YDR113C / PDS1

Securin, inhibits anaphase by binding separin Esp1p; blocks cyclin destruction and mitotic exit, essential for meiotic progression and mitotic cell cycle arrest; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDR113C / PDS1

Click on Significant Values for Screen Details ID:SGTC_35|Compound:0133-0054|FD-Score:-4.78|P-value:1.60E-6 ID:SGTC_41|Compound:0478-0632|FD-Score:8.13|P-value:1.23E-15 ID:SGTC_145|Compound:3737-0113|FD-Score:3.76|P-value:1.26E-4 ID:SGTC_160|Compound:3453-0671|FD-Score:-4.77|P-value:1.70E-6 ID:SGTC_181|Compound:1447-1644|FD-Score:-3.70|P-value:1.56E-4 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:6.44|P-value:1.75E-10 ID:SGTC_264|Compound:promethazine|FD-Score:10.70|P-value:6.57E-26 ID:SGTC_272|Compound:doxorubicin|FD-Score:5.10|P-value:3.28E-7 ID:SGTC_273|Compound:hydroxyurea|FD-Score:4.42|P-value:8.10E-6 ID:SGTC_557|Compound:1315-0110|FD-Score:3.57|P-value:2.55E-4 ID:SGTC_641|Compound:4092-0595|FD-Score:4.29|P-value:1.46E-5 ID:SGTC_670|Compound:4204-0025|FD-Score:3.87|P-value:8.27E-5 ID:SGTC_686|Compound:1319-0111|FD-Score:3.51|P-value:3.14E-4 ID:SGTC_745|Compound:0469-0705|FD-Score:3.50|P-value:3.22E-4 ID:SGTC_854|Compound:0422-0053|FD-Score:4.78|P-value:1.63E-6 ID:SGTC_977|Compound:1348-1378|FD-Score:3.20|P-value:8.99E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:-3.70|P-value:1.58E-4 ID:SGTC_1006|Compound:4099-6547|FD-Score:3.84|P-value:9.24E-5 ID:SGTC_1052|Compound:3253-3998|FD-Score:4.10|P-value:3.19E-5 ID:SGTC_1059|Compound:3448-6867|FD-Score:3.82|P-value:9.68E-5 ID:SGTC_1178|Compound:0988-0033|FD-Score:3.77|P-value:1.18E-4 ID:SGTC_1325|Compound:1431-0015|FD-Score:3.49|P-value:3.31E-4 ID:SGTC_1446|Compound:4239-0190|FD-Score:4.25|P-value:1.71E-5 ID:SGTC_1511|Compound:0906-3109|FD-Score:-3.53|P-value:2.93E-4 ID:SGTC_1534|Compound:6-azauridine|FD-Score:3.32|P-value:5.99E-4 ID:SGTC_1730|Compound:st033808|FD-Score:3.25|P-value:7.70E-4 ID:SGTC_1770|Compound:st043884|FD-Score:3.32|P-value:6.16E-4 ID:SGTC_2002|Compound:4023503|FD-Score:-4.31|P-value:1.37E-5 ID:SGTC_2007|Compound:4011539|FD-Score:4.22|P-value:1.92E-5 ID:SGTC_2495|Compound:cafestol|FD-Score:6.06|P-value:1.79E-9 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:4.20|P-value:2.16E-5 ID:SGTC_2587|Compound:piperic acid|FD-Score:3.27|P-value:7.08E-4 ID:SGTC_2655|Compound:perillic acid|FD-Score:3.53|P-value:2.90E-4 ID:SGTC_2696|Compound:st077691|FD-Score:3.19|P-value:9.29E-4 ID:SGTC_2712|Compound:st079126|FD-Score:3.20|P-value:9.13E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:3.53|P-value:2.91E-4 ID:SGTC_2811|Compound:7967822|FD-Score:-5.88|P-value:5.28E-9 ID:SGTC_2941|Compound:9056145|FD-Score:-3.98|P-value:5.44E-5 ID:SGTC_3108|Compound:9121785|FD-Score:-3.81|P-value:1.03E-4 ID:SGTC_3248|Compound:9135562|FD-Score:3.40|P-value:4.56E-4 ID:SGTC_3257|Compound:9139206|FD-Score:-3.78|P-value:1.17E-4 ID:SGTC_3289|Compound:9119912|FD-Score:4.52|P-value:5.35E-6 ID:SGTC_3314|Compound:9135860|FD-Score:-3.34|P-value:5.68E-4 ID:SGTC_35|Compound:0133-0054|FD-Score:-4.78|P-value:1.60E-6 ID:SGTC_41|Compound:0478-0632|FD-Score:8.13|P-value:1.23E-15 