YDR098C / GRX3

Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx4p and Grx5p; protects cells from oxidative damage; evidence exists indicating that the translation start site is not Met1 as currently annotated, but rather Met36

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR098C / GRX3

Click on Significant Values for Screen Details ID:SGTC_166|Compound:k072-0058|FD-Score:-3.17|P-value:3.08E-4 ID:SGTC_314|Compound:1671-0008|FD-Score:4.15|P-value:4.07E-6 ID:SGTC_339|Compound:3091-4833|FD-Score:4.13|P-value:4.53E-6 ID:SGTC_354|Compound:2783-3500|FD-Score:3.22|P-value:2.76E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:6.97|P-value:3.19E-14 ID:SGTC_372|Compound:0155-0182|FD-Score:5.34|P-value:4.85E-9 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:4.15|P-value:4.14E-6 ID:SGTC_517|Compound:1365-0151|FD-Score:-3.30|P-value:1.78E-4 ID:SGTC_659|Compound:k018-0002|FD-Score:3.85|P-value:1.73E-5 ID:SGTC_660|Compound:4031-1742|FD-Score:3.19|P-value:3.11E-4 ID:SGTC_728|Compound:3030-5151|FD-Score:-3.59|P-value:5.23E-5 ID:SGTC_731|Compound:3966-0296|FD-Score:-3.06|P-value:4.62E-4 ID:SGTC_824|Compound:1304-0008|FD-Score:6.86|P-value:8.35E-14 ID:SGTC_832|Compound:4083-0019|FD-Score:3.02|P-value:5.85E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:3.06|P-value:5.10E-4 ID:SGTC_1232|Compound:0279-0259|FD-Score:-3.10|P-value:3.93E-4 ID:SGTC_1262|Compound:0737-0114|FD-Score:2.90|P-value:9.31E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:2.94|P-value:8.08E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.47|P-value:8.70E-5 ID:SGTC_1835|Compound:st008666|FD-Score:-3.06|P-value:4.61E-4 ID:SGTC_2046|Compound:4110841|FD-Score:3.42|P-value:1.18E-4 ID:SGTC_2048|Compound:5246248|FD-Score:3.47|P-value:9.69E-5 ID:SGTC_2490|Compound:carminic acid|FD-Score:3.55|P-value:6.83E-5 ID:SGTC_2492|Compound:derrusnin|FD-Score:2.96|P-value:7.39E-4 ID:SGTC_2508|Compound:celastrol|FD-Score:-3.43|P-value:1.03E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:3.23|P-value:2.64E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:-2.89|P-value:9.01E-4 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:-3.11|P-value:3.85E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:-3.98|P-value:8.42E-6 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:8.72|P-value:3.36E-21 ID:SGTC_2616|Compound:abietic acid|FD-Score:4.26|P-value:2.37E-6 ID:SGTC_2803|Compound:7707263|FD-Score:-3.88|P-value:1.35E-5 ID:SGTC_2806|Compound:7952793|FD-Score:2.95|P-value:7.77E-4 ID:SGTC_2810|Compound:7959871|FD-Score:4.70|P-value:2.24E-7 ID:SGTC_2930|Compound:9013230|FD-Score:3.35|P-value:1.63E-4 ID:SGTC_2970|Compound:9090938|FD-Score:3.03|P-value:5.70E-4 ID:SGTC_2974|Compound:9094440|FD-Score:3.13|P-value:3.86E-4 ID:SGTC_2982|Compound:9019404|FD-Score:3.03|P-value:5.71E-4 ID:SGTC_2991|Compound:9074669|FD-Score:5.24|P-value:8.89E-9 ID:SGTC_3215|Compound:9129942|FD-Score:3.03|P-value:5.84E-4 ID:SGTC_3308|Compound:9128332|FD-Score:3.70|P-value:3.60E-5 ID:SGTC_3319|Compound:9138450|FD-Score:-3.94|P-value:1.04E-5 ID:SGTC_166|Compound:k072-0058|FD-Score:-3.17|P-value:3.08E-4 ID:SGTC_314|Compound:1671-0008|FD-Score:4.15|P-value:4.07E-6 ID:SGTC_339|Compound:3091-4833|FD-Score:4.13|P-value:4.53E-6 ID:SGTC_354|Compound:2783-3500|FD-Score:3.22|P-value:2.76E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:6.97|P-value:3.19E-14 ID:SGTC_372|Compound:0155-0182|FD-Score:5.34|P-value:4.85E-9 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:4.15|P-value:4.14E-6 ID:SGTC_517|Compound:1365-0151|FD-Score:-3.30|P-value:1.78E-4 ID:SGTC_659|Compound:k018-0002|FD-Score:3.85|P-value:1.73E-5 ID:SGTC_660|Compound:4031-1742|FD-Score:3.19|P-value:3.11E-4 ID:SGTC_728|Compound:3030-5151|FD-Score:-3.59|P-value:5.23E-5 ID:SGTC_731|Compound:3966-0296|FD-Score:-3.06|P-value:4.62E-4 ID:SGTC_824|Compound:1304-0008|FD-Score:6.86|P-value:8.35E-14 ID:SGTC_832|Compound:4083-0019|FD-Score:3.02|P-value:5.85E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:3.06|P-value:5.10E-4 ID:SGTC_1232|Compound:0279-0259|FD-Score:-3.10|P-value:3.93E-4 ID:SGTC_1262|Compound:0737-0114|FD-Score:2.90|P-value:9.31E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:2.94|P-value:8.08E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.47|P-value:8.70E-5 ID:SGTC_1835|Compound:st008666|FD-Score:-3.06|P-value:4.61E-4 ID:SGTC_2046|Compound:4110841|FD-Score:3.42|P-value:1.18E-4 ID:SGTC_2048|Compound:5246248|FD-Score:3.47|P-value:9.69E-5 ID:SGTC_2490|Compound:carminic acid|FD-Score:3.55|P-value:6.83E-5 ID:SGTC_2492|Compound:derrusnin|FD-Score:2.96|P-value:7.39E-4 ID:SGTC_2508|Compound:celastrol|FD-Score:-3.43|P-value:1.03E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:3.23|P-value:2.64E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:-2.89|P-value:9.01E-4 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:-3.11|P-value:3.85E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:-3.98|P-value:8.42E-6 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:8.72|P-value:3.36E-21 ID:SGTC_2616|Compound:abietic acid|FD-Score:4.26|P-value:2.37E-6 ID:SGTC_2803|Compound:7707263|FD-Score:-3.88|P-value:1.35E-5 ID:SGTC_2806|Compound:7952793|FD-Score:2.95|P-value:7.77E-4 ID:SGTC_2810|Compound:7959871|FD-Score:4.70|P-value:2.24E-7 ID:SGTC_2930|Compound:9013230|FD-Score:3.35|P-value:1.63E-4 ID:SGTC_2970|Compound:9090938|FD-Score:3.03|P-value:5.70E-4 ID:SGTC_2974|Compound:9094440|FD-Score:3.13|P-value:3.86E-4 ID:SGTC_2982|Compound:9019404|FD-Score:3.03|P-value:5.71E-4 ID:SGTC_2991|Compound:9074669|FD-Score:5.24|P-value:8.89E-9 ID:SGTC_3215|Compound:9129942|FD-Score:3.03|P-value:5.84E-4 ID:SGTC_3308|Compound:9128332|FD-Score:3.70|P-value:3.60E-5 ID:SGTC_3319|Compound:9138450|FD-Score:-3.94|P-value:1.04E-5

Top fitness defect scores for YDR098C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 8.72 70.0 µM 3.36E-21 redox potentiating 12 1.44E-18
2 SGTC_363 0455-0021 6.97 3.1 µM 3.19E-14 azole & statin 24 1.55E-12
3 SGTC_824 1304-0008 6.86 100.0 µM 8.35E-14 DNA damage response 6 3.56E-12
4 SGTC_372 0155-0182 5.34 15.9 µM 4.85E-9 mitochondrial response to ROS 9 4.76E-8
5 SGTC_2991 9074669 5.24 71.4 µM 8.89E-9 azole & statin 28 8.05E-8
6 SGTC_2810 7959871 4.70 45.5 µM 2.24E-7 copper-dependent oxidative stress 24 1.32E-6
7 SGTC_2616 abietic acid 4.26 100.0 µM 2.37E-6 25 1.02E-5
8 SGTC_314 1671-0008 4.15 2.7 µM 4.07E-6 45 1.64E-5
9 SGTC_457 grayanotoxin iii 4.15 135.0 µM 4.14E-6 57 1.67E-5
10 SGTC_339 3091-4833 4.13 71.4 µM 4.53E-6 iron homeostasis 18 1.80E-5
11 SGTC_659 k018-0002 3.85 107.0 µM 1.73E-5 20 5.80E-5
12 SGTC_3308 9128332 3.70 17.6 µM 3.60E-5 plasma membrane duress 88 1.09E-4
13 SGTC_2490 carminic acid 3.55 95.4 µM 6.83E-5 9 1.91E-4
14 SGTC_2048 5246248 3.47 200.0 µM 9.69E-5 15 2.59E-4
15 SGTC_2046 4110841 3.42 106.0 µM 1.18E-4 iron homeostasis 38 3.09E-4
16 SGTC_2930 9013230 3.35 14.9 µM 1.63E-4 heme biosynthesis & mitochondrial translocase 65 4.07E-4
17 SGTC_2568 diosmetin 3.23 100.0 µM 2.64E-4 57 6.22E-4
18 SGTC_354 2783-3500 3.22 4.9 µM 2.76E-4 cell wall 78 6.46E-4
19 SGTC_660 4031-1742 3.19 102.0 µM 3.11E-4 redox potentiating 93 7.17E-4
20 SGTC_2974 9094440 3.13 9.7 µM 3.86E-4 ergosterol biosynthesis 85 8.65E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.154 3.49E-19 YGR170W PSD2 hom Phosphatidylserine decarboxylase of the Golgi and vacuolar membranes, converts phosphatidylserine to phosphatidylethanolamine
0.149 4.44E-18 YDR353W TRR1 het Cytoplasmic thioredoxin reductase; key regulatory enzyme that determines the redox state of the thioredoxin system, which acts as a disulfide reductase system and protects cells against both oxidative and reductive stress; protein abundance increases in response to DNA replication stress; TRR1 has a paralog, TRR2, that arose from the whole genome duplication
0.145 2.94E-17 YJR137C MET5 hom Sulfite reductase beta subunit, involved in amino acid biosynthesis, transcription repressed by methionine
0.142 1.20E-16 YJR146W_p YJR146W_p hom Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps HMS2
0.142 1.55E-16 YMR230W-A_p YMR230W-A_p hom Putative protein of unknown function
0.140 3.19E-16 YIL056W VHR1 hom Transcriptional activator; required for the vitamin H-responsive element (VHRE) mediated induction of VHT1 (Vitamin H transporter) and BIO5 (biotin biosynthesis intermediate transporter) in response to low biotin concentrations; VHR1 has a paralog, VHR2, that arose from the whole genome duplication
0.137 2.15E-15 YFL020C PAU5 hom Member of the seripauperin multigene family encoded mainly in subtelomeric regions; induced during alcoholic fermentation; induced by low temperature and also by anaerobic conditions; negatively regulated by oxygen and repressed by heme
0.122 1.43E-12 YGL045W RIM8 hom Protein involved in proteolytic activation of Rim101p in response to alkaline pH; interacts with ESCRT-1 subunits Stp22p and Vps28p; essential for anaerobic growth; member of the arrestin-related trafficking adaptor family
0.120 3.16E-12 YDR321W ASP1 hom Cytosolic L-asparaginase, involved in asparagine catabolism; catalyzes hydrolysis of L-asparagine to aspartic acid and ammonia, has an important role in therapy of acute lymphoblastic leukemia; synthesized constitutively
0.118 7.86E-12 YLR412W BER1 hom Protein involved in microtubule-related processes, N-acetylation; GFP-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YLR412W is not an essential gene; similar to Arabidopsis SRR1 gene
0.116 1.74E-11 YDR271C_d YDR271C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CCC2/YDR270W
0.115 2.27E-11 YMR154C RIM13 hom Calpain-like cysteine protease; involved in proteolytic activation of Rim101p in response to alkaline pH; localizes to punctate structures in alkaline conditions and in vps4 mutant; has similarity to A. nidulans palB
0.113 6.16E-11 YKR034W DAL80 hom Negative regulator of genes in multiple nitrogen degradation pathways; expression is regulated by nitrogen levels and by Gln3p; member of the GATA-binding family, forms homodimers and heterodimers with Gzf3p; DAL80 has a paralog, GZF3, that arose from the whole genome duplication
0.111 1.42E-10 YLR330W CHS5 hom Component of the exomer complex, which also contains Csh6p, Bch1p, Bch2p, and Bud7p and is involved in export of selected proteins, such as chitin synthase Chs3p, from the Golgi to the plasma membrane
0.110 1.83E-10 YDL199C_p YDL199C_p hom Putative transporter, member of the sugar porter family