YDR075W / PPH3

Catalytic subunit of protein phosphatase PP4 complex; active complex is composed of Pph3p and Psy2p, with Psy4p apparently providing additional substrate specificity in some cases; regulates recovery from the DNA damage checkpoint and also the gene conversion- and single-strand annealing-mediated pathways of meiotic double-strand break repair; involved in activation of Gln3p to alleviate nitrogen catabolite repression; Pph3p and Psy2p localize to foci on meiotic chromosomes

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR075W / PPH3

Click on Significant Values for Screen Details ID:SGTC_8|Compound:0354-0001|FD-Score:3.68|P-value:2.65E-5 ID:SGTC_11|Compound:0438-0307|FD-Score:2.89|P-value:7.37E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:4.56|P-value:2.84E-7 ID:SGTC_45|Compound:0kpi-0036|FD-Score:3.52|P-value:5.62E-5 ID:SGTC_90|Compound:0870-0863|FD-Score:3.14|P-value:2.80E-4 ID:SGTC_97|Compound:0535-0701|FD-Score:-3.43|P-value:9.51E-5 ID:SGTC_143|Compound:4032-1194|FD-Score:3.21|P-value:2.07E-4 ID:SGTC_196|Compound:k015-0023|FD-Score:3.79|P-value:1.57E-5 ID:SGTC_207|Compound:4185-0010|FD-Score:4.04|P-value:4.54E-6 ID:SGTC_268|Compound:camptothecin|FD-Score:6.51|P-value:4.92E-13 ID:SGTC_335|Compound:4077-0256|FD-Score:2.91|P-value:6.89E-4 ID:SGTC_348|Compound:k064-0012|FD-Score:-4.77|P-value:1.03E-7 ID:SGTC_359|Compound:0081-0058|FD-Score:3.53|P-value:5.30E-5 ID:SGTC_405|Compound:ebelactone b|FD-Score:-3.44|P-value:8.99E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.01|P-value:4.73E-4 ID:SGTC_581|Compound:0958-0271|FD-Score:-2.96|P-value:6.55E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:3.37|P-value:1.09E-4 ID:SGTC_702|Compound:1488-0190|FD-Score:3.06|P-value:3.93E-4 ID:SGTC_773|Compound:4358-1457|FD-Score:4.84|P-value:5.41E-8 ID:SGTC_829|Compound:1635-0120|FD-Score:6.62|P-value:2.03E-13 ID:SGTC_885|Compound:0865-0106|FD-Score:-4.24|P-value:1.92E-6 ID:SGTC_896|Compound:0964-0007|FD-Score:3.36|P-value:1.12E-4 ID:SGTC_928|Compound:2764-0428|FD-Score:-2.89|P-value:8.41E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:-4.32|P-value:1.30E-6 ID:SGTC_934|Compound:2950-0684|FD-Score:-3.04|P-value:4.80E-4 ID:SGTC_961|Compound:1252-1571|FD-Score:3.03|P-value:4.28E-4 ID:SGTC_984|Compound:1492-0255|FD-Score:3.30|P-value:1.43E-4 ID:SGTC_997|Compound:3996-0078|FD-Score:3.66|P-value:2.92E-5 ID:SGTC_1075|Compound:aripiprazole|FD-Score:4.44|P-value:5.48E-7 ID:SGTC_1079|Compound:idarubicin|FD-Score:3.91|P-value:8.98E-6 ID:SGTC_1089|Compound:terbinafine|FD-Score:3.83|P-value:1.29E-5 ID:SGTC_1121|Compound:fusaric acid|FD-Score:-4.67|P-value:1.83E-7 ID:SGTC_1123|Compound:mangostin|FD-Score:-3.54|P-value:5.87E-5 ID:SGTC_1137|Compound:ixabepilone|FD-Score:-3.00|P-value:5.54E-4 ID:SGTC_1145|Compound:3546-0597|FD-Score:3.31|P-value:1.41E-4 ID:SGTC_1152|Compound:3909-8331|FD-Score:3.49|P-value:6.31E-5 ID:SGTC_1153|Compound:4055-0057|FD-Score:4.59|P-value:2.40E-7 ID:SGTC_1155|Compound:4088-0394|FD-Score:4.85|P-value:5.11E-8 ID:SGTC_1198|Compound:1612-1005|FD-Score:3.28|P-value:1.57E-4 ID:SGTC_1286|Compound:0929-0070|FD-Score:2.97|P-value:5.42E-4 ID:SGTC_1345|Compound:1488-0192|FD-Score:3.28|P-value:1.59E-4 ID:SGTC_1362|Compound:1611-0397|FD-Score:5.19|P-value:6.24E-9 ID:SGTC_1363|Compound:1636-0063|FD-Score:3.18|P-value:2.36E-4 ID:SGTC_1396|Compound:3511-0007|FD-Score:-3.15|P-value:3.10E-4 ID:SGTC_1402|Compound:3909-7673|FD-Score:2.96|P-value:5.80E-4 ID:SGTC_1457|Compound:k015-0032|FD-Score:3.11|P-value:3.12E-4 ID:SGTC_1479|Compound:0549-0158|FD-Score:2.83|P-value:9.34E-4 ID:SGTC_1487|Compound:3970-0795|FD-Score:3.24|P-value:1.83E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:3.33|P-value:1.28E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:-4.44|P-value:6.53E-7 ID:SGTC_1521|Compound:st012942|FD-Score:3.63|P-value:3.33E-5 ID:SGTC_1522|Compound:st012842|FD-Score:4.86|P-value:4.96E-8 ID:SGTC_1642|Compound:st009582|FD-Score:3.11|P-value:3.12E-4 ID:SGTC_1648|Compound:st011736|FD-Score:3.16|P-value:2.59E-4 ID:SGTC_1687|Compound:st020778|FD-Score:2.91|P-value:7.04E-4 ID:SGTC_1707|Compound:st032323|FD-Score:12.20|P-value:1.11E-40 ID:SGTC_1712|Compound:st032288|FD-Score:3.82|P-value:1.40E-5 ID:SGTC_1780|Compound:st038448|FD-Score:3.48|P-value:6.62E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:-4.01|P-value:6.29E-6 ID:SGTC_1862|Compound:st057513|FD-Score:-3.44|P-value:9.07E-5 ID:SGTC_1866|Compound:st057638|FD-Score:4.09|P-value:3.50E-6 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:-2.85|P-value:9.82E-4 ID:SGTC_1874|Compound:staurosporine|FD-Score:2.82|P-value:9.51E-4 ID:SGTC_1999|Compound:st074831|FD-Score:-2.89|P-value:8.39E-4 ID:SGTC_2038|Compound:4100038|FD-Score:-3.19|P-value:2.58E-4 ID:SGTC_2049|Compound:5262831|FD-Score:-3.00|P-value:5.57E-4 ID:SGTC_2057|Compound:5236571|FD-Score:9.13|P-value:7.86E-24 ID:SGTC_2058|Compound:5236698|FD-Score:2.91|P-value:6.94E-4 ID:SGTC_2427|Compound:5545055|FD-Score:-3.10|P-value:3.70E-4 ID:SGTC_2431|Compound:5490079|FD-Score:3.44|P-value:7.95E-5 ID:SGTC_2441|Compound:5730946|FD-Score:3.03|P-value:4.28E-4 ID:SGTC_2476|Compound:5806916|FD-Score:2.82|P-value:9.55E-4 ID:SGTC_2482|Compound:5981709|FD-Score:3.28|P-value:1.54E-4 ID:SGTC_2485|Compound:5633444|FD-Score:3.08|P-value:3.62E-4 ID:SGTC_2486|Compound:5283202|FD-Score:-3.68|P-value:3.15E-5 ID:SGTC_2752|Compound:diclazuril|FD-Score:2.83|P-value:9.40E-4 ID:SGTC_2788|Compound:5282734|FD-Score:4.49|P-value:4.27E-7 ID:SGTC_3041|Compound:9091929|FD-Score:-2.90|P-value:7.99E-4 ID:SGTC_3155|Compound:9099265|FD-Score:3.30|P-value:1.44E-4 ID:SGTC_3218|Compound:9131285|FD-Score:4.92|P-value:3.49E-8 ID:SGTC_3237|Compound:9133362|FD-Score:2.89|P-value:7.39E-4 ID:SGTC_3247|Compound:9135149|FD-Score:3.15|P-value:2.74E-4 ID:SGTC_8|Compound:0354-0001|FD-Score:3.68|P-value:2.65E-5 ID:SGTC_11|Compound:0438-0307|FD-Score:2.89|P-value:7.37E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:4.56|P-value:2.84E-7 ID:SGTC_45|Compound:0kpi-0036|FD-Score:3.52|P-value:5.62E-5 ID:SGTC_90|Compound:0870-0863|FD-Score:3.14|P-value:2.80E-4 ID:SGTC_97|Compound:0535-0701|FD-Score:-3.43|P-value:9.51E-5 ID:SGTC_143|Compound:4032-1194|FD-Score:3.21|P-value:2.07E-4 ID:SGTC_196|Compound:k015-0023|FD-Score:3.79|P-value:1.57E-5 ID:SGTC_207|Compound:4185-0010|FD-Score:4.04|P-value:4.54E-6 ID:SGTC_268|Compound:camptothecin|FD-Score:6.51|P-value:4.92E-13 ID:SGTC_335|Compound:4077-0256|FD-Score:2.91|P-value:6.89E-4 ID:SGTC_348|Compound:k064-0012|FD-Score:-4.77|P-value:1.03E-7 ID:SGTC_359|Compound:0081-0058|FD-Score:3.53|P-value:5.30E-5 ID:SGTC_405|Compound:ebelactone b|FD-Score:-3.44|P-value:8.99E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.01|P-value:4.73E-4 ID:SGTC_581|Compound:0958-0271|FD-Score:-2.96|P-value:6.55E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:3.37|P-value:1.09E-4 ID:SGTC_702|Compound:1488-0190|FD-Score:3.06|P-value:3.93E-4 ID:SGTC_773|Compound:4358-1457|FD-Score:4.84|P-value:5.41E-8 ID:SGTC_829|Compound:1635-0120|FD-Score:6.62|P-value:2.03E-13 ID:SGTC_885|Compound:0865-0106|FD-Score:-4.24|P-value:1.92E-6 ID:SGTC_896|Compound:0964-0007|FD-Score:3.36|P-value:1.12E-4 ID:SGTC_928|Compound:2764-0428|FD-Score:-2.89|P-value:8.41E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:-4.32|P-value:1.30E-6 ID:SGTC_934|Compound:2950-0684|FD-Score:-3.04|P-value:4.80E-4 ID:SGTC_961|Compound:1252-1571|FD-Score:3.03|P-value:4.28E-4 ID:SGTC_984|Compound:1492-0255|FD-Score:3.30|P-value:1.43E-4 ID:SGTC_997|Compound:3996-0078|FD-Score:3.66|P-value:2.92E-5 ID:SGTC_1075|Compound:aripiprazole|FD-Score:4.44|P-value:5.48E-7 ID:SGTC_1079|Compound:idarubicin|FD-Score:3.91|P-value:8.98E-6 ID:SGTC_1089|Compound:terbinafine|FD-Score:3.83|P-value:1.29E-5 ID:SGTC_1121|Compound:fusaric acid|FD-Score:-4.67|P-value:1.83E-7 ID:SGTC_1123|Compound:mangostin|FD-Score:-3.54|P-value:5.87E-5 ID:SGTC_1137|Compound:ixabepilone|FD-Score:-3.00|P-value:5.54E-4 ID:SGTC_1145|Compound:3546-0597|FD-Score:3.31|P-value:1.41E-4 ID:SGTC_1152|Compound:3909-8331|FD-Score:3.49|P-value:6.31E-5 ID:SGTC_1153|Compound:4055-0057|FD-Score:4.59|P-value:2.40E-7 ID:SGTC_1155|Compound:4088-0394|FD-Score:4.85|P-value:5.11E-8 ID:SGTC_1198|Compound:1612-1005|FD-Score:3.28|P-value:1.57E-4 ID:SGTC_1286|Compound:0929-0070|FD-Score:2.97|P-value:5.42E-4 ID:SGTC_1345|Compound:1488-0192|FD-Score:3.28|P-value:1.59E-4 ID:SGTC_1362|Compound:1611-0397|FD-Score:5.19|P-value:6.24E-9 ID:SGTC_1363|Compound:1636-0063|FD-Score:3.18|P-value:2.36E-4 ID:SGTC_1396|Compound:3511-0007|FD-Score:-3.15|P-value:3.10E-4 ID:SGTC_1402|Compound:3909-7673|FD-Score:2.96|P-value:5.80E-4 ID:SGTC_1457|Compound:k015-0032|FD-Score:3.11|P-value:3.12E-4 ID:SGTC_1479|Compound:0549-0158|FD-Score:2.83|P-value:9.34E-4 ID:SGTC_1487|Compound:3970-0795|FD-Score:3.24|P-value:1.83E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:3.33|P-value:1.28E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:-4.44|P-value:6.53E-7 ID:SGTC_1521|Compound:st012942|FD-Score:3.63|P-value:3.33E-5 ID:SGTC_1522|Compound:st012842|FD-Score:4.86|P-value:4.96E-8 ID:SGTC_1642|Compound:st009582|FD-Score:3.11|P-value:3.12E-4 ID:SGTC_1648|Compound:st011736|FD-Score:3.16|P-value:2.59E-4 ID:SGTC_1687|Compound:st020778|FD-Score:2.91|P-value:7.04E-4 ID:SGTC_1707|Compound:st032323|FD-Score:12.20|P-value:1.11E-40 ID:SGTC_1712|Compound:st032288|FD-Score:3.82|P-value:1.40E-5 ID:SGTC_1780|Compound:st038448|FD-Score:3.48|P-value:6.62E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:-4.01|P-value:6.29E-6 ID:SGTC_1862|Compound:st057513|FD-Score:-3.44|P-value:9.07E-5 ID:SGTC_1866|Compound:st057638|FD-Score:4.09|P-value:3.50E-6 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:-2.85|P-value:9.82E-4 ID:SGTC_1874|Compound:staurosporine|FD-Score:2.82|P-value:9.51E-4 ID:SGTC_1999|Compound:st074831|FD-Score:-2.89|P-value:8.39E-4 ID:SGTC_2038|Compound:4100038|FD-Score:-3.19|P-value:2.58E-4 ID:SGTC_2049|Compound:5262831|FD-Score:-3.00|P-value:5.57E-4 ID:SGTC_2057|Compound:5236571|FD-Score:9.13|P-value:7.86E-24 ID:SGTC_2058|Compound:5236698|FD-Score:2.91|P-value:6.94E-4 ID:SGTC_2427|Compound:5545055|FD-Score:-3.10|P-value:3.70E-4 ID:SGTC_2431|Compound:5490079|FD-Score:3.44|P-value:7.95E-5 ID:SGTC_2441|Compound:5730946|FD-Score:3.03|P-value:4.28E-4 ID:SGTC_2476|Compound:5806916|FD-Score:2.82|P-value:9.55E-4 ID:SGTC_2482|Compound:5981709|FD-Score:3.28|P-value:1.54E-4 ID:SGTC_2485|Compound:5633444|FD-Score:3.08|P-value:3.62E-4 ID:SGTC_2486|Compound:5283202|FD-Score:-3.68|P-value:3.15E-5 ID:SGTC_2752|Compound:diclazuril|FD-Score:2.83|P-value:9.40E-4 ID:SGTC_2788|Compound:5282734|FD-Score:4.49|P-value:4.27E-7 ID:SGTC_3041|Compound:9091929|FD-Score:-2.90|P-value:7.99E-4 ID:SGTC_3155|Compound:9099265|FD-Score:3.30|P-value:1.44E-4 ID:SGTC_3218|Compound:9131285|FD-Score:4.92|P-value:3.49E-8 ID:SGTC_3237|Compound:9133362|FD-Score:2.89|P-value:7.39E-4 ID:SGTC_3247|Compound:9135149|FD-Score:3.15|P-value:2.74E-4

Top fitness defect scores for YDR075W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1707 st032323 12.20 6.3 µM 1.11E-40 DNA damage response 6 2.73E-34
2 SGTC_2057 5236571 9.13 38.3 µM 7.86E-24 RPP1 & pyrimidine depletion 1 3.44E-20
3 SGTC_829 1635-0120 6.62 117.0 µM 2.03E-13 DNA damage response 9 1.80E-11
4 SGTC_268 camptothecin 6.51 39.6 µM 4.92E-13 DNA damage response 24 3.77E-11
5 SGTC_1362 1611-0397 5.19 101.0 µM 6.24E-9 4 1.04E-7
6 SGTC_3218 9131285 4.92 49.5 µM 3.49E-8 endomembrane recycling 19 4.41E-7
7 SGTC_1522 st012842 4.86 45.6 µM 4.96E-8 RNA pol III & RNase P/MRP 12 5.92E-7
8 SGTC_1155 4088-0394 4.85 48.2 µM 5.11E-8 10 6.07E-7
9 SGTC_773 4358-1457 4.84 44.6 µM 5.41E-8 23 6.36E-7
10 SGTC_1153 4055-0057 4.59 267.0 µM 2.40E-7 9 2.22E-6
11 SGTC_43 0570-0105 4.56 72.5 µM 2.84E-7 ERG2 66 2.56E-6
12 SGTC_2788 5282734 4.49 71.4 µM 4.27E-7 26 3.61E-6
13 SGTC_1075 aripiprazole 4.44 15.2 µM 5.48E-7 14 4.44E-6
14 SGTC_1866 st057638 4.09 64.0 µM 3.50E-6 11 2.11E-5
15 SGTC_207 4185-0010 4.04 4.5 µM 4.54E-6 endomembrane recycling 84 2.62E-5
16 SGTC_1079 idarubicin 3.91 2.4 µM 8.98E-6 DNA damage response 24 4.66E-5
17 SGTC_1089 terbinafine 3.83 2.2 µM 1.29E-5 15 6.31E-5
18 SGTC_1712 st032288 3.82 53.4 µM 1.40E-5 calcium & mitochondrial duress 195 6.75E-5
19 SGTC_196 k015-0023 3.79 18.1 µM 1.57E-5 PDR1 25 7.45E-5
20 SGTC_8 0354-0001 3.68 70.0 µM 2.65E-5 88 1.16E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.308 1.92E-74 YDL059C RAD59 hom Protein involved DNA double-strand break repair; repairs breaks in DNA during vegetative growth via recombination and single-strand annealing; anneals complementary single-stranded DNA; forms nuclear foci upon DNA replication stress; required for loading of Rad52p to DSBs; paralog of Rad52p
0.268 2.86E-56 YGL175C SAE2 hom Endonuclease that processes hairpin DNA structures with the MRX complex; involved in meiotic and mitotic double-strand break repair; phosphorylated in response to DNA damage and required for normal resistance to DNA-damaging agents
