YDR109C_p

Putative kinase

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR109C / YDR109C

Click on Significant Values for Screen Details ID:SGTC_144|Compound:4161-2749|FD-Score:-4.54|P-value:2.61E-7 ID:SGTC_148|Compound:3253-0744|FD-Score:-5.86|P-value:4.76E-11 ID:SGTC_152|Compound:4469-0003|FD-Score:2.87|P-value:8.21E-4 ID:SGTC_370|Compound:0180-0345|FD-Score:-3.10|P-value:2.92E-4 ID:SGTC_381|Compound:3461-2219|FD-Score:2.93|P-value:6.52E-4 ID:SGTC_383|Compound:2324-0395|FD-Score:3.08|P-value:3.68E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:3.86|P-value:1.16E-5 ID:SGTC_464|Compound:bw-b 70c|FD-Score:3.06|P-value:3.91E-4 ID:SGTC_534|Compound:k292-0788|FD-Score:3.54|P-value:5.27E-5 ID:SGTC_613|Compound:3914-0030|FD-Score:-3.01|P-value:4.21E-4 ID:SGTC_650|Compound:1328-0195|FD-Score:3.58|P-value:4.30E-5 ID:SGTC_705|Compound:1124-0212|FD-Score:3.31|P-value:1.41E-4 ID:SGTC_824|Compound:1304-0008|FD-Score:3.12|P-value:3.09E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:2.91|P-value:7.18E-4 ID:SGTC_945|Compound:3381-0768|FD-Score:2.85|P-value:9.13E-4 ID:SGTC_1094|Compound:duloxetine|FD-Score:-3.10|P-value:2.98E-4 ID:SGTC_1369|Compound:1866-0067|FD-Score:3.96|P-value:6.77E-6 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.20|P-value:1.95E-4 ID:SGTC_1499|Compound:4480-0877|FD-Score:3.90|P-value:9.34E-6 ID:SGTC_1914|Compound:st062367|FD-Score:-3.01|P-value:4.22E-4 ID:SGTC_2025|Compound:5147754|FD-Score:-3.13|P-value:2.65E-4 ID:SGTC_2108|Compound:5365811|FD-Score:2.82|P-value:9.87E-4 ID:SGTC_2238|Compound:6671620|FD-Score:-4.30|P-value:9.58E-7 ID:SGTC_2241|Compound:6772625|FD-Score:-7.09|P-value:2.47E-15 ID:SGTC_2243|Compound:6634756|FD-Score:3.45|P-value:7.62E-5 ID:SGTC_2245|Compound:6637752|FD-Score:4.59|P-value:2.35E-7 ID:SGTC_2315|Compound:7733312|FD-Score:3.53|P-value:5.39E-5 ID:SGTC_2340|Compound:7987427|FD-Score:5.68|P-value:2.23E-10 ID:SGTC_2409|Compound:alverine citrate|FD-Score:3.95|P-value:7.47E-6 ID:SGTC_2458|Compound:5808907|FD-Score:3.26|P-value:1.74E-4 ID:SGTC_2487|Compound:5918373|FD-Score:3.48|P-value:6.90E-5 ID:SGTC_2508|Compound:celastrol|FD-Score:-2.88|P-value:6.96E-4 ID:SGTC_2512|Compound:diallyl trisulfide|FD-Score:-2.94|P-value:5.62E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:3.03|P-value:4.57E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:3.59|P-value:4.04E-5 ID:SGTC_2581|Compound:avocatin a|FD-Score:3.84|P-value:1.26E-5 ID:SGTC_2586|Compound:curcumin|FD-Score:3.66|P-value:2.95E-5 ID:SGTC_2803|Compound:7707263|FD-Score:-2.85|P-value:7.90E-4 ID:SGTC_2936|Compound:9038235|FD-Score:-3.17|P-value:2.21E-4 ID:SGTC_3042|Compound:9091578|FD-Score:2.89|P-value:7.86E-4 ID:SGTC_3162|Compound:9099653|FD-Score:4.26|P-value:1.49E-6 ID:SGTC_3196|Compound:9111891|FD-Score:-3.82|P-value:1.18E-5 ID:SGTC_3200|Compound:9114385|FD-Score:-2.85|P-value:7.79E-4 ID:SGTC_3300|Compound:9124615|FD-Score:3.06|P-value:3.99E-4 ID:SGTC_3307|Compound:9126885|FD-Score:-3.56|P-value:4.04E-5 ID:SGTC_3348|Compound:9149464|FD-Score:-5.69|P-value:1.56E-10 ID:SGTC_3355|Compound:9151058|FD-Score:-3.61|P-value:3.22E-5 ID:SGTC_144|Compound:4161-2749|FD-Score:-4.54|P-value:2.61E-7 ID:SGTC_148|Compound:3253-0744|FD-Score:-5.86|P-value:4.76E-11 ID:SGTC_152|Compound:4469-0003|FD-Score:2.87|P-value:8.21E-4 ID:SGTC_370|Compound:0180-0345|FD-Score:-3.10|P-value:2.92E-4 ID:SGTC_381|Compound:3461-2219|FD-Score:2.93|P-value:6.52E-4 ID:SGTC_383|Compound:2324-0395|FD-Score:3.08|P-value:3.68E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:3.86|P-value:1.16E-5 ID:SGTC_464|Compound:bw-b 70c|FD-Score:3.06|P-value:3.91E-4 ID:SGTC_534|Compound:k292-0788|FD-Score:3.54|P-value:5.27E-5 ID:SGTC_613|Compound:3914-0030|FD-Score:-3.01|P-value:4.21E-4 ID:SGTC_650|Compound:1328-0195|FD-Score:3.58|P-value:4.30E-5 ID:SGTC_705|Compound:1124-0212|FD-Score:3.31|P-value:1.41E-4 ID:SGTC_824|Compound:1304-0008|FD-Score:3.12|P-value:3.09E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:2.91|P-value:7.18E-4 ID:SGTC_945|Compound:3381-0768|FD-Score:2.85|P-value:9.13E-4 ID:SGTC_1094|Compound:duloxetine|FD-Score:-3.10|P-value:2.98E-4 ID:SGTC_1369|Compound:1866-0067|FD-Score:3.96|P-value:6.77E-6 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.20|P-value:1.95E-4 ID:SGTC_1499|Compound:4480-0877|FD-Score:3.90|P-value:9.34E-6 ID:SGTC_1914|Compound:st062367|FD-Score:-3.01|P-value:4.22E-4 ID:SGTC_2025|Compound:5147754|FD-Score:-3.13|P-value:2.65E-4 ID:SGTC_2108|Compound:5365811|FD-Score:2.82|P-value:9.87E-4 ID:SGTC_2238|Compound:6671620|FD-Score:-4.30|P-value:9.58E-7 ID:SGTC_2241|Compound:6772625|FD-Score:-7.09|P-value:2.47E-15 ID:SGTC_2243|Compound:6634756|FD-Score:3.45|P-value:7.62E-5 ID:SGTC_2245|Compound:6637752|FD-Score:4.59|P-value:2.35E-7 ID:SGTC_2315|Compound:7733312|FD-Score:3.53|P-value:5.39E-5 ID:SGTC_2340|Compound:7987427|FD-Score:5.68|P-value:2.23E-10 ID:SGTC_2409|Compound:alverine citrate|FD-Score:3.95|P-value:7.47E-6 ID:SGTC_2458|Compound:5808907|FD-Score:3.26|P-value:1.74E-4 ID:SGTC_2487|Compound:5918373|FD-Score:3.48|P-value:6.90E-5 ID:SGTC_2508|Compound:celastrol|FD-Score:-2.88|P-value:6.96E-4 ID:SGTC_2512|Compound:diallyl trisulfide|FD-Score:-2.94|P-value:5.62E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:3.03|P-value:4.57E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:3.59|P-value:4.04E-5 ID:SGTC_2581|Compound:avocatin a|FD-Score:3.84|P-value:1.26E-5 ID:SGTC_2586|Compound:curcumin|FD-Score:3.66|P-value:2.95E-5 ID:SGTC_2803|Compound:7707263|FD-Score:-2.85|P-value:7.90E-4 ID:SGTC_2936|Compound:9038235|FD-Score:-3.17|P-value:2.21E-4 ID:SGTC_3042|Compound:9091578|FD-Score:2.89|P-value:7.86E-4 ID:SGTC_3162|Compound:9099653|FD-Score:4.26|P-value:1.49E-6 ID:SGTC_3196|Compound:9111891|FD-Score:-3.82|P-value:1.18E-5 ID:SGTC_3200|Compound:9114385|FD-Score:-2.85|P-value:7.79E-4 ID:SGTC_3300|Compound:9124615|FD-Score:3.06|P-value:3.99E-4 ID:SGTC_3307|Compound:9126885|FD-Score:-3.56|P-value:4.04E-5 ID:SGTC_3348|Compound:9149464|FD-Score:-5.69|P-value:1.56E-10 ID:SGTC_3355|Compound:9151058|FD-Score:-3.61|P-value:3.22E-5

Top fitness defect scores for YDR109C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2340 7987427 5.68 183.4 µM 2.23E-10 10 6.88E-9
2 SGTC_2245 6637752 4.59 200.0 µM 2.35E-7 13 2.24E-6
3 SGTC_3162 9099653 4.26 49.5 µM 1.49E-6 2 1.04E-5
4 SGTC_1369 1866-0067 3.96 208.0 µM 6.77E-6 RPP1 & pyrimidine depletion 38 3.67E-5
5 SGTC_2409 alverine citrate 3.95 64.0 µM 7.47E-6 52 3.98E-5
6 SGTC_1499 4480-0877 3.90 67.3 µM 9.34E-6 7 4.80E-5
7 SGTC_431 k089-0097 3.86 107.0 µM 1.16E-5 iron homeostasis 49 5.76E-5
8 SGTC_2581 avocatin a 3.84 64.0 µM 1.26E-5 sphingolipid biosynthesis & PDR1 55 6.16E-5
9 SGTC_2586 curcumin 3.66 80.0 µM 2.95E-5 iron homeostasis 64 1.25E-4
10 SGTC_2564 betulinic acid 3.59 100.0 µM 4.04E-5 42 1.63E-4
11 SGTC_650 1328-0195 3.58 38.0 µM 4.30E-5 28 1.72E-4
12 SGTC_534 k292-0788 3.54 63.4 µM 5.27E-5 mitochondrial processes 43 2.04E-4
13 SGTC_2315 7733312 3.53 200.0 µM 5.39E-5 37 2.07E-4
14 SGTC_2487 5918373 3.48 44.0 µM 6.90E-5 28 2.55E-4
15 SGTC_2243 6634756 3.45 200.0 µM 7.62E-5 33 2.77E-4
16 SGTC_705 1124-0212 3.31 310.0 µM 1.41E-4 38 4.63E-4
17 SGTC_2458 5808907 3.26 16.4 µM 1.74E-4 15 5.54E-4
18 SGTC_824 1304-0008 3.12 100.0 µM 3.09E-4 DNA damage response 76 8.94E-4
19 SGTC_383 2324-0395 3.08 7.4 µM 3.68E-4 azole & statin 85 0.00103
20 SGTC_464 bw-b 70c 3.06 158.0 µM 3.91E-4 68 0.00109

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.335 6.48E-89 YDR107C TMN2 hom Protein with a role in cellular adhesion and filamentous growth; similar to Emp70p and Tmn3p; member of the evolutionarily conserved Transmembrane Nine family of proteins with nine membrane-spanning segments
0.243 2.35E-46 YBL017C PEP1 hom Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between the late-Golgi and prevacuolar endosome-like compartments
0.219 1.10E-37 YDL086W_p YDL086W_p hom Putative carboxymethylenebutenolidase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL086W is not an essential gene
0.212 1.65E-35 YBL001C ECM15 hom Non-essential protein of unknown function, likely exists as tetramer, may be regulated by the binding of small-molecule ligands (possibly sulfate ions), may have a role in yeast cell-wall biogenesis
0.193 1.89E-29 YOR152C_p YOR152C_p hom Putative protein of unknown function; YOR152C is not an essential gene
0.183 1.65E-26 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.181 5.06E-26 YDL230W PTP1 hom Phosphotyrosine-specific protein phosphatase that dephosphorylates a broad range of substrates in vivo, including Fpr3p; localized to the cytoplasm and the mitochondria; proposed to be a negative regulator of filamentation
0.176 9.85E-25 YGR292W MAL12 hom Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL1 complex locus; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose
0.167 2.03E-22 YOL060C MAM3 hom Protein required for normal mitochondrial morphology, has similarity to hemolysins
0.157 6.51E-20 YDL176W YDL176W hom Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene
0.151 1.79E-18 YKR102W FLO10 hom Member of the FLO family of cell wall flocculation proteins; not expressed in most lab strains; overproduction induces flocculation that can be inhibited by mannose, sucrose, or glucose; overproduction also promotes haploid invasive growth and diploid filamentous growth
0.150 2.54E-18 YPR037C ERV2 hom Flavin-linked sulfhydryl oxidase localized to the endoplasmic reticulum lumen, involved in disulfide bond formation within the ER
0.146 2.43E-17 YBR104W YMC2 hom Putative mitochondrial inner membrane transporter; proposed role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; YMC2 has a paralog, YMC1, that arose from the whole genome duplication
0.137 1.37E-15 YOL075C_p YOL075C_p hom Putative ABC transporter
0.130 4.01E-14 YDL222C FMP45 hom Integral membrane protein localized to mitochondria (untagged protein); required for sporulation and maintaining sphingolipid content; has sequence similarity to SUR7 and YNL194C