YDR087C / RRP1

Essential evolutionarily conserved nucleolar protein necessary for biogenesis of 60S ribosomal subunits and processing of pre-rRNAs to mature rRNAs, associated with several distinct 66S pre-ribosomal particles

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDR087C / RRP1

Click on Significant Values for Screen Details ID:SGTC_18|Compound:0111-0177|FD-Score:-3.24|P-value:6.07E-4 ID:SGTC_34|Compound:0469-0683|FD-Score:3.79|P-value:8.12E-5 ID:SGTC_169|Compound:k015-0017|FD-Score:4.01|P-value:3.23E-5 ID:SGTC_301|Compound:4119-0100|FD-Score:-3.22|P-value:6.65E-4 ID:SGTC_929|Compound:2805-0021|FD-Score:6.22|P-value:2.96E-10 ID:SGTC_989|Compound:1501-0895|FD-Score:3.36|P-value:4.16E-4 ID:SGTC_1282|Compound:0886-0010|FD-Score:3.36|P-value:4.17E-4 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:-3.76|P-value:8.76E-5 ID:SGTC_1457|Compound:k015-0032|FD-Score:3.28|P-value:5.45E-4 ID:SGTC_1687|Compound:st020778|FD-Score:-3.35|P-value:4.14E-4 ID:SGTC_1694|Compound:st024011|FD-Score:4.97|P-value:3.67E-7 ID:SGTC_1728|Compound:st035614|FD-Score:4.32|P-value:8.57E-6 ID:SGTC_1752|Compound:st044819|FD-Score:-3.63|P-value:1.46E-4 ID:SGTC_1985|Compound:st071382|FD-Score:3.32|P-value:4.80E-4 ID:SGTC_1993|Compound:st073995|FD-Score:3.42|P-value:3.36E-4 ID:SGTC_2291|Compound:7917025|FD-Score:4.04|P-value:2.84E-5 ID:SGTC_2521|Compound:angolensin|FD-Score:3.28|P-value:5.36E-4 ID:SGTC_3023|Compound:9089636|FD-Score:3.11|P-value:9.91E-4 ID:SGTC_3046|Compound:9092212|FD-Score:3.21|P-value:6.85E-4 ID:SGTC_3202|Compound:9113761|FD-Score:-3.47|P-value:2.68E-4 ID:SGTC_3320|Compound:9137005|FD-Score:3.17|P-value:7.96E-4 ID:SGTC_18|Compound:0111-0177|FD-Score:-3.24|P-value:6.07E-4 ID:SGTC_34|Compound:0469-0683|FD-Score:3.79|P-value:8.12E-5 ID:SGTC_169|Compound:k015-0017|FD-Score:4.01|P-value:3.23E-5 ID:SGTC_301|Compound:4119-0100|FD-Score:-3.22|P-value:6.65E-4 ID:SGTC_929|Compound:2805-0021|FD-Score:6.22|P-value:2.96E-10 ID:SGTC_989|Compound:1501-0895|FD-Score:3.36|P-value:4.16E-4 ID:SGTC_1282|Compound:0886-0010|FD-Score:3.36|P-value:4.17E-4 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:-3.76|P-value:8.76E-5 ID:SGTC_1457|Compound:k015-0032|FD-Score:3.28|P-value:5.45E-4 ID:SGTC_1687|Compound:st020778|FD-Score:-3.35|P-value:4.14E-4 ID:SGTC_1694|Compound:st024011|FD-Score:4.97|P-value:3.67E-7 ID:SGTC_1728|Compound:st035614|FD-Score:4.32|P-value:8.57E-6 ID:SGTC_1752|Compound:st044819|FD-Score:-3.63|P-value:1.46E-4 ID:SGTC_1985|Compound:st071382|FD-Score:3.32|P-value:4.80E-4 ID:SGTC_1993|Compound:st073995|FD-Score:3.42|P-value:3.36E-4 ID:SGTC_2291|Compound:7917025|FD-Score:4.04|P-value:2.84E-5 ID:SGTC_2521|Compound:angolensin|FD-Score:3.28|P-value:5.36E-4 ID:SGTC_3023|Compound:9089636|FD-Score:3.11|P-value:9.91E-4 ID:SGTC_3046|Compound:9092212|FD-Score:3.21|P-value:6.85E-4 ID:SGTC_3202|Compound:9113761|FD-Score:-3.47|P-value:2.68E-4 ID:SGTC_3320|Compound:9137005|FD-Score:3.17|P-value:7.96E-4

Top fitness defect scores for YDR087C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_929 2805-0021 6.22 398.0 µM 2.96E-10 1 2.54E-10 1.52
2 SGTC_1694 st024011 4.97 44.9 µM 3.67E-7 ERG2 2 3.31E-7 0.43
3 SGTC_1728 st035614 4.32 33.8 µM 8.57E-6 3 7.92E-6 0.19
4 SGTC_2291 7917025 4.04 104.3 µM 2.84E-5 iron homeostasis 10 2.65E-5 0.05
5 SGTC_169 k015-0017 4.01 16.0 µM 3.23E-5 3 3.01E-5 0.47
6 SGTC_34 0469-0683 3.79 81.8 µM 8.12E-5 SWF1 & branched chain AA biosynthesis 6 7.63E-5 0.11
7 SGTC_1993 st073995 3.42 70.8 µM 3.36E-4 11 3.19E-4 0.39
8 SGTC_989 1501-0895 3.36 10.3 µM 4.16E-4 4 3.95E-4 0.16
9 SGTC_1282 0886-0010 3.36 32.4 µM 4.17E-4 endomembrane recycling 19 3.96E-4 0.04
10 SGTC_1985 st071382 3.32 65.5 µM 4.80E-4 10 4.57E-4 0.10
11 SGTC_2521 angolensin 3.28 13.4 µM 5.36E-4 6 5.10E-4 0.28
12 SGTC_1457 k015-0032 3.28 57.3 µM 5.45E-4 7 5.18E-4 0.02
13 SGTC_3046 9092212 3.21 49.5 µM 6.85E-4 4 6.53E-4 0.10
14 SGTC_3320 9137005 3.17 35.1 µM 7.96E-4 endomembrane recycling 10 7.59E-4 0.00
15 SGTC_3023 9089636 3.11 49.5 µM 9.91E-4 6 9.47E-4 0.10
16 SGTC_388 3',4'-dichloroisocoumarin 3.08 16.7 µM 0.00107 14 0.00102 0.11
17 SGTC_2905 7799065 3.05 20.1 µM 0.00118 19 0.00113 0.05
18 SGTC_2005 4024620 2.94 188.0 µM 0.00172 12 0.00165 0.15
19 SGTC_357 1325-0123 2.93 420.0 µM 0.00177 13 0.00169 0.07
20 SGTC_1889 st059080 2.87 5.2 µM 0.00215 13 0.00206 4.45E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.186 1.79E-27 YMR058W FET3 hom Ferro-O2-oxidoreductase; required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases; protein abundance increases in response to DNA replication stress
0.122 1.41E-12 YGR108W CLB1 hom B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
0.111 1.05E-10 YDR270W CCC2 hom Cu(+2)-transporting P-type ATPase; required for export of copper from the cytosol into an extracytosolic compartment; has similarity to human proteins involved in Menkes and Wilsons diseases; protein abundance increases in response to DNA replication stress; affects TBSV model (+)RNA virus replication by regulating copper metabolism
0.105 9.40E-10 YDR287W INM2 hom Inositol monophosphatase, involved in biosynthesis of inositol; enzymatic activity requires magnesium ions and is inhibited by lithium and sodium ions; inm1 inm2 double mutant lacks inositol auxotrophy
0.099 1.06E-8 YJL049W_p YJL049W_p hom Putative protein of unknown function; YJL049W is a non-essential gene
0.094 4.83E-8 YIR017C MET28 hom Basic leucine zipper (bZIP) transcriptional activator in the Cbf1p-Met4p-Met28p complex, participates in the regulation of sulfur metabolism
0.092 1.02E-7 YHL016C DUR3 hom Plasma membrane transporter for both urea and polyamines, expression is highly sensitive to nitrogen catabolite repression and induced by allophanate, the last intermediate of the allantoin degradative pathway
0.088 2.95E-7 YOR358W HAP5 hom Subunit of the heme-activated, glucose-repressed Hap2/3/4/5 CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; required for assembly and DNA binding activity of the complex
0.083 1.34E-6 YBR285W_p YBR285W_p hom Putative protein of unknown function; YBR285W is not an essential gene
0.083 1.38E-6 YNL262W POL2 het Catalytic subunit of DNA polymerase (II) epsilon, a chromosomal DNA replication polymerase that exhibits processivity and proofreading exonuclease activity; also involved in DNA synthesis during DNA repair; interacts extensively with Mrc1p
0.083 1.69E-6 YDR153C ENT5 hom Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p, clathrin adaptor complex AP-1, and clathrin
0.081 2.63E-6 YDR051C DET1 hom Acid phosphatase involved in the non-vesicular transport of sterols in both directions between the endoplasmic reticulum and plasma membrane; deletion confers sensitivity to nickel
0.079 4.16E-6 YAR031W PRM9 hom Pheromone-regulated protein with 3 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; member of DUP240 gene family
0.078 6.87E-6 YIL166C_p YIL166C_p hom Putative protein with similarity to the allantoate permease (Dal5p) subfamily of the major facilitator superfamily; mRNA expression is elevated by sulfur limitation; YIL166C is a non-essential gene
0.077 7.85E-6 YBL084C CDC27 het Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition