YDR079W / PET100

Chaperone that specifically facilitates the assembly of cytochrome c oxidase, integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR079W / PET100

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:5.08|P-value:5.97E-7 ID:SGTC_19|Compound:0279-0214|FD-Score:3.29|P-value:8.11E-4 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:3.75|P-value:1.65E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:6.60|P-value:1.43E-10 ID:SGTC_87|Compound:0100-0052|FD-Score:4.85|P-value:1.75E-6 ID:SGTC_100|Compound:0086-0128|FD-Score:4.69|P-value:3.58E-6 ID:SGTC_116|Compound:0155-0182|FD-Score:6.29|P-value:9.02E-10 ID:SGTC_118|Compound:0083-0097|FD-Score:3.97|P-value:7.20E-5 ID:SGTC_119|Compound:0121-0043|FD-Score:5.34|P-value:1.68E-7 ID:SGTC_127|Compound:0180-0333|FD-Score:4.04|P-value:5.49E-5 ID:SGTC_134|Compound:0269-0018|FD-Score:8.39|P-value:5.56E-16 ID:SGTC_151|Compound:3013-0144|FD-Score:-3.58|P-value:3.54E-4 ID:SGTC_161|Compound:4065-0411|FD-Score:3.57|P-value:3.16E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:7.15|P-value:4.27E-12 ID:SGTC_236|Compound:1509-0011|FD-Score:26.90|P-value:2.58E-145 ID:SGTC_275|Compound:trichlorophene|FD-Score:9.72|P-value:8.78E-21 ID:SGTC_310|Compound:1273-0058|FD-Score:6.09|P-value:2.95E-9 ID:SGTC_317|Compound:4495-0002|FD-Score:4.02|P-value:5.99E-5 ID:SGTC_339|Compound:3091-4833|FD-Score:-3.44|P-value:5.71E-4 ID:SGTC_343|Compound:4130-2827|FD-Score:4.40|P-value:1.28E-5 ID:SGTC_349|Compound:k015-0014|FD-Score:3.40|P-value:5.68E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:4.62|P-value:4.93E-6 ID:SGTC_386|Compound:1509-0011|FD-Score:7.52|P-value:3.49E-13 ID:SGTC_437|Compound:s-farnesyl-l-cysteine methyl ester|FD-Score:3.23|P-value:9.77E-4 ID:SGTC_519|Compound:k048-0011|FD-Score:5.38|P-value:1.32E-7 ID:SGTC_625|Compound:k213-0058|FD-Score:3.33|P-value:7.10E-4 ID:SGTC_899|Compound:1083-0020|FD-Score:3.26|P-value:8.94E-4 ID:SGTC_902|Compound:1120-0002|FD-Score:-3.69|P-value:2.33E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:5.15|P-value:4.33E-7 ID:SGTC_910|Compound:3454-3003|FD-Score:3.42|P-value:5.27E-4 ID:SGTC_1188|Compound:1403-0014|FD-Score:6.51|P-value:2.44E-10 ID:SGTC_1426|Compound:4048-4480|FD-Score:3.33|P-value:7.11E-4 ID:SGTC_1605|Compound:st000082|FD-Score:-3.51|P-value:4.36E-4 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:-5.44|P-value:1.24E-7 ID:SGTC_1635|Compound:st007035|FD-Score:11.50|P-value:2.70E-28 ID:SGTC_1742|Compound:st038235|FD-Score:3.43|P-value:5.05E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.46|P-value:1.17E-5 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:4.32|P-value:1.80E-5 ID:SGTC_1891|Compound:st059073|FD-Score:3.82|P-value:1.29E-4 ID:SGTC_2052|Compound:5265182|FD-Score:3.39|P-value:5.78E-4 ID:SGTC_2240|Compound:6690706|FD-Score:-3.89|P-value:1.14E-4 ID:SGTC_2243|Compound:6634756|FD-Score:4.79|P-value:2.35E-6 ID:SGTC_2250|Compound:alverine citrate|FD-Score:5.13|P-value:4.62E-7 ID:SGTC_2291|Compound:7917025|FD-Score:-5.32|P-value:2.21E-7 ID:SGTC_2300|Compound:7976697|FD-Score:-3.39|P-value:6.60E-4 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:3.23|P-value:9.92E-4 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:3.78|P-value:1.49E-4 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:-5.20|P-value:4.00E-7 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:3.28|P-value:8.29E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-9.64|P-value:2.61E-20 ID:SGTC_2586|Compound:curcumin|FD-Score:-6.85|P-value:3.90E-11 ID:SGTC_2666|Compound:tannic acid|FD-Score:-3.79|P-value:1.67E-4 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:-3.71|P-value:2.18E-4 ID:SGTC_2681|Compound:menadione|FD-Score:-3.45|P-value:5.42E-4 ID:SGTC_2821|Compound:7996764|FD-Score:3.70|P-value:1.97E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-4.95|P-value:1.30E-6 ID:SGTC_2972|Compound:9093619|FD-Score:5.19|P-value:3.51E-7 ID:SGTC_3044|Compound:9093193|FD-Score:5.04|P-value:7.28E-7 ID:SGTC_3055|Compound:9094636|FD-Score:3.70|P-value:1.96E-4 ID:SGTC_3059|Compound:1327-0034|FD-Score:-3.92|P-value:1.03E-4 ID:SGTC_3238|Compound:9133470|FD-Score:4.28|P-value:2.07E-5 ID:SGTC_3242|Compound:9133940|FD-Score:-3.55|P-value:3.85E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:5.08|P-value:5.97E-7 ID:SGTC_19|Compound:0279-0214|FD-Score:3.29|P-value:8.11E-4 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:3.75|P-value:1.65E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:6.60|P-value:1.43E-10 ID:SGTC_87|Compound:0100-0052|FD-Score:4.85|P-value:1.75E-6 ID:SGTC_100|Compound:0086-0128|FD-Score:4.69|P-value:3.58E-6 ID:SGTC_116|Compound:0155-0182|FD-Score:6.29|P-value:9.02E-10 ID:SGTC_118|Compound:0083-0097|FD-Score:3.97|P-value:7.20E-5 ID:SGTC_119|Compound:0121-0043|FD-Score:5.34|P-value:1.68E-7 ID:SGTC_127|Compound:0180-0333|FD-Score:4.04|P-value:5.49E-5 ID:SGTC_134|Compound:0269-0018|FD-Score:8.39|P-value:5.56E-16 ID:SGTC_151|Compound:3013-0144|FD-Score:-3.58|P-value:3.54E-4 ID:SGTC_161|Compound:4065-0411|FD-Score:3.57|P-value:3.16E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:7.15|P-value:4.27E-12 ID:SGTC_236|Compound:1509-0011|FD-Score:26.90|P-value:2.58E-145 ID:SGTC_275|Compound:trichlorophene|FD-Score:9.72|P-value:8.78E-21 ID:SGTC_310|Compound:1273-0058|FD-Score:6.09|P-value:2.95E-9 ID:SGTC_317|Compound:4495-0002|FD-Score:4.02|P-value:5.99E-5 ID:SGTC_339|Compound:3091-4833|FD-Score:-3.44|P-value:5.71E-4 ID:SGTC_343|Compound:4130-2827|FD-Score:4.40|P-value:1.28E-5 ID:SGTC_349|Compound:k015-0014|FD-Score:3.40|P-value:5.68E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:4.62|P-value:4.93E-6 ID:SGTC_386|Compound:1509-0011|FD-Score:7.52|P-value:3.49E-13 ID:SGTC_437|Compound:s-farnesyl-l-cysteine methyl ester|FD-Score:3.23|P-value:9.77E-4 ID:SGTC_519|Compound:k048-0011|FD-Score:5.38|P-value:1.32E-7 ID:SGTC_625|Compound:k213-0058|FD-Score:3.33|P-value:7.10E-4 ID:SGTC_899|Compound:1083-0020|FD-Score:3.26|P-value:8.94E-4 ID:SGTC_902|Compound:1120-0002|FD-Score:-3.69|P-value:2.33E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:5.15|P-value:4.33E-7 ID:SGTC_910|Compound:3454-3003|FD-Score:3.42|P-value:5.27E-4 ID:SGTC_1188|Compound:1403-0014|FD-Score:6.51|P-value:2.44E-10 ID:SGTC_1426|Compound:4048-4480|FD-Score:3.33|P-value:7.11E-4 ID:SGTC_1605|Compound:st000082|FD-Score:-3.51|P-value:4.36E-4 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:-5.44|P-value:1.24E-7 ID:SGTC_1635|Compound:st007035|FD-Score:11.50|P-value:2.70E-28 ID:SGTC_1742|Compound:st038235|FD-Score:3.43|P-value:5.05E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.46|P-value:1.17E-5 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:4.32|P-value:1.80E-5 ID:SGTC_1891|Compound:st059073|FD-Score:3.82|P-value:1.29E-4 ID:SGTC_2052|Compound:5265182|FD-Score:3.39|P-value:5.78E-4 ID:SGTC_2240|Compound:6690706|FD-Score:-3.89|P-value:1.14E-4 ID:SGTC_2243|Compound:6634756|FD-Score:4.79|P-value:2.35E-6 ID:SGTC_2250|Compound:alverine citrate|FD-Score:5.13|P-value:4.62E-7 ID:SGTC_2291|Compound:7917025|FD-Score:-5.32|P-value:2.21E-7 ID:SGTC_2300|Compound:7976697|FD-Score:-3.39|P-value:6.60E-4 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:3.23|P-value:9.92E-4 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:3.78|P-value:1.49E-4 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:-5.20|P-value:4.00E-7 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:3.28|P-value:8.29E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-9.64|P-value:2.61E-20 ID:SGTC_2586|Compound:curcumin|FD-Score:-6.85|P-value:3.90E-11 ID:SGTC_2666|Compound:tannic acid|FD-Score:-3.79|P-value:1.67E-4 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:-3.71|P-value:2.18E-4 ID:SGTC_2681|Compound:menadione|FD-Score:-3.45|P-value:5.42E-4 ID:SGTC_2821|Compound:7996764|FD-Score:3.70|P-value:1.97E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-4.95|P-value:1.30E-6 ID:SGTC_2972|Compound:9093619|FD-Score:5.19|P-value:3.51E-7 ID:SGTC_3044|Compound:9093193|FD-Score:5.04|P-value:7.28E-7 ID:SGTC_3055|Compound:9094636|FD-Score:3.70|P-value:1.96E-4 ID:SGTC_3059|Compound:1327-0034|FD-Score:-3.92|P-value:1.03E-4 ID:SGTC_3238|Compound:9133470|FD-Score:4.28|P-value:2.07E-5 ID:SGTC_3242|Compound:9133940|FD-Score:-3.55|P-value:3.85E-4

Top fitness defect scores for YDR079W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 26.90 5.3 µM 2.58E-145 26 1.09E-159
2 SGTC_1635 st007035 11.50 42.4 µM 2.70E-28 64 6.94E-31
3 SGTC_275 trichlorophene 9.72 5.7 µM 8.78E-21 mitochondrial stress 48 1.26E-22
4 SGTC_134 0269-0018 8.39 6.9 µM 5.56E-16 56 2.36E-17
5 SGTC_386 1509-0011 7.52 3.1 µM 3.49E-13 72 2.79E-14
6 SGTC_173 1273-0061 7.15 2.7 µM 4.27E-12 mitochondrial stress 83 4.35E-13
7 SGTC_70 0141-0289 6.60 43.3 µM 1.43E-10 mitochondrial stress 62 2.04E-11
8 SGTC_1188 1403-0014 6.51 4.6 µM 2.44E-10 mitochondrial stress 15 3.69E-11
9 SGTC_116 0155-0182 6.29 31.8 µM 9.02E-10 mitochondrial response to ROS 21 1.54E-10
10 SGTC_310 1273-0058 6.09 1.1 µM 2.95E-9 mitochondrial stress 141 5.66E-10
11 SGTC_519 k048-0011 5.38 62.8 µM 1.32E-7 5 3.65E-8
12 SGTC_119 0121-0043 5.34 24.8 µM 1.68E-7 mitochondrial stress 42 4.75E-8
13 SGTC_2972 9093619 5.19 59.9 µM 3.51E-7 5 1.06E-7
14 SGTC_908 3448-7491 5.15 47.7 µM 4.33E-7 mitochondrial stress 74 1.34E-7
15 SGTC_2250 alverine citrate 5.13 130.0 µM 4.62E-7 90 1.43E-7
16 SGTC_10 0279-0212 5.08 42.6 µM 5.97E-7 TRP & mitochondrial translation 57 1.90E-7
17 SGTC_3044 9093193 5.04 49.5 µM 7.28E-7 8 2.36E-7
18 SGTC_87 0100-0052 4.85 35.5 µM 1.75E-6 61 6.18E-7
19 SGTC_2243 6634756 4.79 200.0 µM 2.35E-6 7 8.52E-7
20 SGTC_100 0086-0128 4.69 49.6 µM 3.58E-6 copper-dependent oxidative stress 29 1.35E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.683 0 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.663 0 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.644 0 YNL252C MRPL17 hom Mitochondrial ribosomal protein of the large subunit
0.611 0 YNL213C RRG9 hom Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.607 0 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.605 0 YGR220C MRPL9 hom Mitochondrial ribosomal protein of the large subunit
0.602 0 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.600 0 YML129C COX14 hom Mitochondrial membrane protein, involved in translational regulation of Cox1p and assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes
0.597 3.95E-323 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.591 3.24E-315 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.588 1.70E-310 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.580 2.45E-301 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.580 1.31E-300 YER141W COX15 hom Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase
0.574 8.39E-294 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.571 1.46E-289 YDR237W MRPL7 hom Mitochondrial ribosomal protein of the large subunit; MRPL7 produces both YmL5 and YmL7, which are two different modified forms of the same protein