YDR082W / STN1

Telomere end-binding and capping protein, plays a key role with Pol12p in linking telomerase action with completion of lagging strand synthesis, and in a regulatory step required for telomere capping

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDR082W / STN1

Click on Significant Values for Screen Details ID:SGTC_24|Compound:0417-1663|FD-Score:3.51|P-value:5.77E-5 ID:SGTC_61|Compound:0978-8327|FD-Score:3.32|P-value:1.33E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:8.52|P-value:4.19E-21 ID:SGTC_181|Compound:1447-1644|FD-Score:-2.98|P-value:5.19E-4 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:4.95|P-value:2.80E-8 ID:SGTC_236|Compound:1509-0011|FD-Score:4.65|P-value:1.66E-7 ID:SGTC_404|Compound:fumagillin|FD-Score:-2.86|P-value:8.31E-4 ID:SGTC_412|Compound:gemfibrozil|FD-Score:3.04|P-value:4.16E-4 ID:SGTC_426|Compound:0988-0037|FD-Score:-3.66|P-value:2.84E-5 ID:SGTC_556|Compound:4058-0063|FD-Score:3.16|P-value:2.65E-4 ID:SGTC_571|Compound:k831-0106|FD-Score:2.85|P-value:8.85E-4 ID:SGTC_678|Compound:1218-2179|FD-Score:-3.05|P-value:4.08E-4 ID:SGTC_1091|Compound:telmisartan|FD-Score:4.03|P-value:4.72E-6 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:3.04|P-value:4.22E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:3.60|P-value:3.92E-5 ID:SGTC_1254|Compound:0550-0035|FD-Score:3.61|P-value:3.71E-5 ID:SGTC_1300|Compound:1094-0077|FD-Score:-4.32|P-value:1.04E-6 ID:SGTC_1315|Compound:1237-0019|FD-Score:3.08|P-value:3.63E-4 ID:SGTC_1335|Compound:1486-0900|FD-Score:-3.31|P-value:1.38E-4 ID:SGTC_1342|Compound:1486-1464|FD-Score:-3.68|P-value:2.61E-5 ID:SGTC_1468|Compound:k284-1086|FD-Score:3.06|P-value:3.86E-4 ID:SGTC_1635|Compound:st007035|FD-Score:3.77|P-value:1.76E-5 ID:SGTC_1778|Compound:st046819|FD-Score:3.14|P-value:2.84E-4 ID:SGTC_1938|Compound:st074717|FD-Score:2.88|P-value:7.75E-4 ID:SGTC_1953|Compound:st076800|FD-Score:-3.28|P-value:1.54E-4 ID:SGTC_2019|Compound:4016004|FD-Score:-4.29|P-value:1.19E-6 ID:SGTC_2023|Compound:5144124|FD-Score:-3.32|P-value:1.34E-4 ID:SGTC_2117|Compound:5521686|FD-Score:-2.89|P-value:7.48E-4 ID:SGTC_2163|Compound:5671233|FD-Score:3.12|P-value:3.12E-4 ID:SGTC_2253|Compound:7938677|FD-Score:-3.22|P-value:2.00E-4 ID:SGTC_2313|Compound:7726885|FD-Score:-3.13|P-value:2.88E-4 ID:SGTC_2314|Compound:7727897|FD-Score:-2.87|P-value:7.99E-4 ID:SGTC_2360|Compound:9040895|FD-Score:4.02|P-value:5.10E-6 ID:SGTC_2432|Compound:5630864|FD-Score:3.25|P-value:1.80E-4 ID:SGTC_2440|Compound:5628896|FD-Score:-3.03|P-value:4.34E-4 ID:SGTC_2448|Compound:5185112|FD-Score:-3.27|P-value:1.61E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:-4.66|P-value:1.56E-7 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:-3.60|P-value:3.83E-5 ID:SGTC_2537|Compound:larixol|FD-Score:-3.73|P-value:2.08E-5 ID:SGTC_2624|Compound:nerol|FD-Score:-3.25|P-value:1.80E-4 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:-2.82|P-value:9.63E-4 ID:SGTC_2664|Compound:lyso-paf C-16|FD-Score:3.32|P-value:1.32E-4 ID:SGTC_2852|Compound:9023854|FD-Score:4.37|P-value:7.96E-7 ID:SGTC_2884|Compound:9058502|FD-Score:3.00|P-value:4.90E-4 ID:SGTC_2900|Compound:5328528|FD-Score:4.21|P-value:1.91E-6 ID:SGTC_2908|Compound:7930301|FD-Score:3.85|P-value:1.16E-5 ID:SGTC_2910|Compound:7948405|FD-Score:3.02|P-value:4.59E-4 ID:SGTC_3062|Compound:9077494|FD-Score:-4.76|P-value:8.72E-8 ID:SGTC_3290|Compound:9121031|FD-Score:-3.32|P-value:1.35E-4 ID:SGTC_24|Compound:0417-1663|FD-Score:3.51|P-value:5.77E-5 ID:SGTC_61|Compound:0978-8327|FD-Score:3.32|P-value:1.33E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:8.52|P-value:4.19E-21 ID:SGTC_181|Compound:1447-1644|FD-Score:-2.98|P-value:5.19E-4 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:4.95|P-value:2.80E-8 ID:SGTC_236|Compound:1509-0011|FD-Score:4.65|P-value:1.66E-7 ID:SGTC_404|Compound:fumagillin|FD-Score:-2.86|P-value:8.31E-4 ID:SGTC_412|Compound:gemfibrozil|FD-Score:3.04|P-value:4.16E-4 ID:SGTC_426|Compound:0988-0037|FD-Score:-3.66|P-value:2.84E-5 ID:SGTC_556|Compound:4058-0063|FD-Score:3.16|P-value:2.65E-4 ID:SGTC_571|Compound:k831-0106|FD-Score:2.85|P-value:8.85E-4 ID:SGTC_678|Compound:1218-2179|FD-Score:-3.05|P-value:4.08E-4 ID:SGTC_1091|Compound:telmisartan|FD-Score:4.03|P-value:4.72E-6 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:3.04|P-value:4.22E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:3.60|P-value:3.92E-5 ID:SGTC_1254|Compound:0550-0035|FD-Score:3.61|P-value:3.71E-5 ID:SGTC_1300|Compound:1094-0077|FD-Score:-4.32|P-value:1.04E-6 ID:SGTC_1315|Compound:1237-0019|FD-Score:3.08|P-value:3.63E-4 ID:SGTC_1335|Compound:1486-0900|FD-Score:-3.31|P-value:1.38E-4 ID:SGTC_1342|Compound:1486-1464|FD-Score:-3.68|P-value:2.61E-5 ID:SGTC_1468|Compound:k284-1086|FD-Score:3.06|P-value:3.86E-4 ID:SGTC_1635|Compound:st007035|FD-Score:3.77|P-value:1.76E-5 ID:SGTC_1778|Compound:st046819|FD-Score:3.14|P-value:2.84E-4 ID:SGTC_1938|Compound:st074717|FD-Score:2.88|P-value:7.75E-4 ID:SGTC_1953|Compound:st076800|FD-Score:-3.28|P-value:1.54E-4 ID:SGTC_2019|Compound:4016004|FD-Score:-4.29|P-value:1.19E-6 ID:SGTC_2023|Compound:5144124|FD-Score:-3.32|P-value:1.34E-4 ID:SGTC_2117|Compound:5521686|FD-Score:-2.89|P-value:7.48E-4 ID:SGTC_2163|Compound:5671233|FD-Score:3.12|P-value:3.12E-4 ID:SGTC_2253|Compound:7938677|FD-Score:-3.22|P-value:2.00E-4 ID:SGTC_2313|Compound:7726885|FD-Score:-3.13|P-value:2.88E-4 ID:SGTC_2314|Compound:7727897|FD-Score:-2.87|P-value:7.99E-4 ID:SGTC_2360|Compound:9040895|FD-Score:4.02|P-value:5.10E-6 ID:SGTC_2432|Compound:5630864|FD-Score:3.25|P-value:1.80E-4 ID:SGTC_2440|Compound:5628896|FD-Score:-3.03|P-value:4.34E-4 ID:SGTC_2448|Compound:5185112|FD-Score:-3.27|P-value:1.61E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:-4.66|P-value:1.56E-7 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:-3.60|P-value:3.83E-5 ID:SGTC_2537|Compound:larixol|FD-Score:-3.73|P-value:2.08E-5 ID:SGTC_2624|Compound:nerol|FD-Score:-3.25|P-value:1.80E-4 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:-2.82|P-value:9.63E-4 ID:SGTC_2664|Compound:lyso-paf C-16|FD-Score:3.32|P-value:1.32E-4 ID:SGTC_2852|Compound:9023854|FD-Score:4.37|P-value:7.96E-7 ID:SGTC_2884|Compound:9058502|FD-Score:3.00|P-value:4.90E-4 ID:SGTC_2900|Compound:5328528|FD-Score:4.21|P-value:1.91E-6 ID:SGTC_2908|Compound:7930301|FD-Score:3.85|P-value:1.16E-5 ID:SGTC_2910|Compound:7948405|FD-Score:3.02|P-value:4.59E-4 ID:SGTC_3062|Compound:9077494|FD-Score:-4.76|P-value:8.72E-8 ID:SGTC_3290|Compound:9121031|FD-Score:-3.32|P-value:1.35E-4

