YDR074W / TPS2

Phosphatase subunit of the trehalose-6-P synthase/phosphatase complex; involved in synthesis of the storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR074W / TPS2

Click on Significant Values for Screen Details ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:3.91|P-value:3.90E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:4.44|P-value:5.90E-5 ID:SGTC_362|Compound:0310-0100|FD-Score:5.10|P-value:4.31E-6 ID:SGTC_365|Compound:0121-0052|FD-Score:4.62|P-value:2.97E-5 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:3.81|P-value:5.41E-4 ID:SGTC_443|Compound:clozapine|FD-Score:-3.39|P-value:4.56E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:3.80|P-value:5.60E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:-4.25|P-value:2.06E-5 ID:SGTC_515|Compound:4092-1064|FD-Score:-7.11|P-value:9.38E-12 ID:SGTC_749|Compound:1000-0129|FD-Score:4.44|P-value:5.94E-5 ID:SGTC_790|Compound:1575-0012|FD-Score:3.67|P-value:8.50E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:-5.37|P-value:1.48E-7 ID:SGTC_922|Compound:1866-0035|FD-Score:-3.49|P-value:3.33E-4 ID:SGTC_934|Compound:2950-0684|FD-Score:4.60|P-value:3.21E-5 ID:SGTC_937|Compound:3122-0005|FD-Score:-4.39|P-value:1.15E-5 ID:SGTC_968|Compound:1309-0633|FD-Score:3.80|P-value:5.53E-4 ID:SGTC_1056|Compound:3448-1962|FD-Score:4.30|P-value:1.01E-4 ID:SGTC_1117|Compound:retinoic acid|FD-Score:5.04|P-value:5.65E-6 ID:SGTC_1127|Compound:asiatic acid|FD-Score:4.66|P-value:2.62E-5 ID:SGTC_1514|Compound:1189-1591|FD-Score:3.99|P-value:2.97E-4 ID:SGTC_1573|Compound:oleylamine|FD-Score:4.43|P-value:6.20E-5 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:4.92|P-value:9.19E-6 ID:SGTC_1713|Compound:st033146|FD-Score:3.92|P-value:3.80E-4 ID:SGTC_1714|Compound:st033236|FD-Score:3.62|P-value:9.91E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:-4.37|P-value:1.30E-5 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:4.40|P-value:6.97E-5 ID:SGTC_1921|Compound:5740136|FD-Score:4.72|P-value:2.02E-5 ID:SGTC_1993|Compound:st073995|FD-Score:-3.87|P-value:8.61E-5 ID:SGTC_2079|Compound:5212404|FD-Score:-3.54|P-value:2.76E-4 ID:SGTC_2284|Compound:7945075|FD-Score:3.65|P-value:8.85E-4 ID:SGTC_2349|Compound:9023730|FD-Score:4.86|P-value:1.16E-5 ID:SGTC_2358|Compound:9037157|FD-Score:3.87|P-value:4.47E-4 ID:SGTC_2481|Compound:5478948|FD-Score:5.33|P-value:1.55E-6 ID:SGTC_2486|Compound:5283202|FD-Score:4.29|P-value:1.05E-4 ID:SGTC_2512|Compound:diallyl trisulfide|FD-Score:3.71|P-value:7.40E-4 ID:SGTC_2678|Compound:equilin|FD-Score:-3.20|P-value:8.45E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-4.73|P-value:2.78E-6 ID:SGTC_2690|Compound:usnic acid|FD-Score:-3.17|P-value:9.18E-4 ID:SGTC_2782|Compound:7736369|FD-Score:-4.39|P-value:1.19E-5 ID:SGTC_2788|Compound:5282734|FD-Score:3.95|P-value:3.42E-4 ID:SGTC_2789|Compound:5281112|FD-Score:4.97|P-value:7.33E-6 ID:SGTC_3049|Compound:9092223|FD-Score:4.46|P-value:5.54E-5 ID:SGTC_3075|Compound:9116269|FD-Score:5.03|P-value:5.66E-6 ID:SGTC_3112|Compound:9123419|FD-Score:3.71|P-value:7.40E-4 ID:SGTC_3155|Compound:9099265|FD-Score:4.38|P-value:7.48E-5 ID:SGTC_3208|Compound:9114115|FD-Score:-4.01|P-value:5.18E-5 ID:SGTC_3225|Compound:9130819|FD-Score:4.15|P-value:1.71E-4 ID:SGTC_3245|Compound:9134821|FD-Score:5.56|P-value:5.46E-7 ID:SGTC_3250|Compound:9135583|FD-Score:4.29|P-value:1.03E-4 ID:SGTC_3258|Compound:9138477|FD-Score:4.94|P-value:8.51E-6 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:3.91|P-value:3.90E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:4.44|P-value:5.90E-5 ID:SGTC_362|Compound:0310-0100|FD-Score:5.10|P-value:4.31E-6 ID:SGTC_365|Compound:0121-0052|FD-Score:4.62|P-value:2.97E-5 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:3.81|P-value:5.41E-4 ID:SGTC_443|Compound:clozapine|FD-Score:-3.39|P-value:4.56E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:3.80|P-value:5.60E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:-4.25|P-value:2.06E-5 ID:SGTC_515|Compound:4092-1064|FD-Score:-7.11|P-value:9.38E-12 ID:SGTC_749|Compound:1000-0129|FD-Score:4.44|P-value:5.94E-5 ID:SGTC_790|Compound:1575-0012|FD-Score:3.67|P-value:8.50E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:-5.37|P-value:1.48E-7 ID:SGTC_922|Compound:1866-0035|FD-Score:-3.49|P-value:3.33E-4 ID:SGTC_934|Compound:2950-0684|FD-Score:4.60|P-value:3.21E-5 ID:SGTC_937|Compound:3122-0005|FD-Score:-4.39|P-value:1.15E-5 ID:SGTC_968|Compound:1309-0633|FD-Score:3.80|P-value:5.53E-4 ID:SGTC_1056|Compound:3448-1962|FD-Score:4.30|P-value:1.01E-4 ID:SGTC_1117|Compound:retinoic acid|FD-Score:5.04|P-value:5.65E-6 ID:SGTC_1127|Compound:asiatic acid|FD-Score:4.66|P-value:2.62E-5 ID:SGTC_1514|Compound:1189-1591|FD-Score:3.99|P-value:2.97E-4 ID:SGTC_1573|Compound:oleylamine|FD-Score:4.43|P-value:6.20E-5 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:4.92|P-value:9.19E-6 ID:SGTC_1713|Compound:st033146|FD-Score:3.92|P-value:3.80E-4 ID:SGTC_1714|Compound:st033236|FD-Score:3.62|P-value:9.91E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:-4.37|P-value:1.30E-5 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:4.40|P-value:6.97E-5 ID:SGTC_1921|Compound:5740136|FD-Score:4.72|P-value:2.02E-5 ID:SGTC_1993|Compound:st073995|FD-Score:-3.87|P-value:8.61E-5 ID:SGTC_2079|Compound:5212404|FD-Score:-3.54|P-value:2.76E-4 ID:SGTC_2284|Compound:7945075|FD-Score:3.65|P-value:8.85E-4 ID:SGTC_2349|Compound:9023730|FD-Score:4.86|P-value:1.16E-5 ID:SGTC_2358|Compound:9037157|FD-Score:3.87|P-value:4.47E-4 ID:SGTC_2481|Compound:5478948|FD-Score:5.33|P-value:1.55E-6 ID:SGTC_2486|Compound:5283202|FD-Score:4.29|P-value:1.05E-4 ID:SGTC_2512|Compound:diallyl trisulfide|FD-Score:3.71|P-value:7.40E-4 ID:SGTC_2678|Compound:equilin|FD-Score:-3.20|P-value:8.45E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-4.73|P-value:2.78E-6 ID:SGTC_2690|Compound:usnic acid|FD-Score:-3.17|P-value:9.18E-4 ID:SGTC_2782|Compound:7736369|FD-Score:-4.39|P-value:1.19E-5 ID:SGTC_2788|Compound:5282734|FD-Score:3.95|P-value:3.42E-4 ID:SGTC_2789|Compound:5281112|FD-Score:4.97|P-value:7.33E-6 ID:SGTC_3049|Compound:9092223|FD-Score:4.46|P-value:5.54E-5 ID:SGTC_3075|Compound:9116269|FD-Score:5.03|P-value:5.66E-6 ID:SGTC_3112|Compound:9123419|FD-Score:3.71|P-value:7.40E-4 ID:SGTC_3155|Compound:9099265|FD-Score:4.38|P-value:7.48E-5 ID:SGTC_3208|Compound:9114115|FD-Score:-4.01|P-value:5.18E-5 ID:SGTC_3225|Compound:9130819|FD-Score:4.15|P-value:1.71E-4 ID:SGTC_3245|Compound:9134821|FD-Score:5.56|P-value:5.46E-7 ID:SGTC_3250|Compound:9135583|FD-Score:4.29|P-value:1.03E-4 ID:SGTC_3258|Compound:9138477|FD-Score:4.94|P-value:8.51E-6

Top fitness defect scores for YDR074W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3245 9134821 5.56 49.5 µM 5.46E-7 1 1.32E-8
2 SGTC_2481 5478948 5.33 45.2 µM 1.55E-6 PDR1 12 4.81E-8
3 SGTC_362 0310-0100 5.10 9.0 µM 4.31E-6 RPP1 & pyrimidine depletion 7 1.71E-7
4 SGTC_1117 retinoic acid 5.04 1.1 µM 5.65E-6 7 2.39E-7
5 SGTC_3075 9116269 5.03 49.5 µM 5.66E-6 9 2.39E-7
6 SGTC_2789 5281112 4.97 71.4 µM 7.33E-6 13 3.30E-7
7 SGTC_3258 9138477 4.94 49.5 µM 8.51E-6 2 3.97E-7
8 SGTC_1599 8-chlro-1-tetrahydronorharmanone 4.92 90.6 µM 9.19E-6 15 4.37E-7
9 SGTC_2349 9023730 4.86 187.1 µM 1.16E-5 7 5.82E-7
10 SGTC_1921 5740136 4.72 50.0 µM 2.02E-5 TRP & mitochondrial translation 38 1.16E-6
11 SGTC_1127 asiatic acid 4.66 681.4 nM 2.62E-5 11 1.61E-6
12 SGTC_365 0121-0052 4.62 13.6 µM 2.97E-5 mitochondrial response to ROS 37 1.88E-6
13 SGTC_934 2950-0684 4.60 338.0 µM 3.21E-5 10 2.07E-6
14 SGTC_3049 9092223 4.46 49.5 µM 5.54E-5 11 4.08E-6
15 SGTC_361 000s-0510 4.44 1.4 µM 5.90E-5 23 4.41E-6
16 SGTC_749 1000-0129 4.44 128.0 µM 5.94E-5 amide catabolism 10 4.45E-6
17 SGTC_1573 oleylamine 4.43 1.1 µM 6.20E-5 18 4.70E-6
18 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 4.40 70.1 µM 6.97E-5 14 5.43E-6
19 SGTC_3155 9099265 4.38 49.5 µM 7.48E-5 18 5.93E-6
20 SGTC_1056 3448-1962 4.30 115.0 µM 1.01E-4 amide catabolism 15 8.61E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.130 4.59E-14 YJL176C SWI3 hom Subunit of the SWI/SNF chromatin remodeling complex; SWI/SNF regulates transcription by remodeling chromosomes; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2; relocates to the cytosol under hypoxic conditions
0.120 3.00E-12 YAR007C RFA1 het Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination
0.114 4.01E-11 YNL135C FPR1 hom Peptidyl-prolyl cis-trans isomerase (PPIase), binds to the drugs FK506 and rapamycin; also binds to the nonhistone chromatin binding protein Hmo1p and may regulate its assembly or function
0.107 5.59E-10 YKL080W VMA5 hom Subunit C of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane
0.099 8.67E-9 YNL244C SUI1 het Translation initiation factor eIF1; component of a complex involved in recognition of the initiator codon; modulates translation accuracy at the initiation phase
0.091 1.30E-7 YDR429C TIF35 het eIF3g subunit of the core complex of translation initiation factor 3 (eIF3), which is essential for translation; stimulates resumption of ribosomal scanning during translation reinitiation
0.090 1.52E-7 YPR088C SRP54 het Signal recognition particle (SRP) subunit (homolog of mammalian SRP54); contains the signal sequence-binding activity of SRP, interacts with the SRP RNA, and mediates binding of SRP to signal receptor; contains GTPase domain
0.086 5.34E-7 YPL139C UME1 hom Negative regulator of meiosis, required for repression of a subset of meiotic genes during vegetative growth, binding of histone deacetylase Rpd3p required for activity, contains a NEE box and a WD repeat motif; homologous with Wtm1p, Wtm2p
0.085 8.33E-7 YMR205C PFK2 hom Beta subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes
0.081 2.38E-6 YNL199C GCR2 hom Transcriptional activator of genes involved in glycolysis; interacts and functions with the DNA-binding protein Gcr1p
0.078 5.87E-6 YFL021W GAT1 hom Transcriptional activator of genes involved in nitrogen catabolite repression; contains a GATA-1-type zinc finger DNA-binding motif; activity and localization regulated by nitrogen limitation and Ure2p
0.076 9.20E-6 YDR102C_d YDR102C_d hom Dubious open reading frame; homozygous diploid deletion strain exhibits high budding index
0.076 9.94E-6 YGL167C PMR1 hom High affinity Ca2+/Mn2+ P-type ATPase required for Ca2+ and Mn2+ transport into Golgi; involved in Ca2+ dependent protein sorting and processing; mutations in human homolog ATP2C1 cause acantholytic skin condition Hailey-Hailey disease
0.075 1.41E-5 YER107C GLE2 hom RNA export factor associated with the nuclear pore complex (NPC); associates with NUP116p; required for polyadenylated RNA export but not for protein import; homologous to S. pombe Rae1p and human RAE1
0.074 1.91E-5 YML025C YML6 het Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L4 ribosomal protein and human mitoribosomal MRP-L4 protein; essential for viability, unlike most other mitoribosomal proteins