YDR120C / TRM1

tRNA methyltransferase; two forms of the protein are made by alternative translation starts; localizes to both the nucleus and mitochondrion to produce the modified base N2,N2-dimethylguanosine in tRNAs in both compartments

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR120C / TRM1

Click on Significant Values for Screen Details ID:SGTC_23|Compound:0213-0011|FD-Score:23.90|P-value:4.85E-114 ID:SGTC_43|Compound:0570-0105|FD-Score:5.06|P-value:7.83E-7 ID:SGTC_59|Compound:0330-0160|FD-Score:4.46|P-value:1.15E-5 ID:SGTC_70|Compound:0141-0289|FD-Score:3.98|P-value:7.94E-5 ID:SGTC_103|Compound:0844-0104|FD-Score:4.53|P-value:8.74E-6 ID:SGTC_108|Compound:0509-0257|FD-Score:4.40|P-value:1.53E-5 ID:SGTC_115|Compound:0527-0192|FD-Score:4.61|P-value:6.08E-6 ID:SGTC_138|Compound:0850-0259|FD-Score:-3.65|P-value:2.80E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:-3.69|P-value:2.38E-4 ID:SGTC_143|Compound:4032-1194|FD-Score:5.42|P-value:1.39E-7 ID:SGTC_178|Compound:4092-0806|FD-Score:-4.53|P-value:9.15E-6 ID:SGTC_184|Compound:1494-0393|FD-Score:3.58|P-value:3.44E-4 ID:SGTC_293|Compound:4049-0273|FD-Score:3.33|P-value:8.01E-4 ID:SGTC_314|Compound:1671-0008|FD-Score:-3.31|P-value:8.69E-4 ID:SGTC_318|Compound:1488-0629|FD-Score:7.52|P-value:5.12E-13 ID:SGTC_352|Compound:k048-0007|FD-Score:4.73|P-value:3.66E-6 ID:SGTC_355|Compound:1311-2252|FD-Score:3.89|P-value:1.14E-4 ID:SGTC_384|Compound:k007-0144|FD-Score:3.58|P-value:3.43E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:6.02|P-value:5.80E-9 ID:SGTC_470|Compound:aa-861|FD-Score:3.87|P-value:1.20E-4 ID:SGTC_488|Compound:nitrendipine|FD-Score:5.27|P-value:2.89E-7 ID:SGTC_505|Compound:gw-5074|FD-Score:4.62|P-value:5.84E-6 ID:SGTC_528|Compound:3492-0019|FD-Score:5.66|P-value:3.96E-8 ID:SGTC_575|Compound:k072-0246|FD-Score:5.35|P-value:1.99E-7 ID:SGTC_612|Compound:0302-0167|FD-Score:15.60|P-value:7.14E-50 ID:SGTC_673|Compound:1082-0474|FD-Score:-3.44|P-value:5.65E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:7.55|P-value:4.21E-13 ID:SGTC_683|Compound:panaxydol|FD-Score:3.91|P-value:1.03E-4 ID:SGTC_720|Compound:r052-1644|FD-Score:3.61|P-value:3.02E-4 ID:SGTC_731|Compound:3966-0296|FD-Score:3.75|P-value:1.88E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:3.50|P-value:4.49E-4 ID:SGTC_743|Compound:1275-0778|FD-Score:7.54|P-value:4.43E-13 ID:SGTC_792|Compound:4534-1957|FD-Score:-3.42|P-value:6.00E-4 ID:SGTC_804|Compound:1595-0054|FD-Score:4.54|P-value:8.34E-6 ID:SGTC_805|Compound:3852-0218|FD-Score:3.55|P-value:3.83E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:4.09|P-value:5.16E-5 ID:SGTC_932|Compound:2857-0803|FD-Score:-3.30|P-value:8.90E-4 ID:SGTC_1001|Compound:4048-4355|FD-Score:4.61|P-value:6.23E-6 ID:SGTC_1026|Compound:k007-1105|FD-Score:4.39|P-value:1.56E-5 ID:SGTC_1168|Compound:k815-0004|FD-Score:3.50|P-value:4.46E-4 ID:SGTC_1277|Compound:0873-0036|FD-Score:5.23|P-value:3.44E-7 