YDR073W / SNF11

Subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; interacts with a highly conserved 40-residue sequence of Snf2p; relocates to the cytosol under hypoxic conditions

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR073W / SNF11

Click on Significant Values for Screen Details ID:SGTC_8|Compound:0354-0001|FD-Score:4.82|P-value:1.09E-7 ID:SGTC_40|Compound:0327-0103|FD-Score:-4.38|P-value:1.48E-6 ID:SGTC_46|Compound:0329-0187a|FD-Score:4.58|P-value:4.37E-7 ID:SGTC_67|Compound:0335-0847|FD-Score:3.00|P-value:6.21E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:3.78|P-value:2.39E-5 ID:SGTC_263|Compound:alizarin|FD-Score:4.01|P-value:7.89E-6 ID:SGTC_266|Compound:formosanin C|FD-Score:6.11|P-value:2.73E-11 ID:SGTC_341|Compound:1486-1430|FD-Score:-4.07|P-value:7.22E-6 ID:SGTC_342|Compound:k048-0088|FD-Score:3.10|P-value:4.28E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:-3.36|P-value:1.71E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:-3.80|P-value:2.56E-5 ID:SGTC_371|Compound:0195-0006|FD-Score:4.54|P-value:5.20E-7 ID:SGTC_374|Compound:0880-0231|FD-Score:3.23|P-value:2.53E-4 ID:SGTC_377|Compound:3970-0964|FD-Score:3.88|P-value:1.48E-5 ID:SGTC_386|Compound:1509-0011|FD-Score:-3.04|P-value:6.04E-4 ID:SGTC_389|Compound:tpck|FD-Score:-3.26|P-value:2.55E-4 ID:SGTC_393|Compound:acivicin|FD-Score:5.81|P-value:2.24E-10 ID:SGTC_407|Compound:eburnamonine|FD-Score:-4.06|P-value:7.55E-6 ID:SGTC_409|Compound:arachidonic acid|FD-Score:3.06|P-value:4.96E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:5.80|P-value:2.30E-10 ID:SGTC_496|Compound:calpeptin|FD-Score:2.94|P-value:7.58E-4 ID:SGTC_505|Compound:gw-5074|FD-Score:3.75|P-value:2.80E-5 ID:SGTC_669|Compound:0108-0021|FD-Score:3.33|P-value:1.66E-4 ID:SGTC_670|Compound:4204-0025|FD-Score:4.02|P-value:7.53E-6 ID:SGTC_672|Compound:1441-0018|FD-Score:3.15|P-value:3.45E-4 ID:SGTC_683|Compound:panaxydol|FD-Score:6.92|P-value:5.39E-14 ID:SGTC_706|Compound:4262-0057|FD-Score:3.49|P-value:8.53E-5 ID:SGTC_779|Compound:1360-0071|FD-Score:3.00|P-value:6.06E-4 ID:SGTC_924|Compound:2046-0044|FD-Score:-5.64|P-value:8.79E-10 ID:SGTC_927|Compound:2425-1185|FD-Score:-4.50|P-value:8.15E-7 ID:SGTC_931|Compound:2812-0076|FD-Score:-3.83|P-value:2.23E-5 ID:SGTC_1202|Compound:1988-0068|FD-Score:3.61|P-value:5.18E-5 ID:SGTC_1242|Compound:0402-0103|FD-Score:-3.06|P-value:5.68E-4 ID:SGTC_1244|Compound:0416-0015|FD-Score:3.49|P-value:8.67E-5 ID:SGTC_1251|Compound:0490-5699|FD-Score:5.14|P-value:1.71E-8 ID:SGTC_1287|Compound:0971-0001|FD-Score:6.24|P-value:1.05E-11 ID:SGTC_1515|Compound:3460-0031|FD-Score:-3.06|P-value:5.63E-4 ID:SGTC_1518|Compound:st038567|FD-Score:-3.07|P-value:5.44E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:3.24|P-value:2.43E-4 ID:SGTC_1698|Compound:5-fluorocytosine|FD-Score:3.04|P-value:5.39E-4 ID:SGTC_1754|Compound:st042065|FD-Score:3.90|P-value:1.35E-5 ID:SGTC_1800|Compound:st050079|FD-Score:4.33|P-value:1.58E-6 ID:SGTC_1801|Compound:st050089|FD-Score:4.31|P-value:1.77E-6 ID:SGTC_1803|Compound:st050068|FD-Score:4.52|P-value:6.03E-7 ID:SGTC_1941|Compound:st076221|FD-Score:7.79|P-value:3.17E-17 ID:SGTC_2006|Compound:4011487|FD-Score:3.04|P-value:5.36E-4 ID:SGTC_2014|Compound:4013930|FD-Score:3.70|P-value:3.39E-5 ID:SGTC_2090|Compound:5301565|FD-Score:-2.97|P-value:7.98E-4 ID:SGTC_2091|Compound:4-phenylthiadiazole|FD-Score:-3.34|P-value:1.92E-4 ID:SGTC_2178|Compound:5812956|FD-Score:-3.35|P-value:1.84E-4 ID:SGTC_2238|Compound:6671620|FD-Score:-4.30|P-value:2.29E-6 ID:SGTC_2257|Compound:7960413|FD-Score:3.72|P-value:3.12E-5 ID:SGTC_2310|Compound:7668677|FD-Score:-3.44|P-value:1.22E-4 ID:SGTC_2415|Compound:st077333|FD-Score:3.24|P-value:2.47E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-3.26|P-value:2.63E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:-2.94|P-value:8.76E-4 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:2.99|P-value:6.36E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-3.82|P-value:2.30E-5 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.98|P-value:9.10E-6 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:2.93|P-value:7.87E-4 ID:SGTC_2801|Compound:7907800|FD-Score:-7.20|P-value:7.53E-15 ID:SGTC_2858|Compound:9025781|FD-Score:6.49|P-value:1.55E-12 ID:SGTC_3196|Compound:9111891|FD-Score:-2.97|P-value:7.96E-4 ID:SGTC_3303|Compound:9125618|FD-Score:-3.22|P-value:2.99E-4 ID:SGTC_3306|Compound:9127676|FD-Score:3.97|P-value:9.73E-6 ID:SGTC_3344|Compound:9148862|FD-Score:3.38|P-value:1.35E-4 ID:SGTC_8|Compound:0354-0001|FD-Score:4.82|P-value:1.09E-7 ID:SGTC_40|Compound:0327-0103|FD-Score:-4.38|P-value:1.48E-6 ID:SGTC_46|Compound:0329-0187a|FD-Score:4.58|P-value:4.37E-7 ID:SGTC_67|Compound:0335-0847|FD-Score:3.00|P-value:6.21E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:3.78|P-value:2.39E-5 ID:SGTC_263|Compound:alizarin|FD-Score:4.01|P-value:7.89E-6 ID:SGTC_266|Compound:formosanin C|FD-Score:6.11|P-value:2.73E-11 ID:SGTC_341|Compound:1486-1430|FD-Score:-4.07|P-value:7.22E-6 ID:SGTC_342|Compound:k048-0088|FD-Score:3.10|P-value:4.28E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:-3.36|P-value:1.71E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:-3.80|P-value:2.56E-5 ID:SGTC_371|Compound:0195-0006|FD-Score:4.54|P-value:5.20E-7 ID:SGTC_374|Compound:0880-0231|FD-Score:3.23|P-value:2.53E-4 ID:SGTC_377|Compound:3970-0964|FD-Score:3.88|P-value:1.48E-5 ID:SGTC_386|Compound:1509-0011|FD-Score:-3.04|P-value:6.04E-4 ID:SGTC_389|Compound:tpck|FD-Score:-3.26|P-value:2.55E-4 ID:SGTC_393|Compound:acivicin|FD-Score:5.81|P-value:2.24E-10 ID:SGTC_407|Compound:eburnamonine|FD-Score:-4.06|P-value:7.55E-6 ID:SGTC_409|Compound:arachidonic acid|FD-Score:3.06|P-value:4.96E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:5.80|P-value:2.30E-10 ID:SGTC_496|Compound:calpeptin|FD-Score:2.94|P-value:7.58E-4 ID:SGTC_505|Compound:gw-5074|FD-Score:3.75|P-value:2.80E-5 ID:SGTC_669|Compound:0108-0021|FD-Score:3.33|P-value:1.66E-4 ID:SGTC_670|Compound:4204-0025|FD-Score:4.02|P-value:7.53E-6 ID:SGTC_672|Compound:1441-0018|FD-Score:3.15|P-value:3.45E-4 ID:SGTC_683|Compound:panaxydol|FD-Score:6.92|P-value:5.39E-14 ID:SGTC_706|Compound:4262-0057|FD-Score:3.49|P-value:8.53E-5 ID:SGTC_779|Compound:1360-0071|FD-Score:3.00|P-value:6.06E-4 ID:SGTC_924|Compound:2046-0044|FD-Score:-5.64|P-value:8.79E-10 ID:SGTC_927|Compound:2425-1185|FD-Score:-4.50|P-value:8.15E-7 ID:SGTC_931|Compound:2812-0076|FD-Score:-3.83|P-value:2.23E-5 ID:SGTC_1202|Compound:1988-0068|FD-Score:3.61|P-value:5.18E-5 ID:SGTC_1242|Compound:0402-0103|FD-Score:-3.06|P-value:5.68E-4 ID:SGTC_1244|Compound:0416-0015|FD-Score:3.49|P-value:8.67E-5 ID:SGTC_1251|Compound:0490-5699|FD-Score:5.14|P-value:1.71E-8 ID:SGTC_1287|Compound:0971-0001|FD-Score:6.24|P-value:1.05E-11 ID:SGTC_1515|Compound:3460-0031|FD-Score:-3.06|P-value:5.63E-4 ID:SGTC_1518|Compound:st038567|FD-Score:-3.07|P-value:5.44E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:3.24|P-value:2.43E-4 ID:SGTC_1698|Compound:5-fluorocytosine|FD-Score:3.04|P-value:5.39E-4 ID:SGTC_1754|Compound:st042065|FD-Score:3.90|P-value:1.35E-5 ID:SGTC_1800|Compound:st050079|FD-Score:4.33|P-value:1.58E-6 ID:SGTC_1801|Compound:st050089|FD-Score:4.31|P-value:1.77E-6 ID:SGTC_1803|Compound:st050068|FD-Score:4.52|P-value:6.03E-7 ID:SGTC_1941|Compound:st076221|FD-Score:7.79|P-value:3.17E-17 ID:SGTC_2006|Compound:4011487|FD-Score:3.04|P-value:5.36E-4 ID:SGTC_2014|Compound:4013930|FD-Score:3.70|P-value:3.39E-5 ID:SGTC_2090|Compound:5301565|FD-Score:-2.97|P-value:7.98E-4 ID:SGTC_2091|Compound:4-phenylthiadiazole|FD-Score:-3.34|P-value:1.92E-4 ID:SGTC_2178|Compound:5812956|FD-Score:-3.35|P-value:1.84E-4 ID:SGTC_2238|Compound:6671620|FD-Score:-4.30|P-value:2.29E-6 ID:SGTC_2257|Compound:7960413|FD-Score:3.72|P-value:3.12E-5 ID:SGTC_2310|Compound:7668677|FD-Score:-3.44|P-value:1.22E-4 ID:SGTC_2415|Compound:st077333|FD-Score:3.24|P-value:2.47E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-3.26|P-value:2.63E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:-2.94|P-value:8.76E-4 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:2.99|P-value:6.36E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-3.82|P-value:2.30E-5 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.98|P-value:9.10E-6 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:2.93|P-value:7.87E-4 ID:SGTC_2801|Compound:7907800|FD-Score:-7.20|P-value:7.53E-15 ID:SGTC_2858|Compound:9025781|FD-Score:6.49|P-value:1.55E-12 ID:SGTC_3196|Compound:9111891|FD-Score:-2.97|P-value:7.96E-4 ID:SGTC_3303|Compound:9125618|FD-Score:-3.22|P-value:2.99E-4 ID:SGTC_3306|Compound:9127676|FD-Score:3.97|P-value:9.73E-6 ID:SGTC_3344|Compound:9148862|FD-Score:3.38|P-value:1.35E-4

Top fitness defect scores for YDR073W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1941 st076221 7.79 61.8 µM 3.17E-17 sphingolipid biosynthesis & PDR1 22 3.38E-15
2 SGTC_683 panaxydol 6.92 45.0 µM 5.39E-14 sphingolipid biosynthesis & PDR1 11 2.22E-12
3 SGTC_2858 9025781 6.49 9.0 µM 1.55E-12 sphingolipid biosynthesis & PDR1 40 4.17E-11
4 SGTC_1287 0971-0001 6.24 34.6 µM 1.05E-11 sphingolipid biosynthesis & PDR1 20 2.20E-10
5 SGTC_266 formosanin C 6.11 406.0 nM 2.73E-11 sphingolipid biosynthesis & PDR1 25 5.08E-10
6 SGTC_393 acivicin 5.81 6.2 µM 2.24E-10 6 3.19E-9
7 SGTC_453 enantio-paf c16 5.80 10.0 µM 2.30E-10 59 3.27E-9
8 SGTC_1251 0490-5699 5.14 265.0 µM 1.71E-8 15 1.40E-7
9 SGTC_8 0354-0001 4.82 70.0 µM 1.09E-7 49 7.09E-7
10 SGTC_46 0329-0187a 4.58 2.2 µM 4.37E-7 51 2.38E-6
11 SGTC_371 0195-0006 4.54 7.4 µM 5.20E-7 11 2.77E-6
12 SGTC_1803 st050068 4.52 52.4 µM 6.03E-7 NEO1-PIK1 139 3.15E-6
13 SGTC_1800 st050079 4.33 29.1 µM 1.58E-6 NEO1-PIK1 106 7.29E-6
14 SGTC_1801 st050089 4.31 28.4 µM 1.77E-6 NEO1-PIK1 100 8.09E-6
15 SGTC_670 4204-0025 4.02 119.0 µM 7.53E-6 copper-dependent oxidative stress 29 2.86E-5
16 SGTC_263 alizarin 4.01 107.9 µM 7.89E-6 iron homeostasis 60 2.98E-5
17 SGTC_2752 diclazuril 3.98 33.1 µM 9.10E-6 116 3.38E-5
18 SGTC_3306 9127676 3.97 59.8 µM 9.73E-6 22 3.58E-5
19 SGTC_1754 st042065 3.90 16.1 µM 1.35E-5 NEO1-PIK1 182 4.77E-5
20 SGTC_377 3970-0964 3.88 33.1 µM 1.48E-5 43 5.16E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.308 1.75E-74 YLR055C SPT8 hom Subunit of the SAGA transcriptional regulatory complex but not present in SAGA-like complex SLIK/SALSA, required for SAGA-mediated inhibition at some promoters
0.269 1.74E-56 YDR392W SPT3 hom Subunit of the SAGA and SAGA-like transcriptional regulatory complexes, interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters
0.231 8.96E-42 YGR164W_d YGR164W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.229 4.60E-41 YIL170W HXT12 hom Possible pseudogene in strain S288C; YIL170W/HXT12 and the adjacent ORF, YIL171W, together encode a non-functional member of the hexose transporter family
0.213 1.40E-35 YDR326C YSP2 hom Protein involved in programmed cell death; mutant shows resistance to cell death induced by amiodarone or intracellular acidification; YSP2 has a paralog, YHR080C, that arose from the whole genome duplication
0.212 2.19E-35 YDR120C TRM1 hom tRNA methyltransferase; two forms of the protein are made by alternative translation starts; localizes to both the nucleus and mitochondrion to produce the modified base N2,N2-dimethylguanosine in tRNAs in both compartments
0.212 2.96E-35 YBR246W RRT2 hom Protein required for last step of diphthamide biosynthesis; deletion leads to resistance to sordarin and accumulation of diphthine; WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rtt10p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription
0.205 3.95E-33 YMR031W-A_d YMR031W-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays shortened telomeres; partially overlaps the uncharacterized ORF YMR031C
0.191 8.02E-29 YMR102C_p YMR102C_p hom Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene
0.183 1.14E-26 YNL229C URE2 hom Nitrogen catabolite repression transcriptional regulator that acts by inhibition of GLN3 transcription in good nitrogen source; has glutathione peroxidase activity and can mutate to acquire GST activity; altered form creates [URE3] prion
0.180 8.11E-26 YPL057C SUR1 hom Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Csh1p; SUR1 has a paralog, CSH1, that arose from the whole genome duplication
0.179 1.29E-25 YNL257C SIP3 hom Transcription cofactor; acts through interaction with DNA-bound Snf1p; C-terminal region has a putative leucine zipper motif; potential Cdc28p substrate; SIP3 has a paralog, YSP1, that arose from the whole genome duplication
0.177 4.09E-25 YPR091C NVJ2 hom Lipid-binding ER protein, enriched at nucleus-vacuolar junctions (NVJ); may be involved in sterol metabolism or signaling at the NVJ; contains a synaptotagmin-like-mitochondrial- lipid binding protein (SMP) domain; binds phosphatidylinositols and other lipids in a large-scale study; may interact with ribosomes, based on co-purification experiments
0.176 7.18E-25 YKR093W PTR2 hom Integral membrane peptide transporter, mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p
0.174 3.31E-24 YNL183C NPR1 hom Protein kinase that stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation; phosphorylates Aly2p; negatively regulates Ldb19p-mediated endocytosis through phosphorylation of Ldb19p, which prevents its association with the plasma membrane; Npr1p activity is negatively regulated via phosphorylation by the TOR complex