YDR079C-A / TFB5

Component of the RNA polymerase II general transcription and DNA repair factor TFIIH; involved in transcription initiation and in nucleotide-excision repair; homolog of Chlamydomonas reinhardtii REX1-S protein involved in DNA repair

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR079C-A / TFB5

Click on Significant Values for Screen Details ID:SGTC_43|Compound:0570-0105|FD-Score:3.81|P-value:6.12E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.46|P-value:2.32E-4 ID:SGTC_75|Compound:0159-0059|FD-Score:-3.06|P-value:9.91E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:3.63|P-value:1.24E-4 ID:SGTC_177|Compound:1327-0068|FD-Score:3.15|P-value:7.47E-4 ID:SGTC_179|Compound:1273-0063|FD-Score:3.49|P-value:2.14E-4 ID:SGTC_375|Compound:3970-0961|FD-Score:3.09|P-value:8.95E-4 ID:SGTC_405|Compound:ebelactone b|FD-Score:6.98|P-value:9.06E-13 ID:SGTC_551|Compound:k048-0028|FD-Score:3.60|P-value:1.41E-4 ID:SGTC_569|Compound:4130-2812|FD-Score:3.50|P-value:2.04E-4 ID:SGTC_575|Compound:k072-0246|FD-Score:4.53|P-value:2.39E-6 ID:SGTC_588|Compound:3970-1144|FD-Score:3.21|P-value:6.04E-4 ID:SGTC_679|Compound:0422-0091|FD-Score:4.63|P-value:1.49E-6 ID:SGTC_718|Compound:1130-0073|FD-Score:5.28|P-value:5.04E-8 ID:SGTC_724|Compound:3910-0327|FD-Score:3.42|P-value:2.83E-4 ID:SGTC_731|Compound:3966-0296|FD-Score:3.38|P-value:3.25E-4 ID:SGTC_736|Compound:0958-0254|FD-Score:5.21|P-value:7.08E-8 ID:SGTC_738|Compound:1315-0003|FD-Score:5.03|P-value:1.93E-7 ID:SGTC_871|Compound:0574-0004|FD-Score:3.31|P-value:4.14E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:3.17|P-value:6.94E-4 ID:SGTC_895|Compound:0964-0006|FD-Score:4.51|P-value:2.70E-6 ID:SGTC_930|Compound:2810-3379|FD-Score:4.47|P-value:3.16E-6 ID:SGTC_948|Compound:3448-0295|FD-Score:3.37|P-value:3.40E-4 ID:SGTC_1034|Compound:k072-0165|FD-Score:3.69|P-value:9.69E-5 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:-3.13|P-value:7.90E-4 ID:SGTC_1329|Compound:1447-1697|FD-Score:5.79|P-value:2.53E-9 ID:SGTC_1419|Compound:3993-2473|FD-Score:4.38|P-value:4.88E-6 ID:SGTC_1545|Compound:lovastatin|FD-Score:4.14|P-value:1.50E-5 ID:SGTC_1629|Compound:st005085|FD-Score:3.27|P-value:4.76E-4 ID:SGTC_1638|Compound:st008370|FD-Score:3.60|P-value:1.39E-4 ID:SGTC_1754|Compound:st042065|FD-Score:-3.10|P-value:8.77E-4 ID:SGTC_1848|Compound:st056003|FD-Score:3.12|P-value:8.12E-4 ID:SGTC_1921|Compound:5740136|FD-Score:4.47|P-value:3.18E-6 ID:SGTC_1922|Compound:5578187|FD-Score:4.01|P-value:2.56E-5 ID:SGTC_1928|Compound:4'-methoxychalcone|FD-Score:3.50|P-value:2.03E-4 ID:SGTC_1991|Compound:st073000|FD-Score:4.78|P-value:7.00E-7 ID:SGTC_1999|Compound:st074831|FD-Score:3.16|P-value:7.23E-4 ID:SGTC_2004|Compound:4023728|FD-Score:4.11|P-value:1.65E-5 ID:SGTC_2069|Compound:5228469|FD-Score:3.35|P-value:3.61E-4 ID:SGTC_2085|Compound:5307070|FD-Score:3.31|P-value:4.21E-4 ID:SGTC_2088|Compound:5278280|FD-Score:3.46|P-value:2.35E-4 ID:SGTC_2089|Compound:5281248|FD-Score:5.95|P-value:9.24E-10 ID:SGTC_2110|Compound:5483698|FD-Score:3.54|P-value:1.76E-4 ID:SGTC_2331|Compound:7980721|FD-Score:4.38|P-value:4.95E-6 ID:SGTC_2370|Compound:9071495|FD-Score:4.18|P-value:1.26E-5 