YDR072C / IPT1

Inositolphosphotransferase, involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C), the most abundant sphingolipid; can mutate to resistance to the antifungals syringomycin E and DmAMP1 and to K. lactis zymocin

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR072C / IPT1

Click on Significant Values for Screen Details ID:SGTC_2|Compound:0422-0095|FD-Score:3.68|P-value:1.13E-4 ID:SGTC_15|Compound:0266-0086|FD-Score:16.40|P-value:4.17E-61 ID:SGTC_55|Compound:0767-0285|FD-Score:3.37|P-value:3.64E-4 ID:SGTC_79|Compound:0052-0007|FD-Score:4.91|P-value:4.35E-7 ID:SGTC_98|Compound:0074-0023|FD-Score:4.81|P-value:7.29E-7 ID:SGTC_134|Compound:0269-0018|FD-Score:3.11|P-value:9.27E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:5.19|P-value:9.85E-8 ID:SGTC_155|Compound:k072-0202|FD-Score:3.31|P-value:4.53E-4 ID:SGTC_206|Compound:4546-0025|FD-Score:4.13|P-value:1.79E-5 ID:SGTC_221|Compound:trifluoperazine|FD-Score:5.51|P-value:1.72E-8 ID:SGTC_255|Compound:tunicamycin|FD-Score:4.68|P-value:1.35E-6 ID:SGTC_266|Compound:formosanin C|FD-Score:23.20|P-value:3.56E-120 ID:SGTC_298|Compound:1391-0729|FD-Score:-3.29|P-value:4.90E-4 ID:SGTC_305|Compound:1682-2595|FD-Score:3.19|P-value:7.03E-4 ID:SGTC_308|Compound:4092-1169|FD-Score:-4.22|P-value:1.22E-5 ID:SGTC_309|Compound:k408-0051|FD-Score:5.41|P-value:2.98E-8 ID:SGTC_310|Compound:1273-0058|FD-Score:-5.51|P-value:1.77E-8 ID:SGTC_312|Compound:4092-0653|FD-Score:-4.78|P-value:8.47E-7 ID:SGTC_314|Compound:1671-0008|FD-Score:-3.53|P-value:2.09E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:4.87|P-value:5.34E-7 ID:SGTC_384|Compound:k007-0144|FD-Score:6.34|P-value:1.04E-10 ID:SGTC_439|Compound:amiodarone|FD-Score:14.60|P-value:8.69E-49 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.82|P-value:6.50E-5 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:5.50|P-value:1.84E-8 ID:SGTC_462|Compound:ag-879|FD-Score:5.76|P-value:4.01E-9 ID:SGTC_467|Compound:ro 31-8220|FD-Score:3.11|P-value:9.15E-4 ID:SGTC_470|Compound:aa-861|FD-Score:23.70|P-value:2.18E-124 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:3.47|P-value:2.53E-4 ID:SGTC_512|Compound:prima-1|FD-Score:5.84|P-value:2.48E-9 ID:SGTC_539|Compound:4859-0462|FD-Score:6.45|P-value:5.32E-11 ID:SGTC_548|Compound:1436-0017|FD-Score:4.14|P-value:1.71E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:4.97|P-value:3.16E-7 ID:SGTC_628|Compound:1636-0253|FD-Score:5.52|P-value:1.57E-8 ID:SGTC_637|Compound:1181-0519|FD-Score:3.72|P-value:9.88E-5 ID:SGTC_658|Compound:3253-0951|FD-Score:4.39|P-value:5.36E-6 ID:SGTC_660|Compound:4031-1742|FD-Score:-4.06|P-value:2.42E-5 ID:SGTC_664|Compound:1222-0054|FD-Score:11.80|P-value:1.39E-32 ID:SGTC_668|Compound:1682-0499|FD-Score:3.52|P-value:2.08E-4 ID:SGTC_683|Compound:panaxydol|FD-Score:7.72|P-value:5.20E-15 ID:SGTC_743|Compound:1275-0778|FD-Score:3.22|P-value:6.27E-4 ID:SGTC_764|Compound:1951-2361|FD-Score:4.68|P-value:1.36E-6 ID:SGTC_804|Compound:1595-0054|FD-Score:3.11|P-value:9.25E-4 ID:SGTC_825|Compound:1988-2224|FD-Score:3.74|P-value:9.10E-5 ID:SGTC_940|Compound:3232-1287|FD-Score:4.84|P-value:6.37E-7 ID:SGTC_951|Compound:1171-0579|FD-Score:-3.55|P-value:1.88E-4 ID:SGTC_954|Compound:1189-0853|FD-Score:-3.54|P-value:1.98E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:11.20|P-value:1.45E-29 ID:SGTC_987|Compound:1497-1013|FD-Score:3.16|P-value:7.66E-4 ID:SGTC_1011|Compound:4112-3381|FD-Score:-3.43|P-value:3.02E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:4.29|P-value:8.56E-6 ID:SGTC_1082|Compound:camptothecin|FD-Score:-5.15|P-value:1.30E-7 ID:SGTC_1161|Compound:k007-0610|FD-Score:5.62|P-value:8.95E-9 ID:SGTC_1222|Compound:0366-0074|FD-Score:3.83|P-value:6.24E-5 ID:SGTC_1228|Compound:0124-0032|FD-Score:3.37|P-value:3.73E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:3.99|P-value:3.20E-5 ID:SGTC_1270|Compound:0831-1170|FD-Score:3.21|P-value:6.42E-4 ID:SGTC_1276|Compound:0871-0068|FD-Score:4.38|P-value:5.83E-6 ID:SGTC_1282|Compound:0886-0010|FD-Score:7.44|P-value:4.61E-14 ID:SGTC_1290|Compound:0986-0249|FD-Score:-3.68|P-value:1.14E-4 ID:SGTC_1315|Compound:1237-0019|FD-Score:3.18|P-value:7.22E-4 ID:SGTC_1458|Compound:k015-0034|FD-Score:3.31|P-value:4.54E-4 ID:SGTC_1658|Compound:st012944|FD-Score:3.26|P-value:5.42E-4 ID:SGTC_1712|Compound:st032288|FD-Score:-3.65|P-value:1.28E-4 ID:SGTC_1736|Compound:st036774|FD-Score:4.18|P-value:1.39E-5 ID:SGTC_1752|Compound:st044819|FD-Score:-5.27|P-value:6.63E-8 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.59|P-value:2.23E-6 ID:SGTC_1844|Compound:rapamycin|FD-Score:-3.38|P-value:3.66E-4 ID:SGTC_1858|Compound:4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione|FD-Score:3.19|P-value:6.89E-4 ID:SGTC_1872|Compound:amphotericin b|FD-Score:3.61|P-value:1.49E-4 ID:SGTC_1924|Compound:st058459|FD-Score:3.54|P-value:1.95E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.32|P-value:4.53E-4 ID:SGTC_1941|Compound:st076221|FD-Score:7.96|P-value:7.86E-16 ID:SGTC_1991|Compound:st073000|FD-Score:7.11|P-value:5.28E-13 ID:SGTC_2125|Compound:5246583|FD-Score:6.14|P-value:3.92E-10 ID:SGTC_2129|Compound:girgensonine|FD-Score:3.93|P-value:4.14E-5 ID:SGTC_2239|Compound:6685329|FD-Score:3.47|P-value:2.50E-4 ID:SGTC_2248|Compound:tofa|FD-Score:4.88|P-value:5.21E-7 ID:SGTC_2249|Compound:haloperidol|FD-Score:-3.60|P-value:1.60E-4 ID:SGTC_2316|Compound:5844804|FD-Score:5.24|P-value:7.70E-8 ID:SGTC_2327|Compound:6189656|FD-Score:-4.26|P-value:9.91E-6 ID:SGTC_2359|Compound:9039622|FD-Score:4.36|P-value:6.29E-6 ID:SGTC_2387|Compound:9077560|FD-Score:-3.40|P-value:3.32E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:3.76|P-value:8.28E-5 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:7.35|P-value:8.78E-14 ID:SGTC_2581|Compound:avocatin a|FD-Score:5.40|P-value:3.12E-8 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.13|P-value:8.43E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:4.30|P-value:8.32E-6 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:6.21|P-value:2.42E-10 ID:SGTC_2679|Compound:rapamycin|FD-Score:-3.34|P-value:4.20E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:6.50|P-value:3.74E-11 ID:SGTC_2733|Compound:amorolfine|FD-Score:-3.25|P-value:5.72E-4 ID:SGTC_2736|Compound:butenafine|FD-Score:6.53|P-value:3.10E-11 ID:SGTC_2754|Compound:granisetron|FD-Score:3.51|P-value:2.22E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:-3.30|P-value:4.76E-4 ID:SGTC_2858|Compound:9025781|FD-Score:6.04|P-value:7.06E-10 ID:SGTC_2873|Compound:9040596|FD-Score:4.55|P-value:2.57E-6 ID:SGTC_2896|Compound:9052656|FD-Score:-4.52|P-value:3.02E-6 ID:SGTC_2956|Compound:9076196|FD-Score:-3.96|P-value:3.68E-5 ID:SGTC_2957|Compound:9076800|FD-Score:3.31|P-value:4.61E-4 ID:SGTC_2961|Compound:9083290|FD-Score:-6.28|P-value:1.60E-10 ID:SGTC_2962|Compound:9082311|FD-Score:-4.82|P-value:7.09E-7 ID:SGTC_2965|Compound:9082772|FD-Score:4.39|P-value:5.42E-6 ID:SGTC_3025|Compound:9087895|FD-Score:3.26|P-value:5.43E-4 ID:SGTC_3336|Compound:9143619|FD-Score:4.20|P-value:1.29E-5 ID:SGTC_3342|Compound:9147791|FD-Score:3.51|P-value:2.20E-4 ID:SGTC_3354|Compound:9151612|FD-Score:4.62|P-value:1.85E-6 ID:SGTC_2|Compound:0422-0095|FD-Score:3.68|P-value:1.13E-4 ID:SGTC_15|Compound:0266-0086|FD-Score:16.40|P-value:4.17E-61 ID:SGTC_55|Compound:0767-0285|FD-Score:3.37|P-value:3.64E-4 ID:SGTC_79|Compound:0052-0007|FD-Score:4.91|P-value:4.35E-7 ID:SGTC_98|Compound:0074-0023|FD-Score:4.81|P-value:7.29E-7 ID:SGTC_134|Compound:0269-0018|FD-Score:3.11|P-value:9.27E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:5.19|P-value:9.85E-8 ID:SGTC_155|Compound:k072-0202|FD-Score:3.31|P-value:4.53E-4 ID:SGTC_206|Compound:4546-0025|FD-Score:4.13|P-value:1.79E-5 ID:SGTC_221|Compound:trifluoperazine|FD-Score:5.51|P-value:1.72E-8 ID:SGTC_255|Compound:tunicamycin|FD-Score:4.68|P-value:1.35E-6 ID:SGTC_266|Compound:formosanin C|FD-Score:23.20|P-value:3.56E-120 ID:SGTC_298|Compound:1391-0729|FD-Score:-3.29|P-value:4.90E-4 ID:SGTC_305|Compound:1682-2595|FD-Score:3.19|P-value:7.03E-4 ID:SGTC_308|Compound:4092-1169|FD-Score:-4.22|P-value:1.22E-5 ID:SGTC_309|Compound:k408-0051|FD-Score:5.41|P-value:2.98E-8 ID:SGTC_310|Compound:1273-0058|FD-Score:-5.51|P-value:1.77E-8 ID:SGTC_312|Compound:4092-0653|FD-Score:-4.78|P-value:8.47E-7 ID:SGTC_314|Compound:1671-0008|FD-Score:-3.53|P-value:2.09E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:4.87|P-value:5.34E-7 ID:SGTC_384|Compound:k007-0144|FD-Score:6.34|P-value:1.04E-10 ID:SGTC_439|Compound:amiodarone|FD-Score:14.60|P-value:8.69E-49 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.82|P-value:6.50E-5 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:5.50|P-value:1.84E-8 ID:SGTC_462|Compound:ag-879|FD-Score:5.76|P-value:4.01E-9 ID:SGTC_467|Compound:ro 31-8220|FD-Score:3.11|P-value:9.15E-4 ID:SGTC_470|Compound:aa-861|FD-Score:23.70|P-value:2.18E-124 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:3.47|P-value:2.53E-4 ID:SGTC_512|Compound:prima-1|FD-Score:5.84|P-value:2.48E-9 ID:SGTC_539|Compound:4859-0462|FD-Score:6.45|P-value:5.32E-11 ID:SGTC_548|Compound:1436-0017|FD-Score:4.14|P-value:1.71E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:4.97|P-value:3.16E-7 ID:SGTC_628|Compound:1636-0253|FD-Score:5.52|P-value:1.57E-8 ID:SGTC_637|Compound:1181-0519|FD-Score:3.72|P-value:9.88E-5 ID:SGTC_658|Compound:3253-0951|FD-Score:4.39|P-value:5.36E-6 ID:SGTC_660|Compound:4031-1742|FD-Score:-4.06|P-value:2.42E-5 ID:SGTC_664|Compound:1222-0054|FD-Score:11.80|P-value:1.39E-32 ID:SGTC_668|Compound:1682-0499|FD-Score:3.52|P-value:2.08E-4 ID:SGTC_683|Compound:panaxydol|FD-Score:7.72|P-value:5.20E-15 ID:SGTC_743|Compound:1275-0778|FD-Score:3.22|P-value:6.27E-4 ID:SGTC_764|Compound:1951-2361|FD-Score:4.68|P-value:1.36E-6 ID:SGTC_804|Compound:1595-0054|FD-Score:3.11|P-value:9.25E-4 ID:SGTC_825|Compound:1988-2224|FD-Score:3.74|P-value:9.10E-5 ID:SGTC_940|Compound:3232-1287|FD-Score:4.84|P-value:6.37E-7 ID:SGTC_951|Compound:1171-0579|FD-Score:-3.55|P-value:1.88E-4 ID:SGTC_954|Compound:1189-0853|FD-Score:-3.54|P-value:1.98E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:11.20|P-value:1.45E-29 ID:SGTC_987|Compound:1497-1013|FD-Score:3.16|P-value:7.66E-4 ID:SGTC_1011|Compound:4112-3381|FD-Score:-3.43|P-value:3.02E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:4.29|P-value:8.56E-6 ID:SGTC_1082|Compound:camptothecin|FD-Score:-5.15|P-value:1.30E-7 ID:SGTC_1161|Compound:k007-0610|FD-Score:5.62|P-value:8.95E-9 ID:SGTC_1222|Compound:0366-0074|FD-Score:3.83|P-value:6.24E-5 ID:SGTC_1228|Compound:0124-0032|FD-Score:3.37|P-value:3.73E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:3.99|P-value:3.20E-5 ID:SGTC_1270|Compound:0831-1170|FD-Score:3.21|P-value:6.42E-4 ID:SGTC_1276|Compound:0871-0068|FD-Score:4.38|P-value:5.83E-6 ID:SGTC_1282|Compound:0886-0010|FD-Score:7.44|P-value:4.61E-14 ID:SGTC_1290|Compound:0986-0249|FD-Score:-3.68|P-value:1.14E-4 ID:SGTC_1315|Compound:1237-0019|FD-Score:3.18|P-value:7.22E-4 ID:SGTC_1458|Compound:k015-0034|FD-Score:3.31|P-value:4.54E-4 ID:SGTC_1658|Compound:st012944|FD-Score:3.26|P-value:5.42E-4 ID:SGTC_1712|Compound:st032288|FD-Score:-3.65|P-value:1.28E-4 ID:SGTC_1736|Compound:st036774|FD-Score:4.18|P-value:1.39E-5 ID:SGTC_1752|Compound:st044819|FD-Score:-5.27|P-value:6.63E-8 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.59|P-value:2.23E-6 ID:SGTC_1844|Compound:rapamycin|FD-Score:-3.38|P-value:3.66E-4 ID:SGTC_1858|Compound:4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione|FD-Score:3.19|P-value:6.89E-4 ID:SGTC_1872|Compound:amphotericin b|FD-Score:3.61|P-value:1.49E-4 ID:SGTC_1924|Compound:st058459|FD-Score:3.54|P-value:1.95E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.32|P-value:4.53E-4 ID:SGTC_1941|Compound:st076221|FD-Score:7.96|P-value:7.86E-16 ID:SGTC_1991|Compound:st073000|FD-Score:7.11|P-value:5.28E-13 ID:SGTC_2125|Compound:5246583|FD-Score:6.14|P-value:3.92E-10 ID:SGTC_2129|Compound:girgensonine|FD-Score:3.93|P-value:4.14E-5 ID:SGTC_2239|Compound:6685329|FD-Score:3.47|P-value:2.50E-4 ID:SGTC_2248|Compound:tofa|FD-Score:4.88|P-value:5.21E-7 ID:SGTC_2249|Compound:haloperidol|FD-Score:-3.60|P-value:1.60E-4 ID:SGTC_2316|Compound:5844804|FD-Score:5.24|P-value:7.70E-8 ID:SGTC_2327|Compound:6189656|FD-Score:-4.26|P-value:9.91E-6 ID:SGTC_2359|Compound:9039622|FD-Score:4.36|P-value:6.29E-6 ID:SGTC_2387|Compound:9077560|FD-Score:-3.40|P-value:3.32E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:3.76|P-value:8.28E-5 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:7.35|P-value:8.78E-14 ID:SGTC_2581|Compound:avocatin a|FD-Score:5.40|P-value:3.12E-8 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.13|P-value:8.43E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:4.30|P-value:8.32E-6 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:6.21|P-value:2.42E-10 ID:SGTC_2679|Compound:rapamycin|FD-Score:-3.34|P-value:4.20E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:6.50|P-value:3.74E-11 ID:SGTC_2733|Compound:amorolfine|FD-Score:-3.25|P-value:5.72E-4 ID:SGTC_2736|Compound:butenafine|FD-Score:6.53|P-value:3.10E-11 ID:SGTC_2754|Compound:granisetron|FD-Score:3.51|P-value:2.22E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:-3.30|P-value:4.76E-4 ID:SGTC_2858|Compound:9025781|FD-Score:6.04|P-value:7.06E-10 ID:SGTC_2873|Compound:9040596|FD-Score:4.55|P-value:2.57E-6 ID:SGTC_2896|Compound:9052656|FD-Score:-4.52|P-value:3.02E-6 ID:SGTC_2956|Compound:9076196|FD-Score:-3.96|P-value:3.68E-5 ID:SGTC_2957|Compound:9076800|FD-Score:3.31|P-value:4.61E-4 ID:SGTC_2961|Compound:9083290|FD-Score:-6.28|P-value:1.60E-10 ID:SGTC_2962|Compound:9082311|FD-Score:-4.82|P-value:7.09E-7 ID:SGTC_2965|Compound:9082772|FD-Score:4.39|P-value:5.42E-6 ID:SGTC_3025|Compound:9087895|FD-Score:3.26|P-value:5.43E-4 ID:SGTC_3336|Compound:9143619|FD-Score:4.20|P-value:1.29E-5 ID:SGTC_3342|Compound:9147791|FD-Score:3.51|P-value:2.20E-4 ID:SGTC_3354|Compound:9151612|FD-Score:4.62|P-value:1.85E-6

Top fitness defect scores for YDR072C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_470 aa-861 23.70 153.0 µM 2.18E-124 sphingolipid biosynthesis & PDR1 1 4.73E-124
2 SGTC_266 formosanin C 23.20 406.0 nM 3.56E-120 sphingolipid biosynthesis & PDR1 3 7.54E-120
3 SGTC_15 0266-0086 16.40 27.1 µM 4.17E-61 endomembrane recycling 1 6.13E-61
4 SGTC_439 amiodarone 14.60 34.4 µM 8.69E-49 NEO1-PIK1 5 1.18E-48
5 SGTC_664 1222-0054 11.80 14.9 µM 1.39E-32 sphingolipid biosynthesis & PDR1 7 1.71E-32
6 SGTC_955 1216-0110 11.20 33.0 µM 1.45E-29 sphingolipid biosynthesis & PDR1 11 1.75E-29
7 SGTC_1941 st076221 7.96 61.8 µM 7.86E-16 sphingolipid biosynthesis & PDR1 21 8.70E-16
8 SGTC_683 panaxydol 7.72 45.0 µM 5.20E-15 sphingolipid biosynthesis & PDR1 5 5.72E-15
9 SGTC_1282 0886-0010 7.44 32.4 µM 4.61E-14 endomembrane recycling 2 5.04E-14
10 SGTC_2567 aureobasidin a 7.35 60.0 nM 8.78E-14 27 9.59E-14
11 SGTC_1991 st073000 7.11 8.9 µM 5.28E-13 NEO1 23 5.73E-13
12 SGTC_2736 butenafine 6.53 14.7 µM 3.10E-11 7 3.33E-11
13 SGTC_2688 kanamycin b 6.50 96.7 µM 3.74E-11 calcium & mitochondrial duress 131 4.02E-11
14 SGTC_539 4859-0462 6.45 2.5 µM 5.32E-11 RNA pol III & RNase P/MRP 2 5.70E-11
15 SGTC_384 k007-0144 6.34 5.2 µM 1.04E-10 ERAD & cell cycle 23 1.12E-10
16 SGTC_2658 polymyxin b sulfate 6.21 77.0 µM 2.42E-10 NEO1 18 2.58E-10
17 SGTC_2125 5246583 6.14 200.0 µM 3.92E-10 tubulin folding & SWR complex 14 4.18E-10
18 SGTC_2858 9025781 6.04 9.0 µM 7.06E-10 sphingolipid biosynthesis & PDR1 45 7.51E-10
19 SGTC_512 prima-1 5.84 270.0 µM 2.48E-9 DNA intercalators 5 2.63E-9
20 SGTC_462 ag-879 5.76 158.0 µM 4.01E-9 8 4.25E-9

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Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.573 3.51E-292 YPL057C SUR1 hom Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Csh1p; SUR1 has a paralog, CSH1, that arose from the whole genome duplication
0.469 1.48E-183 YBR036C CSG2 hom Endoplasmic reticulum membrane protein, required for mannosylation of inositolphosphorylceramide and for growth at high calcium concentrations; protein abundance increases in response to DNA replication stress
0.384 5.18E-118 YMR102C_p YMR102C_p hom Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene
0.361 1.08E-103 YDR326C YSP2 hom Protein involved in programmed cell death; mutant shows resistance to cell death induced by amiodarone or intracellular acidification; YSP2 has a paralog, YHR080C, that arose from the whole genome duplication
0.313 3.19E-77 YPL056C_p LCL1_p hom Putative protein of unknown function; deletion mutant is fluconazole resistant and has long chronological lifespan
0.278 1.68E-60 YJR059W PTK2 hom Putative serine/threonine protein kinase involved in regulation of ion transport across plasma membrane; enhances spermine uptake
0.273 1.50E-58 YNL257C SIP3 hom Transcription cofactor; acts through interaction with DNA-bound Snf1p; C-terminal region has a putative leucine zipper motif; potential Cdc28p substrate; SIP3 has a paralog, YSP1, that arose from the whole genome duplication
0.251 2.63E-49 YLR055C SPT8 hom Subunit of the SAGA transcriptional regulatory complex but not present in SAGA-like complex SLIK/SALSA, required for SAGA-mediated inhibition at some promoters
0.244 1.11E-46 YKL190W CNB1 hom Calcineurin B; the regulatory subunit of calcineurin, a Ca++/calmodulin-regulated type 2B protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is encoded by CNA1 and/or CMP1; protein abundance increases in response to DNA replication stress
0.238 1.90E-44 YOR061W CKA2 hom Alpha' catalytic subunit of casein kinase 2 (CK2); CK2 is a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases; protein abundance increases in response to DNA replication stress; regulates Fkh1p-mediated donor preference during mating-type switching
0.235 2.57E-43 YDR392W SPT3 hom Subunit of the SAGA and SAGA-like transcriptional regulatory complexes, interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters
0.224 2.15E-39 YDR372C VPS74 hom Golgi phosphatidylinositol-4-kinase effector and PtdIns4P sensor; interacts with the cytosolic domains of cis and medial glycosyltransferases, and in the PtdIns4P-bound state mediates the targeting of these enzymes to the Golgi; interacts with the catalytic domain of Sac1p, the major cellular PtdIns4P phosphatase, to direct dephosphosphorylation of the Golgi pool of PtdIns4P; tetramerization required for function; ortholog of human GOLPH3/GPP34/GMx33
0.222 1.04E-38 YGL253W HXK2 hom Hexokinase isoenzyme 2; catalyzes phosphorylation of glucose in the cytosol; predominant hexokinase during growth on glucose; functions in the nucleus to repress expression of HXK1 and GLK1 and to induce expression of its own gene; phosphorylation/dephosphorylation at serine-14 by protein kinase Snf1p and protein phosphatase Glc7p-Reg1p regulates nucleocytoplasmic shuttling of Hxk2p; HXK2 has a paralog, HXK1, that arose from the whole genome duplication
0.219 7.35E-38 YGR143W SKN1 hom Protein involved in sphingolipid biosynthesis; type II membrane protein with similarity to Kre6p
0.214 3.22E-36 YOL050C_d YOL050C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps verified gene GAL11; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)