YDR058C / TGL2

Triacylglycerol lipase that is localized to the mitochondria; has lipolytic activity towards triacylglycerols and diacylglycerols when expressed in E. coli

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR058C / TGL2

Click on Significant Values for Screen Details ID:SGTC_17|Compound:0960-0276|FD-Score:3.91|P-value:5.22E-5 ID:SGTC_22|Compound:0964-0034|FD-Score:-3.86|P-value:5.55E-5 ID:SGTC_98|Compound:0074-0023|FD-Score:3.41|P-value:3.65E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:4.67|P-value:1.79E-6 ID:SGTC_138|Compound:0850-0259|FD-Score:3.33|P-value:4.81E-4 ID:SGTC_338|Compound:4055-0136|FD-Score:3.80|P-value:8.31E-5 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:3.18|P-value:8.07E-4 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:3.19|P-value:7.77E-4 ID:SGTC_497|Compound:capsazepine|FD-Score:3.25|P-value:6.47E-4 ID:SGTC_511|Compound:blebbistatin|FD-Score:3.38|P-value:4.02E-4 ID:SGTC_520|Compound:3584-0023|FD-Score:3.30|P-value:5.38E-4 ID:SGTC_578|Compound:3460-0051|FD-Score:3.74|P-value:1.03E-4 ID:SGTC_684|Compound:1140-0066|FD-Score:3.34|P-value:4.57E-4 ID:SGTC_726|Compound:3448-4391|FD-Score:-3.68|P-value:1.15E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:5.38|P-value:4.54E-8 ID:SGTC_818|Compound:4072-2707|FD-Score:3.53|P-value:2.35E-4 ID:SGTC_877|Compound:0771-0151|FD-Score:3.13|P-value:9.57E-4 ID:SGTC_921|Compound:1561-0023|FD-Score:5.08|P-value:2.23E-7 ID:SGTC_925|Compound:2064-1272|FD-Score:3.49|P-value:2.73E-4 ID:SGTC_1049|Compound:3226-0134|FD-Score:-3.83|P-value:6.41E-5 ID:SGTC_1066|Compound:ketoconazole|FD-Score:3.20|P-value:7.53E-4 ID:SGTC_1292|Compound:0kpi-0043|FD-Score:3.81|P-value:7.96E-5 ID:SGTC_1305|Compound:1181-0477|FD-Score:3.45|P-value:3.13E-4 ID:SGTC_1312|Compound:1218-2183|FD-Score:6.00|P-value:1.23E-9 ID:SGTC_1342|Compound:1486-1464|FD-Score:3.17|P-value:8.26E-4 ID:SGTC_1415|Compound:3966-0071|FD-Score:4.45|P-value:5.08E-6 ID:SGTC_1429|Compound:4049-0205|FD-Score:3.48|P-value:2.76E-4 ID:SGTC_1624|Compound:st003710|FD-Score:3.26|P-value:6.12E-4 ID:SGTC_1795|Compound:st049545|FD-Score:-3.12|P-value:9.01E-4 ID:SGTC_1895|Compound:st058434|FD-Score:5.07|P-value:2.41E-7 ID:SGTC_2013|Compound:4024628|FD-Score:3.24|P-value:6.54E-4 ID:SGTC_2015|Compound:5119600|FD-Score:3.16|P-value:8.78E-4 ID:SGTC_2073|Compound:5212005|FD-Score:-3.57|P-value:1.73E-4 ID:SGTC_2132|Compound:5317594|FD-Score:6.57|P-value:3.17E-11 ID:SGTC_2133|Compound:5320837|FD-Score:4.88|P-value:6.30E-7 ID:SGTC_2134|Compound:5324836|FD-Score:3.48|P-value:2.74E-4 ID:SGTC_2137|Compound:5261020|FD-Score:5.43|P-value:3.44E-8 ID:SGTC_2138|Compound:5575593|FD-Score:3.21|P-value:7.22E-4 ID:SGTC_2145|Compound:5634607|FD-Score:3.91|P-value:5.13E-5 ID:SGTC_2190|Compound:6049624|FD-Score:-3.19|P-value:7.04E-4 ID:SGTC_2211|Compound:7117706|FD-Score:3.28|P-value:5.63E-4 ID:SGTC_2225|Compound:6654152|FD-Score:-3.25|P-value:5.71E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:3.13|P-value:9.74E-4 ID:SGTC_2259|Compound:7964009|FD-Score:3.19|P-value:7.89E-4 ID:SGTC_2315|Compound:7733312|FD-Score:-5.10|P-value:1.70E-7 ID:SGTC_2335|Compound:9018011|FD-Score:-3.12|P-value:8.81E-4 ID:SGTC_2338|Compound:7999974|FD-Score:3.41|P-value:3.55E-4 ID:SGTC_2342|Compound:7990637|FD-Score:-4.46|P-value:4.04E-6 ID:SGTC_2358|Compound:9037157|FD-Score:5.37|P-value:4.69E-8 ID:SGTC_2393|Compound:9031399|FD-Score:3.90|P-value:5.34E-5 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:-3.73|P-value:9.43E-5 ID:SGTC_2660|Compound:2',4'-dihydroxychalcone|FD-Score:3.28|P-value:5.78E-4 ID:SGTC_2686|Compound:alizarin|FD-Score:3.15|P-value:9.04E-4 ID:SGTC_2804|Compound:7954240|FD-Score:-3.51|P-value:2.19E-4 ID:SGTC_2885|Compound:9057732|FD-Score:-3.17|P-value:7.42E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-4.03|P-value:2.74E-5 ID:SGTC_2920|Compound:7982904|FD-Score:4.51|P-value:3.81E-6 ID:SGTC_2931|Compound:9014674|FD-Score:3.25|P-value:6.37E-4 ID:SGTC_2934|Compound:9036370|FD-Score:3.30|P-value:5.43E-4 ID:SGTC_2981|Compound:9013952|FD-Score:4.01|P-value:3.39E-5 ID:SGTC_3274|Compound:9138298|FD-Score:3.42|P-value:3.54E-4 ID:SGTC_17|Compound:0960-0276|FD-Score:3.91|P-value:5.22E-5 ID:SGTC_22|Compound:0964-0034|FD-Score:-3.86|P-value:5.55E-5 ID:SGTC_98|Compound:0074-0023|FD-Score:3.41|P-value:3.65E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:4.67|P-value:1.79E-6 ID:SGTC_138|Compound:0850-0259|FD-Score:3.33|P-value:4.81E-4 ID:SGTC_338|Compound:4055-0136|FD-Score:3.80|P-value:8.31E-5 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:3.18|P-value:8.07E-4 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:3.19|P-value:7.77E-4 ID:SGTC_497|Compound:capsazepine|FD-Score:3.25|P-value:6.47E-4 ID:SGTC_511|Compound:blebbistatin|FD-Score:3.38|P-value:4.02E-4 ID:SGTC_520|Compound:3584-0023|FD-Score:3.30|P-value:5.38E-4 ID:SGTC_578|Compound:3460-0051|FD-Score:3.74|P-value:1.03E-4 ID:SGTC_684|Compound:1140-0066|FD-Score:3.34|P-value:4.57E-4 ID:SGTC_726|Compound:3448-4391|FD-Score:-3.68|P-value:1.15E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:5.38|P-value:4.54E-8 ID:SGTC_818|Compound:4072-2707|FD-Score:3.53|P-value:2.35E-4 ID:SGTC_877|Compound:0771-0151|FD-Score:3.13|P-value:9.57E-4 ID:SGTC_921|Compound:1561-0023|FD-Score:5.08|P-value:2.23E-7 ID:SGTC_925|Compound:2064-1272|FD-Score:3.49|P-value:2.73E-4 ID:SGTC_1049|Compound:3226-0134|FD-Score:-3.83|P-value:6.41E-5 ID:SGTC_1066|Compound:ketoconazole|FD-Score:3.20|P-value:7.53E-4 ID:SGTC_1292|Compound:0kpi-0043|FD-Score:3.81|P-value:7.96E-5 ID:SGTC_1305|Compound:1181-0477|FD-Score:3.45|P-value:3.13E-4 ID:SGTC_1312|Compound:1218-2183|FD-Score:6.00|P-value:1.23E-9 ID:SGTC_1342|Compound:1486-1464|FD-Score:3.17|P-value:8.26E-4 ID:SGTC_1415|Compound:3966-0071|FD-Score:4.45|P-value:5.08E-6 ID:SGTC_1429|Compound:4049-0205|FD-Score:3.48|P-value:2.76E-4 ID:SGTC_1624|Compound:st003710|FD-Score:3.26|P-value:6.12E-4 ID:SGTC_1795|Compound:st049545|FD-Score:-3.12|P-value:9.01E-4 ID:SGTC_1895|Compound:st058434|FD-Score:5.07|P-value:2.41E-7 ID:SGTC_2013|Compound:4024628|FD-Score:3.24|P-value:6.54E-4 ID:SGTC_2015|Compound:5119600|FD-Score:3.16|P-value:8.78E-4 ID:SGTC_2073|Compound:5212005|FD-Score:-3.57|P-value:1.73E-4 ID:SGTC_2132|Compound:5317594|FD-Score:6.57|P-value:3.17E-11 ID:SGTC_2133|Compound:5320837|FD-Score:4.88|P-value:6.30E-7 ID:SGTC_2134|Compound:5324836|FD-Score:3.48|P-value:2.74E-4 ID:SGTC_2137|Compound:5261020|FD-Score:5.43|P-value:3.44E-8 ID:SGTC_2138|Compound:5575593|FD-Score:3.21|P-value:7.22E-4 ID:SGTC_2145|Compound:5634607|FD-Score:3.91|P-value:5.13E-5 ID:SGTC_2190|Compound:6049624|FD-Score:-3.19|P-value:7.04E-4 ID:SGTC_2211|Compound:7117706|FD-Score:3.28|P-value:5.63E-4 ID:SGTC_2225|Compound:6654152|FD-Score:-3.25|P-value:5.71E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:3.13|P-value:9.74E-4 ID:SGTC_2259|Compound:7964009|FD-Score:3.19|P-value:7.89E-4 ID:SGTC_2315|Compound:7733312|FD-Score:-5.10|P-value:1.70E-7 ID:SGTC_2335|Compound:9018011|FD-Score:-3.12|P-value:8.81E-4 ID:SGTC_2338|Compound:7999974|FD-Score:3.41|P-value:3.55E-4 ID:SGTC_2342|Compound:7990637|FD-Score:-4.46|P-value:4.04E-6 ID:SGTC_2358|Compound:9037157|FD-Score:5.37|P-value:4.69E-8 ID:SGTC_2393|Compound:9031399|FD-Score:3.90|P-value:5.34E-5 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:-3.73|P-value:9.43E-5 ID:SGTC_2660|Compound:2',4'-dihydroxychalcone|FD-Score:3.28|P-value:5.78E-4 ID:SGTC_2686|Compound:alizarin|FD-Score:3.15|P-value:9.04E-4 ID:SGTC_2804|Compound:7954240|FD-Score:-3.51|P-value:2.19E-4 ID:SGTC_2885|Compound:9057732|FD-Score:-3.17|P-value:7.42E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-4.03|P-value:2.74E-5 ID:SGTC_2920|Compound:7982904|FD-Score:4.51|P-value:3.81E-6 ID:SGTC_2931|Compound:9014674|FD-Score:3.25|P-value:6.37E-4 ID:SGTC_2934|Compound:9036370|FD-Score:3.30|P-value:5.43E-4 ID:SGTC_2981|Compound:9013952|FD-Score:4.01|P-value:3.39E-5 ID:SGTC_3274|Compound:9138298|FD-Score:3.42|P-value:3.54E-4

Top fitness defect scores for YDR058C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2132 5317594 6.57 122.7 µM 3.17E-11 SWF1 & branched chain AA biosynthesis 11 2.44E-11
2 SGTC_1312 1218-2183 6.00 165.0 µM 1.23E-9 1 9.77E-10
3 SGTC_2137 5261020 5.43 140.0 µM 3.44E-8 17 2.82E-8
4 SGTC_769 0302-0231 5.38 76.0 µM 4.54E-8 12 3.74E-8
5 SGTC_2358 9037157 5.37 4.0 µM 4.69E-8 8 3.86E-8
6 SGTC_921 1561-0023 5.08 372.0 µM 2.23E-7 6 1.86E-7
7 SGTC_1895 st058434 5.07 18.3 µM 2.41E-7 5 2.02E-7
8 SGTC_2133 5320837 4.88 200.0 µM 6.30E-7 ERG2 12 5.32E-7
9 SGTC_115 0527-0192 4.67 112.0 µM 1.79E-6 43 1.53E-6
10 SGTC_2920 7982904 4.51 15.8 µM 3.81E-6 10 3.27E-6
11 SGTC_1415 3966-0071 4.45 78.1 µM 5.08E-6 DNA intercalators 6 4.38E-6
12 SGTC_2981 9013952 4.01 39.0 µM 3.39E-5 44 2.98E-5
13 SGTC_2145 5634607 3.91 200.0 µM 5.13E-5 6 4.53E-5
14 SGTC_17 0960-0276 3.91 49.8 µM 5.22E-5 32 4.61E-5
15 SGTC_2393 9031399 3.90 185.9 µM 5.34E-5 RNA processing & uracil transport 26 4.72E-5
16 SGTC_1292 0kpi-0043 3.81 232.0 µM 7.96E-5 17 7.06E-5
17 SGTC_338 4055-0136 3.80 114.0 µM 8.31E-5 12 7.37E-5
18 SGTC_578 3460-0051 3.74 92.0 µM 1.03E-4 15 9.17E-5
19 SGTC_818 4072-2707 3.53 53.5 µM 2.35E-4 26 2.11E-4
20 SGTC_925 2064-1272 3.49 59.6 µM 2.73E-4 39 2.46E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.098 1.51E-8 YMR115W MGR3 hom Subunit of the mitochondrial (mt) i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr1p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA
0.092 9.85E-8 YER009W NTF2 het Nuclear envelope protein, interacts with GDP-bound Gsp1p and with proteins of the nuclear pore to transport Gsp1p into the nucleus where it is an essential player in nucleocytoplasmic transport
0.090 1.64E-7 YHR083W SAM35 het Essential component of the sorting and assembly machinery (SAM complex or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their insertion into the outer membrane
0.085 7.16E-7 YER122C GLO3 hom ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Gcs1p
0.085 9.18E-7 YBR258C SHG1 hom Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres
0.080 3.04E-6 YDL044C MTF2 hom Mitochondrial matrix protein that interacts with an N-terminal region of mitochondrial RNA polymerase (Rpo41p) and couples RNA processing and translation to transcription
0.079 4.89E-6 YGL067W NPY1 hom NADH diphosphatase (pyrophosphatase), hydrolyzes the pyrophosphate linkage in NADH and related nucleotides; localizes to peroxisomes; nudix hydrolase family member
0.078 6.67E-6 YOR170W_d YOR170W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene LCB4
0.077 7.84E-6 YMR219W ESC1 hom Protein localized to the nuclear periphery, involved in telomeric silencing; interacts with PAD4-domain of Sir4p
0.076 1.18E-5 YHL014C YLF2 hom Protein of unknown function, has weak similarity to E. coli GTP-binding protein gtp1; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.073 2.11E-5 YNL155W YNL155W hom Protein of unknown function; contains a DHHC domain and an AN1-type zinc finger; predicted to have thiol-disulfide oxidoreductase active site; transcriptionally regulated by Rpn4p along with proteasome subunit genes; putative ortholog of human AIRAP, which stimulates proteasome activity in response to arsenic; protein abundance increases in response to DNA replication stress
0.070 4.74E-5 YBR021W FUR4 hom Plasma membrane localized uracil permease; expression is tightly regulated by uracil levels and environmental cues; conformational alterations induced by unfolding or substrate binding result in Rsp5p-mediated ubiquitination and degradation
0.070 4.96E-5 YOR352W TFB6 hom Subunit of TFIIH complex; facilities dissociation of the Ssl2p helices from TFIIH; expression levels regulated by Arg5,6p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
0.069 7.01E-5 YML024W RPS17A hom Ribosomal protein 51 (rp51) of the small (40s) subunit; homologous to mammalian ribosomal protein S17, no bacterial homolog; RPS17A has a paralog, RPS17B, that arose from the whole genome duplication
0.067 9.95E-5 YPR143W RRP15 het Nucleolar protein, constituent of pre-60S ribosomal particles; required for proper processing of the 27S pre-rRNA at the A3 and B1 sites to yield mature 5.8S and 25S rRNAs