YDR086C / SSS1

Subunit of the Sec61p translocation complex (Sec61p-Sss1p-Sbh1p) that forms a channel for passage of secretory proteins through the endoplasmic reticulum membrane, and of the Ssh1p complex (Ssh1p-Sbh2p-Sss1p); interacts with Ost4p and Wbp1p

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDR086C / SSS1

Click on Significant Values for Screen Details ID:SGTC_16|Compound:erodoxin|FD-Score:3.28|P-value:2.22E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:5.40|P-value:5.25E-9 ID:SGTC_64|Compound:000l-0018|FD-Score:4.04|P-value:8.33E-6 ID:SGTC_67|Compound:0335-0847|FD-Score:6.70|P-value:7.17E-13 ID:SGTC_86|Compound:0417-1630|FD-Score:10.70|P-value:1.01E-29 ID:SGTC_137|Compound:0438-0332|FD-Score:16.50|P-value:1.96E-67 ID:SGTC_139|Compound:0099-0334|FD-Score:4.00|P-value:1.02E-5 ID:SGTC_142|Compound:0335-0849|FD-Score:13.60|P-value:2.48E-46 ID:SGTC_158|Compound:k038-0087|FD-Score:9.30|P-value:6.12E-23 ID:SGTC_165|Compound:k038-0023|FD-Score:12.30|P-value:1.12E-38 ID:SGTC_200|Compound:k038-0079|FD-Score:4.72|P-value:2.73E-7 ID:SGTC_216|Compound:k038-0035|FD-Score:5.47|P-value:3.37E-9 ID:SGTC_263|Compound:alizarin|FD-Score:3.47|P-value:1.03E-4 ID:SGTC_294|Compound:k038-0071|FD-Score:7.44|P-value:2.09E-15 ID:SGTC_340|Compound:k038-0059|FD-Score:6.83|P-value:2.66E-13 ID:SGTC_367|Compound:0335-0881|FD-Score:11.50|P-value:7.84E-34 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:4.98|P-value:6.12E-8 ID:SGTC_444|Compound:curcumin|FD-Score:3.33|P-value:1.79E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:8.54|P-value:1.20E-19 ID:SGTC_525|Compound:k781-2675|FD-Score:3.33|P-value:1.82E-4 ID:SGTC_553|Compound:k007-0256|FD-Score:3.21|P-value:2.95E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:3.42|P-value:1.28E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:4.56|P-value:6.39E-7 ID:SGTC_635|Compound:k038-0028|FD-Score:13.30|P-value:1.19E-44 ID:SGTC_642|Compound:0335-0876|FD-Score:9.07|P-value:6.51E-22 ID:SGTC_669|Compound:0108-0021|FD-Score:4.81|P-value:1.62E-7 ID:SGTC_676|Compound:falcarinol|FD-Score:6.73|P-value:5.91E-13 ID:SGTC_720|Compound:r052-1644|FD-Score:8.40|P-value:4.26E-19 ID:SGTC_742|Compound:0kpi-0133|FD-Score:2.90|P-value:9.27E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:6.34|P-value:1.03E-11 ID:SGTC_794|Compound:k038-0031|FD-Score:5.76|P-value:5.27E-10 ID:SGTC_800|Compound:3448-7362|FD-Score:3.44|P-value:1.17E-4 ID:SGTC_837|Compound:0091-0265|FD-Score:5.47|P-value:3.36E-9 ID:SGTC_842|Compound:0271-0008|FD-Score:3.00|P-value:6.32E-4 ID:SGTC_846|Compound:0335-0850|FD-Score:8.86|P-value:5.38E-21 ID:SGTC_851|Compound:0394-0702|FD-Score:3.42|P-value:1.27E-4 ID:SGTC_898|Compound:1000-0849|FD-Score:7.47|P-value:1.66E-15 ID:SGTC_930|Compound:2810-3379|FD-Score:-4.54|P-value:1.70E-6 ID:SGTC_992|Compound:3909-8734|FD-Score:-3.63|P-value:1.13E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:4.74|P-value:2.42E-7 ID:SGTC_1034|Compound:k072-0165|FD-Score:3.53|P-value:8.03E-5 ID:SGTC_1044|Compound:1222-0021|FD-Score:12.10|P-value:2.25E-37 ID:SGTC_1075|Compound:aripiprazole|FD-Score:4.55|P-value:6.63E-7 ID:SGTC_1124|Compound:fisetin|FD-Score:3.60|P-value:5.93E-5 ID:SGTC_1203|Compound:3992-3522|FD-Score:2.95|P-value:7.77E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:3.42|P-value:1.25E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:3.14|P-value:3.85E-4 ID:SGTC_1259|Compound:0671-0132|FD-Score:3.58|P-value:6.61E-5 ID:SGTC_1378|Compound:2093-0007|FD-Score:2.91|P-value:8.89E-4 ID:SGTC_1422|Compound:4031-0024|FD-Score:3.46|P-value:1.07E-4 ID:SGTC_1651|Compound:st011928|FD-Score:3.14|P-value:3.78E-4 ID:SGTC_1682|Compound:st012968|FD-Score:-3.06|P-value:9.59E-4 ID:SGTC_1683|Compound:st010134|FD-Score:-3.21|P-value:5.61E-4 ID:SGTC_1696|Compound:st025591|FD-Score:3.22|P-value:2.76E-4 ID:SGTC_1700|Compound:st030840|FD-Score:2.91|P-value:8.81E-4 ID:SGTC_1848|Compound:st056003|FD-Score:-4.13|P-value:1.24E-5 ID:SGTC_1880|Compound:MG-132|FD-Score:23.60|P-value:7.28E-135 ID:SGTC_1884|Compound:5633444|FD-Score:5.28|P-value:1.11E-8 ID:SGTC_1885|Compound:st057546|FD-Score:3.18|P-value:3.28E-4 ID:SGTC_1911|Compound:st060208|FD-Score:-3.20|P-value:5.99E-4 ID:SGTC_1962|Compound:st076595|FD-Score:5.81|P-value:3.85E-10 ID:SGTC_2021|Compound:4019055|FD-Score:4.82|P-value:1.56E-7 ID:SGTC_2027|Compound:5150920|FD-Score:4.46|P-value:1.03E-6 ID:SGTC_2044|Compound:5102272|FD-Score:3.10|P-value:4.40E-4 ID:SGTC_2046|Compound:4110841|FD-Score:3.77|P-value:2.84E-5 ID:SGTC_2075|Compound:5212009|FD-Score:5.02|P-value:5.11E-8 ID:SGTC_2129|Compound:girgensonine|FD-Score:3.91|P-value:1.50E-5 ID:SGTC_2157|Compound:5649910|FD-Score:3.20|P-value:3.09E-4 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:8.24|P-value:1.85E-18 ID:SGTC_2226|Compound:7298446|FD-Score:3.46|P-value:1.10E-4 ID:SGTC_2283|Compound:7944793|FD-Score:-3.60|P-value:1.26E-4 ID:SGTC_2289|Compound:7946404|FD-Score:13.90|P-value:2.17E-48 ID:SGTC_2308|Compound:7584454|FD-Score:3.50|P-value:9.10E-5 ID:SGTC_2342|Compound:7990637|FD-Score:-3.11|P-value:8.01E-4 ID:SGTC_2373|Compound:9071805|FD-Score:3.72|P-value:3.56E-5 ID:SGTC_2401|Compound:5128683|FD-Score:3.08|P-value:4.68E-4 ID:SGTC_2423|Compound:st077119|FD-Score:3.37|P-value:1.58E-4 ID:SGTC_2434|Compound:5670830|FD-Score:-3.77|P-value:6.12E-5 ID:SGTC_2436|Compound:5633522|FD-Score:3.42|P-value:1.26E-4 ID:SGTC_2477|Compound:5967686|FD-Score:3.94|P-value:1.36E-5 ID:SGTC_2485|Compound:5633444|FD-Score:8.87|P-value:4.70E-21 ID:SGTC_2526|Compound:patulin|FD-Score:5.37|P-value:6.27E-9 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-3.06|P-value:9.59E-4 ID:SGTC_2663|Compound:amphotericin b|FD-Score:2.94|P-value:8.07E-4 ID:SGTC_2666|Compound:tannic acid|FD-Score:6.52|P-value:2.87E-12 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:4.25|P-value:3.04E-6 ID:SGTC_2701|Compound:st077767|FD-Score:3.15|P-value:3.71E-4 ID:SGTC_2703|Compound:st077852|FD-Score:-4.33|P-value:4.91E-6 ID:SGTC_2725|Compound:haloperidol|FD-Score:3.70|P-value:3.89E-5 ID:SGTC_2737|Compound:bleomycin|FD-Score:4.97|P-value:6.81E-8 