YDR065W / RRG1

Protein of unknown function, required for vacuolar acidification and mitochondrial genome maintenance; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR065W / RRG1

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:5.18|P-value:1.24E-7 ID:SGTC_19|Compound:0279-0214|FD-Score:3.58|P-value:1.75E-4 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:3.19|P-value:7.19E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:-3.24|P-value:6.95E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:3.79|P-value:7.76E-5 ID:SGTC_70|Compound:0141-0289|FD-Score:12.60|P-value:2.60E-36 ID:SGTC_118|Compound:0083-0097|FD-Score:3.11|P-value:9.63E-4 ID:SGTC_127|Compound:0180-0333|FD-Score:4.81|P-value:8.16E-7 ID:SGTC_134|Compound:0269-0018|FD-Score:3.87|P-value:5.74E-5 ID:SGTC_141|Compound:0443-0274|FD-Score:3.41|P-value:3.29E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:-3.17|P-value:8.87E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:3.15|P-value:8.40E-4 ID:SGTC_161|Compound:4065-0411|FD-Score:3.44|P-value:2.99E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:4.46|P-value:4.48E-6 ID:SGTC_173|Compound:1273-0061|FD-Score:8.77|P-value:1.39E-18 ID:SGTC_236|Compound:1509-0011|FD-Score:9.62|P-value:5.98E-22 ID:SGTC_275|Compound:trichlorophene|FD-Score:4.63|P-value:1.98E-6 ID:SGTC_310|Compound:1273-0058|FD-Score:8.42|P-value:2.76E-17 ID:SGTC_360|Compound:0957-0399|FD-Score:-3.15|P-value:9.45E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:-4.18|P-value:1.85E-5 ID:SGTC_431|Compound:k089-0097|FD-Score:-4.40|P-value:6.90E-6 ID:SGTC_444|Compound:curcumin|FD-Score:-3.55|P-value:2.32E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-5.26|P-value:9.84E-8 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-3.28|P-value:6.14E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:-4.74|P-value:1.43E-6 ID:SGTC_519|Compound:k048-0011|FD-Score:3.90|P-value:4.99E-5 ID:SGTC_524|Compound:r073-0010|FD-Score:-3.53|P-value:2.51E-4 ID:SGTC_530|Compound:4358-1714|FD-Score:3.65|P-value:1.38E-4 ID:SGTC_581|Compound:0958-0271|FD-Score:3.11|P-value:9.44E-4 ID:SGTC_583|Compound:1488-1091|FD-Score:3.16|P-value:8.17E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:3.92|P-value:4.62E-5 ID:SGTC_778|Compound:3456-2434|FD-Score:4.89|P-value:5.55E-7 ID:SGTC_791|Compound:1348-1292|FD-Score:4.57|P-value:2.71E-6 ID:SGTC_800|Compound:3448-7362|FD-Score:6.42|P-value:8.62E-11 ID:SGTC_830|Compound:4076-0286|FD-Score:3.22|P-value:6.55E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:5.29|P-value:6.80E-8 ID:SGTC_896|Compound:0964-0007|FD-Score:-3.29|P-value:5.83E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:3.22|P-value:6.57E-4 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:4.62|P-value:2.11E-6 ID:SGTC_948|Compound:3448-0295|FD-Score:3.67|P-value:1.25E-4 ID:SGTC_1018|Compound:4259-0013|FD-Score:3.68|P-value:1.23E-4 ID:SGTC_1166|Compound:k206-0078|FD-Score:3.36|P-value:3.96E-4 ID:SGTC_1440|Compound:4100-1550|FD-Score:3.44|P-value:3.02E-4 ID:SGTC_1596|Compound:piperlongumine|FD-Score:3.50|P-value:2.40E-4 ID:SGTC_1742|Compound:st038235|FD-Score:5.26|P-value:8.07E-8 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.89|P-value:6.21E-5 ID:SGTC_2187|Compound:6125751|FD-Score:3.26|P-value:5.64E-4 ID:SGTC_2188|Compound:6126565|FD-Score:-3.44|P-value:3.42E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:4.28|P-value:9.89E-6 ID:SGTC_2233|Compound:sulbentine|FD-Score:4.04|P-value:2.79E-5 ID:SGTC_2336|Compound:9001819|FD-Score:-3.14|P-value:9.67E-4 ID:SGTC_2402|Compound:5553605|FD-Score:3.58|P-value:1.81E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:-4.14|P-value:2.19E-5 ID:SGTC_2416|Compound:tofa|FD-Score:-3.22|P-value:7.48E-4 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:4.70|P-value:1.42E-6 ID:SGTC_2467|Compound:5474540|FD-Score:3.71|P-value:1.06E-4 ID:SGTC_2526|Compound:patulin|FD-Score:4.79|P-value:9.05E-7 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:-3.42|P-value:3.70E-4 ID:SGTC_2810|Compound:7959871|FD-Score:-3.53|P-value:2.46E-4 ID:SGTC_2858|Compound:9025781|FD-Score:-3.65|P-value:1.59E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-3.45|P-value:3.25E-4 ID:SGTC_2921|Compound:7974240|FD-Score:3.73|P-value:1.01E-4 ID:SGTC_2944|Compound:9067346|FD-Score:3.52|P-value:2.23E-4 ID:SGTC_3038|Compound:9091290|FD-Score:-3.68|P-value:1.38E-4 ID:SGTC_3043|Compound:9092303|FD-Score:3.11|P-value:9.64E-4 ID:SGTC_3047|Compound:9092122|FD-Score:3.65|P-value:1.35E-4 ID:SGTC_3049|Compound:9092223|FD-Score:3.64|P-value:1.42E-4 ID:SGTC_3114|Compound:9122766|FD-Score:3.38|P-value:3.68E-4 ID:SGTC_3140|Compound:9094243|FD-Score:5.05|P-value:2.41E-7 ID:SGTC_3206|Compound:9114350|FD-Score:-3.95|P-value:4.83E-5 ID:SGTC_3210|Compound:9128157|FD-Score:-3.36|P-value:4.56E-4 ID:SGTC_3278|Compound:9139605|FD-Score:3.12|P-value:9.20E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:5.18|P-value:1.24E-7 ID:SGTC_19|Compound:0279-0214|FD-Score:3.58|P-value:1.75E-4 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:3.19|P-value:7.19E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:-3.24|P-value:6.95E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:3.79|P-value:7.76E-5 ID:SGTC_70|Compound:0141-0289|FD-Score:12.60|P-value:2.60E-36 ID:SGTC_118|Compound:0083-0097|FD-Score:3.11|P-value:9.63E-4 ID:SGTC_127|Compound:0180-0333|FD-Score:4.81|P-value:8.16E-7 ID:SGTC_134|Compound:0269-0018|FD-Score:3.87|P-value:5.74E-5 ID:SGTC_141|Compound:0443-0274|FD-Score:3.41|P-value:3.29E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:-3.17|P-value:8.87E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:3.15|P-value:8.40E-4 ID:SGTC_161|Compound:4065-0411|FD-Score:3.44|P-value:2.99E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:4.46|P-value:4.48E-6 ID:SGTC_173|Compound:1273-0061|FD-Score:8.77|P-value:1.39E-18 ID:SGTC_236|Compound:1509-0011|FD-Score:9.62|P-value:5.98E-22 ID:SGTC_275|Compound:trichlorophene|FD-Score:4.63|P-value:1.98E-6 ID:SGTC_310|Compound:1273-0058|FD-Score:8.42|P-value:2.76E-17 ID:SGTC_360|Compound:0957-0399|FD-Score:-3.15|P-value:9.45E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:-4.18|P-value:1.85E-5 ID:SGTC_431|Compound:k089-0097|FD-Score:-4.40|P-value:6.90E-6 ID:SGTC_444|Compound:curcumin|FD-Score:-3.55|P-value:2.32E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-5.26|P-value:9.84E-8 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-3.28|P-value:6.14E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:-4.74|P-value:1.43E-6 ID:SGTC_519|Compound:k048-0011|FD-Score:3.90|P-value:4.99E-5 ID:SGTC_524|Compound:r073-0010|FD-Score:-3.53|P-value:2.51E-4 ID:SGTC_530|Compound:4358-1714|FD-Score:3.65|P-value:1.38E-4 ID:SGTC_581|Compound:0958-0271|FD-Score:3.11|P-value:9.44E-4 ID:SGTC_583|Compound:1488-1091|FD-Score:3.16|P-value:8.17E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:3.92|P-value:4.62E-5 ID:SGTC_778|Compound:3456-2434|FD-Score:4.89|P-value:5.55E-7 ID:SGTC_791|Compound:1348-1292|FD-Score:4.57|P-value:2.71E-6 ID:SGTC_800|Compound:3448-7362|FD-Score:6.42|P-value:8.62E-11 ID:SGTC_830|Compound:4076-0286|FD-Score:3.22|P-value:6.55E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:5.29|P-value:6.80E-8 ID:SGTC_896|Compound:0964-0007|FD-Score:-3.29|P-value:5.83E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:3.22|P-value:6.57E-4 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:4.62|P-value:2.11E-6 ID:SGTC_948|Compound:3448-0295|FD-Score:3.67|P-value:1.25E-4 ID:SGTC_1018|Compound:4259-0013|FD-Score:3.68|P-value:1.23E-4 ID:SGTC_1166|Compound:k206-0078|FD-Score:3.36|P-value:3.96E-4 ID:SGTC_1440|Compound:4100-1550|FD-Score:3.44|P-value:3.02E-4 ID:SGTC_1596|Compound:piperlongumine|FD-Score:3.50|P-value:2.40E-4 ID:SGTC_1742|Compound:st038235|FD-Score:5.26|P-value:8.07E-8 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.89|P-value:6.21E-5 ID:SGTC_2187|Compound:6125751|FD-Score:3.26|P-value:5.64E-4 ID:SGTC_2188|Compound:6126565|FD-Score:-3.44|P-value:3.42E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:4.28|P-value:9.89E-6 ID:SGTC_2233|Compound:sulbentine|FD-Score:4.04|P-value:2.79E-5 ID:SGTC_2336|Compound:9001819|FD-Score:-3.14|P-value:9.67E-4 ID:SGTC_2402|Compound:5553605|FD-Score:3.58|P-value:1.81E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:-4.14|P-value:2.19E-5 ID:SGTC_2416|Compound:tofa|FD-Score:-3.22|P-value:7.48E-4 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:4.70|P-value:1.42E-6 ID:SGTC_2467|Compound:5474540|FD-Score:3.71|P-value:1.06E-4 ID:SGTC_2526|Compound:patulin|FD-Score:4.79|P-value:9.05E-7 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:-3.42|P-value:3.70E-4 ID:SGTC_2810|Compound:7959871|FD-Score:-3.53|P-value:2.46E-4 ID:SGTC_2858|Compound:9025781|FD-Score:-3.65|P-value:1.59E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-3.45|P-value:3.25E-4 ID:SGTC_2921|Compound:7974240|FD-Score:3.73|P-value:1.01E-4 ID:SGTC_2944|Compound:9067346|FD-Score:3.52|P-value:2.23E-4 ID:SGTC_3038|Compound:9091290|FD-Score:-3.68|P-value:1.38E-4 ID:SGTC_3043|Compound:9092303|FD-Score:3.11|P-value:9.64E-4 ID:SGTC_3047|Compound:9092122|FD-Score:3.65|P-value:1.35E-4 ID:SGTC_3049|Compound:9092223|FD-Score:3.64|P-value:1.42E-4 ID:SGTC_3114|Compound:9122766|FD-Score:3.38|P-value:3.68E-4 ID:SGTC_3140|Compound:9094243|FD-Score:5.05|P-value:2.41E-7 ID:SGTC_3206|Compound:9114350|FD-Score:-3.95|P-value:4.83E-5 ID:SGTC_3210|Compound:9128157|FD-Score:-3.36|P-value:4.56E-4 ID:SGTC_3278|Compound:9139605|FD-Score:3.12|P-value:9.20E-4

Top fitness defect scores for YDR065W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_70 0141-0289 12.60 43.3 µM 2.60E-36 mitochondrial stress 14 9.44E-37
2 SGTC_236 1509-0011 9.62 5.3 µM 5.98E-22 203 3.46E-22
3 SGTC_173 1273-0061 8.77 2.7 µM 1.39E-18 mitochondrial stress 55 8.90E-19
4 SGTC_310 1273-0058 8.42 1.1 µM 2.76E-17 mitochondrial stress 76 1.84E-17
5 SGTC_800 3448-7362 6.42 155.0 µM 8.62E-11 translation 35 7.00E-11
6 SGTC_892 0929-0076 5.29 29.0 µM 6.80E-8 TRP & mitochondrial translation 12 5.99E-8
7 SGTC_1742 st038235 5.26 28.9 µM 8.07E-8 mitochondrial stress 69 7.13E-8
8 SGTC_10 0279-0212 5.18 42.6 µM 1.24E-7 TRP & mitochondrial translation 53 1.10E-7
9 SGTC_3140 9094243 5.05 49.5 µM 2.41E-7 14 2.16E-7
10 SGTC_778 3456-2434 4.89 196.0 µM 5.55E-7 mitochondrial response to ROS 49 5.01E-7
11 SGTC_127 0180-0333 4.81 59.1 µM 8.16E-7 mitochondrial response to ROS 19 7.41E-7
12 SGTC_2526 patulin 4.79 37.6 µM 9.05E-7 51 8.23E-7
13 SGTC_2422 chlorphenesin carbamate 4.70 384.2 µM 1.42E-6 12 1.30E-6
14 SGTC_275 trichlorophene 4.63 5.7 µM 1.98E-6 mitochondrial stress 191 1.81E-6
15 SGTC_920 mycophenolic acid 4.62 780.4 nM 2.11E-6 15 1.94E-6
16 SGTC_791 1348-1292 4.57 225.0 µM 2.71E-6 22 2.49E-6
17 SGTC_168 3970-0862 4.46 530.5 µM 4.48E-6 90 4.15E-6
18 SGTC_2232 chlorophetanol 4.28 41.5 µM 9.89E-6 TRP & mitochondrial translation 108 9.24E-6
19 SGTC_2233 sulbentine 4.04 40.4 µM 2.79E-5 61 2.63E-5
20 SGTC_625 k213-0058 3.92 121.0 µM 4.62E-5 translation 106 4.39E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.488 7.94E-201 YKL170W MRPL38 hom Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL34 and YmL38) on two-dimensional SDS gels; protein abundance increases in response to DNA replication stress
0.486 1.65E-198 YGL064C MRH4 hom Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function
0.451 3.72E-167 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.440 1.06E-158 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.425 3.47E-147 YMR072W ABF2 hom Mitochondrial DNA-binding protein involved in mitochondrial DNA replication and recombination, member of HMG1 DNA-binding protein family; activity may be regulated by protein kinase A phosphorylation
0.423 1.28E-145 YDR337W MRPS28 hom Mitochondrial ribosomal protein of the small subunit
0.423 1.28E-145 YMR228W MTF1 hom Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation
0.420 8.16E-144 YMR193W MRPL24 hom Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene
0.420 9.98E-144 YDR509W_d YDR509W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.412 7.11E-138 YJR144W MGM101 hom Protein with a role in mitochondrial DNA recombinational repair;also involved in interstrand cross-link repair; binds to and catalyzes the annealing of single-stranded mtDNA; oligomerizes to form rings and filaments; related to Rad52-type recombination proteins, with limited overall similarity but sharing conserved functionally important residues; component of the mitochondrial nucleoid, required for the repair of oxidative mtDNA damage
0.411 2.64E-137 YER087W AIM10 hom Protein with similarity to tRNA synthetases; non-tagged protein is detected in purified mitochondria; null mutant is viable and displays elevated frequency of mitochondrial genome loss
0.410 5.99E-136 YGR215W RSM27 hom Mitochondrial ribosomal protein of the small subunit
0.409 1.92E-135 YPR166C MRP2 hom Mitochondrial ribosomal protein of the small subunit
0.408 3.58E-135 YDR529C QCR7 hom Subunit 7 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the mitochondrial matrix; N-terminus appears to play a role in complex assembly
0.406 4.16E-133 YDR079W PET100 hom Chaperone that specifically facilitates the assembly of cytochrome c oxidase, integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme