YDR071C / PAA1

Polyamine acetyltransferase; acetylates polyamines (e.g. putrescine, spermidine, spermine) and also aralkylamines (e.g. tryptamine, phenylethylamine); may be involved in transcription and/or DNA replication

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR071C / PAA1

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:3.30|P-value:8.20E-4 ID:SGTC_29|Compound:0299-0004|FD-Score:3.33|P-value:7.43E-4 ID:SGTC_51|Compound:1013-0126|FD-Score:6.57|P-value:1.77E-10 ID:SGTC_103|Compound:0844-0104|FD-Score:6.24|P-value:1.26E-9 ID:SGTC_115|Compound:0527-0192|FD-Score:3.73|P-value:1.85E-4 ID:SGTC_350|Compound:k064-0020|FD-Score:3.43|P-value:5.34E-4 ID:SGTC_353|Compound:1988-1175|FD-Score:3.42|P-value:5.52E-4 ID:SGTC_356|Compound:1634-0012|FD-Score:-4.24|P-value:2.60E-5 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:3.64|P-value:2.55E-4 ID:SGTC_432|Compound:NS 1619|FD-Score:3.77|P-value:1.61E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:5.40|P-value:1.26E-7 ID:SGTC_501|Compound:nsc-95397|FD-Score:3.43|P-value:5.27E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:-4.31|P-value:1.94E-5 ID:SGTC_600|Compound:1495-0418|FD-Score:3.54|P-value:3.64E-4 ID:SGTC_606|Compound:k015-0008|FD-Score:3.68|P-value:2.18E-4 ID:SGTC_624|Compound:k048-0052|FD-Score:3.53|P-value:3.75E-4 ID:SGTC_628|Compound:1636-0253|FD-Score:3.80|P-value:1.40E-4 ID:SGTC_658|Compound:3253-0951|FD-Score:3.55|P-value:3.47E-4 ID:SGTC_684|Compound:1140-0066|FD-Score:-3.33|P-value:7.28E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:5.23|P-value:2.91E-7 ID:SGTC_695|Compound:3505-6186|FD-Score:3.55|P-value:3.51E-4 ID:SGTC_696|Compound:1560-0013|FD-Score:-3.27|P-value:8.82E-4 ID:SGTC_786|Compound:4544-0069|FD-Score:5.83|P-value:1.29E-8 ID:SGTC_787|Compound:4152-0075|FD-Score:-3.28|P-value:8.68E-4 ID:SGTC_1021|Compound:4476-0760|FD-Score:3.40|P-value:5.85E-4 ID:SGTC_1093|Compound:fluphenazine|FD-Score:4.72|P-value:3.31E-6 ID:SGTC_1109|Compound:tnp00067|FD-Score:-4.60|P-value:5.56E-6 ID:SGTC_1111|Compound:tnp00062|FD-Score:-3.55|P-value:3.47E-4 ID:SGTC_1202|Compound:1988-0068|FD-Score:-3.72|P-value:1.87E-4 ID:SGTC_1351|Compound:1496-0003|FD-Score:5.08|P-value:6.11E-7 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:3.85|P-value:1.19E-4 ID:SGTC_1633|Compound:st005664|FD-Score:3.96|P-value:7.89E-5 ID:SGTC_1640|Compound:st009078|FD-Score:4.51|P-value:8.40E-6 ID:SGTC_1645|Compound:Cervolide|FD-Score:-3.60|P-value:2.94E-4 ID:SGTC_1651|Compound:st011928|FD-Score:3.92|P-value:8.89E-5 ID:SGTC_1652|Compound:st011932|FD-Score:3.26|P-value:9.16E-4 ID:SGTC_1876|Compound:myriocin|FD-Score:20.80|P-value:7.52E-88 ID:SGTC_1941|Compound:st076221|FD-Score:4.10|P-value:4.44E-5 ID:SGTC_2034|Compound:5197015|FD-Score:3.68|P-value:2.20E-4 ID:SGTC_2060|Compound:5238662|FD-Score:6.03|P-value:4.20E-9 ID:SGTC_2135|Compound:5326629|FD-Score:3.67|P-value:2.28E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.28|P-value:8.75E-4 ID:SGTC_2311|Compound:7694451|FD-Score:-3.88|P-value:1.05E-4 ID:SGTC_2314|Compound:7727897|FD-Score:3.45|P-value:4.92E-4 ID:SGTC_2330|Compound:7979373|FD-Score:4.56|P-value:6.73E-6 ID:SGTC_2333|Compound:9017922|FD-Score:-5.43|P-value:1.05E-7 ID:SGTC_2349|Compound:9023730|FD-Score:3.70|P-value:2.07E-4 ID:SGTC_2398|Compound:5228213|FD-Score:4.79|P-value:2.33E-6 ID:SGTC_2469|Compound:5655019|FD-Score:4.70|P-value:3.60E-6 ID:SGTC_2473|Compound:5854593|FD-Score:4.37|P-value:1.51E-5 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:-3.90|P-value:9.81E-5 ID:SGTC_2584|Compound:androsterone|FD-Score:4.43|P-value:1.14E-5 ID:SGTC_2781|Compound:5567276|FD-Score:6.66|P-value:9.71E-11 ID:SGTC_2786|Compound:7743617|FD-Score:4.97|P-value:1.03E-6 ID:SGTC_2789|Compound:5281112|FD-Score:4.16|P-value:3.55E-5 ID:SGTC_2831|Compound:7999036|FD-Score:5.48|P-value:8.17E-8 ID:SGTC_2913|Compound:7966556|FD-Score:3.88|P-value:1.03E-4 ID:SGTC_3002|Compound:9075603|FD-Score:-3.68|P-value:2.19E-4 ID:SGTC_3049|Compound:9092223|FD-Score:3.93|P-value:8.78E-5 ID:SGTC_3236|Compound:9132701|FD-Score:4.21|P-value:2.93E-5 ID:SGTC_3260|Compound:9137109|FD-Score:5.17|P-value:3.92E-7 ID:SGTC_3269|Compound:9137823|FD-Score:4.15|P-value:3.72E-5 ID:SGTC_3281|Compound:9140613|FD-Score:3.41|P-value:5.58E-4 ID:SGTC_3343|Compound:9148379|FD-Score:3.35|P-value:6.83E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:3.30|P-value:8.20E-4 ID:SGTC_29|Compound:0299-0004|FD-Score:3.33|P-value:7.43E-4 ID:SGTC_51|Compound:1013-0126|FD-Score:6.57|P-value:1.77E-10 ID:SGTC_103|Compound:0844-0104|FD-Score:6.24|P-value:1.26E-9 ID:SGTC_115|Compound:0527-0192|FD-Score:3.73|P-value:1.85E-4 ID:SGTC_350|Compound:k064-0020|FD-Score:3.43|P-value:5.34E-4 ID:SGTC_353|Compound:1988-1175|FD-Score:3.42|P-value:5.52E-4 ID:SGTC_356|Compound:1634-0012|FD-Score:-4.24|P-value:2.60E-5 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:3.64|P-value:2.55E-4 ID:SGTC_432|Compound:NS 1619|FD-Score:3.77|P-value:1.61E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:5.40|P-value:1.26E-7 ID:SGTC_501|Compound:nsc-95397|FD-Score:3.43|P-value:5.27E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:-4.31|P-value:1.94E-5 ID:SGTC_600|Compound:1495-0418|FD-Score:3.54|P-value:3.64E-4 ID:SGTC_606|Compound:k015-0008|FD-Score:3.68|P-value:2.18E-4 ID:SGTC_624|Compound:k048-0052|FD-Score:3.53|P-value:3.75E-4 ID:SGTC_628|Compound:1636-0253|FD-Score:3.80|P-value:1.40E-4 ID:SGTC_658|Compound:3253-0951|FD-Score:3.55|P-value:3.47E-4 ID:SGTC_684|Compound:1140-0066|FD-Score:-3.33|P-value:7.28E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:5.23|P-value:2.91E-7 ID:SGTC_695|Compound:3505-6186|FD-Score:3.55|P-value:3.51E-4 ID:SGTC_696|Compound:1560-0013|FD-Score:-3.27|P-value:8.82E-4 ID:SGTC_786|Compound:4544-0069|FD-Score:5.83|P-value:1.29E-8 ID:SGTC_787|Compound:4152-0075|FD-Score:-3.28|P-value:8.68E-4 ID:SGTC_1021|Compound:4476-0760|FD-Score:3.40|P-value:5.85E-4 ID:SGTC_1093|Compound:fluphenazine|FD-Score:4.72|P-value:3.31E-6 ID:SGTC_1109|Compound:tnp00067|FD-Score:-4.60|P-value:5.56E-6 ID:SGTC_1111|Compound:tnp00062|FD-Score:-3.55|P-value:3.47E-4 ID:SGTC_1202|Compound:1988-0068|FD-Score:-3.72|P-value:1.87E-4 ID:SGTC_1351|Compound:1496-0003|FD-Score:5.08|P-value:6.11E-7 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:3.85|P-value:1.19E-4 ID:SGTC_1633|Compound:st005664|FD-Score:3.96|P-value:7.89E-5 ID:SGTC_1640|Compound:st009078|FD-Score:4.51|P-value:8.40E-6 ID:SGTC_1645|Compound:Cervolide|FD-Score:-3.60|P-value:2.94E-4 ID:SGTC_1651|Compound:st011928|FD-Score:3.92|P-value:8.89E-5 ID:SGTC_1652|Compound:st011932|FD-Score:3.26|P-value:9.16E-4 ID:SGTC_1876|Compound:myriocin|FD-Score:20.80|P-value:7.52E-88 ID:SGTC_1941|Compound:st076221|FD-Score:4.10|P-value:4.44E-5 ID:SGTC_2034|Compound:5197015|FD-Score:3.68|P-value:2.20E-4 ID:SGTC_2060|Compound:5238662|FD-Score:6.03|P-value:4.20E-9 ID:SGTC_2135|Compound:5326629|FD-Score:3.67|P-value:2.28E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.28|P-value:8.75E-4 ID:SGTC_2311|Compound:7694451|FD-Score:-3.88|P-value:1.05E-4 ID:SGTC_2314|Compound:7727897|FD-Score:3.45|P-value:4.92E-4 ID:SGTC_2330|Compound:7979373|FD-Score:4.56|P-value:6.73E-6 ID:SGTC_2333|Compound:9017922|FD-Score:-5.43|P-value:1.05E-7 ID:SGTC_2349|Compound:9023730|FD-Score:3.70|P-value:2.07E-4 ID:SGTC_2398|Compound:5228213|FD-Score:4.79|P-value:2.33E-6 ID:SGTC_2469|Compound:5655019|FD-Score:4.70|P-value:3.60E-6 ID:SGTC_2473|Compound:5854593|FD-Score:4.37|P-value:1.51E-5 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:-3.90|P-value:9.81E-5 ID:SGTC_2584|Compound:androsterone|FD-Score:4.43|P-value:1.14E-5 ID:SGTC_2781|Compound:5567276|FD-Score:6.66|P-value:9.71E-11 ID:SGTC_2786|Compound:7743617|FD-Score:4.97|P-value:1.03E-6 ID:SGTC_2789|Compound:5281112|FD-Score:4.16|P-value:3.55E-5 ID:SGTC_2831|Compound:7999036|FD-Score:5.48|P-value:8.17E-8 ID:SGTC_2913|Compound:7966556|FD-Score:3.88|P-value:1.03E-4 ID:SGTC_3002|Compound:9075603|FD-Score:-3.68|P-value:2.19E-4 ID:SGTC_3049|Compound:9092223|FD-Score:3.93|P-value:8.78E-5 ID:SGTC_3236|Compound:9132701|FD-Score:4.21|P-value:2.93E-5 ID:SGTC_3260|Compound:9137109|FD-Score:5.17|P-value:3.92E-7 ID:SGTC_3269|Compound:9137823|FD-Score:4.15|P-value:3.72E-5 ID:SGTC_3281|Compound:9140613|FD-Score:3.41|P-value:5.58E-4 ID:SGTC_3343|Compound:9148379|FD-Score:3.35|P-value:6.83E-4

Top fitness defect scores for YDR071C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1876 myriocin 20.80 605.0 nM 7.52E-88 2 4.43E-96
2 SGTC_2781 5567276 6.66 71.4 µM 9.71E-11 9 1.33E-11
3 SGTC_51 1013-0126 6.57 23.4 µM 1.77E-10 13 2.56E-11
4 SGTC_103 0844-0104 6.24 51.8 µM 1.26E-9 ERAD & cell cycle 75 2.20E-10
5 SGTC_2060 5238662 6.03 140.0 µM 4.20E-9 5 8.17E-10
6 SGTC_786 4544-0069 5.83 423.0 µM 1.29E-8 7 2.78E-9
7 SGTC_2831 7999036 5.48 19.5 µM 8.17E-8 10 2.10E-8
8 SGTC_436 n,n-dimethylsphingosine 5.40 3.3 µM 1.26E-7 7 3.38E-8
9 SGTC_690 glyoxal 5.23 20.3 µM 2.91E-7 57 8.41E-8
10 SGTC_3260 9137109 5.17 49.5 µM 3.92E-7 60S ribosome export 4 1.16E-7
11 SGTC_1351 1496-0003 5.08 46.5 µM 6.11E-7 6 1.89E-7
12 SGTC_2786 7743617 4.97 45.5 µM 1.03E-6 8 3.35E-7
13 SGTC_2398 5228213 4.79 48.8 µM 2.33E-6 iron homeostasis 18 8.16E-7
14 SGTC_1093 fluphenazine 4.72 8.0 µM 3.31E-6 6 1.20E-6
15 SGTC_2469 5655019 4.70 90.8 µM 3.60E-6 13 1.31E-6
16 SGTC_2330 7979373 4.56 200.0 µM 6.73E-6 60S ribosome export 22 2.60E-6
17 SGTC_1640 st009078 4.51 66.4 µM 8.40E-6 4 3.31E-6
18 SGTC_2584 androsterone 4.43 48.7 µM 1.14E-5 cell wall 97 4.61E-6
19 SGTC_2473 5854593 4.37 8.9 µM 1.51E-5 5 6.28E-6