ID:SGTC_1280|Compound:0880-0253|FD-Score:3.76|P-value:1.80E-4 ID:SGTC_1287|Compound:0971-0001|FD-Score:5.11|P-value:6.28E-7 ID:SGTC_1378|Compound:2093-0007|FD-Score:-3.29|P-value:9.27E-4 ID:SGTC_1425|Compound:4048-4433|FD-Score:6.12|P-value:3.28E-9 ID:SGTC_1506|Compound:4226-2149|FD-Score:4.37|P-value:1.68E-5 ID:SGTC_1543|Compound:azetidyl-2-carboxylic acid|FD-Score:5.28|P-value:2.81E-7 ID:SGTC_1621|Compound:st003705|FD-Score:3.56|P-value:3.65E-4 ID:SGTC_1687|Compound:st020778|FD-Score:15.00|P-value:2.09E-46 ID:SGTC_1722|Compound:st034304|FD-Score:3.56|P-value:3.67E-4 ID:SGTC_1729|Compound:st035615|FD-Score:-4.54|P-value:8.83E-6 ID:SGTC_1801|Compound:st050089|FD-Score:3.76|P-value:1.81E-4 ID:SGTC_1875|Compound:nocodazole|FD-Score:6.71|P-value:9.78E-11 ID:SGTC_1877|Compound:wortmannin|FD-Score:6.78|P-value:6.55E-11 ID:SGTC_1922|Compound:5578187|FD-Score:-3.87|P-value:1.25E-4 ID:SGTC_1927|Compound:st060202|FD-Score:-3.48|P-value:4.98E-4 ID:SGTC_1941|Compound:st076221|FD-Score:17.60|P-value:1.10E-62 ID:SGTC_2015|Compound:5119600|FD-Score:3.35|P-value:7.42E-4 ID:SGTC_2023|Compound:5144124|FD-Score:-3.99|P-value:8.02E-5 ID:SGTC_2242|Compound:6630449|FD-Score:3.28|P-value:9.30E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-3.62|P-value:3.04E-4 ID:SGTC_2291|Compound:7917025|FD-Score:4.57|P-value:7.37E-6 ID:SGTC_2322|Compound:7413319|FD-Score:16.90|P-value:6.16E-58 ID:SGTC_2417|Compound:cerulenin|FD-Score:4.21|P-value:3.31E-5 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:-3.79|P-value:1.65E-4 ID:SGTC_2461|Compound:5755302|FD-Score:3.36|P-value:7.07E-4 ID:SGTC_2473|Compound:5854593|FD-Score:3.42|P-value:5.85E-4 ID:SGTC_2482|Compound:5981709|FD-Score:4.86|P-value:2.04E-6 ID:SGTC_2483|Compound:5729050|FD-Score:6.02|P-value:5.73E-9 ID:SGTC_2648|Compound:atorvastatin|FD-Score:-3.30|P-value:8.92E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:5.91|P-value:1.07E-8 ID:SGTC_2752|Compound:diclazuril|FD-Score:14.80|P-value:7.05E-45 ID:SGTC_2858|Compound:9025781|FD-Score:8.15|P-value:5.65E-15 ID:SGTC_2918|Compound:7977171|FD-Score:3.85|P-value:1.30E-4 ID:SGTC_2932|Compound:9016711|FD-Score:3.37|P-value:6.84E-4 ID:SGTC_2997|Compound:9067075|FD-Score:4.90|P-value:1.71E-6 ID:SGTC_3152|Compound:9099253|FD-Score:-3.56|P-value:3.78E-4 ID:SGTC_3232|Compound:9132874|FD-Score:-3.44|P-value:5.60E-4 ID:SGTC_23|Compound:0213-0011|FD-Score:23.90|P-value:4.85E-114 ID:SGTC_43|Compound:0570-0105|FD-Score:5.06|P-value:7.83E-7 ID:SGTC_59|Compound:0330-0160|FD-Score:4.46|P-value:1.15E-5 ID:SGTC_70|Compound:0141-0289|FD-Score:3.98|P-value:7.94E-5 ID:SGTC_103|Compound:0844-0104|FD-Score:4.53|P-value:8.74E-6 ID:SGTC_108|Compound:0509-0257|FD-Score:4.40|P-value:1.53E-5 ID:SGTC_115|Compound:0527-0192|FD-Score:4.61|P-value:6.08E-6 ID:SGTC_138|Compound:0850-0259|FD-Score:-3.65|P-value:2.80E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:-3.69|P-value:2.38E-4 ID:SGTC_143|Compound:4032-1194|FD-Score:5.42|P-value:1.39E-7 ID:SGTC_178|Compound:4092-0806|FD-Score:-4.53|P-value:9.15E-6 ID:SGTC_184|Compound:1494-0393|FD-Score:3.58|P-value:3.44E-4 ID:SGTC_293|Compound:4049-0273|FD-Score:3.33|P-value:8.01E-4 ID:SGTC_314|Compound:1671-0008|FD-Score:-3.31|P-value:8.69E-4 ID:SGTC_318|Compound:1488-0629|FD-Score:7.52|P-value:5.12E-13 ID:SGTC_352|Compound:k048-0007|FD-Score:4.73|P-value:3.66E-6 ID:SGTC_355|Compound:1311-2252|FD-Score:3.89|P-value:1.14E-4 ID:SGTC_384|Compound:k007-0144|FD-Score:3.58|P-value:3.43E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:6.02|P-value:5.80E-9 ID:SGTC_470|Compound:aa-861|FD-Score:3.87|P-value:1.20E-4 ID:SGTC_488|Compound:nitrendipine|FD-Score:5.27|P-value:2.89E-7 ID:SGTC_505|Compound:gw-5074|FD-Score:4.62|P-value:5.84E-6 ID:SGTC_528|Compound:3492-0019|FD-Score:5.66|P-value:3.96E-8 ID:SGTC_575|Compound:k072-0246|FD-Score:5.35|P-value:1.99E-7 ID:SGTC_612|Compound:0302-0167|FD-Score:15.60|P-value:7.14E-50 ID:SGTC_673|Compound:1082-0474|FD-Score:-3.44|P-value:5.65E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:7.55|P-value:4.21E-13 ID:SGTC_683|Compound:panaxydol|FD-Score:3.91|P-value:1.03E-4 ID:SGTC_720|Compound:r052-1644|FD-Score:3.61|P-value:3.02E-4 ID:SGTC_731|Compound:3966-0296|FD-Score:3.75|P-value:1.88E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:3.50|P-value:4.49E-4 ID:SGTC_743|Compound:1275-0778|FD-Score:7.54|P-value:4.43E-13 ID:SGTC_792|Compound:4534-1957|FD-Score:-3.42|P-value:6.00E-4 ID:SGTC_804|Compound:1595-0054|FD-Score:4.54|P-value:8.34E-6 ID:SGTC_805|Compound:3852-0218|FD-Score:3.55|P-value:3.83E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:4.09|P-value:5.16E-5 ID:SGTC_932|Compound:2857-0803|FD-Score:-3.30|P-value:8.90E-4 ID:SGTC_1001|Compound:4048-4355|FD-Score:4.61|P-value:6.23E-6 ID:SGTC_1026|Compound:k007-1105|FD-Score:4.39|P-value:1.56E-5 ID:SGTC_1168|Compound:k815-0004|FD-Score:3.50|P-value:4.46E-4 ID:SGTC_1277|Compound:0873-0036|FD-Score:5.23|P-value:3.44E-7 ID:SGTC_1280|Compound:0880-0253|FD-Score:3.76|P-value:1.80E-4 ID:SGTC_1287|Compound:0971-0001|FD-Score:5.11|P-value:6.28E-7 ID:SGTC_1378|Compound:2093-0007|FD-Score:-3.29|P-value:9.27E-4 ID:SGTC_1425|Compound:4048-4433|FD-Score:6.12|P-value:3.28E-9 ID:SGTC_1506|Compound:4226-2149|FD-Score:4.37|P-value:1.68E-5 ID:SGTC_1543|Compound:azetidyl-2-carboxylic acid|FD-Score:5.28|P-value:2.81E-7 ID:SGTC_1621|Compound:st003705|FD-Score:3.56|P-value:3.65E-4 ID:SGTC_1687|Compound:st020778|FD-Score:15.00|P-value:2.09E-46 ID:SGTC_1722|Compound:st034304|FD-Score:3.56|P-value:3.67E-4 ID:SGTC_1729|Compound:st035615|FD-Score:-4.54|P-value:8.83E-6 ID:SGTC_1801|Compound:st050089|FD-Score:3.76|P-value:1.81E-4 ID:SGTC_1875|Compound:nocodazole|FD-Score:6.71|P-value:9.78E-11 ID:SGTC_1877|Compound:wortmannin|FD-Score:6.78|P-value:6.55E-11 ID:SGTC_1922|Compound:5578187|FD-Score:-3.87|P-value:1.25E-4 ID:SGTC_1927|Compound:st060202|FD-Score:-3.48|P-value:4.98E-4 