HIPHOP chemogenomics database

YDR079W / PET100

Chaperone that specifically facilitates the assembly of cytochrome c oxidase, integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme

Zygosity: Homozygous strain

fixedexpanded
Profile for YDR079W / PET100

Click on Significant Values for Screen Details

Top fitness defect scores for YDR079W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_236	1509-0011	26.90	5.3 µM	2.58E-145		26	1.09E-159
2	SGTC_1635	st007035	11.50	42.4 µM	2.70E-28		64	6.94E-31
3	SGTC_275	trichlorophene	9.72	5.7 µM	8.78E-21	mitochondrial stress	48	1.26E-22
4	SGTC_134	0269-0018	8.39	6.9 µM	5.56E-16		56	2.36E-17
5	SGTC_386	1509-0011	7.52	3.1 µM	3.49E-13		72	2.79E-14
6	SGTC_173	1273-0061	7.15	2.7 µM	4.27E-12	mitochondrial stress	83	4.35E-13
7	SGTC_70	0141-0289	6.60	43.3 µM	1.43E-10	mitochondrial stress	62	2.04E-11
8	SGTC_1188	1403-0014	6.51	4.6 µM	2.44E-10	mitochondrial stress	15	3.69E-11
9	SGTC_116	0155-0182	6.29	31.8 µM	9.02E-10	mitochondrial response to ROS	21	1.54E-10
10	SGTC_310	1273-0058	6.09	1.1 µM	2.95E-9	mitochondrial stress	141	5.66E-10
11	SGTC_519	k048-0011	5.38	62.8 µM	1.32E-7		5	3.65E-8
12	SGTC_119	0121-0043	5.34	24.8 µM	1.68E-7	mitochondrial stress	42	4.75E-8
13	SGTC_2972	9093619	5.19	59.9 µM	3.51E-7		5	1.06E-7
14	SGTC_908	3448-7491	5.15	47.7 µM	4.33E-7	mitochondrial stress	74	1.34E-7
15	SGTC_2250	alverine citrate	5.13	130.0 µM	4.62E-7		90	1.43E-7
16	SGTC_10	0279-0212	5.08	42.6 µM	5.97E-7	TRP & mitochondrial translation	57	1.90E-7
17	SGTC_3044	9093193	5.04	49.5 µM	7.28E-7		8	2.36E-7
18	SGTC_87	0100-0052	4.85	35.5 µM	1.75E-6		61	6.18E-7
19	SGTC_2243	6634756	4.79	200.0 µM	2.35E-6		7	8.52E-7
20	SGTC_100	0086-0128	4.69	49.6 µM	3.58E-6	copper-dependent oxidative stress	29	1.35E-6

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.683	0	YDR518W	EUG1	hom	Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.663	0	YOR330C	MIP1	hom	Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.644	0	YNL252C	MRPL17	hom	Mitochondrial ribosomal protein of the large subunit
0.611	0	YNL213C	RRG9	hom	Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.607	0	YJL023C	PET130	hom	Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.605	0	YGR220C	MRPL9	hom	Mitochondrial ribosomal protein of the large subunit
0.602	0	YDR462W	MRPL28	hom	Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.600	0	YML129C	COX14	hom	Mitochondrial membrane protein, involved in translational regulation of Cox1p and assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes
0.597	3.95E-323	YPL013C	MRPS16	hom	Mitochondrial ribosomal protein of the small subunit
0.591	3.24E-315	YMR035W	IMP2	hom	Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.588	1.70E-310	YDR230W_d	YDR230W_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.580	2.45E-301	YDR375C	BCS1	hom	Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.580	1.31E-300	YER141W	COX15	hom	Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase
0.574	8.39E-294	YJL166W	QCR8	hom	Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.571	1.46E-289	YDR237W	MRPL7	hom	Mitochondrial ribosomal protein of the large subunit; MRPL7 produces both YmL5 and YmL7, which are two different modified forms of the same protein