YDR115W

Putative mitochondrial ribosomal protein of the large subunit; similar to E. coli L34 ribosomal protein; required for respiratory growth, as are most mitochondrial ribosomal proteins; protein increases in abundance and relocalizes to the plasma membrane upon DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR115W / YDR115W

Click on Significant Values for Screen Details

Top fitness defect scores for YDR115W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_275 trichlorophene 10.80 5.7 µM 4.58E-29 mitochondrial stress 35 1.18E-27
2 SGTC_1455 4262-0120 5.09 131.0 µM 9.05E-8 plasma membrane duress 13 1.75E-7
3 SGTC_2109 5483026 5.02 200.0 µM 1.36E-7 RSC complex & mRNA processing 11 2.58E-7
4 SGTC_2371 9071574 4.94 200.0 µM 2.10E-7 5 3.89E-7
5 SGTC_365 0121-0052 4.93 13.6 µM 2.25E-7 mitochondrial response to ROS 33 4.16E-7
6 SGTC_2054 5233173 4.90 129.0 µM 2.60E-7 mitochondrial response to ROS 30 4.77E-7
7 SGTC_908 3448-7491 4.73 47.7 µM 6.31E-7 mitochondrial stress 87 1.11E-6
8 SGTC_1883 5-benzylidenerhodanine 4.71 20.0 µM 7.10E-7 TRP & mitochondrial translation 40 1.24E-6
9 SGTC_3311 9131146 4.63 2.9 µM 1.07E-6 cell wall 95 1.82E-6
10 SGTC_2380 9035439 4.59 200.0 µM 1.31E-6 endomembrane recycling 9 2.22E-6
11 SGTC_2911 7942208 4.32 15.6 µM 4.91E-6 mitochondrial response to ROS 14 7.78E-6
12 SGTC_1727 st034309 4.27 9.9 µM 6.27E-6 27 9.83E-6
13 SGTC_2750 bromebric acid 3.76 70.2 µM 6.09E-5 36 8.55E-5
14 SGTC_236 1509-0011 3.74 5.3 µM 6.48E-5 396 9.08E-5
15 SGTC_2942 9052777 3.73 62.2 µM 6.72E-5 41 9.39E-5
16 SGTC_310 1273-0058 3.72 1.1 µM 7.28E-5 mitochondrial stress 261 1.01E-4
17 SGTC_2232 chlorophetanol 3.69 41.5 µM 8.24E-5 TRP & mitochondrial translation 141 1.14E-4
18 SGTC_741 4582-0002 3.63 126.0 µM 1.05E-4 16 1.44E-4
19 SGTC_1730 st033808 3.59 45.1 µM 1.20E-4 45 1.63E-4
20 SGTC_2233 sulbentine 3.58 40.4 µM 1.24E-4 74 1.69E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.316 1.04E-78 YPR166C MRP2 hom Mitochondrial ribosomal protein of the small subunit
0.306 1.38E-73 YBL080C PET112 hom Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; mutation is functionally complemented by the bacterial GatB ortholog
0.293 1.31E-67 YFL036W RPO41 hom Mitochondrial RNA polymerase; single subunit enzyme similar to those of T3 and T7 bacteriophages; requires a specificity subunit encoded by MTF1 for promoter recognition; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation
0.293 3.04E-67 YIL093C RSM25 hom Mitochondrial ribosomal protein of the small subunit
0.289 1.08E-65 YNR037C RSM19 hom Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S19 ribosomal protein
0.287 8.15E-65 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.285 1.40E-63 YNL184C_p YNL184C_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.283 9.19E-63 YGR215W RSM27 hom Mitochondrial ribosomal protein of the small subunit
0.281 7.34E-62 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.281 8.46E-62 YLR091W GEP5 hom Protein of unknown function, required for mitochondrial genome maintenance; detected in highly purified mitochondria in high-throughput studies; null mutant has decreased levels of cardiolipin and phosphatidylethanolamine
0.278 2.10E-60 YNL252C MRPL17 hom Mitochondrial ribosomal protein of the large subunit
0.277 4.83E-60 YJL096W MRPL49 hom Mitochondrial ribosomal protein of the large subunit
0.277 5.87E-60 YLR067C PET309 hom Specific translational activator for the COX1 mRNA, also influences stability of intron-containing COX1 primary transcripts; localizes to the mitochondrial inner membrane; contains seven pentatricopeptide repeats (PPRs)
0.273 2.90E-58 YDR337W MRPS28 hom Mitochondrial ribosomal protein of the small subunit
0.272 4.44E-58 YGR102C GTF1 hom Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria