YDR112W_d / IRC2

Dubious open reading frame, unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR111C; null mutant displays increased levels of spontaneous Rad52p foci

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR112W / IRC2

Click on Significant Values for Screen Details ID:SGTC_111|Compound:0083-0039|FD-Score:3.62|P-value:9.06E-5 ID:SGTC_183|Compound:3914-0051|FD-Score:4.33|P-value:3.84E-6 ID:SGTC_228|Compound:caffeine|FD-Score:-3.01|P-value:8.48E-4 ID:SGTC_419|Compound:nsc-638432|FD-Score:3.58|P-value:1.06E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:3.20|P-value:4.84E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.70|P-value:5.70E-7 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.32|P-value:2.98E-4 ID:SGTC_667|Compound:1498-1044|FD-Score:-3.10|P-value:6.17E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:3.18|P-value:5.05E-4 ID:SGTC_751|Compound:0833-0568|FD-Score:4.09|P-value:1.17E-5 ID:SGTC_753|Compound:1322-0200|FD-Score:4.30|P-value:4.43E-6 ID:SGTC_778|Compound:3456-2434|FD-Score:3.88|P-value:3.07E-5 ID:SGTC_900|Compound:1112-0045|FD-Score:4.62|P-value:8.82E-7 ID:SGTC_927|Compound:2425-1185|FD-Score:-4.76|P-value:3.80E-7 ID:SGTC_930|Compound:2810-3379|FD-Score:-3.26|P-value:3.38E-4 ID:SGTC_958|Compound:1222-0007|FD-Score:3.72|P-value:6.06E-5 ID:SGTC_963|Compound:1269-2853|FD-Score:4.38|P-value:2.98E-6 ID:SGTC_966|Compound:1300-0360|FD-Score:4.91|P-value:1.90E-7 ID:SGTC_968|Compound:1309-0633|FD-Score:4.06|P-value:1.37E-5 ID:SGTC_1017|Compound:4239-0030|FD-Score:3.23|P-value:4.26E-4 ID:SGTC_1051|Compound:3253-3903|FD-Score:-3.34|P-value:2.52E-4 ID:SGTC_1055|Compound:3448-0672|FD-Score:3.80|P-value:4.32E-5 ID:SGTC_1058|Compound:3448-5425|FD-Score:3.00|P-value:9.78E-4 ID:SGTC_1084|Compound:voriconazole|FD-Score:3.33|P-value:2.94E-4 ID:SGTC_1170|Compound:0310-0127|FD-Score:3.32|P-value:3.06E-4 ID:SGTC_1316|Compound:1272-0050|FD-Score:-3.03|P-value:8.00E-4 ID:SGTC_1383|Compound:3049-0032|FD-Score:-3.06|P-value:7.22E-4 ID:SGTC_1509|Compound:1326-1131|FD-Score:3.43|P-value:1.98E-4 ID:SGTC_1581|Compound:himbacine|FD-Score:3.81|P-value:4.03E-5 ID:SGTC_1758|Compound:st042942|FD-Score:3.69|P-value:6.80E-5 ID:SGTC_1779|Compound:st039427|FD-Score:5.06|P-value:8.10E-8 ID:SGTC_1789|Compound:tunicamycin|FD-Score:12.90|P-value:6.99E-41 ID:SGTC_1902|Compound:st060212|FD-Score:3.11|P-value:6.58E-4 ID:SGTC_1941|Compound:st076221|FD-Score:4.02|P-value:1.63E-5 ID:SGTC_1944|Compound:st076371|FD-Score:-4.39|P-value:2.48E-6 ID:SGTC_1984|Compound:st072354|FD-Score:-2.98|P-value:9.56E-4 ID:SGTC_1994|Compound:st072947|FD-Score:3.51|P-value:1.45E-4 ID:SGTC_2044|Compound:5102272|FD-Score:3.19|P-value:4.88E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:3.61|P-value:9.65E-5 ID:SGTC_2181|Compound:6316240|FD-Score:3.60|P-value:9.88E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-3.87|P-value:2.81E-5 ID:SGTC_2255|Compound:7941087|FD-Score:3.67|P-value:7.32E-5 ID:SGTC_2306|Compound:7482397|FD-Score:3.16|P-value:5.47E-4 ID:SGTC_2335|Compound:9018011|FD-Score:3.09|P-value:7.12E-4 ID:SGTC_2411|Compound:st077133|FD-Score:4.50|P-value:1.65E-6 ID:SGTC_2456|Compound:5770359|FD-Score:3.06|P-value:7.75E-4 ID:SGTC_2841|Compound:9004761|FD-Score:-3.40|P-value:1.99E-4 ID:SGTC_2991|Compound:9074669|FD-Score:3.23|P-value:4.23E-4 ID:SGTC_3137|Compound:9097352|FD-Score:3.05|P-value:8.08E-4 ID:SGTC_3153|Compound:9100258|FD-Score:3.19|P-value:4.88E-4 ID:SGTC_3154|Compound:9100113|FD-Score:-3.24|P-value:3.75E-4 ID:SGTC_3213|Compound:9129884|FD-Score:-4.04|P-value:1.30E-5 ID:SGTC_3289|Compound:9119912|FD-Score:4.41|P-value:2.60E-6 ID:SGTC_111|Compound:0083-0039|FD-Score:3.62|P-value:9.06E-5 ID:SGTC_183|Compound:3914-0051|FD-Score:4.33|P-value:3.84E-6 ID:SGTC_228|Compound:caffeine|FD-Score:-3.01|P-value:8.48E-4 ID:SGTC_419|Compound:nsc-638432|FD-Score:3.58|P-value:1.06E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:3.20|P-value:4.84E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.70|P-value:5.70E-7 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.32|P-value:2.98E-4 ID:SGTC_667|Compound:1498-1044|FD-Score:-3.10|P-value:6.17E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:3.18|P-value:5.05E-4 ID:SGTC_751|Compound:0833-0568|FD-Score:4.09|P-value:1.17E-5 ID:SGTC_753|Compound:1322-0200|FD-Score:4.30|P-value:4.43E-6 ID:SGTC_778|Compound:3456-2434|FD-Score:3.88|P-value:3.07E-5 ID:SGTC_900|Compound:1112-0045|FD-Score:4.62|P-value:8.82E-7 ID:SGTC_927|Compound:2425-1185|FD-Score:-4.76|P-value:3.80E-7 ID:SGTC_930|Compound:2810-3379|FD-Score:-3.26|P-value:3.38E-4 ID:SGTC_958|Compound:1222-0007|FD-Score:3.72|P-value:6.06E-5 ID:SGTC_963|Compound:1269-2853|FD-Score:4.38|P-value:2.98E-6 ID:SGTC_966|Compound:1300-0360|FD-Score:4.91|P-value:1.90E-7 ID:SGTC_968|Compound:1309-0633|FD-Score:4.06|P-value:1.37E-5 ID:SGTC_1017|Compound:4239-0030|FD-Score:3.23|P-value:4.26E-4 ID:SGTC_1051|Compound:3253-3903|FD-Score:-3.34|P-value:2.52E-4 ID:SGTC_1055|Compound:3448-0672|FD-Score:3.80|P-value:4.32E-5 ID:SGTC_1058|Compound:3448-5425|FD-Score:3.00|P-value:9.78E-4 ID:SGTC_1084|Compound:voriconazole|FD-Score:3.33|P-value:2.94E-4 ID:SGTC_1170|Compound:0310-0127|FD-Score:3.32|P-value:3.06E-4 ID:SGTC_1316|Compound:1272-0050|FD-Score:-3.03|P-value:8.00E-4 ID:SGTC_1383|Compound:3049-0032|FD-Score:-3.06|P-value:7.22E-4 ID:SGTC_1509|Compound:1326-1131|FD-Score:3.43|P-value:1.98E-4 ID:SGTC_1581|Compound:himbacine|FD-Score:3.81|P-value:4.03E-5 ID:SGTC_1758|Compound:st042942|FD-Score:3.69|P-value:6.80E-5 ID:SGTC_1779|Compound:st039427|FD-Score:5.06|P-value:8.10E-8 ID:SGTC_1789|Compound:tunicamycin|FD-Score:12.90|P-value:6.99E-41 ID:SGTC_1902|Compound:st060212|FD-Score:3.11|P-value:6.58E-4 ID:SGTC_1941|Compound:st076221|FD-Score:4.02|P-value:1.63E-5 ID:SGTC_1944|Compound:st076371|FD-Score:-4.39|P-value:2.48E-6 ID:SGTC_1984|Compound:st072354|FD-Score:-2.98|P-value:9.56E-4 ID:SGTC_1994|Compound:st072947|FD-Score:3.51|P-value:1.45E-4 ID:SGTC_2044|Compound:5102272|FD-Score:3.19|P-value:4.88E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:3.61|P-value:9.65E-5 ID:SGTC_2181|Compound:6316240|FD-Score:3.60|P-value:9.88E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-3.87|P-value:2.81E-5 ID:SGTC_2255|Compound:7941087|FD-Score:3.67|P-value:7.32E-5 ID:SGTC_2306|Compound:7482397|FD-Score:3.16|P-value:5.47E-4 ID:SGTC_2335|Compound:9018011|FD-Score:3.09|P-value:7.12E-4 ID:SGTC_2411|Compound:st077133|FD-Score:4.50|P-value:1.65E-6 ID:SGTC_2456|Compound:5770359|FD-Score:3.06|P-value:7.75E-4 ID:SGTC_2841|Compound:9004761|FD-Score:-3.40|P-value:1.99E-4 ID:SGTC_2991|Compound:9074669|FD-Score:3.23|P-value:4.23E-4 ID:SGTC_3137|Compound:9097352|FD-Score:3.05|P-value:8.08E-4 ID:SGTC_3153|Compound:9100258|FD-Score:3.19|P-value:4.88E-4 ID:SGTC_3154|Compound:9100113|FD-Score:-3.24|P-value:3.75E-4 ID:SGTC_3213|Compound:9129884|FD-Score:-4.04|P-value:1.30E-5 ID:SGTC_3289|Compound:9119912|FD-Score:4.41|P-value:2.60E-6

Top fitness defect scores for YDR112W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1789 tunicamycin 12.90 25.0 nM 6.99E-41 unfolded protein response 4 3.15E-38
2 SGTC_1779 st039427 5.06 55.0 µM 8.10E-8 5 2.05E-7
3 SGTC_966 1300-0360 4.91 30.2 µM 1.90E-7 heme requiring 10 4.55E-7
4 SGTC_453 enantio-paf c16 4.70 10.0 µM 5.70E-7 99 1.27E-6
5 SGTC_900 1112-0045 4.62 141.0 µM 8.82E-7 NEO1 18 1.91E-6
6 SGTC_2411 st077133 4.50 39.9 µM 1.65E-6 RNA pol III & RNase P/MRP 18 3.42E-6
7 SGTC_3289 9119912 4.41 71.4 µM 2.60E-6 7 5.24E-6
8 SGTC_963 1269-2853 4.38 151.0 µM 2.98E-6 20 5.96E-6
9 SGTC_183 3914-0051 4.33 30.6 µM 3.84E-6 60S ribosome export 14 7.55E-6
10 SGTC_753 1322-0200 4.30 289.0 µM 4.43E-6 10 8.63E-6
11 SGTC_751 0833-0568 4.09 350.0 µM 1.17E-5 17 2.14E-5
12 SGTC_968 1309-0633 4.06 340.0 µM 1.37E-5 10 2.47E-5
13 SGTC_1941 st076221 4.02 61.8 µM 1.63E-5 sphingolipid biosynthesis & PDR1 78 2.92E-5
14 SGTC_778 3456-2434 3.88 196.0 µM 3.07E-5 mitochondrial response to ROS 79 5.28E-5
15 SGTC_1581 himbacine 3.81 57.9 µM 4.03E-5 Golgi 53 6.81E-5
16 SGTC_1055 3448-0672 3.80 86.0 µM 4.32E-5 33 7.28E-5
17 SGTC_958 1222-0007 3.72 33.0 µM 6.06E-5 35 9.98E-5
18 SGTC_1758 st042942 3.69 75.2 µM 6.80E-5 28 1.11E-4
19 SGTC_2255 7941087 3.67 197.4 µM 7.32E-5 38 1.19E-4
20 SGTC_111 0083-0039 3.62 52.5 µM 9.06E-5 5 1.45E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.188 5.53E-28 YBR243C ALG7 het UDP-N-acetyl-glucosamine-1-P transferase, transfers Glc-Nac-P from UDP-GlcNac to Dol-P in the ER in the first step of the dolichol pathway of protein asparagine-linked glycosylation; inhibited by tunicamycin
0.132 1.99E-14 YDL145C COP1 het Alpha subunit of COPI vesicle coatomer complex, which surrounds transport vesicles in the early secretory pathway
0.127 2.16E-13 YOL102C TPT1 het tRNA 2'-phosphotransferase, catalyzes the final step in yeast tRNA splicing: the transfer of the 2'-PO(4) from the splice junction to NAD(+) to form ADP-ribose 1''-2''cyclic phosphate and nicotinamide
0.125 3.81E-13 YFR051C RET2 het Delta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER
0.106 8.78E-10 YNL287W SEC21 het Gamma subunit of coatomer, a heptameric protein complex that together with Arf1p forms the COPI coat; involved in ER to Golgi transport of selective cargo
0.106 9.02E-10 YIL162W SUC2 hom Invertase, sucrose hydrolyzing enzyme; a secreted, glycosylated form is regulated by glucose repression, and an intracellular, nonglycosylated enzyme is produced constitutively
0.105 1.40E-9 YOR292C_p YOR292C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YOR292C is not an essential gene
0.104 1.53E-9 YGR012W YGR012W hom Putative cysteine synthase, localized to the mitochondrial outer membrane
0.103 2.48E-9 YDR238C SEC26 het Essential beta-coat protein of the COPI coatomer, involved in ER-to-Golgi protein trafficking and maintenance of normal ER morphology; shares 43% sequence identity with mammalian beta-coat protein (beta-COP)
0.099 1.09E-8 YJL010C NOP9 het Essential subunit of U3-containing 90S preribosome involved in production of 18S rRNA and assembly of small ribosomal subunit; also part of pre-40S ribosome and required for its export into cytoplasm; binds RNA and contains pumilio domain
0.096 2.78E-8 YIR006C PAN1 het Part of actin cytoskeleton-regulatory complex Pan1p-Sla1p-End3p, associates with actin patches on the cell cortex; promotes protein-protein interactions essential for endocytosis; binds to and activates the Arp2/3 complex in vitro; previously thought to be a subunit of poly(A) ribonuclease
0.094 6.25E-8 YKL041W VPS24 hom One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); forms an ESCRT-III subcomplex with Did4p; involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway
0.093 6.89E-8 YDR292C SRP101 het Signal recognition particle (SRP) receptor alpha subunit; contain GTPase domains; involved in SRP-dependent protein targeting; interacts with the beta subunit, Srp102p
0.093 8.48E-8 YDL194W SNF3 hom Plasma membrane low glucose sensor, regulates glucose transport; contains 12 predicted transmembrane segments and a long C-terminal tail required for induction of hexose transporters; also senses fructose and mannose; SNF3 has a paralog, RGT2, that arose from the whole genome duplication
0.092 9.32E-8 YKR033C_d YKR033C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene DAL80