YDR053W_d

Putative protein of unknown function; open reading frame overlaps 5' end of essential DBF4 gene encoding the regulatory subunit of the Cdc7p-Dbf4p kinase complex

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDR053W / YDR053W

Click on Significant Values for Screen Details ID:SGTC_64|Compound:000l-0018|FD-Score:-3.20|P-value:5.15E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:-4.40|P-value:3.36E-6 ID:SGTC_75|Compound:0159-0059|FD-Score:6.29|P-value:1.06E-10 ID:SGTC_121|Compound:0557-0495|FD-Score:3.72|P-value:9.00E-5 ID:SGTC_163|Compound:1327-0036|FD-Score:-4.31|P-value:5.29E-6 ID:SGTC_167|Compound:3672-0051|FD-Score:5.11|P-value:1.27E-7 ID:SGTC_256|Compound:clotrimazole|FD-Score:4.10|P-value:1.84E-5 ID:SGTC_266|Compound:formosanin C|FD-Score:3.72|P-value:9.32E-5 ID:SGTC_354|Compound:2783-3500|FD-Score:4.27|P-value:8.42E-6 ID:SGTC_419|Compound:nsc-638432|FD-Score:-3.67|P-value:8.73E-5 ID:SGTC_514|Compound:4466-0038|FD-Score:5.48|P-value:1.65E-8 ID:SGTC_528|Compound:3492-0019|FD-Score:5.53|P-value:1.24E-8 ID:SGTC_540|Compound:1187-0821|FD-Score:-3.09|P-value:7.69E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:3.36|P-value:3.72E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:3.47|P-value:2.47E-4 ID:SGTC_734|Compound:2023-0417|FD-Score:-3.71|P-value:7.28E-5 ID:SGTC_745|Compound:0469-0705|FD-Score:-3.18|P-value:5.61E-4 ID:SGTC_797|Compound:k781-0471|FD-Score:3.23|P-value:5.91E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:3.16|P-value:7.57E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:14.80|P-value:2.64E-51 ID:SGTC_1134|Compound:3477-0009|FD-Score:6.70|P-value:6.64E-12 ID:SGTC_1165|Compound:k072-0275|FD-Score:3.28|P-value:4.98E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:3.15|P-value:7.81E-4 ID:SGTC_1365|Compound:1672-3266|FD-Score:3.42|P-value:2.92E-4 ID:SGTC_1665|Compound:st014639|FD-Score:3.13|P-value:8.27E-4 ID:SGTC_1712|Compound:st032288|FD-Score:3.76|P-value:7.95E-5 ID:SGTC_1754|Compound:st042065|FD-Score:3.99|P-value:2.94E-5 ID:SGTC_1778|Compound:st046819|FD-Score:5.25|P-value:6.06E-8 ID:SGTC_1801|Compound:st050089|FD-Score:5.21|P-value:7.37E-8 ID:SGTC_1803|Compound:st050068|FD-Score:3.26|P-value:5.24E-4 ID:SGTC_1916|Compound:st067606|FD-Score:-3.03|P-value:9.44E-4 ID:SGTC_1919|Compound:st067113|FD-Score:-3.66|P-value:8.93E-5 ID:SGTC_1921|Compound:5740136|FD-Score:-3.48|P-value:1.83E-4 ID:SGTC_1923|Compound:st058458|FD-Score:-4.60|P-value:1.28E-6 ID:SGTC_1934|Compound:st074720|FD-Score:7.36|P-value:5.41E-14 ID:SGTC_1937|Compound:st074714|FD-Score:3.47|P-value:2.39E-4 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:3.21|P-value:6.37E-4 ID:SGTC_2021|Compound:4019055|FD-Score:3.97|P-value:3.30E-5 ID:SGTC_2033|Compound:5192550|FD-Score:4.37|P-value:5.35E-6 ID:SGTC_2036|Compound:5160441|FD-Score:3.39|P-value:3.33E-4 ID:SGTC_2038|Compound:4100038|FD-Score:3.98|P-value:3.15E-5 ID:SGTC_2090|Compound:5301565|FD-Score:3.17|P-value:7.23E-4 ID:SGTC_2137|Compound:5261020|FD-Score:3.45|P-value:2.60E-4 ID:SGTC_2171|Compound:5739187|FD-Score:-3.85|P-value:4.15E-5 ID:SGTC_2181|Compound:6316240|FD-Score:-3.45|P-value:2.05E-4 ID:SGTC_2185|Compound:6113692|FD-Score:3.18|P-value:7.02E-4 ID:SGTC_2323|Compound:6148992|FD-Score:3.38|P-value:3.43E-4 ID:SGTC_2349|Compound:9023730|FD-Score:3.16|P-value:7.67E-4 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:3.09|P-value:9.68E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:4.31|P-value:7.13E-6 ID:SGTC_2684|Compound:capsaicin|FD-Score:3.93|P-value:3.77E-5 ID:SGTC_2736|Compound:butenafine|FD-Score:4.56|P-value:2.23E-6 ID:SGTC_2740|Compound:felodipine|FD-Score:-4.27|P-value:6.24E-6 ID:SGTC_2741|Compound:miltefosine|FD-Score:3.22|P-value:6.08E-4 ID:SGTC_2773|Compound:thioridazine|FD-Score:3.38|P-value:3.44E-4 ID:SGTC_2774|Compound:tamoxifen|FD-Score:3.44|P-value:2.75E-4 ID:SGTC_2800|Compound:7887935|FD-Score:3.50|P-value:2.17E-4 ID:SGTC_2806|Compound:7952793|FD-Score:-3.68|P-value:8.24E-5 ID:SGTC_2896|Compound:9052656|FD-Score:3.82|P-value:6.01E-5 ID:SGTC_3155|Compound:9099265|FD-Score:3.36|P-value:3.63E-4 ID:SGTC_3159|Compound:9100096|FD-Score:3.49|P-value:2.25E-4 ID:SGTC_3242|Compound:9133940|FD-Score:-3.21|P-value:4.94E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:-3.20|P-value:5.15E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:-4.40|P-value:3.36E-6 ID:SGTC_75|Compound:0159-0059|FD-Score:6.29|P-value:1.06E-10 ID:SGTC_121|Compound:0557-0495|FD-Score:3.72|P-value:9.00E-5 ID:SGTC_163|Compound:1327-0036|FD-Score:-4.31|P-value:5.29E-6 ID:SGTC_167|Compound:3672-0051|FD-Score:5.11|P-value:1.27E-7 ID:SGTC_256|Compound:clotrimazole|FD-Score:4.10|P-value:1.84E-5 ID:SGTC_266|Compound:formosanin C|FD-Score:3.72|P-value:9.32E-5 ID:SGTC_354|Compound:2783-3500|FD-Score:4.27|P-value:8.42E-6 ID:SGTC_419|Compound:nsc-638432|FD-Score:-3.67|P-value:8.73E-5 ID:SGTC_514|Compound:4466-0038|FD-Score:5.48|P-value:1.65E-8 ID:SGTC_528|Compound:3492-0019|FD-Score:5.53|P-value:1.24E-8 ID:SGTC_540|Compound:1187-0821|FD-Score:-3.09|P-value:7.69E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:3.36|P-value:3.72E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:3.47|P-value:2.47E-4 ID:SGTC_734|Compound:2023-0417|FD-Score:-3.71|P-value:7.28E-5 ID:SGTC_745|Compound:0469-0705|FD-Score:-3.18|P-value:5.61E-4 ID:SGTC_797|Compound:k781-0471|FD-Score:3.23|P-value:5.91E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:3.16|P-value:7.57E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:14.80|P-value:2.64E-51 ID:SGTC_1134|Compound:3477-0009|FD-Score:6.70|P-value:6.64E-12 ID:SGTC_1165|Compound:k072-0275|FD-Score:3.28|P-value:4.98E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:3.15|P-value:7.81E-4 ID:SGTC_1365|Compound:1672-3266|FD-Score:3.42|P-value:2.92E-4 ID:SGTC_1665|Compound:st014639|FD-Score:3.13|P-value:8.27E-4 ID:SGTC_1712|Compound:st032288|FD-Score:3.76|P-value:7.95E-5 ID:SGTC_1754|Compound:st042065|FD-Score:3.99|P-value:2.94E-5 ID:SGTC_1778|Compound:st046819|FD-Score:5.25|P-value:6.06E-8 ID:SGTC_1801|Compound:st050089|FD-Score:5.21|P-value:7.37E-8 ID:SGTC_1803|Compound:st050068|FD-Score:3.26|P-value:5.24E-4 ID:SGTC_1916|Compound:st067606|FD-Score:-3.03|P-value:9.44E-4 ID:SGTC_1919|Compound:st067113|FD-Score:-3.66|P-value:8.93E-5 ID:SGTC_1921|Compound:5740136|FD-Score:-3.48|P-value:1.83E-4 ID:SGTC_1923|Compound:st058458|FD-Score:-4.60|P-value:1.28E-6 ID:SGTC_1934|Compound:st074720|FD-Score:7.36|P-value:5.41E-14 ID:SGTC_1937|Compound:st074714|FD-Score:3.47|P-value:2.39E-4 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:3.21|P-value:6.37E-4 ID:SGTC_2021|Compound:4019055|FD-Score:3.97|P-value:3.30E-5 ID:SGTC_2033|Compound:5192550|FD-Score:4.37|P-value:5.35E-6 ID:SGTC_2036|Compound:5160441|FD-Score:3.39|P-value:3.33E-4 ID:SGTC_2038|Compound:4100038|FD-Score:3.98|P-value:3.15E-5 ID:SGTC_2090|Compound:5301565|FD-Score:3.17|P-value:7.23E-4 ID:SGTC_2137|Compound:5261020|FD-Score:3.45|P-value:2.60E-4 ID:SGTC_2171|Compound:5739187|FD-Score:-3.85|P-value:4.15E-5 ID:SGTC_2181|Compound:6316240|FD-Score:-3.45|P-value:2.05E-4 ID:SGTC_2185|Compound:6113692|FD-Score:3.18|P-value:7.02E-4 ID:SGTC_2323|Compound:6148992|FD-Score:3.38|P-value:3.43E-4 ID:SGTC_2349|Compound:9023730|FD-Score:3.16|P-value:7.67E-4 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:3.09|P-value:9.68E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:4.31|P-value:7.13E-6 ID:SGTC_2684|Compound:capsaicin|FD-Score:3.93|P-value:3.77E-5 ID:SGTC_2736|Compound:butenafine|FD-Score:4.56|P-value:2.23E-6 ID:SGTC_2740|Compound:felodipine|FD-Score:-4.27|P-value:6.24E-6 ID:SGTC_2741|Compound:miltefosine|FD-Score:3.22|P-value:6.08E-4 ID:SGTC_2773|Compound:thioridazine|FD-Score:3.38|P-value:3.44E-4 ID:SGTC_2774|Compound:tamoxifen|FD-Score:3.44|P-value:2.75E-4 ID:SGTC_2800|Compound:7887935|FD-Score:3.50|P-value:2.17E-4 ID:SGTC_2806|Compound:7952793|FD-Score:-3.68|P-value:8.24E-5 ID:SGTC_2896|Compound:9052656|FD-Score:3.82|P-value:6.01E-5 ID:SGTC_3155|Compound:9099265|FD-Score:3.36|P-value:3.63E-4 ID:SGTC_3159|Compound:9100096|FD-Score:3.49|P-value:2.25E-4 ID:SGTC_3242|Compound:9133940|FD-Score:-3.21|P-value:4.94E-4

Top fitness defect scores for YDR053W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_916 4466-0038 14.80 42.0 nM 2.64E-51 cell wall 3 4.14E-50 3.77
2 SGTC_1934 st074720 7.36 32.6 µM 5.41E-14 1 9.46E-14 1.64
3 SGTC_1134 3477-0009 6.70 42.5 µM 6.64E-12 3 1.04E-11 0.91
4 SGTC_75 0159-0059 6.29 199.0 µM 1.06E-10 fatty acid desaturase (OLE1) 1 1.55E-10 0.77
5 SGTC_528 3492-0019 5.53 172.0 µM 1.24E-8 calcium & mitochondrial duress 12 1.63E-8 0.37
6 SGTC_514 4466-0038 5.48 2.6 nM 1.65E-8 cell wall 22 2.15E-8 0.08
7 SGTC_1778 st046819 5.25 58.9 µM 6.06E-8 2 7.68E-8 0.58
8 SGTC_1801 st050089 5.21 28.4 µM 7.37E-8 NEO1-PIK1 5 9.29E-8 0.31
9 SGTC_167 3672-0051 5.11 66.2 µM 1.27E-7 3 1.59E-7 0.53
10 SGTC_2736 butenafine 4.56 14.7 µM 2.23E-6 4 2.61E-6 0.18
11 SGTC_2033 5192550 4.37 145.0 µM 5.35E-6 3 6.16E-6 0.18
12 SGTC_2584 androsterone 4.31 48.7 µM 7.13E-6 cell wall 24 8.16E-6 0.14
13 SGTC_354 2783-3500 4.27 4.9 µM 8.42E-6 cell wall 24 9.61E-6 0.08
14 SGTC_256 clotrimazole 4.10 625.0 nM 1.84E-5 ergosterol depletion effects on membrane 20 2.06E-5 0.10
15 SGTC_1754 st042065 3.99 16.1 µM 2.94E-5 NEO1-PIK1 31 3.27E-5 0.04
16 SGTC_2038 4100038 3.98 31.0 µM 3.15E-5 plasma membrane duress 15 3.50E-5 0.09
17 SGTC_2021 4019055 3.97 173.0 µM 3.30E-5 endomembrane recycling 33 3.66E-5 0.09
18 SGTC_2684 capsaicin 3.93 100.0 µM 3.77E-5 5 4.17E-5 0.04
19 SGTC_2896 9052656 3.82 71.4 µM 6.01E-5 endomembrane recycling 23 6.59E-5 0.03
20 SGTC_1712 st032288 3.76 53.4 µM 7.95E-5 calcium & mitochondrial duress 39 8.67E-5 0.13

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.286 4.20E-64 YMR124W_p YMR124W_p hom Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene; predicted to have a role in organelle organization
0.239 5.66E-45 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.225 9.79E-40 YLR212C TUB4 het Gamma-tubulin; involved in nucleating microtubules from both the cytoplasmic and nuclear faces of the spindle pole body; protein abundance increases in response to DNA replication stress
0.221 2.79E-38 YBL061C SKT5 hom Activator of Chs3p (chitin synthase III) during vegetative growth; recruits Chs3p to the bud neck via interaction with Bni4p; SKT5 has a paralog, SHC1, that arose from the whole genome duplication
0.203 1.72E-32 YGL035C MIG1 hom Transcription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and the GLC7 phosphatase; regulates filamentous growth along with Mig2p in response to glucose depletion
0.196 2.23E-30 YGL116W CDC20 het Activator of anaphase-promoting complex/cyclosome (APC/C); APC/C is required for metaphase/anaphase transition; directs ubiquitination of mitotic cyclins, Pds1p, and other anaphase inhibitors; cell-cycle regulated; potential Cdc28p substrate; relative distribution to the nucleus increases upon DNA replication stress
0.195 3.54E-30 YDR475C JIP4 hom Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence
0.193 1.40E-29 YDR121W DPB4 hom Subunit of DNA pol epsilon and of ISW2 chromatin accessibility complex; involved in both chromosomal DNA replication and inheritance of telomeric silencing; stabilizes the interaction of Pol epsilon with primer-template DNA, positively affecting the processivity of the polymerase and exonuclease activities of Pol epsilon; interacts with extranucleosomal DNA and acts as anchor point for ISW2 complex that retains its position on DNA during nucleosome mobilization
0.189 3.14E-28 YPR143W RRP15 het Nucleolar protein, constituent of pre-60S ribosomal particles; required for proper processing of the 27S pre-rRNA at the A3 and B1 sites to yield mature 5.8S and 25S rRNAs
0.187 6.52E-28 YDR093W DNF2 hom Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase
0.185 2.46E-27 YBL085W BOI1 hom Protein implicated in polar growth; functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; relocalizes from bud neck to cytoplasm upon DNA replication stress; BOI1 has a paralog, BOI2, that arose from the whole genome duplication
0.181 2.96E-26 YLR330W CHS5 hom Component of the exomer complex, which also contains Csh6p, Bch1p, Bch2p, and Bud7p and is involved in export of selected proteins, such as chitin synthase Chs3p, from the Golgi to the plasma membrane
0.181 4.53E-26 YNL288W CAF40 hom Evolutionarily conserved subunit of the CCR4-NOT complex involved in controlling mRNA initiation, elongation and degradation; binds Cdc39p
0.172 1.07E-23 YBL022C PIM1 hom ATP-dependent Lon protease, involved in degradation of misfolded proteins in mitochondria; required for biogenesis and maintenance of mitochondria
0.167 2.16E-22 YLL032C YLL032C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene