGTC_2938|Compound:9059746|FD-Score:3.36|P-value:2.26E-4 ID:SGTC_2954|Compound:9074818|FD-Score:-3.53|P-value:1.73E-4 ID:SGTC_2957|Compound:9076800|FD-Score:-3.49|P-value:2.08E-4 ID:SGTC_2963|Compound:9082507|FD-Score:7.44|P-value:7.10E-15 ID:SGTC_2965|Compound:9082772|FD-Score:3.83|P-value:3.30E-5 ID:SGTC_2988|Compound:9073640|FD-Score:-3.21|P-value:5.83E-4 ID:SGTC_2993|Compound:9054257|FD-Score:4.99|P-value:1.14E-7 ID:SGTC_3027|Compound:9089541|FD-Score:3.69|P-value:5.93E-5 ID:SGTC_3071|Compound:9117417|FD-Score:4.89|P-value:1.87E-7 ID:SGTC_3081|Compound:9117243|FD-Score:8.48|P-value:9.34E-19 ID:SGTC_3214|Compound:9129694|FD-Score:3.18|P-value:4.56E-4 ID:SGTC_3334|Compound:9142812|FD-Score:3.15|P-value:5.10E-4 ID:SGTC_3351|Compound:9150312|FD-Score:3.24|P-value:3.60E-4 ID:SGTC_3355|Compound:9151058|FD-Score:-3.27|P-value:4.76E-4

Top fitness defect scores for YDR047W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_273 hydroxyurea 49.80 18.1 mM 0 heme biosynthesis & mitochondrial translocase 1 0 41.10
2 SGTC_1 0258-0098 27.30 57.4 µM 7.76E-174 heme biosynthesis & mitochondrial translocase 1 3.41E-164 18.90
3 SGTC_2617 dihydrotanshinone i 20.10 20.8 µM 5.67E-96 copper-dependent oxidative stress 1 1.39E-90 6.82
4 SGTC_2336 9001819 20.00 198.7 µM 1.63E-94 heme biosynthesis & mitochondrial translocase 1 3.32E-89 4.29
5 SGTC_1057 3448-5381 19.10 134.0 µM 1.49E-86 calcium & mitochondrial duress 1 1.11E-81 5.48
6 SGTC_1113 artemisinin 15.80 1.2 µM 5.04E-60 heme biosynthesis & mitochondrial translocase 1 1.28E-56 4.38
7 SGTC_1556 plumbagin 15.40 1.5 µM 5.34E-57 superoxide 2 9.23E-54 2.56
8 SGTC_2519 cryptotanshinone 13.20 88.0 µM 2.76E-42 heme biosynthesis & mitochondrial translocase 2 7.21E-40 1.18
9 SGTC_208 k072-0098 12.80 12.4 µM 2.45E-40 heme biosynthesis & mitochondrial translocase 2 4.98E-38 2.20
10 SGTC_842 0271-0008 12.80 11.1 µM 4.25E-40 heme biosynthesis & mitochondrial translocase 2 8.36E-38 2.88
11 SGTC_203 k066-0004 11.50 30.9 µM 1.18E-32 RSC & ERG11 2 8.85E-31 3.88
12 SGTC_1475 4092-1048 11.30 11.7 µM 1.00E-31 plasma membrane duress 1 6.64E-30 5.10
13 SGTC_2225 6654152 11.20 15.4 µM 2.10E-31 8 1.33E-29 0.86
14 SGTC_2066 5222451 11.00 176.0 µM 3.35E-30 heme biosynthesis & mitochondrial translocase 4 1.83E-28 2.45
15 SGTC_2344 7990960 10.50 77.0 µM 1.81E-27 6 6.91E-26 0.96
16 SGTC_2129 girgensonine 10.40 121.0 µM 2.74E-27 heme biosynthesis & mitochondrial translocase 4 1.02E-25 2.17
17 SGTC_623 k072-0108 10.30 16.9 µM 8.08E-27 heme biosynthesis & mitochondrial translocase 4 2.83E-25 0.30
18 SGTC_1552 6-methylflavone 10.30 10.6 µM 9.49E-27 superoxide 2 3.29E-25 2.67
19 SGTC_966 1300-0360 10.20 30.2 µM 1.88E-26 heme requiring 1 6.27E-25 2.11
20 SGTC_1098 clofazimine 10.00 15.1 µM 2.44E-25 heme biosynthesis & mitochondrial translocase 4 7.04E-24 0.95

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.477 3.84E-190 YDL205C HEM3 het Porphobilinogen deaminase, catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane, the third step in heme biosynthesis; localizes to the cytoplasm and nucleus; expression is regulated by Hap2p-Hap3p, but not by levels of heme
0.386 6.48E-120 YJL027C_p YJL027C_p hom Putative protein of unknown function
0.304 1.30E-72 YKL195W MIA40 het Oxidoreductase that mediates mitochondrial intermembrane space import; substrates include small proteins containing twin cysteine motifs; acts in concert with Erv1p, which oxidizes the cysteine residues of Mia40p to comprise a disulfide relay system that catalyzes import; also mediates folding of Atp23p
0.295 2.37E-68 YBR192W RIM2 het Mitochondrial pyrimidine nucleotide transporter; imports pyrimidine nucleoside triphosphates and exports pyrimidine nucleoside monophosphates; member of the mitochondrial carrier family
0.272 4.40E-58 YEL034W HYP2 het Translation elongation factor eIF-5A; may function in translation initiation; structural homolog of bacterial EF-P; undergoes an essential hypusination modification; HYP2 has a paralog, ANB1, that arose from the whole genome duplication
0.268 2.87E-56 YER021W RPN3 het Essential, non-ATPase regulatory subunit of the 26S proteasome lid, similar to the p58 subunit of the human 26S proteasome; temperature-sensitive alleles cause metaphase arrest, suggesting a role for the proteasome in cell cycle control
0.254 1.07E-50 YDL147W RPN5 het Subunit of the COP9 signalosome (CSN) and non-ATPase regulatory subunit of the 26S proteasome lid, similar to mammalian p55 subunit and to another S. cerevisiae regulatory subunit, Rpn7p; Rpn5p is an essential protein
0.249 2.31E-48 YMR203W TOM40 het Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; constitutes the core element of the protein conducting pore
0.242 6.50E-46 YJL031C BET4 het Alpha subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p
0.234 6.35E-43 YBL105C PKC1 het Protein serine/threonine kinase essential for cell wall remodeling during growth; localized to sites of polarized growth and the mother-daughter bud neck; homolog of the alpha, beta, and gamma isoforms of mammalian protein kinase C (PKC)
0.231 6.15E-42 YGL040C HEM2 het Aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of 5-aminolevulinate to porphobilinogen, the second step in heme biosynthesis; enzymatic activity is zinc-dependent; localizes to the cytoplasm and nucleus
0.225 9.60E-40 YNL112W DBP2 het ATP-dependent RNA helicase of the DEAD-box protein family; has a strong preference for dsRNA; involved mRNA decay and rRNA processing; may be involved in suppression of transcription from cryptic initiation sites
0.221 2.81E-38 YKR008W RSC4 het Component of the RSC chromatin remodeling complex; found in close proximity to nucleosomal DNA; displaced from the surface of nucleosomal DNA after chromatin remodeling; acetylated (K25) by Gcn5p, altering replication stress tolerance; contains tandem bromodomains that recognize histone H3 acetylated on K14 (H3K14ac) by Gcn5p
0.217 4.00E-37 YDL196W_d YDL196W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame is located in promoter region of essential gene SEC31
0.215 2.09E-36 YOR117W RPT5 het One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; recruited to the GAL1-10 promoter region upon induction of transcription; similar to human TBP1