YDR107C / TMN2

Protein with a role in cellular adhesion and filamentous growth; similar to Emp70p and Tmn3p; member of the evolutionarily conserved Transmembrane Nine family of proteins with nine membrane-spanning segments

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR107C / TMN2

Click on Significant Values for Screen Details ID:SGTC_110|Compound:0850-0284|FD-Score:2.80|P-value:3.59E-4 ID:SGTC_148|Compound:3253-0744|FD-Score:-3.24|P-value:4.44E-5 ID:SGTC_264|Compound:promethazine|FD-Score:-2.72|P-value:5.12E-4 ID:SGTC_332|Compound:4112-0506|FD-Score:-2.98|P-value:1.61E-4 ID:SGTC_380|Compound:3970-0968|FD-Score:-2.76|P-value:4.18E-4 ID:SGTC_385|Compound:1494-0393|FD-Score:-2.77|P-value:4.15E-4 ID:SGTC_406|Compound:estrone|FD-Score:2.75|P-value:4.51E-4 ID:SGTC_407|Compound:eburnamonine|FD-Score:-2.72|P-value:5.14E-4 ID:SGTC_417|Compound:st075190|FD-Score:3.49|P-value:1.28E-5 ID:SGTC_701|Compound:4424-0219|FD-Score:2.78|P-value:3.89E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:-3.75|P-value:2.94E-6 ID:SGTC_711|Compound:k292-0785|FD-Score:-2.69|P-value:5.64E-4 ID:SGTC_716|Compound:1683-5115|FD-Score:2.61|P-value:8.09E-4 ID:SGTC_732|Compound:3970-1727|FD-Score:2.65|P-value:7.04E-4 ID:SGTC_870|Compound:0573-2213|FD-Score:-2.86|P-value:2.71E-4 ID:SGTC_923|Compound:1900-2434|FD-Score:-2.57|P-value:9.40E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.16|P-value:6.64E-5 ID:SGTC_1463|Compound:k081-0032|FD-Score:-2.76|P-value:4.18E-4 ID:SGTC_1499|Compound:4480-0877|FD-Score:3.52|P-value:1.07E-5 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:2.92|P-value:2.14E-4 ID:SGTC_1966|Compound:st070145|FD-Score:-3.07|P-value:1.01E-4 ID:SGTC_1973|Compound:st070275|FD-Score:3.05|P-value:1.18E-4 ID:SGTC_2238|Compound:6671620|FD-Score:-3.94|P-value:9.37E-7 ID:SGTC_2241|Compound:6772625|FD-Score:-4.87|P-value:1.98E-9 ID:SGTC_2451|Compound:5856223|FD-Score:-3.14|P-value:7.53E-5 ID:SGTC_2452|Compound:5863136|FD-Score:-2.77|P-value:4.08E-4 ID:SGTC_2477|Compound:5967686|FD-Score:-2.89|P-value:2.38E-4 ID:SGTC_2512|Compound:diallyl trisulfide|FD-Score:-2.92|P-value:2.09E-4 ID:SGTC_2516|Compound:gossypol|FD-Score:2.68|P-value:6.12E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:2.87|P-value:2.65E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:-3.76|P-value:2.76E-6 ID:SGTC_2625|Compound:euphol|FD-Score:2.90|P-value:2.36E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:-3.59|P-value:7.17E-6 ID:SGTC_2899|Compound:9053889|FD-Score:3.11|P-value:8.88E-5 ID:SGTC_2936|Compound:9038235|FD-Score:-2.99|P-value:1.50E-4 ID:SGTC_3210|Compound:9128157|FD-Score:-3.15|P-value:7.18E-5 ID:SGTC_3291|Compound:9121177|FD-Score:-2.71|P-value:5.20E-4 ID:SGTC_110|Compound:0850-0284|FD-Score:2.80|P-value:3.59E-4 ID:SGTC_148|Compound:3253-0744|FD-Score:-3.24|P-value:4.44E-5 ID:SGTC_264|Compound:promethazine|FD-Score:-2.72|P-value:5.12E-4 ID:SGTC_332|Compound:4112-0506|FD-Score:-2.98|P-value:1.61E-4 ID:SGTC_380|Compound:3970-0968|FD-Score:-2.76|P-value:4.18E-4 ID:SGTC_385|Compound:1494-0393|FD-Score:-2.77|P-value:4.15E-4 ID:SGTC_406|Compound:estrone|FD-Score:2.75|P-value:4.51E-4 ID:SGTC_407|Compound:eburnamonine|FD-Score:-2.72|P-value:5.14E-4 ID:SGTC_417|Compound:st075190|FD-Score:3.49|P-value:1.28E-5 ID:SGTC_701|Compound:4424-0219|FD-Score:2.78|P-value:3.89E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:-3.75|P-value:2.94E-6 ID:SGTC_711|Compound:k292-0785|FD-Score:-2.69|P-value:5.64E-4 ID:SGTC_716|Compound:1683-5115|FD-Score:2.61|P-value:8.09E-4 ID:SGTC_732|Compound:3970-1727|FD-Score:2.65|P-value:7.04E-4 ID:SGTC_870|Compound:0573-2213|FD-Score:-2.86|P-value:2.71E-4 ID:SGTC_923|Compound:1900-2434|FD-Score:-2.57|P-value:9.40E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.16|P-value:6.64E-5 ID:SGTC_1463|Compound:k081-0032|FD-Score:-2.76|P-value:4.18E-4 ID:SGTC_1499|Compound:4480-0877|FD-Score:3.52|P-value:1.07E-5 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:2.92|P-value:2.14E-4 ID:SGTC_1966|Compound:st070145|FD-Score:-3.07|P-value:1.01E-4 ID:SGTC_1973|Compound:st070275|FD-Score:3.05|P-value:1.18E-4 ID:SGTC_2238|Compound:6671620|FD-Score:-3.94|P-value:9.37E-7 ID:SGTC_2241|Compound:6772625|FD-Score:-4.87|P-value:1.98E-9 ID:SGTC_2451|Compound:5856223|FD-Score:-3.14|P-value:7.53E-5 ID:SGTC_2452|Compound:5863136|FD-Score:-2.77|P-value:4.08E-4 ID:SGTC_2477|Compound:5967686|FD-Score:-2.89|P-value:2.38E-4 ID:SGTC_2512|Compound:diallyl trisulfide|FD-Score:-2.92|P-value:2.09E-4 ID:SGTC_2516|Compound:gossypol|FD-Score:2.68|P-value:6.12E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:2.87|P-value:2.65E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:-3.76|P-value:2.76E-6 ID:SGTC_2625|Compound:euphol|FD-Score:2.90|P-value:2.36E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:-3.59|P-value:7.17E-6 ID:SGTC_2899|Compound:9053889|FD-Score:3.11|P-value:8.88E-5 ID:SGTC_2936|Compound:9038235|FD-Score:-2.99|P-value:1.50E-4 ID:SGTC_3210|Compound:9128157|FD-Score:-3.15|P-value:7.18E-5 ID:SGTC_3291|Compound:9121177|FD-Score:-2.71|P-value:5.20E-4

Top fitness defect scores for YDR107C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1499 4480-0877 3.52 67.3 µM 1.07E-5 12 2.16E-4
2 SGTC_417 st075190 3.49 100.0 µM 1.28E-5 22 2.45E-4
3 SGTC_2899 9053889 3.11 58.4 µM 8.88E-5 28 9.51E-4
4 SGTC_1973 st070275 3.05 50.2 µM 1.18E-4 39 0.00116
5 SGTC_1525 8-methoxypsoralen 2.92 92.5 µM 2.14E-4 DNA damage response 93 0.00176
6 SGTC_2625 euphol 2.90 100.0 µM 2.36E-4 93 0.00189
7 SGTC_2584 androsterone 2.87 48.7 µM 2.65E-4 cell wall 226 0.00205
8 SGTC_110 0850-0284 2.80 111.6 µM 3.59E-4 42 0.00254
9 SGTC_701 4424-0219 2.78 185.0 µM 3.89E-4 calcium & mitochondrial duress 74 0.00269
10 SGTC_406 estrone 2.75 100.0 µM 4.51E-4 64 0.00298
11 SGTC_2516 gossypol 2.68 71.5 µM 6.12E-4 84 0.00370
12 SGTC_732 3970-1727 2.65 52.7 µM 7.04E-4 64 0.00408
13 SGTC_716 1683-5115 2.61 658.0 µM 8.09E-4 108 0.00451
14 SGTC_358 0075-0058 2.55 9.4 µM 0.00105 200 0.00543
15 SGTC_3297 9117502 2.49 71.4 µM 0.00134 85 0.00645
16 SGTC_2585 alliin 2.43 100.0 µM 0.00169 145 0.00758
17 SGTC_774 k060-0086 2.41 136.0 µM 0.00182 144 0.00800
18 SGTC_2487 5918373 2.41 44.0 µM 0.00184 124 0.00808
19 SGTC_626 0214-0009 2.35 33.0 µM 0.00226 copper-dependent oxidative stress 130 0.00933
20 SGTC_1969 st069479 2.35 40.1 µM 0.00226 107 0.00934

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.335 6.48E-89 YDR109C_p YDR109C_p hom Putative kinase
0.328 3.33E-85 YBL017C PEP1 hom Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between the late-Golgi and prevacuolar endosome-like compartments
0.285 5.92E-64 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.284 3.21E-63 YKR102W FLO10 hom Member of the FLO family of cell wall flocculation proteins; not expressed in most lab strains; overproduction induces flocculation that can be inhibited by mannose, sucrose, or glucose; overproduction also promotes haploid invasive growth and diploid filamentous growth
0.234 4.08E-43 YDL086W_p YDL086W_p hom Putative carboxymethylenebutenolidase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL086W is not an essential gene
0.232 2.43E-42 YBL001C ECM15 hom Non-essential protein of unknown function, likely exists as tetramer, may be regulated by the binding of small-molecule ligands (possibly sulfate ions), may have a role in yeast cell-wall biogenesis
0.218 1.77E-37 YEL060C PRB1 hom Vacuolar proteinase B (yscB); serine protease of the subtilisin family; involved in protein degradation in the vacuole and required for full protein degradation during sporulation; activity inhibited by Pbi2p; protein abundance increases in response to DNA replication stress
0.206 1.42E-33 YGR292W MAL12 hom Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL1 complex locus; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose
0.206 1.68E-33 YGL260W_p YGL260W_p hom Putative protein of unknown function; transcription is significantly increased in a NAP1 deletion background; deletion mutant has increased accumulation of nickel and selenium
0.200 9.54E-32 YOL060C MAM3 hom Protein required for normal mitochondrial morphology, has similarity to hemolysins
0.196 1.58E-30 YDL230W PTP1 hom Phosphotyrosine-specific protein phosphatase that dephosphorylates a broad range of substrates in vivo, including Fpr3p; localized to the cytoplasm and the mitochondria; proposed to be a negative regulator of filamentation
0.190 1.43E-28 YDL222C FMP45 hom Integral membrane protein localized to mitochondria (untagged protein); required for sporulation and maintaining sphingolipid content; has sequence similarity to SUR7 and YNL194C
0.190 1.61E-28 YJL051W IRC8 hom Bud tip localized protein of unknown function; mRNA is targeted to the bud by a She2p dependent transport system; mRNA is cell cycle regulated via Fkh2p, peaking in G2/M phase; null mutant displays increased levels of spontaneous Rad52p foc
0.178 2.79E-25 YDL176W YDL176W hom Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene
0.176 1.08E-24 YGR123C PPT1 hom Protein serine/threonine phosphatase, regulates Hsp90 chaperone by affecting its ATPase and cochaperone binding activities; has similarity to human phosphatase PP5; present in both the nucleus and cytoplasm; expressed during logarithmic growth