20 SGTC_3236 9132701 4.21 49.5 µM 2.93E-5 TSC3-RPN4 19 1.29E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.449 3.31E-166 YGR212W SLI1 hom N-acetyltransferase, confers resistance to the sphingolipid biosynthesis inhibitor myriocin (ISP-1) by converting it into N-acetyl-myriocin, co-operates with Ypk1p in mediating resistance to myriocin
0.293 1.56E-67 YMR296C LCB1 het Component of serine palmitoyltransferase, responsible along with Lcb2p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine
0.258 2.74E-52 YBR125C PTC4 hom Cytoplasmic type 2C protein phosphatase (PP2C); identified as a high-copy number suppressor of cnb1 mpk1 synthetic lethality; overexpression decreases high-osmolarity induced Hog1p phosphorylation and kinase activity
0.201 8.71E-32 YGR213C RTA1 hom Protein involved in 7-aminocholesterol resistance; has seven potential membrane-spanning regions; expression is induced under both low-heme and low-oxygen conditions; member of the fungal lipid-translocating exporter (LTE) family of protein
0.141 2.29E-16 YJL213W YJL213W hom Protein of unknown function that may interact with ribosomes; periodically expressed during the yeast metabolic cycle; phosphorylated in vitro by the mitotic exit network (MEN) kinase complex, Dbf2p/Mob1p
0.130 4.26E-14 YDR062W LCB2 het Component of serine palmitoyltransferase, responsible along with Lcb1p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine
0.127 1.76E-13 YNL307C MCK1 hom Protein serine/threonine/tyrosine (dual-specificity) kinase; involved in control of chromosome segregation and in regulating entry into meiosis; interacts with Clb2p and Mih1p; inhibits Clb2p-Cdk1 activity; related to mammalian glycogen synthase kinases of the GSK-3 family
0.126 2.60E-13 YHR041C SRB2 hom Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; general transcription factor involved in telomere maintenance
0.123 7.83E-13 YHR059W FYV4 hom Protein of unknown function, required for survival upon exposure to K1 killer toxin
0.118 6.72E-12 YER027C GAL83 hom One of three possible beta-subunits of the Snf1 kinase complex, allows nuclear localization of the Snf1 kinase complex in the presence of a nonfermentable carbon source; contains glycogen-binding domain
0.114 2.95E-11 YNR031C SSK2 hom MAP kinase kinase kinase of the HOG1 mitogen-activated signaling pathway; interacts with Ssk1p, leading to autophosphorylation and activation of Ssk2p which phosphorylates Pbs2p; also mediates actin cytoskeleton recovery from osmotic stress
0.114 3.81E-11 YMR153C-A_d YMR153C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NUP53
0.111 1.19E-10 YAL051W OAF1 hom Oleate-activated transcription factor; acts alone and as a heterodimer with Pip2p; activates genes involved in beta-oxidation of fatty acids and peroxisome organization and biogenesis; OAF1 has a paralog, PIP2, that arose from the whole genome duplication
0.110 1.87E-10 YKL008C LAC1 hom Ceramide synthase component, involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lag1p
0.110 2.17E-10 YKL213C DOA1 hom WD repeat protein required for ubiquitin-mediated protein degradation; forms a complex with Cdc48p; plays a role in controlling cellular ubiquitin concentration; also promotes efficient NHEJ in postdiauxic/stationary phase; protein increases in abundance and relocalizes from nucleus to nuclear periphery upon DNA replication stress