ID:SGTC_1941|Compound:st076221|FD-Score:17.60|P-value:1.10E-62 ID:SGTC_2015|Compound:5119600|FD-Score:3.35|P-value:7.42E-4 ID:SGTC_2023|Compound:5144124|FD-Score:-3.99|P-value:8.02E-5 ID:SGTC_2242|Compound:6630449|FD-Score:3.28|P-value:9.30E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-3.62|P-value:3.04E-4 ID:SGTC_2291|Compound:7917025|FD-Score:4.57|P-value:7.37E-6 ID:SGTC_2322|Compound:7413319|FD-Score:16.90|P-value:6.16E-58 ID:SGTC_2417|Compound:cerulenin|FD-Score:4.21|P-value:3.31E-5 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:-3.79|P-value:1.65E-4 ID:SGTC_2461|Compound:5755302|FD-Score:3.36|P-value:7.07E-4 ID:SGTC_2473|Compound:5854593|FD-Score:3.42|P-value:5.85E-4 ID:SGTC_2482|Compound:5981709|FD-Score:4.86|P-value:2.04E-6 ID:SGTC_2483|Compound:5729050|FD-Score:6.02|P-value:5.73E-9 ID:SGTC_2648|Compound:atorvastatin|FD-Score:-3.30|P-value:8.92E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:5.91|P-value:1.07E-8 ID:SGTC_2752|Compound:diclazuril|FD-Score:14.80|P-value:7.05E-45 ID:SGTC_2858|Compound:9025781|FD-Score:8.15|P-value:5.65E-15 ID:SGTC_2918|Compound:7977171|FD-Score:3.85|P-value:1.30E-4 ID:SGTC_2932|Compound:9016711|FD-Score:3.37|P-value:6.84E-4 ID:SGTC_2997|Compound:9067075|FD-Score:4.90|P-value:1.71E-6 ID:SGTC_3152|Compound:9099253|FD-Score:-3.56|P-value:3.78E-4 ID:SGTC_3232|Compound:9132874|FD-Score:-3.44|P-value:5.60E-4

Top fitness defect scores for YDR120C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_23 0213-0011 23.90 40.0 µM 4.85E-114 copper-dependent oxidative stress 1 1.03E-126
2 SGTC_1941 st076221 17.60 61.8 µM 1.10E-62 sphingolipid biosynthesis & PDR1 1 1.53E-69
3 SGTC_2322 7413319 16.90 38.2 µM 6.16E-58 ERAD & cell cycle 5 2.96E-64
4 SGTC_612 0302-0167 15.60 22.4 µM 7.14E-50 copper-dependent oxidative stress 1 2.80E-55
5 SGTC_1687 st020778 15.00 55.4 µM 2.09E-46 19 2.02E-51
6 SGTC_2752 diclazuril 14.80 33.1 µM 7.05E-45 8 1.01E-49
7 SGTC_2858 9025781 8.15 9.0 µM 5.65E-15 sphingolipid biosynthesis & PDR1 26 1.87E-16
8 SGTC_682 0kpi-0099 7.55 17.0 µM 4.21E-13 14 2.25E-14
9 SGTC_743 1275-0778 7.54 158.0 µM 4.43E-13 excess fatty acid 6 2.38E-14
10 SGTC_318 1488-0629 7.52 67.2 µM 5.12E-13 copper-dependent oxidative stress 8 2.80E-14
11 SGTC_1877 wortmannin 6.78 25.0 µM 6.55E-11 36 6.13E-12
12 SGTC_1875 nocodazole 6.71 6.0 µM 9.78E-11 tubulin folding & SWR complex 23 9.57E-12
13 SGTC_1425 4048-4433 6.12 7.3 µM 3.28E-9 copper-dependent oxidative stress 8 4.74E-10
14 SGTC_2483 5729050 6.02 27.2 µM 5.73E-9 5 8.78E-10
15 SGTC_453 enantio-paf c16 6.02 10.0 µM 5.80E-9 49 8.90E-10
16 SGTC_2651 1327-0036 5.91 5.0 µM 1.07E-8 76 1.76E-9
17 SGTC_528 3492-0019 5.66 172.0 µM 3.96E-8 calcium & mitochondrial duress 133 7.51E-9
18 SGTC_143 4032-1194 5.42 15.7 µM 1.39E-7 23 3.02E-8
19 SGTC_575 k072-0246 5.35 11.9 µM 1.99E-7 9 4.50E-8
20 SGTC_1543 azetidyl-2-carboxylic acid 5.28 198.0 µM 2.81E-7 1 6.59E-8

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.442 1.27E-160 YGR164W_d YGR164W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.374 4.33E-112 YGL232W TAN1 hom Putative tRNA acetyltransferase; RNA-binding protein required for the formation of the modified nucleoside N(4)-acetylcytidine in serine and leucine tRNAs but not required for the same modification in 18S rRNA; protein abundance increases in response to DNA replication stress
0.359 1.75E-102 YBL079W NUP170 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC assembly and nucleocytoplasmic transport; both Nup170p and NUP157p are similar to human Nup155p; NUP170 has a paralog, NUP157, that arose from the whole genome duplication
0.342 2.67E-92 YMR031W-A_d YMR031W-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays shortened telomeres; partially overlaps the uncharacterized ORF YMR031C
0.334 2.40E-88 YLR204W QRI5 hom Mitochondrial inner membrane protein, required for accumulation of spliced COX1 mRNA; may have an additional role in translation of COX1 mRNA
0.330 4.57E-86 YLR087C CSF1 hom Protein required for fermentation at low temperature; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.284 4.12E-63 YDR392W SPT3 hom Subunit of the SAGA and SAGA-like transcriptional regulatory complexes, interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters
0.274 8.76E-59 YNL237W YTP1 hom Probable type-III integral membrane protein of unknown function, has regions of similarity to mitochondrial electron transport proteins
0.267 6.16E-56 YLR055C SPT8 hom Subunit of the SAGA transcriptional regulatory complex but not present in SAGA-like complex SLIK/SALSA, required for SAGA-mediated inhibition at some promoters
0.259 1.23E-52 YJR074W MOG1 hom Conserved nuclear protein that interacts with GTP-Gsp1p, which is a Ran homolog of the Ras GTPase family, and stimulates nucleotide release, involved in nuclear protein import, nucleotide release is inhibited by Yrb1p
0.256 2.72E-51 YOL050C_d YOL050C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps verified gene GAL11; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
0.247 6.93E-48 YGL025C PGD1 hom Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for basal and activated transcription; direct target of Cyc8p-Tup1p transcriptional corepressor
0.243 2.84E-46 YIL170W HXT12 hom Possible pseudogene in strain S288C; YIL170W/HXT12 and the adjacent ORF, YIL171W, together encode a non-functional member of the hexose transporter family
0.224 1.60E-39 YGL013C PDR1 hom Transcription factor that regulates the pleiotropic drug response; zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance genes; PDR1 has a paralog, PDR3, that arose from the whole genome duplication
0.223 4.00E-39 YPL265W DIP5 hom Dicarboxylic amino acid permease; mediates high-affinity and high-capacity transport of L-glutamate and L-aspartate; also a transporter for Gln, Asn, Ser, Ala, and Gly; relocalizes from plasma membrane to vacuole upon DNA replication stress