ID:SGTC_2401|Compound:5128683|FD-Score:3.45|P-value:2.49E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:9.18|P-value:9.25E-21 ID:SGTC_2483|Compound:5729050|FD-Score:4.88|P-value:4.15E-7 ID:SGTC_2576|Compound:guaiol|FD-Score:3.53|P-value:1.85E-4 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:5.22|P-value:6.90E-8 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:3.57|P-value:1.57E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.54|P-value:1.78E-4 ID:SGTC_2729|Compound:fluphenazine|FD-Score:3.73|P-value:8.51E-5 ID:SGTC_2750|Compound:bromebric acid|FD-Score:3.10|P-value:8.85E-4 ID:SGTC_2828|Compound:7998861|FD-Score:3.21|P-value:6.09E-4 ID:SGTC_2885|Compound:9057732|FD-Score:4.45|P-value:3.47E-6 ID:SGTC_2970|Compound:9090938|FD-Score:3.36|P-value:3.54E-4 ID:SGTC_2991|Compound:9074669|FD-Score:-3.08|P-value:9.39E-4 ID:SGTC_3000|Compound:9075062|FD-Score:4.60|P-value:1.75E-6 ID:SGTC_3002|Compound:9075603|FD-Score:4.49|P-value:2.92E-6 ID:SGTC_3151|Compound:9099821|FD-Score:3.92|P-value:3.78E-5 ID:SGTC_3219|Compound:9131112|FD-Score:-3.44|P-value:2.51E-4 ID:SGTC_3234|Compound:9132280|FD-Score:3.71|P-value:8.93E-5 ID:SGTC_3294|Compound:9122953|FD-Score:4.23|P-value:9.63E-6 ID:SGTC_3308|Compound:9128332|FD-Score:3.73|P-value:8.32E-5 ID:SGTC_43|Compound:0570-0105|FD-Score:3.81|P-value:6.12E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.46|P-value:2.32E-4 ID:SGTC_75|Compound:0159-0059|FD-Score:-3.06|P-value:9.91E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:3.63|P-value:1.24E-4 ID:SGTC_177|Compound:1327-0068|FD-Score:3.15|P-value:7.47E-4 ID:SGTC_179|Compound:1273-0063|FD-Score:3.49|P-value:2.14E-4 ID:SGTC_375|Compound:3970-0961|FD-Score:3.09|P-value:8.95E-4 ID:SGTC_405|Compound:ebelactone b|FD-Score:6.98|P-value:9.06E-13 ID:SGTC_551|Compound:k048-0028|FD-Score:3.60|P-value:1.41E-4 ID:SGTC_569|Compound:4130-2812|FD-Score:3.50|P-value:2.04E-4 ID:SGTC_575|Compound:k072-0246|FD-Score:4.53|P-value:2.39E-6 ID:SGTC_588|Compound:3970-1144|FD-Score:3.21|P-value:6.04E-4 ID:SGTC_679|Compound:0422-0091|FD-Score:4.63|P-value:1.49E-6 ID:SGTC_718|Compound:1130-0073|FD-Score:5.28|P-value:5.04E-8 ID:SGTC_724|Compound:3910-0327|FD-Score:3.42|P-value:2.83E-4 ID:SGTC_731|Compound:3966-0296|FD-Score:3.38|P-value:3.25E-4 ID:SGTC_736|Compound:0958-0254|FD-Score:5.21|P-value:7.08E-8 ID:SGTC_738|Compound:1315-0003|FD-Score:5.03|P-value:1.93E-7 ID:SGTC_871|Compound:0574-0004|FD-Score:3.31|P-value:4.14E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:3.17|P-value:6.94E-4 ID:SGTC_895|Compound:0964-0006|FD-Score:4.51|P-value:2.70E-6 ID:SGTC_930|Compound:2810-3379|FD-Score:4.47|P-value:3.16E-6 ID:SGTC_948|Compound:3448-0295|FD-Score:3.37|P-value:3.40E-4 ID:SGTC_1034|Compound:k072-0165|FD-Score:3.69|P-value:9.69E-5 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:-3.13|P-value:7.90E-4 ID:SGTC_1329|Compound:1447-1697|FD-Score:5.79|P-value:2.53E-9 ID:SGTC_1419|Compound:3993-2473|FD-Score:4.38|P-value:4.88E-6 ID:SGTC_1545|Compound:lovastatin|FD-Score:4.14|P-value:1.50E-5 ID:SGTC_1629|Compound:st005085|FD-Score:3.27|P-value:4.76E-4 ID:SGTC_1638|Compound:st008370|FD-Score:3.60|P-value:1.39E-4 ID:SGTC_1754|Compound:st042065|FD-Score:-3.10|P-value:8.77E-4 ID:SGTC_1848|Compound:st056003|FD-Score:3.12|P-value:8.12E-4 ID:SGTC_1921|Compound:5740136|FD-Score:4.47|P-value:3.18E-6 ID:SGTC_1922|Compound:5578187|FD-Score:4.01|P-value:2.56E-5 ID:SGTC_1928|Compound:4'-methoxychalcone|FD-Score:3.50|P-value:2.03E-4 ID:SGTC_1991|Compound:st073000|FD-Score:4.78|P-value:7.00E-7 ID:SGTC_1999|Compound:st074831|FD-Score:3.16|P-value:7.23E-4 ID:SGTC_2004|Compound:4023728|FD-Score:4.11|P-value:1.65E-5 ID:SGTC_2069|Compound:5228469|FD-Score:3.35|P-value:3.61E-4 ID:SGTC_2085|Compound:5307070|FD-Score:3.31|P-value:4.21E-4 ID:SGTC_2088|Compound:5278280|FD-Score:3.46|P-value:2.35E-4 ID:SGTC_2089|Compound:5281248|FD-Score:5.95|P-value:9.24E-10 ID:SGTC_2110|Compound:5483698|FD-Score:3.54|P-value:1.76E-4 ID:SGTC_2331|Compound:7980721|FD-Score:4.38|P-value:4.95E-6 ID:SGTC_2370|Compound:9071495|FD-Score:4.18|P-value:1.26E-5 ID:SGTC_2401|Compound:5128683|FD-Score:3.45|P-value:2.49E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:9.18|P-value:9.25E-21 ID:SGTC_2483|Compound:5729050|FD-Score:4.88|P-value:4.15E-7 ID:SGTC_2576|Compound:guaiol|FD-Score:3.53|P-value:1.85E-4 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:5.22|P-value:6.90E-8 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:3.57|P-value:1.57E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.54|P-value:1.78E-4 ID:SGTC_2729|Compound:fluphenazine|FD-Score:3.73|P-value:8.51E-5 ID:SGTC_2750|Compound:bromebric acid|FD-Score:3.10|P-value:8.85E-4 ID:SGTC_2828|Compound:7998861|FD-Score:3.21|P-value:6.09E-4 ID:SGTC_2885|Compound:9057732|FD-Score:4.45|P-value:3.47E-6 ID:SGTC_2970|Compound:9090938|FD-Score:3.36|P-value:3.54E-4 ID:SGTC_2991|Compound:9074669|FD-Score:-3.08|P-value:9.39E-4 ID:SGTC_3000|Compound:9075062|FD-Score:4.60|P-value:1.75E-6 ID:SGTC_3002|Compound:9075603|FD-Score:4.49|P-value:2.92E-6 ID:SGTC_3151|Compound:9099821|FD-Score:3.92|P-value:3.78E-5 ID:SGTC_3219|Compound:9131112|FD-Score:-3.44|P-value:2.51E-4 ID:SGTC_3234|Compound:9132280|FD-Score:3.71|P-value:8.93E-5 ID:SGTC_3294|Compound:9122953|FD-Score:4.23|P-value:9.63E-6 ID:SGTC_3308|Compound:9128332|FD-Score:3.73|P-value:8.32E-5

Top fitness defect scores for YDR079C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2407 paclitaxel 9.18 400.0 µM 9.25E-21 3 2.09E-20
2 SGTC_405 ebelactone b 6.98 50.0 µM 9.06E-13 1 1.45E-12
3 SGTC_2089 5281248 5.95 129.7 µM 9.24E-10 superoxide 7 1.31E-9
4 SGTC_1329 1447-1697 5.79 50.6 µM 2.53E-9 4 3.50E-9
5 SGTC_718 1130-0073 5.28 349.0 µM 5.04E-8 7 6.61E-8
6 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 5.22 15.3 µM 6.90E-8 13 9.00E-8
7 SGTC_736 0958-0254 5.21 92.6 µM 7.08E-8 Golgi 9 9.23E-8
8 SGTC_738 1315-0003 5.03 72.4 µM 1.93E-7 7 2.47E-7
9 SGTC_2483 5729050 4.88 27.2 µM 4.15E-7 11 5.24E-7
10 SGTC_1991 st073000 4.78 8.9 µM 7.00E-7 NEO1 57 8.75E-7
11 SGTC_679 0422-0091 4.63 41.4 µM 1.49E-6 Golgi 16 1.84E-6
12 SGTC_3000 9075062 4.60 71.4 µM 1.75E-6 7 2.15E-6
13 SGTC_575 k072-0246 4.53 11.9 µM 2.39E-6 13 2.93E-6
14 SGTC_895 0964-0006 4.51 13.7 µM 2.70E-6 5 3.30E-6
15 SGTC_3002 9075603 4.49 71.4 µM 2.92E-6 9 3.56E-6
16 SGTC_930 2810-3379 4.47 265.0 µM 3.16E-6 6 3.85E-6
17 SGTC_1921 5740136 4.47 50.0 µM 3.18E-6 TRP & mitochondrial translation 40 3.87E-6
18 SGTC_2885 9057732 4.45 52.0 µM 3.47E-6 9 4.22E-6
19 SGTC_1419 3993-2473 4.38 62.6 µM 4.88E-6 9 5.90E-6
20 SGTC_2331 7980721 4.38 200.0 µM 4.95E-6 18 5.97E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.125 3.39E-13 YDR510W SMT3 het Ubiquitin-like protein of the SUMO family, conjugated to lysine residues of target proteins; regulates chromatid cohesion, chromosome segregation, APC-mediated proteolysis, DNA replication and septin ring dynamics; phosphorylated at Ser2
0.108 3.69E-10 YBR181C RPS6B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S6, no bacterial homolog; RPS6B has a paralog, RPS6A, that arose from the whole genome duplication
0.108 4.11E-10 YER087C-A_d YER087C-A_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; overlaps the uncharacterized gene YER087W, a putative tRNA synthetase
0.095 3.78E-8 YLR024C UBR2 hom Cytoplasmic ubiquitin-protein ligase (E3); required for ubiquitylation of Rpn4p; mediates formation of a Mub1p-Ubr2p-Rad6p complex
0.095 4.11E-8 YPL171C OYE3 hom Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN), homologous to Oye2p with different ligand binding and catalytic properties; has potential roles in oxidative stress response and programmed cell death
0.093 6.13E-8 YER157W COG3 het Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
0.093 7.26E-8 YHL010C ETP1 hom Putative protein of unknown function that is required for growth on ethanol; contains a zinc finger region and has homology to human BRAP2, which is a cytoplasmic protein that binds nuclear localization sequences
0.091 1.20E-7 YHR041C SRB2 hom Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; general transcription factor involved in telomere maintenance
0.087 4.22E-7 YDR443C SSN2 hom Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for stable association of Srb10p-Srb11p kinase; essential for transcriptional regulation
0.085 8.57E-7 YLL044W_d YLL044W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YLL044W and the overlapping gene RPL8B is reduced in the gcr1 null mutant
0.084 1.18E-6 YCR015C_p YCR015C_p hom Putative protein of unknown function; YCR015C is not an essential gene
0.081 3.00E-6 YDL053C PBP4 hom Pbp1p binding protein; interacts strongly with Pab1p-binding protein 1 (Pbp1p) in the yeast two-hybrid system; also interacts with Lsm12p in a copurification assay; relative distribution to the nucleus increases upon DNA replication stress
0.080 3.14E-6 YIL069C RPS24B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S24, no bacterial homolog; RPS24B has a paralog, RPS24A, that arose from the whole genome duplication
0.079 4.27E-6 YBR252W DUT1 het deoxyuridine triphosphate diphosphatase (dUTPase); catalyzes hydrolysis of dUTP to dUMP and PPi, thereby preventing incorporation of uracil into DNA during replication; critical for the maintenance of genetic stability; also has diphosphatase activity on deoxyinosine triphosphate
0.076 1.08E-5 YNL258C DSL1 het Peripheral membrane protein needed for Golgi-to-ER retrograde traffic; forms a complex with Sec39p and Tip20p that interacts with ER SNAREs Sec20p and Use1p; component of the ER target site that interacts with coatomer; interacts with Cin5p; similar to the fly and human ZW10 gene