ID:SGTC_145|Compound:3737-0113|FD-Score:3.76|P-value:1.26E-4 ID:SGTC_160|Compound:3453-0671|FD-Score:-4.77|P-value:1.70E-6 ID:SGTC_181|Compound:1447-1644|FD-Score:-3.70|P-value:1.56E-4 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:6.44|P-value:1.75E-10 ID:SGTC_264|Compound:promethazine|FD-Score:10.70|P-value:6.57E-26 ID:SGTC_272|Compound:doxorubicin|FD-Score:5.10|P-value:3.28E-7 ID:SGTC_273|Compound:hydroxyurea|FD-Score:4.42|P-value:8.10E-6 ID:SGTC_557|Compound:1315-0110|FD-Score:3.57|P-value:2.55E-4 ID:SGTC_641|Compound:4092-0595|FD-Score:4.29|P-value:1.46E-5 ID:SGTC_670|Compound:4204-0025|FD-Score:3.87|P-value:8.27E-5 ID:SGTC_686|Compound:1319-0111|FD-Score:3.51|P-value:3.14E-4 ID:SGTC_745|Compound:0469-0705|FD-Score:3.50|P-value:3.22E-4 ID:SGTC_854|Compound:0422-0053|FD-Score:4.78|P-value:1.63E-6 ID:SGTC_977|Compound:1348-1378|FD-Score:3.20|P-value:8.99E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:-3.70|P-value:1.58E-4 ID:SGTC_1006|Compound:4099-6547|FD-Score:3.84|P-value:9.24E-5 ID:SGTC_1052|Compound:3253-3998|FD-Score:4.10|P-value:3.19E-5 ID:SGTC_1059|Compound:3448-6867|FD-Score:3.82|P-value:9.68E-5 ID:SGTC_1178|Compound:0988-0033|FD-Score:3.77|P-value:1.18E-4 ID:SGTC_1325|Compound:1431-0015|FD-Score:3.49|P-value:3.31E-4 ID:SGTC_1446|Compound:4239-0190|FD-Score:4.25|P-value:1.71E-5 ID:SGTC_1511|Compound:0906-3109|FD-Score:-3.53|P-value:2.93E-4 ID:SGTC_1534|Compound:6-azauridine|FD-Score:3.32|P-value:5.99E-4 ID:SGTC_1730|Compound:st033808|FD-Score:3.25|P-value:7.70E-4 ID:SGTC_1770|Compound:st043884|FD-Score:3.32|P-value:6.16E-4 ID:SGTC_2002|Compound:4023503|FD-Score:-4.31|P-value:1.37E-5 ID:SGTC_2007|Compound:4011539|FD-Score:4.22|P-value:1.92E-5 ID:SGTC_2495|Compound:cafestol|FD-Score:6.06|P-value:1.79E-9 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:4.20|P-value:2.16E-5 ID:SGTC_2587|Compound:piperic acid|FD-Score:3.27|P-value:7.08E-4 ID:SGTC_2655|Compound:perillic acid|FD-Score:3.53|P-value:2.90E-4 ID:SGTC_2696|Compound:st077691|FD-Score:3.19|P-value:9.29E-4 ID:SGTC_2712|Compound:st079126|FD-Score:3.20|P-value:9.13E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:3.53|P-value:2.91E-4 ID:SGTC_2811|Compound:7967822|FD-Score:-5.88|P-value:5.28E-9 ID:SGTC_2941|Compound:9056145|FD-Score:-3.98|P-value:5.44E-5 ID:SGTC_3108|Compound:9121785|FD-Score:-3.81|P-value:1.03E-4 ID:SGTC_3248|Compound:9135562|FD-Score:3.40|P-value:4.56E-4 ID:SGTC_3257|Compound:9139206|FD-Score:-3.78|P-value:1.17E-4 ID:SGTC_3289|Compound:9119912|FD-Score:4.52|P-value:5.35E-6 ID:SGTC_3314|Compound:9135860|FD-Score:-3.34|P-value:5.68E-4

Top fitness defect scores for YDR113C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_264 promethazine 10.70 12.5 mM 6.57E-26 DNA intercalators 3 3.38E-27 0.73
2 SGTC_41 0478-0632 8.13 82.6 µM 1.23E-15 3 2.23E-16 2.23
3 SGTC_219 mitoxanthrone 6.44 164.4 µM 1.75E-10 DNA intercalators 5 5.97E-11 0.07
4 SGTC_2495 cafestol 6.06 54.5 µM 1.79E-9 Golgi 1 6.87E-10 0.88
5 SGTC_272 doxorubicin 5.10 8.1 µM 3.28E-7 anthracycline transcription coupled DNA repair 6 1.66E-7 0.31
6 SGTC_854 0422-0053 4.78 192.0 µM 1.63E-6 PDR1 2 8.96E-7 0.33
7 SGTC_3289 9119912 4.52 71.4 µM 5.35E-6 2 3.12E-6 0.38
8 SGTC_273 hydroxyurea 4.42 18.1 mM 8.10E-6 heme biosynthesis & mitochondrial translocase 19 4.83E-6 0.18
9 SGTC_641 4092-0595 4.29 30.0 µM 1.46E-5 7 8.95E-6 0.04
10 SGTC_1446 4239-0190 4.25 62.0 µM 1.71E-5 7 1.06E-5 0.16
11 SGTC_2007 4011539 4.22 71.8 µM 1.92E-5 cell wall signaling 7 1.19E-5 0.11
12 SGTC_2520 obtusaquinone 4.20 4.7 µM 2.16E-5 2 1.35E-5 0.09
13 SGTC_1052 3253-3998 4.10 198.0 µM 3.19E-5 5 2.04E-5 0.01
14 SGTC_670 4204-0025 3.87 119.0 µM 8.27E-5 copper-dependent oxidative stress 4 5.55E-5 0.51
15 SGTC_1006 4099-6547 3.84 255.0 µM 9.24E-5 4 6.24E-5 0.18
16 SGTC_1059 3448-6867 3.82 171.0 µM 9.68E-5 6 6.55E-5 0.02
17 SGTC_1178 0988-0033 3.77 191.0 µM 1.18E-4 9 8.08E-5 0.32
18 SGTC_145 3737-0113 3.76 38.4 µM 1.26E-4 DNA intercalators 56 8.65E-5 0.10
19 SGTC_557 1315-0110 3.57 16.2 µM 2.55E-4 Golgi 8 1.81E-4 0.02
20 SGTC_2655 perillic acid 3.53 100.0 µM 2.90E-4 2 2.07E-4 0.13

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.278 1.74E-60 YMR168C CEP3 het Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain
0.277 6.09E-60 YHL039W EFM1 hom Lysine methyltransferase involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.254 1.34E-50 YMR166C_p YMR166C_p hom Predicted transporter of the mitochondrial inner membrane; has similarity to human mitochondrial ATP-Mg/Pi carriers; YMR166C is not an essential gene
0.204 9.84E-33 YMR289W ABZ2 hom Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase), catalyzes the third step in para-aminobenzoic acid biosynthesis; involved in folic acid biosynthesis
0.185 5.18E-27 YDL223C HBT1 hom Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis
0.183 1.05E-26 YGR065C VHT1 het High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin
0.170 3.60E-23 YOR133W EFT1 hom Elongation factor 2 (EF-2), also encoded by EFT2; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; EFT1 has a paralog, EFT2, that arose from the whole genome duplication
0.168 1.27E-22 YMR262W_p YMR262W_p hom Protein of unknown function; interacts weakly with Knr4p; YMR262W is not an essential gene
0.164 1.20E-21 YGL118C_d YGL118C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.149 3.61E-18 YGL041C_d YGL041C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.141 2.09E-16 YBR196C-B_p YBR196C-B_p hom Putative protein of unknown function; identified by expression profiling and mass spectrometry
0.130 3.64E-14 YDR401W_d YDR401W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.128 1.30E-13 YOR064C YNG1 hom Subunit of the NuA3 histone acetyltransferase complex that acetylates histone H3; contains PHD finger domain that interacts with methylated histone H3, has similarity to the human tumor suppressor ING1
0.127 1.77E-13 YNL264C PDR17 hom Phosphatidylinositol transfer protein (PITP), downregulates Plb1p-mediated turnover of phosphatidylcholine, found in the cytosol and microsomes, homologous to Pdr16p, deletion affects phospholipid composition
0.124 5.06E-13 YEL032W MCM3 het Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex