YDR064W / RPS13

Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S13 and bacterial S15

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDR064W / RPS13

Click on Significant Values for Screen Details ID:SGTC_36|Compound:0335-0881|FD-Score:-3.54|P-value:2.25E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:3.62|P-value:2.90E-4 ID:SGTC_97|Compound:0535-0701|FD-Score:-3.47|P-value:2.96E-4 ID:SGTC_99|Compound:0109-0120|FD-Score:3.42|P-value:5.84E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:3.75|P-value:1.81E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:4.74|P-value:3.00E-6 ID:SGTC_180|Compound:1486-1293|FD-Score:4.09|P-value:4.87E-5 ID:SGTC_309|Compound:k408-0051|FD-Score:3.79|P-value:1.58E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:3.53|P-value:4.03E-4 ID:SGTC_537|Compound:1334-0398|FD-Score:3.84|P-value:1.32E-4 ID:SGTC_539|Compound:4859-0462|FD-Score:-3.71|P-value:1.19E-4 ID:SGTC_540|Compound:1187-0821|FD-Score:-4.28|P-value:1.22E-5 ID:SGTC_654|Compound:1124-0271|FD-Score:3.64|P-value:2.70E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:7.76|P-value:4.46E-14 ID:SGTC_831|Compound:k061-1017|FD-Score:3.38|P-value:6.83E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:3.55|P-value:3.72E-4 ID:SGTC_838|Compound:0109-0203|FD-Score:3.80|P-value:1.52E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:-3.16|P-value:8.57E-4 ID:SGTC_865|Compound:0488-0499|FD-Score:3.27|P-value:9.70E-4 ID:SGTC_866|Compound:0495-0101|FD-Score:-4.15|P-value:2.07E-5 ID:SGTC_990|Compound:3985-0011|FD-Score:-3.46|P-value:3.06E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.20|P-value:7.45E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:-6.07|P-value:1.31E-9 ID:SGTC_1206|Compound:3978-0017|FD-Score:-7.35|P-value:3.03E-13 ID:SGTC_1249|Compound:0481-0015|FD-Score:5.23|P-value:2.83E-7 ID:SGTC_1269|Compound:0831-0796|FD-Score:-3.16|P-value:8.45E-4 ID:SGTC_1304|Compound:1165-0502|FD-Score:3.95|P-value:8.40E-5 ID:SGTC_1404|Compound:3909-7820|FD-Score:-3.98|P-value:4.29E-5 ID:SGTC_1405|Compound:3909-7894|FD-Score:-3.17|P-value:8.17E-4 ID:SGTC_1406|Compound:3909-7906|FD-Score:-3.21|P-value:7.29E-4 ID:SGTC_1476|Compound:4112-3294|FD-Score:-3.96|P-value:4.57E-5 ID:SGTC_1510|Compound:1123-0200|FD-Score:5.38|P-value:1.36E-7 ID:SGTC_1522|Compound:st012842|FD-Score:-3.49|P-value:2.70E-4 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:-3.65|P-value:1.55E-4 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:4.92|P-value:1.32E-6 ID:SGTC_1700|Compound:st030840|FD-Score:3.53|P-value:3.99E-4 ID:SGTC_1827|Compound:berberine|FD-Score:-3.22|P-value:7.05E-4 ID:SGTC_1829|Compound:berberine|FD-Score:-3.70|P-value:1.28E-4 ID:SGTC_1870|Compound:st057514|FD-Score:-3.13|P-value:9.43E-4 ID:SGTC_1876|Compound:myriocin|FD-Score:3.43|P-value:5.76E-4 ID:SGTC_1995|Compound:st072814|FD-Score:5.63|P-value:3.56E-8 ID:SGTC_2015|Compound:5119600|FD-Score:6.76|P-value:4.36E-11 ID:SGTC_2019|Compound:4016004|FD-Score:-3.38|P-value:4.03E-4 ID:SGTC_2034|Compound:5197015|FD-Score:3.49|P-value:4.69E-4 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:4.41|P-value:1.28E-5 ID:SGTC_2048|Compound:5246248|FD-Score:4.59|P-value:6.09E-6 ID:SGTC_2158|Compound:5657123|FD-Score:4.58|P-value:6.18E-6 ID:SGTC_2162|Compound:5663267|FD-Score:-3.23|P-value:6.67E-4 ID:SGTC_2263|Compound:7948595|FD-Score:3.51|P-value:4.31E-4 ID:SGTC_2310|Compound:7668677|FD-Score:3.30|P-value:8.70E-4 ID:SGTC_2322|Compound:7413319|FD-Score:3.34|P-value:7.77E-4 ID:SGTC_2331|Compound:7980721|FD-Score:7.56|P-value:1.96E-13 ID:SGTC_2336|Compound:9001819|FD-Score:-6.26|P-value:4.15E-10 ID:SGTC_2338|Compound:7999974|FD-Score:-3.95|P-value:4.83E-5 ID:SGTC_2397|Compound:5161689|FD-Score:4.26|P-value:2.49E-5 ID:SGTC_2404|Compound:5161160|FD-Score:-3.37|P-value:4.21E-4 ID:SGTC_2460|Compound:5552655|FD-Score:4.24|P-value:2.64E-5 ID:SGTC_2475|Compound:5812728|FD-Score:-3.38|P-value:4.05E-4 ID:SGTC_2511|Compound:berberine|FD-Score:-3.45|P-value:3.11E-4 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:-3.69|P-value:1.33E-4 ID:SGTC_2534|Compound:helenine|FD-Score:-3.66|P-value:1.46E-4 ID:SGTC_2570|Compound:licareol|FD-Score:4.25|P-value:2.55E-5 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:6.06|P-value:3.17E-9 ID:SGTC_2739|Compound:tacrine|FD-Score:-3.74|P-value:1.10E-4 ID:SGTC_2766|Compound:oltipraz|FD-Score:-3.66|P-value:1.49E-4 ID:SGTC_2781|Compound:5567276|FD-Score:4.00|P-value:6.95E-5 ID:SGTC_2838|Compound:9002687|FD-Score:4.45|P-value:1.10E-5 ID:SGTC_2850|Compound:9015429|FD-Score:3.65|P-value:2.67E-4 ID:SGTC_2854|Compound:9024559|FD-Score:9.94|P-value:5.38E-22 ID:SGTC_2858|Compound:9025781|FD-Score:-3.26|P-value:6.04E-4 ID:SGTC_2859|Compound:9028643|FD-Score:4.07|P-value:5.44E-5 ID:SGTC_2860|Compound:9025725|FD-Score:3.55|P-value:3.72E-4 ID:SGTC_2893|Compound:9048488|FD-Score:3.61|P-value:3.00E-4 ID:SGTC_2909|Compound:7941780|FD-Score:3.35|P-value:7.41E-4 ID:SGTC_2952|Compound:9073731|FD-Score:5.30|P-value:2.03E-7 ID:SGTC_2957|Compound:9076800|FD-Score:-3.18|P-value:8.07E-4 ID:SGTC_2962|Compound:9082311|FD-Score:-3.20|P-value:7.57E-4 ID:SGTC_2964|Compound:9083345|FD-Score:3.57|P-value:3.46E-4 ID:SGTC_2965|Compound:9082772|FD-Score:-5.81|P-value:5.81E-9 ID:SGTC_2968|Compound:9090663|FD-Score:-10.40|P-value:1.39E-24 ID:SGTC_2969|Compound:9091408|FD-Score:-9.39|P-value:2.30E-20 ID:SGTC_2980|Compound:9014342|FD-Score:-3.79|P-value:9.08E-5 ID:SGTC_3000|Compound:9075062|FD-Score:-4.44|P-value:5.99E-6 ID:SGTC_3113|Compound:9123498|FD-Score:3.71|P-value:2.08E-4 ID:SGTC_3138|Compound:9097216|FD-Score:4.11|P-value:4.59E-5 ID:SGTC_3211|Compound:9128781|FD-Score:-5.54|P-value:2.66E-8 ID:SGTC_3238|Compound:9133470|FD-Score:4.07|P-value:5.40E-5 ID:SGTC_3260|Compound:9137109|FD-Score:3.77|P-value:1.70E-4 ID:SGTC_3262|Compound:9137218|FD-Score:3.59|P-value:3.25E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-3.43|P-value:3.37E-4 ID:SGTC_3280|Compound:9140961|FD-Score:-3.49|P-value:2.69E-4 ID:SGTC_3339|Compound:9145883|FD-Score:-3.50|P-value:2.66E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:-3.54|P-value:2.25E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:3.62|P-value:2.90E-4 ID:SGTC_97|Compound:0535-0701|FD-Score:-3.47|P-value:2.96E-4 ID:SGTC_99|Compound:0109-0120|FD-Score:3.42|P-value:5.84E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:3.75|P-value:1.81E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:4.74|P-value:3.00E-6 ID:SGTC_180|Compound:1486-1293|FD-Score:4.09|P-value:4.87E-5 ID:SGTC_309|Compound:k408-0051|FD-Score:3.79|P-value:1.58E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:3.53|P-value:4.03E-4 ID:SGTC_537|Compound:1334-0398|FD-Score:3.84|P-value:1.32E-4 ID:SGTC_539|Compound:4859-0462|FD-Score:-3.71|P-value:1.19E-4 ID:SGTC_540|Compound:1187-0821|FD-Score:-4.28|P-value:1.22E-5 ID:SGTC_654|Compound:1124-0271|FD-Score:3.64|P-value:2.70E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:7.76|P-value:4.46E-14 ID:SGTC_831|Compound:k061-1017|FD-Score:3.38|P-value:6.83E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:3.55|P-value:3.72E-4 ID:SGTC_838|Compound:0109-0203|FD-Score:3.80|P-value:1.52E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:-3.16|P-value:8.57E-4 ID:SGTC_865|Compound:0488-0499|FD-Score:3.27|P-value:9.70E-4 ID:SGTC_866|Compound:0495-0101|FD-Score:-4.15|P-value:2.07E-5 ID:SGTC_990|Compound:3985-0011|FD-Score:-3.46|P-value:3.06E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.20|P-value:7.45E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:-6.07|P-value:1.31E-9 ID:SGTC_1206|Compound:3978-0017|FD-Score:-7.35|P-value:3.03E-13 ID:SGTC_1249|Compound:0481-0015|FD-Score:5.23|P-value:2.83E-7 ID:SGTC_1269|Compound:0831-0796|FD-Score:-3.16|P-value:8.45E-4 ID:SGTC_1304|Compound:1165-0502|FD-Score:3.95|P-value:8.40E-5 ID:SGTC_1404|Compound:3909-7820|FD-Score:-3.98|P-value:4.29E-5 ID:SGTC_1405|Compound:3909-7894|FD-Score:-3.17|P-value:8.17E-4 ID:SGTC_1406|Compound:3909-7906|FD-Score:-3.21|P-value:7.29E-4 ID:SGTC_1476|Compound:4112-3294|FD-Score:-3.96|P-value:4.57E-5 ID:SGTC_1510|Compound:1123-0200|FD-Score:5.38|P-value:1.36E-7 ID:SGTC_1522|Compound:st012842|FD-Score:-3.49|P-value:2.70E-4 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:-3.65|P-value:1.55E-4 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:4.92|P-value:1.32E-6 ID:SGTC_1700|Compound:st030840|FD-Score:3.53|P-value:3.99E-4 ID:SGTC_1827|Compound:berberine|FD-Score:-3.22|P-value:7.05E-4 ID:SGTC_1829|Compound:berberine|FD-Score:-3.70|P-value:1.28E-4 ID:SGTC_1870|Compound:st057514|FD-Score:-3.13|P-value:9.43E-4 ID:SGTC_1876|Compound:myriocin|FD-Score:3.43|P-value:5.76E-4 ID:SGTC_1995|Compound:st072814|FD-Score:5.63|P-value:3.56E-8 ID:SGTC_2015|Compound:5119600|FD-Score:6.76|P-value:4.36E-11 ID:SGTC_2019|Compound:4016004|FD-Score:-3.38|P-value:4.03E-4 ID:SGTC_2034|Compound:5197015|FD-Score:3.49|P-value:4.69E-4 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:4.41|P-value:1.28E-5 ID:SGTC_2048|Compound:5246248|FD-Score:4.59|P-value:6.09E-6 ID:SGTC_2158|Compound:5657123|FD-Score:4.58|P-value:6.18E-6 ID:SGTC_2162|Compound:5663267|FD-Score:-3.23|P-value:6.67E-4 ID:SGTC_2263|Compound:7948595|FD-Score:3.51|P-value:4.31E-4 ID:SGTC_2310|Compound:7668677|FD-Score:3.30|P-value:8.70E-4 ID:SGTC_2322|Compound:7413319|FD-Score:3.34|P-value:7.77E-4 ID:SGTC_2331|Compound:7980721|FD-Score:7.56|P-value:1.96E-13 ID:SGTC_2336|Compound:9001819|FD-Score:-6.26|P-value:4.15E-10 ID:SGTC_2338|Compound:7999974|FD-Score:-3.95|P-value:4.83E-5 ID:SGTC_2397|Compound:5161689|FD-Score:4.26|P-value:2.49E-5 ID:SGTC_2404|Compound:5161160|FD-Score:-3.37|P-value:4.21E-4 ID:SGTC_2460|Compound:5552655|FD-Score:4.24|P-value:2.64E-5 ID:SGTC_2475|Compound:5812728|FD-Score:-3.38|P-value:4.05E-4 ID:SGTC_2511|Compound:berberine|FD-Score:-3.45|P-value:3.11E-4 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:-3.69|P-value:1.33E-4 ID:SGTC_2534|Compound:helenine|FD-Score:-3.66|P-value:1.46E-4 ID:SGTC_2570|Compound:licareol|FD-Score:4.25|P-value:2.55E-5 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:6.06|P-value:3.17E-9 ID:SGTC_2739|Compound:tacrine|FD-Score:-3.74|P-value:1.10E-4 ID:SGTC_2766|Compound:oltipraz|FD-Score:-3.66|P-value:1.49E-4 ID:SGTC_2781|Compound:5567276|FD-Score:4.00|P-value:6.95E-5 ID:SGTC_2838|Compound:9002687|FD-Score:4.45|P-value:1.10E-5 ID:SGTC_2850|Compound:9015429|FD-Score:3.65|P-value:2.67E-4 ID:SGTC_2854|Compound:9024559|FD-Score:9.94|P-value:5.38E-22 ID:SGTC_2858|Compound:9025781|FD-Score:-3.26|P-value:6.04E-4 ID:SGTC_2859|Compound:9028643|FD-Score:4.07|P-value:5.44E-5 ID:SGTC_2860|Compound:9025725|FD-Score:3.55|P-value:3.72E-4 ID:SGTC_2893|Compound:9048488|FD-Score:3.61|P-value:3.00E-4 ID:SGTC_2909|Compound:7941780|FD-Score:3.35|P-value:7.41E-4 ID:SGTC_2952|Compound:9073731|FD-Score:5.30|P-value:2.03E-7 ID:SGTC_2957|Compound:9076800|FD-Score:-3.18|P-value:8.07E-4 ID:SGTC_2962|Compound:9082311|FD-Score:-3.20|P-value:7.57E-4 ID:SGTC_2964|Compound:9083345|FD-Score:3.57|P-value:3.46E-4 ID:SGTC_2965|Compound:9082772|FD-Score:-5.81|P-value:5.81E-9 ID:SGTC_2968|Compound:9090663|FD-Score:-10.40|P-value:1.39E-24 ID:SGTC_2969|Compound:9091408|FD-Score:-9.39|P-value:2.30E-20 ID:SGTC_2980|Compound:9014342|FD-Score:-3.79|P-value:9.08E-5 ID:SGTC_3000|Compound:9075062|FD-Score:-4.44|P-value:5.99E-6 ID:SGTC_3113|Compound:9123498|FD-Score:3.71|P-value:2.08E-4 ID:SGTC_3138|Compound:9097216|FD-Score:4.11|P-value:4.59E-5 ID:SGTC_3211|Compound:9128781|FD-Score:-5.54|P-value:2.66E-8 ID:SGTC_3238|Compound:9133470|FD-Score:4.07|P-value:5.40E-5 ID:SGTC_3260|Compound:9137109|FD-Score:3.77|P-value:1.70E-4 ID:SGTC_3262|Compound:9137218|FD-Score:3.59|P-value:3.25E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-3.43|P-value:3.37E-4 ID:SGTC_3280|Compound:9140961|FD-Score:-3.49|P-value:2.69E-4 ID:SGTC_3339|Compound:9145883|FD-Score:-3.50|P-value:2.66E-4

Top fitness defect scores for YDR064W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2854 9024559 9.94 71.4 µM 5.38E-22 1 1.36E-23 2.51
2 SGTC_800 3448-7362 7.76 155.0 µM 4.46E-14 translation 12 4.14E-15 0.01
3 SGTC_2331 7980721 7.56 200.0 µM 1.96E-13 1 2.02E-14 1.16
4 SGTC_2015 5119600 6.76 184.0 µM 4.36E-11 1 6.69E-12 1.10
5 SGTC_2658 polymyxin b sulfate 6.06 77.0 µM 3.17E-9 NEO1 6 6.67E-10 0.65
6 SGTC_1995 st072814 5.63 61.1 µM 3.56E-8 1 8.99E-9 1.07
7 SGTC_1510 1123-0200 5.38 71.5 µM 1.36E-7 5 3.78E-8 0.07
8 SGTC_2952 9073731 5.30 13.8 µM 2.03E-7 tubulin folding & SWR complex 6 5.82E-8 0.45
9 SGTC_1249 0481-0015 5.23 10.2 µM 2.83E-7 1 8.35E-8 0.51
10 SGTC_1680 diphenhydramine 4.92 100.0 µM 1.32E-6 NEO1 6 4.37E-7 0.08
11 SGTC_176 1486-1328 4.74 72.8 µM 3.00E-6 6 1.06E-6 0.48
12 SGTC_2048 5246248 4.59 200.0 µM 6.09E-6 2 2.27E-6 0.75
13 SGTC_2158 5657123 4.58 3.6 µM 6.18E-6 11 2.31E-6 0.18
14 SGTC_2838 9002687 4.45 71.4 µM 1.10E-5 fatty acid desaturase (OLE1) 11 4.28E-6 0.10
15 SGTC_2042 p-Dimethylaminoacetophenone 4.41 200.0 µM 1.28E-5 3 5.05E-6 0.17
16 SGTC_2397 5161689 4.26 200.0 µM 2.49E-5 4 1.04E-5 0.16
17 SGTC_2570 licareol 4.25 100.0 µM 2.55E-5 3 1.06E-5 0.36
18 SGTC_2460 5552655 4.24 174.2 µM 2.64E-5 amide catabolism 6 1.10E-5 0.10
19 SGTC_3138 9097216 4.11 49.5 µM 4.59E-5 4 2.00E-5 0.06
20 SGTC_180 1486-1293 4.09 102.8 µM 4.87E-5 5 2.13E-5 0.06

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.263 4.30E-54 YPR137W RRP9 het Protein involved in pre-rRNA processing, associated with U3 snRNP; component of small ribosomal subunit (SSU) processosome; ortholog of the human U3-55k protein
0.216 1.27E-36 YHL015W RPS20 het Protein component of the small (40S) ribosomal subunit; overproduction suppresses mutations affecting RNA polymerase III-dependent transcription; homologous to mammalian ribosomal protein S20 and bacterial S10
0.214 4.15E-36 YLR222C UTP13 het Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
0.182 2.45E-26 YGL123W RPS2 het Protein component of the small (40S) subunit; essential for control of translational accuracy; phosphorylation by C-terminal domain kinase I (CTDK-I) enhances translational accuracy; methylated on one or more arginine residues by Hmt1p; homologous to mammalian ribosomal protein S2 and bacterial S5
0.181 3.90E-26 YNL178W RPS3 het Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; homologous to mammalian ribosomal protein S3 and bacterial S3
0.171 1.87E-23 YPR136C_d YPR136C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF RRP9
0.163 2.06E-21 YOL040C RPS15 het Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15 and bacterial S19
0.143 7.91E-17 YOR146W_d YOR146W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene PNO1/YOR145C
0.140 3.86E-16 YMR093W UTP15 het Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
0.137 1.57E-15 YOL120C RPL18A het Ribosomal 60S subunit protein L18A; intron of RPL18A pre-mRNA forms stem-loop structures that are a target for Rnt1p cleavage leading to degradation; homologous to mammalian ribosomal protein L18, no bacterial homolog; RPL18A has a paralog, RPL18B, that arose from the whole genome duplication
0.134 5.51E-15 YPL238C_d YPL238C_d het Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified essential gene SUI3/YPL237W
0.134 5.50E-15 YJL111W CCT7 het Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo; mutant has increased aneuploidy tolerance
0.132 1.80E-14 YJL069C UTP18 het Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data
0.132 1.84E-14 YPL237W SUI3 het Beta subunit of the translation initiation factor eIF2, involved in the identification of the start codon; proposed to be involved in mRNA binding
0.126 2.84E-13 YPL131W RPL5 het Ribosomal 60S subunit protein L5; homologous to mammalian ribosomal protein L5 and bacterial L18; binds 5S rRNA and is required for 60S subunit assembly