0.225 7.39E-40 YMR048W CSM3 hom Replication fork associated factor; required for stable replication fork pausing; component of the DNA replication checkpoint pathway; required for accurate chromosome segregation during meiosis; forms nuclear foci upon DNA replication stress
0.217 3.62E-37 YOR191W ULS1 hom Protein involved in proteolytic control of sumoylated substrates; contains RING finger domain; interacts with SUMO (Smt3p); member of the SWI/SNF family of DNA-dependent ATPases; plays a role in antagonizing silencing during mating-type switching; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.211 5.27E-35 YDR076W RAD55 hom Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad57p
0.196 1.91E-30 YJL092W SRS2 hom DNA helicase and DNA-dependent ATPase involved in DNA repair and checkpoint recovery, needed for proper timing of commitment to meiotic recombination and transition from Meiosis I to II; blocks trinucleotide repeat expansion; affects genome stability
0.192 3.17E-29 YDR004W RAD57 hom Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad55p
0.188 3.89E-28 YDR386W MUS81 hom Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in DNA repair, replication fork stability, and joint molecule formation/resolution during meiotic recombination; helix-hairpin-helix protein; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates the function of Mms4p-Mus81p
0.177 4.71E-25 YBR099C_d YBR099C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene MMS4
0.176 8.65E-25 YBR098W MMS4 hom Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in recombination, DNA repair, and joint molecule formation/resolution during meiotic recombination; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates the function of Mms4p-Mus81p
0.172 1.41E-23 YGL163C RAD54 hom DNA-dependent ATPase that stimulates strand exchange; modifies the topology of double-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; member of the SWI/SNF family; forms nuclear foci upon DNA replication stress
0.156 1.20E-19 YNL273W TOF1 hom Subunit of a replication-pausing checkpoint complex (Tof1p-Mrc1p-Csm3p) that acts at the stalled replication fork to promote sister chromatid cohesion after DNA damage, facilitating gap repair of damaged DNA; interacts with the MCM helicase
0.155 1.57E-19 YLR135W SLX4 hom Endonuclease involved in processing DNA; acts during recombination and repair; cleaves branched structures in a complex with Slx1p; involved interstrand cross-link repair and in Rad1p/Rad10p-dependent removal of 3'-nonhomologous tails during DSBR via single-strand annealing; relative distribution to nuclear foci increases upon DNA replication stress
0.136 2.14E-15 YKL175W ZRT3 hom Vacuolar membrane zinc transporter, transports zinc from storage in the vacuole to the cytoplasm when needed; transcription is induced under conditions of zinc deficiency
0.134 5.67E-15 YBL088C TEL1 hom Protein kinase primarily involved in telomere length regulation; contributes to cell cycle checkpoint control in response to DNA damage; functionally redundant with Mec1p; regulates P-body formation induced by replication stress; homolog of human ataxia-telangiectasia mutated (ATM) gene, the gene responsible for ataxia telangiectasia (AT) (OMIM 607585)