Top fitness defect scores for YDR082W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_134 0269-0018 8.52 6.9 µM 4.19E-21 4 8.03E-18 1.27
2 SGTC_219 mitoxanthrone 4.95 164.4 µM 2.80E-8 DNA intercalators 8 3.77E-7 0.21
3 SGTC_236 1509-0011 4.65 5.3 µM 1.66E-7 18 1.66E-6 0.00
4 SGTC_2852 9023854 4.37 52.0 µM 7.96E-7 5 6.17E-6 0.39
5 SGTC_2900 5328528 4.21 85.3 µM 1.91E-6 Golgi 4 1.28E-5 0.14
6 SGTC_1091 telmisartan 4.03 47.6 µM 4.72E-6 2 2.73E-5 0.35
7 SGTC_2360 9040895 4.02 200.0 µM 5.10E-6 RPP1 & pyrimidine depletion 8 2.92E-5 0.16
8 SGTC_2908 7930301 3.85 100.0 µM 1.16E-5 5 5.79E-5 0.05
9 SGTC_1635 st007035 3.77 42.4 µM 1.76E-5 22 8.23E-5 0.03
10 SGTC_1254 0550-0035 3.61 264.0 µM 3.71E-5 11 1.53E-4 0.09
11 SGTC_1246 0422-0085 3.60 105.0 µM 3.92E-5 12 1.61E-4 0.05
12 SGTC_24 0417-1663 3.51 219.0 µM 5.77E-5 2 2.22E-4 0.32
13 SGTC_2664 lyso-paf C-16 3.32 73.5 µM 1.32E-4 6 4.44E-4 0.02
14 SGTC_61 0978-8327 3.32 98.6 µM 1.33E-4 ergosterol biosynthesis 15 4.47E-4 0.02
15 SGTC_2432 5630864 3.25 12.2 µM 1.80E-4 15 5.77E-4 0.05
16 SGTC_556 4058-0063 3.16 51.5 µM 2.65E-4 11 7.98E-4 0.07
17 SGTC_1778 st046819 3.14 58.9 µM 2.84E-4 14 8.45E-4 0.13
18 SGTC_2163 5671233 3.12 125.0 µM 3.12E-4 25 9.16E-4 0.01
19 SGTC_1315 1237-0019 3.08 3.7 µM 3.63E-4 15 0.00104 0.07
20 SGTC_1468 k284-1086 3.06 134.0 µM 3.86E-4 DNA intercalators 25 0.00109 0.05

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.345 1.80E-94 YPL132W COX11 hom Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p
0.327 3.92E-84 YNR045W PET494 hom Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet122p; located in the mitochondrial inner membrane
0.323 5.31E-82 YDR231C COX20 hom Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase
0.317 2.67E-79 YML129C COX14 hom Mitochondrial membrane protein, involved in translational regulation of Cox1p and assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes
0.307 5.80E-74 YDL107W MSS2 hom Peripherally bound inner membrane protein of the mitochondrial matrix involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p
0.294 1.11E-67 YJL209W CBP1 hom Mitochondrial protein, regulator of COB mRNA stability and translation; interacts with the 5'-untranslated region of the COB mRNA; found in a complex at the inner membrane along with Pet309p; localizes to mitochondrial foci upon DNA replication stress
0.287 9.34E-65 YGR183C QCR9 hom Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex
0.287 1.71E-64 YLL009C COX17 hom Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs
0.287 1.88E-64 YEL059C-A SOM1 hom Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.281 9.64E-62 YER058W PET117 hom Protein required for assembly of cytochrome c oxidase
0.279 5.07E-61 YDL067C COX9 hom Subunit VIIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
0.267 8.23E-56 YHL038C CBP2 hom Required for splicing of the group I intron bI5 of the COB pre-mRNA; nuclear-encoded mitochondrial protein that binds to the RNA to promote splicing; also involved in but not essential for splicing of the COB bI2 intron and the intron in the 21S rRNA gene
0.263 4.97E-54 YJL062W-A COA3 hom Mitochondrial inner membrane protein that participates in regulation of COX1 translation, Cox1p stabilization, and cytochrome oxidase assembly
0.261 1.75E-53 YLR038C COX12 hom Subunit VIb of cytochrome c oxidase; cytochrome c oxidase is also known as respiratory Complex IV and is the terminal member of the mitochondrial inner membrane electron transport chain; required for assembly of cytochrome c oxidase but not required for activity after assembly; phosphorylated; easily released from the intermembrane space, suggesting a loose association with Complex IV
0.260 1.01E-52 YIR021W MRS1 hom Protein required for the splicing of two mitochondrial group I introns (BI3 in COB and AI5beta in COX1); forms a splicing complex, containing four subunits of Mrs1p and two subunits of the BI3-encoded maturase, that binds to the BI3 RNA