Putative protein of unknown function; deletion mutant exhibits poor growth at elevated pH and calcium
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YDR114C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.469 | 3.05E-183 | YGR215W | RSM27 | hom | Mitochondrial ribosomal protein of the small subunit |
0.463 | 9.22E-178 | YPL183W-A | RTC6 | hom | Protein involved in translation; mutants have defects in biogenesis of nuclear ribosomes; sequence similar to prokaryotic ribosomal protein L36, may be a mitochondrial ribosomal protein; protein abundance increases in response to DNA replication stress |
0.460 | 4.21E-175 | YER050C | RSM18 | hom | Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein |
0.453 | 2.71E-169 | YNL177C | MRPL22 | hom | Mitochondrial ribosomal protein of the large subunit |
0.441 | 1.85E-159 | YDR462W | MRPL28 | hom | Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress |
0.439 | 1.92E-157 | YMR098C | ATP25 | hom | Mitochondrial protein required for the stability of Oli1p (Atp9p) mRNA and for the Oli1p ring formation; YMR098C is not an essential gene |
0.437 | 7.18E-156 | YMR287C | DSS1 | hom | 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs |
0.433 | 9.44E-154 | YDR518W | EUG1 | hom | Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER |
0.423 | 1.10E-145 | YPL040C | ISM1 | hom | Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth |
0.422 | 1.01E-144 | YDR194C | MSS116 | hom | DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing |
0.417 | 5.15E-141 | YJL023C | PET130 | hom | Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies |
0.412 | 9.21E-138 | YKL016C | ATP7 | hom | Subunit d of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis |
0.410 | 7.46E-136 | YMR267W | PPA2 | hom | Mitochondrial inorganic pyrophosphatase, required for mitochondrial function and possibly involved in energy generation from inorganic pyrophosphate |
0.409 | 2.73E-135 | YML061C | PIF1 | hom | DNA helicase; exists in a nuclear form that acts as a catalytic inhibitor of telomerase; and as a mitochondrial form involved in repair and recombination of mitochondrial DNA; mutations affect zinc and iron homeostasis; regulated by Rad53p-dependent phosphorylation in rho0 cells |
0.404 | 1.63E-131 | YGR165W | MRPS35 | hom | Mitochondrial ribosomal protein of the small subunit; null mutant does not grow on glycerol, is sensitive to 2,4-dichlorophenol, and accumulates large lipid droplets |