YDR090C_p

Putative protein of unknown function

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR090C / YDR090C

Click on Significant Values for Screen Details ID:SGTC_24|Compound:0417-1663|FD-Score:-3.49|P-value:2.76E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:4.13|P-value:3.49E-5 ID:SGTC_43|Compound:0570-0105|FD-Score:6.39|P-value:3.17E-10 ID:SGTC_44|Compound:0929-0055|FD-Score:-4.01|P-value:3.77E-5 ID:SGTC_59|Compound:0330-0160|FD-Score:4.19|P-value:2.73E-5 ID:SGTC_266|Compound:formosanin C|FD-Score:4.22|P-value:2.39E-5 ID:SGTC_357|Compound:1325-0123|FD-Score:-3.99|P-value:4.01E-5 ID:SGTC_520|Compound:3584-0023|FD-Score:-3.77|P-value:9.59E-5 ID:SGTC_706|Compound:4262-0057|FD-Score:3.52|P-value:3.63E-4 ID:SGTC_1004|Compound:4084-0029|FD-Score:3.24|P-value:9.34E-4 ID:SGTC_1172|Compound:0370-0043|FD-Score:4.30|P-value:1.77E-5 ID:SGTC_1173|Compound:0443-0020|FD-Score:3.63|P-value:2.40E-4 ID:SGTC_1174|Compound:0739-0097|FD-Score:3.50|P-value:3.91E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:3.88|P-value:9.70E-5 ID:SGTC_1241|Compound:0364-0022|FD-Score:4.03|P-value:5.30E-5 ID:SGTC_1249|Compound:0481-0015|FD-Score:-3.24|P-value:6.70E-4 ID:SGTC_1737|Compound:st035557|FD-Score:-3.23|P-value:6.84E-4 ID:SGTC_1786|Compound:berberine|FD-Score:-4.41|P-value:6.88E-6 ID:SGTC_1829|Compound:berberine|FD-Score:-3.44|P-value:3.33E-4 ID:SGTC_1833|Compound:st055984|FD-Score:3.55|P-value:3.21E-4 ID:SGTC_1839|Compound:st053978|FD-Score:5.37|P-value:1.09E-7 ID:SGTC_1845|Compound:st056753|FD-Score:-4.08|P-value:2.85E-5 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:3.55|P-value:3.28E-4 ID:SGTC_2003|Compound:4023581|FD-Score:3.44|P-value:4.77E-4 ID:SGTC_2255|Compound:7941087|FD-Score:-3.46|P-value:3.04E-4 ID:SGTC_2345|Compound:9052315|FD-Score:-3.58|P-value:2.01E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:-6.18|P-value:6.21E-10 ID:SGTC_2511|Compound:berberine|FD-Score:-3.53|P-value:2.42E-4 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:5.55|P-value:4.22E-8 ID:SGTC_2544|Compound:sphondin|FD-Score:-3.80|P-value:8.79E-5 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:-4.04|P-value:3.26E-5 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:4.28|P-value:1.92E-5 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:-3.18|P-value:8.03E-4 ID:SGTC_2710|Compound:st078562|FD-Score:3.77|P-value:1.48E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:-3.47|P-value:2.96E-4 ID:SGTC_2787|Compound:5284540|FD-Score:-3.84|P-value:7.38E-5 ID:SGTC_2804|Compound:7954240|FD-Score:-3.65|P-value:1.50E-4 ID:SGTC_2813|Compound:7971799|FD-Score:3.48|P-value:4.12E-4 ID:SGTC_2836|Compound:9010338|FD-Score:5.29|P-value:1.61E-7 ID:SGTC_2874|Compound:9043904|FD-Score:-6.06|P-value:1.29E-9 ID:SGTC_2878|Compound:9043973|FD-Score:-5.96|P-value:2.34E-9 ID:SGTC_3004|Compound:9076122|FD-Score:3.29|P-value:8.09E-4 ID:SGTC_3026|Compound:9090633|FD-Score:3.64|P-value:2.38E-4 ID:SGTC_3128|Compound:9127691|FD-Score:3.48|P-value:4.11E-4 ID:SGTC_3143|Compound:9086658|FD-Score:3.36|P-value:6.27E-4 ID:SGTC_3233|Compound:9132340|FD-Score:-4.67|P-value:2.10E-6 ID:SGTC_3253|Compound:9135987|FD-Score:-3.39|P-value:3.91E-4 ID:SGTC_3294|Compound:9122953|FD-Score:3.59|P-value:2.84E-4 ID:SGTC_3295|Compound:9122362|FD-Score:5.93|P-value:5.07E-9 ID:SGTC_3332|Compound:9141069|FD-Score:-3.80|P-value:8.63E-5 ID:SGTC_24|Compound:0417-1663|FD-Score:-3.49|P-value:2.76E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:4.13|P-value:3.49E-5 ID:SGTC_43|Compound:0570-0105|FD-Score:6.39|P-value:3.17E-10 ID:SGTC_44|Compound:0929-0055|FD-Score:-4.01|P-value:3.77E-5 ID:SGTC_59|Compound:0330-0160|FD-Score:4.19|P-value:2.73E-5 ID:SGTC_266|Compound:formosanin C|FD-Score:4.22|P-value:2.39E-5 ID:SGTC_357|Compound:1325-0123|FD-Score:-3.99|P-value:4.01E-5 ID:SGTC_520|Compound:3584-0023|FD-Score:-3.77|P-value:9.59E-5 ID:SGTC_706|Compound:4262-0057|FD-Score:3.52|P-value:3.63E-4 ID:SGTC_1004|Compound:4084-0029|FD-Score:3.24|P-value:9.34E-4 ID:SGTC_1172|Compound:0370-0043|FD-Score:4.30|P-value:1.77E-5 ID:SGTC_1173|Compound:0443-0020|FD-Score:3.63|P-value:2.40E-4 ID:SGTC_1174|Compound:0739-0097|FD-Score:3.50|P-value:3.91E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:3.88|P-value:9.70E-5 ID:SGTC_1241|Compound:0364-0022|FD-Score:4.03|P-value:5.30E-5 ID:SGTC_1249|Compound:0481-0015|FD-Score:-3.24|P-value:6.70E-4 ID:SGTC_1737|Compound:st035557|FD-Score:-3.23|P-value:6.84E-4 ID:SGTC_1786|Compound:berberine|FD-Score:-4.41|P-value:6.88E-6 ID:SGTC_1829|Compound:berberine|FD-Score:-3.44|P-value:3.33E-4 ID:SGTC_1833|Compound:st055984|FD-Score:3.55|P-value:3.21E-4 ID:SGTC_1839|Compound:st053978|FD-Score:5.37|P-value:1.09E-7 ID:SGTC_1845|Compound:st056753|FD-Score:-4.08|P-value:2.85E-5 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:3.55|P-value:3.28E-4 ID:SGTC_2003|Compound:4023581|FD-Score:3.44|P-value:4.77E-4 ID:SGTC_2255|Compound:7941087|FD-Score:-3.46|P-value:3.04E-4 ID:SGTC_2345|Compound:9052315|FD-Score:-3.58|P-value:2.01E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:-6.18|P-value:6.21E-10 ID:SGTC_2511|Compound:berberine|FD-Score:-3.53|P-value:2.42E-4 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:5.55|P-value:4.22E-8 ID:SGTC_2544|Compound:sphondin|FD-Score:-3.80|P-value:8.79E-5 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:-4.04|P-value:3.26E-5 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:4.28|P-value:1.92E-5 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:-3.18|P-value:8.03E-4 ID:SGTC_2710|Compound:st078562|FD-Score:3.77|P-value:1.48E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:-3.47|P-value:2.96E-4 ID:SGTC_2787|Compound:5284540|FD-Score:-3.84|P-value:7.38E-5 ID:SGTC_2804|Compound:7954240|FD-Score:-3.65|P-value:1.50E-4 ID:SGTC_2813|Compound:7971799|FD-Score:3.48|P-value:4.12E-4 ID:SGTC_2836|Compound:9010338|FD-Score:5.29|P-value:1.61E-7 ID:SGTC_2874|Compound:9043904|FD-Score:-6.06|P-value:1.29E-9 ID:SGTC_2878|Compound:9043973|FD-Score:-5.96|P-value:2.34E-9 ID:SGTC_3004|Compound:9076122|FD-Score:3.29|P-value:8.09E-4 ID:SGTC_3026|Compound:9090633|FD-Score:3.64|P-value:2.38E-4 ID:SGTC_3128|Compound:9127691|FD-Score:3.48|P-value:4.11E-4 ID:SGTC_3143|Compound:9086658|FD-Score:3.36|P-value:6.27E-4 ID:SGTC_3233|Compound:9132340|FD-Score:-4.67|P-value:2.10E-6 ID:SGTC_3253|Compound:9135987|FD-Score:-3.39|P-value:3.91E-4 ID:SGTC_3294|Compound:9122953|FD-Score:3.59|P-value:2.84E-4 ID:SGTC_3295|Compound:9122362|FD-Score:5.93|P-value:5.07E-9 ID:SGTC_3332|Compound:9141069|FD-Score:-3.80|P-value:8.63E-5

Top fitness defect scores for YDR090C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_43 0570-0105 6.39 72.5 µM 3.17E-10 ERG2 28 8.09E-11
2 SGTC_3295 9122362 5.93 53.6 µM 5.07E-9 1 1.53E-9
3 SGTC_2540 epiandrosterone 5.55 100.0 µM 4.22E-8 23 1.44E-8
4 SGTC_1839 st053978 5.37 48.0 µM 1.09E-7 2 3.94E-8
5 SGTC_2836 9010338 5.29 19.5 µM 1.61E-7 RPP1 & pyrimidine depletion 8 5.95E-8
6 SGTC_1172 0370-0043 4.30 85.0 µM 1.77E-5 16 8.71E-6
7 SGTC_2604 4'-hydroxychalcone 4.28 11.3 µM 1.92E-5 28 9.51E-6
8 SGTC_266 formosanin C 4.22 406.0 nM 2.39E-5 sphingolipid biosynthesis & PDR1 59 1.20E-5
9 SGTC_59 0330-0160 4.19 1.3 µM 2.73E-5 100 1.38E-5
10 SGTC_36 0335-0881 4.13 14.2 µM 3.49E-5 ubiquinone biosynthesis & proteasome 115 1.80E-5
11 SGTC_1241 0364-0022 4.03 50.8 µM 5.30E-5 ERG2 27 2.80E-5
12 SGTC_1204 4049-0315 3.88 18.3 µM 9.70E-5 29 5.32E-5
13 SGTC_2710 st078562 3.77 53.7 µM 1.48E-4 24 8.32E-5
14 SGTC_3026 9090633 3.64 49.5 µM 2.38E-4 35 1.38E-4
15 SGTC_1173 0443-0020 3.63 122.0 µM 2.40E-4 TSC3-RPN4 49 1.39E-4
16 SGTC_3294 9122953 3.59 26.3 µM 2.84E-4 tubulin folding & SWR complex 42 1.67E-4
17 SGTC_1833 st055984 3.55 71.0 µM 3.21E-4 28 1.90E-4
18 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 3.55 70.1 µM 3.28E-4 45 1.94E-4
19 SGTC_706 4262-0057 3.52 46.9 µM 3.63E-4 fatty acid desaturase (OLE1) 51 2.16E-4
20 SGTC_1174 0739-0097 3.50 51.1 µM 3.91E-4 redox potentiating 48 2.34E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.145 4.19E-17 YBL065W_d YBL065W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF SEF1/YBL066C; YBL065W is a non-essential gene
0.142 2.10E-16 YOR092W ECM3 hom Non-essential protein of unknown function; involved in signal transduction and the genotoxic response; induced rapidly in response to treatment with 8-methoxypsoralen and UVA irradiation; relocalizes from ER to cytoplasm upon DNA replication stress; ECM3 has a paralog, YNL095C, that arose from the whole genome duplication
0.139 6.05E-16 YDL190C UFD2 hom Ubiquitin chain assembly factor (E4) that cooperates with a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2), and a ubiquitin protein ligase (E3) to conjugate ubiquitin to substrates; also functions as an E3
0.109 2.81E-10 YOR234C RPL33B hom Ribosomal 60S subunit protein L33B; rpl33b null mutant exhibits normal growth while rpl33a rpl33b double null mutant is inviable; homologous to mammalian ribosomal protein L35A, no bacterial homolog; RPL33B has a paralog, RPL33A, that arose from the whole genome duplication
0.108 3.28E-10 YDR221W GTB1 hom Glucosidase II beta subunit, forms a complex with alpha subunit Rot2p; involved in removal of two glucose residues from N-linked glycans during glycoprotein biogenesis in the ER; relocalizes from ER to cytoplasm upon DNA replication stress
0.107 4.36E-10 YJL046W AIM22 hom Putative lipoate-protein ligase, required along with Lip2 and Lip5 for lipoylation of Lat1p and Kgd2p; similar to E. coli LplA; null mutant displays reduced frequency of mitochondrial genome loss
0.105 9.81E-10 YPR096C YPR096C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments
0.102 2.71E-9 YJR088C EMC2 hom Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm Y57G7A.10/EMC-2, fly CG17556, human TTC35
0.101 4.52E-9 YHR029C YHI9 hom Protein of unknown function; null mutant is defective in unfolded protein response; possibly involved in a membrane regulation metabolic pathway; member of the PhzF superfamily, though most likely not involved in phenazine production
0.101 4.41E-9 YOL102C TPT1 het tRNA 2'-phosphotransferase, catalyzes the final step in yeast tRNA splicing: the transfer of the 2'-PO(4) from the splice junction to NAD(+) to form ADP-ribose 1''-2''cyclic phosphate and nicotinamide
0.101 4.55E-9 YFL014W HSP12 hom Plasma membrane protein involved in maintaining membrane organization in stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; protein abundance increased in response to DNA replication stress and dietary restriction; regulated by the HOG and Ras-Pka pathways; required for dietary restriction-induced lifespan extension
0.099 8.81E-9 YOR220W RCN2 hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; phosphorylated in response to alpha factor; protein abundance increases in response to DNA replication stress
0.099 1.20E-8 YDR291W HRQ1 hom 3'-5'DNA helicase that has DNA strand annealing activity; helicase activity is stimulated by fork structure and 3'-tail length of substrates; belongs to the widely conserved RecQ family of proteins which are involved in maintaining genomic integrity; similar to the human RecQ4p implicated in Rothmund-Thomson syndrome(RTS)
0.098 1.41E-8 YGR295C COS6 hom Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
0.096 2.89E-8 YNL257C SIP3 hom Transcription cofactor; acts through interaction with DNA-bound Snf1p; C-terminal region has a putative leucine zipper motif; potential Cdc28p substrate; SIP3 has a paralog, YSP1, that arose from the whole genome duplication