ID:SGTC_2759|Compound:disulfiram|FD-Score:3.97|P-value:1.15E-5 ID:SGTC_2784|Compound:7567673|FD-Score:6.27|P-value:1.66E-11 ID:SGTC_2842|Compound:9000675|FD-Score:-3.12|P-value:7.81E-4 ID:SGTC_2955|Compound:9076254|FD-Score:4.00|P-value:1.02E-5 ID:SGTC_2958|Compound:9077254|FD-Score:4.07|P-value:7.43E-6 ID:SGTC_2969|Compound:9091408|FD-Score:4.99|P-value:6.09E-8 ID:SGTC_3066|Compound:9117245|FD-Score:-4.48|P-value:2.34E-6 ID:SGTC_3071|Compound:9117417|FD-Score:4.09|P-value:6.60E-6 ID:SGTC_3074|Compound:9116018|FD-Score:-4.32|P-value:5.23E-6 ID:SGTC_3077|Compound:9117319|FD-Score:-3.85|P-value:4.38E-5 ID:SGTC_3081|Compound:9117243|FD-Score:2.93|P-value:8.34E-4 ID:SGTC_3105|Compound:9121040|FD-Score:3.14|P-value:3.80E-4 ID:SGTC_3126|Compound:9127922|FD-Score:4.46|P-value:1.05E-6 ID:SGTC_3175|Compound:9106517|FD-Score:4.27|P-value:2.71E-6 ID:SGTC_3181|Compound:9108277|FD-Score:3.80|P-value:2.52E-5 ID:SGTC_3199|Compound:9111318|FD-Score:3.18|P-value:3.30E-4 ID:SGTC_3208|Compound:9114115|FD-Score:3.04|P-value:5.55E-4 ID:SGTC_3214|Compound:9129694|FD-Score:4.17|P-value:4.42E-6 ID:SGTC_3253|Compound:9135987|FD-Score:3.06|P-value:5.11E-4 ID:SGTC_16|Compound:erodoxin|FD-Score:3.28|P-value:2.22E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:5.40|P-value:5.25E-9 ID:SGTC_64|Compound:000l-0018|FD-Score:4.04|P-value:8.33E-6 ID:SGTC_67|Compound:0335-0847|FD-Score:6.70|P-value:7.17E-13 ID:SGTC_86|Compound:0417-1630|FD-Score:10.70|P-value:1.01E-29 ID:SGTC_137|Compound:0438-0332|FD-Score:16.50|P-value:1.96E-67 ID:SGTC_139|Compound:0099-0334|FD-Score:4.00|P-value:1.02E-5 ID:SGTC_142|Compound:0335-0849|FD-Score:13.60|P-value:2.48E-46 ID:SGTC_158|Compound:k038-0087|FD-Score:9.30|P-value:6.12E-23 ID:SGTC_165|Compound:k038-0023|FD-Score:12.30|P-value:1.12E-38 ID:SGTC_200|Compound:k038-0079|FD-Score:4.72|P-value:2.73E-7 ID:SGTC_216|Compound:k038-0035|FD-Score:5.47|P-value:3.37E-9 ID:SGTC_263|Compound:alizarin|FD-Score:3.47|P-value:1.03E-4 ID:SGTC_294|Compound:k038-0071|FD-Score:7.44|P-value:2.09E-15 ID:SGTC_340|Compound:k038-0059|FD-Score:6.83|P-value:2.66E-13 ID:SGTC_367|Compound:0335-0881|FD-Score:11.50|P-value:7.84E-34 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:4.98|P-value:6.12E-8 ID:SGTC_444|Compound:curcumin|FD-Score:3.33|P-value:1.79E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:8.54|P-value:1.20E-19 ID:SGTC_525|Compound:k781-2675|FD-Score:3.33|P-value:1.82E-4 ID:SGTC_553|Compound:k007-0256|FD-Score:3.21|P-value:2.95E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:3.42|P-value:1.28E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:4.56|P-value:6.39E-7 ID:SGTC_635|Compound:k038-0028|FD-Score:13.30|P-value:1.19E-44 ID:SGTC_642|Compound:0335-0876|FD-Score:9.07|P-value:6.51E-22 ID:SGTC_669|Compound:0108-0021|FD-Score:4.81|P-value:1.62E-7 ID:SGTC_676|Compound:falcarinol|FD-Score:6.73|P-value:5.91E-13 ID:SGTC_720|Compound:r052-1644|FD-Score:8.40|P-value:4.26E-19 ID:SGTC_742|Compound:0kpi-0133|FD-Score:2.90|P-value:9.27E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:6.34|P-value:1.03E-11 ID:SGTC_794|Compound:k038-0031|FD-Score:5.76|P-value:5.27E-10 ID:SGTC_800|Compound:3448-7362|FD-Score:3.44|P-value:1.17E-4 ID:SGTC_837|Compound:0091-0265|FD-Score:5.47|P-value:3.36E-9 ID:SGTC_842|Compound:0271-0008|FD-Score:3.00|P-value:6.32E-4 ID:SGTC_846|Compound:0335-0850|FD-Score:8.86|P-value:5.38E-21 ID:SGTC_851|Compound:0394-0702|FD-Score:3.42|P-value:1.27E-4 ID:SGTC_898|Compound:1000-0849|FD-Score:7.47|P-value:1.66E-15 ID:SGTC_930|Compound:2810-3379|FD-Score:-4.54|P-value:1.70E-6 ID:SGTC_992|Compound:3909-8734|FD-Score:-3.63|P-value:1.13E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:4.74|P-value:2.42E-7 ID:SGTC_1034|Compound:k072-0165|FD-Score:3.53|P-value:8.03E-5 ID:SGTC_1044|Compound:1222-0021|FD-Score:12.10|P-value:2.25E-37 ID:SGTC_1075|Compound:aripiprazole|FD-Score:4.55|P-value:6.63E-7 ID:SGTC_1124|Compound:fisetin|FD-Score:3.60|P-value:5.93E-5 ID:SGTC_1203|Compound:3992-3522|FD-Score:2.95|P-value:7.77E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:3.42|P-value:1.25E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:3.14|P-value:3.85E-4 ID:SGTC_1259|Compound:0671-0132|FD-Score:3.58|P-value:6.61E-5 ID:SGTC_1378|Compound:2093-0007|FD-Score:2.91|P-value:8.89E-4 ID:SGTC_1422|Compound:4031-0024|FD-Score:3.46|P-value:1.07E-4 ID:SGTC_1651|Compound:st011928|FD-Score:3.14|P-value:3.78E-4 ID:SGTC_1682|Compound:st012968|FD-Score:-3.06|P-value:9.59E-4 ID:SGTC_1683|Compound:st010134|FD-Score:-3.21|P-value:5.61E-4 ID:SGTC_1696|Compound:st025591|FD-Score:3.22|P-value:2.76E-4 ID:SGTC_1700|Compound:st030840|FD-Score:2.91|P-value:8.81E-4 ID:SGTC_1848|Compound:st056003|FD-Score:-4.13|P-value:1.24E-5 ID:SGTC_1880|Compound:MG-132|FD-Score:23.60|P-value:7.28E-135 ID:SGTC_1884|Compound:5633444|FD-Score:5.28|P-value:1.11E-8 ID:SGTC_1885|Compound:st057546|FD-Score:3.18|P-value:3.28E-4 ID:SGTC_1911|Compound:st060208|FD-Score:-3.20|P-value:5.99E-4 ID:SGTC_1962|Compound:st076595|FD-Score:5.81|P-value:3.85E-10 ID:SGTC_2021|Compound:4019055|FD-Score:4.82|P-value:1.56E-7 ID:SGTC_2027|Compound:5150920|FD-Score:4.46|P-value:1.03E-6 ID:SGTC_2044|Compound:5102272|FD-Score:3.10|P-value:4.40E-4 ID:SGTC_2046|Compound:4110841|FD-Score:3.77|P-value:2.84E-5 ID:SGTC_2075|Compound:5212009|FD-Score:5.02|P-value:5.11E-8 ID:SGTC_2129|Compound:girgensonine|FD-Score:3.91|P-value:1.50E-5 ID:SGTC_2157|Compound:5649910|FD-Score:3.20|P-value:3.09E-4 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:8.24|P-value:1.85E-18 ID:SGTC_2226|Compound:7298446|FD-Score:3.46|P-value:1.10E-4 ID:SGTC_2283|Compound:7944793|FD-Score:-3.60|P-value:1.26E-4 ID:SGTC_2289|Compound:7946404|FD-Score:13.90|P-value:2.17E-48 ID:SGTC_2308|Compound:7584454|FD-Score:3.50|P-value:9.10E-5 ID:SGTC_2342|Compound:7990637|FD-Score:-3.11|P-value:8.01E-4 ID:SGTC_2373|Compound:9071805|FD-Score:3.72|P-value:3.56E-5 ID:SGTC_2401|Compound:5128683|FD-Score:3.08|P-value:4.68E-4 ID:SGTC_2423|Compound:st077119|FD-Score:3.37|P-value:1.58E-4 ID:SGTC_2434|Compound:5670830|FD-Score:-3.77|P-value:6.12E-5 ID:SGTC_2436|Compound:5633522|FD-Score:3.42|P-value:1.26E-4 ID:SGTC_2477|Compound:5967686|FD-Score:3.94|P-value:1.36E-5 ID:SGTC_2485|Compound:5633444|FD-Score:8.87|P-value:4.70E-21 ID:SGTC_2526|Compound:patulin|FD-Score:5.37|P-value:6.27E-9 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-3.06|P-value:9.59E-4 ID:SGTC_2663|Compound:amphotericin b|FD-Score:2.94|P-value:8.07E-4 ID:SGTC_2666|Compound:tannic acid|FD-Score:6.52|P-value:2.87E-12 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:4.25|P-value:3.04E-6 ID:SGTC_2701|Compound:st077767|FD-Score:3.15|P-value:3.71E-4 ID:SGTC_2703|Compound:st077852|FD-Score:-4.33|P-value:4.91E-6 ID:SGTC_2725|Compound:haloperidol|FD-Score:3.70|P-value:3.89E-5 ID:SGTC_2737|Compound:bleomycin|FD-Score:4.97|P-value:6.81E-8 ID:SGTC_2759|Compound:disulfiram|FD-Score:3.97|P-value:1.15E-5 ID:SGTC_2784|Compound:7567673|FD-Score:6.27|P-value:1.66E-11 ID:SGTC_2842|Compound:9000675|FD-Score:-3.12|P-value:7.81E-4 ID:SGTC_2955|Compound:9076254|FD-Score:4.00|P-value:1.02E-5 ID:SGTC_2958|Compound:9077254|FD-Score:4.07|P-value:7.43E-6 ID:SGTC_2969|Compound:9091408|FD-Score:4.99|P-value:6.09E-8 ID:SGTC_3066|Compound:9117245|FD-Score:-4.48|P-value:2.34E-6 ID:SGTC_3071|Compound:9117417|FD-Score:4.09|P-value:6.60E-6 ID:SGTC_3074|Compound:9116018|FD-Score:-4.32|P-value:5.23E-6 ID:SGTC_3077|Compound:9117319|FD-Score:-3.85|P-value:4.38E-5 ID:SGTC_3081|Compound:9117243|FD-Score:2.93|P-value:8.34E-4 ID:SGTC_3105|Compound:9121040|FD-Score:3.14|P-value:3.80E-4 ID:SGTC_3126|Compound:9127922|FD-Score:4.46|P-value:1.05E-6 ID:SGTC_3175|Compound:9106517|FD-Score:4.27|P-value:2.71E-6 ID:SGTC_3181|Compound:9108277|FD-Score:3.80|P-value:2.52E-5 ID:SGTC_3199|Compound:9111318|FD-Score:3.18|P-value:3.30E-4 ID:SGTC_3208|Compound:9114115|FD-Score:3.04|P-value:5.55E-4 ID:SGTC_3214|Compound:9129694|FD-Score:4.17|P-value:4.42E-6 ID:SGTC_3253|Compound:9135987|FD-Score:3.06|P-value:5.11E-4

Top fitness defect scores for YDR086C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1880 MG-132 23.60 525.0 µM 7.28E-135 1 2.50E-123 12.30
2 SGTC_137 0438-0332 16.50 85.4 µM 1.96E-67 ubiquinone biosynthesis & proteasome 4 1.46E-61 1.77
3 SGTC_2289 7946404 13.90 165.1 µM 2.17E-48 3 3.87E-44 2.04
4 SGTC_142 0335-0849 13.60 62.7 µM 2.48E-46 ubiquinone biosynthesis & proteasome 4 2.95E-42 4.22
5 SGTC_635 k038-0028 13.30 24.7 µM 1.19E-44 ubiquinone biosynthesis & proteasome 2 1.02E-40 4.84
6 SGTC_165 k038-0023 12.30 64.4 µM 1.12E-38 ubiquinone biosynthesis & proteasome 2 2.92E-35 3.19
7 SGTC_1044 1222-0021 12.10 1.8 µM 2.25E-37 heme biosynthesis & mitochondrial translocase 2 4.55E-34 0.52
8 SGTC_367 0335-0881 11.50 7.1 µM 7.84E-34 ubiquinone biosynthesis & proteasome 2 7.82E-31 2.35
9 SGTC_86 0417-1630 10.70 471.9 µM 1.01E-29 ubiquinone biosynthesis & proteasome 4 4.43E-27 2.99
10 SGTC_158 k038-0087 9.30 26.4 µM 6.12E-23 ubiquinone biosynthesis & proteasome 6 6.86E-21 1.23
11 SGTC_642 0335-0876 9.07 158.0 µM 6.51E-22 ubiquinone biosynthesis & proteasome 2 5.93E-20 2.35
12 SGTC_2485 5633444 8.87 17.8 µM 4.70E-21 redox potentiating 1 3.60E-19 2.90
13 SGTC_846 0335-0850 8.86 148.0 µM 5.38E-21 ubiquinone biosynthesis & proteasome 2 4.07E-19 2.38
14 SGTC_513 4245-1575 8.54 41.7 µM 1.20E-19 unfolded protein response 3 6.91E-18 0.25
15 SGTC_720 r052-1644 8.40 49.9 µM 4.26E-19 TSC3-RPN4 3 2.19E-17 0.97
16 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 8.24 49.5 µM 1.85E-18 2 8.36E-17 1.33
17 SGTC_898 1000-0849 7.47 28.3 µM 1.66E-15 1 4.08E-14 3.16
18 SGTC_294 k038-0071 7.44 157.0 µM 2.09E-15 ubiquinone biosynthesis & proteasome 3 5.03E-14 0.04
19 SGTC_340 k038-0059 6.83 454.0 µM 2.66E-13 ubiquinone biosynthesis & proteasome 4 4.16E-12 1.79
20 SGTC_676 falcarinol 6.73 140.0 µM 5.91E-13 2 8.59E-12 0.33

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.477 5.68E-190 YLR378C SEC61 het Essential subunit of Sec61 complex (Sec61p, Sbh1p, and Sss1p); forms a channel for SRP-dependent protein import and retrograde transport of misfolded proteins out of the ER; with Sec63 complex allows SRP-independent protein import into ER
0.476 1.56E-189 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.466 1.45E-180 YML034C-A_d YML034C-A_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.391 2.72E-123 YBR275C RIF1 hom Protein that binds to the Rap1p C-terminus and acts synergistically with Rif2p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation
0.384 5.32E-118 YMR110C HFD1 hom Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder
0.377 1.29E-113 YPR065W ROX1 hom Heme-dependent repressor of hypoxic genes; mediates aerobic transcriptional repression of hypoxia induced genes such as COX5b and CYC7; repressor function regulated through decreased promoter occupancy in response to oxidative stress; contains an HMG domain that is responsible for DNA bending activity; involved in the hyperosmotic stress resistance
0.376 6.69E-113 YML034W SRC1 hom Inner nuclear membrane protein; functions in regulation of subtelomeric genes and is linked to TREX (transcription export) factors; SRC1 produces 2 splice variant proteins with different functions; alternative splicing of SRC1 pre-mRNA is promoted by Hub1p; mutant has aneuploidy tolerance
0.354 9.94E-100 YNR041C COQ2 hom Para hydroxybenzoate: polyprenyl transferase, catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis
0.354 1.74E-99 YLR201C COQ9 hom Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.350 1.87E-97 YBR003W COQ1 hom Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis
0.348 2.11E-96 YNR042W_d YNR042W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
0.343 2.59E-93 YGL119W COQ8 hom Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication
0.343 3.18E-93 YJL193W_p YJL193W_p hom Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect
0.340 2.32E-91 YPR146C_d YPR146C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.339 2.88E-91 YPR064W_d YPR064W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data