YDR123C / INO2

Component of the heteromeric Ino2p/Ino4p basic helix-loop-helix transcription activator that binds inositol/choline-responsive elements (ICREs), required for derepression of phospholipid biosynthetic genes in response to inositol depletion

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR123C / INO2

Click on Significant Values for Screen Details ID:SGTC_12|Compound:0849-0099|FD-Score:3.26|P-value:8.88E-4 ID:SGTC_15|Compound:0266-0086|FD-Score:-4.06|P-value:4.84E-5 ID:SGTC_20|Compound:0481-0013|FD-Score:-4.21|P-value:2.68E-5 ID:SGTC_103|Compound:0844-0104|FD-Score:5.37|P-value:1.29E-7 ID:SGTC_107|Compound:0358-0022|FD-Score:3.85|P-value:1.12E-4 ID:SGTC_153|Compound:4077-0274|FD-Score:3.73|P-value:1.77E-4 ID:SGTC_226|Compound:1,3-diallylurea|FD-Score:13.60|P-value:3.26E-39 ID:SGTC_266|Compound:formosanin C|FD-Score:3.62|P-value:2.60E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:3.34|P-value:6.79E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:4.08|P-value:4.49E-5 ID:SGTC_476|Compound:mead acid|FD-Score:3.96|P-value:7.24E-5 ID:SGTC_479|Compound:n-linoleoylglycine|FD-Score:-3.44|P-value:4.79E-4 ID:SGTC_488|Compound:nitrendipine|FD-Score:3.47|P-value:4.36E-4 ID:SGTC_639|Compound:0833-0042|FD-Score:5.94|P-value:5.93E-9 ID:SGTC_664|Compound:1222-0054|FD-Score:3.93|P-value:8.32E-5 ID:SGTC_772|Compound:k072-0172|FD-Score:-4.41|P-value:1.15E-5 ID:SGTC_773|Compound:4358-1457|FD-Score:-4.20|P-value:2.77E-5 ID:SGTC_852|Compound:0418-0143|FD-Score:3.41|P-value:5.46E-4 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:4.80|P-value:2.08E-6 ID:SGTC_975|Compound:1335-0046|FD-Score:3.26|P-value:9.01E-4 ID:SGTC_982|Compound:1491-0518|FD-Score:3.39|P-value:5.81E-4 ID:SGTC_1117|Compound:retinoic acid|FD-Score:-3.33|P-value:6.79E-4 ID:SGTC_1144|Compound:3486-0183|FD-Score:4.17|P-value:3.13E-5 ID:SGTC_1180|Compound:1193-0155|FD-Score:-3.25|P-value:9.00E-4 ID:SGTC_1265|Compound:0819-1001|FD-Score:4.29|P-value:1.98E-5 ID:SGTC_1310|Compound:1188-0297|FD-Score:4.28|P-value:2.06E-5 ID:SGTC_1311|Compound:1190-0148|FD-Score:4.19|P-value:2.95E-5 ID:SGTC_1452|Compound:4194-0072|FD-Score:4.79|P-value:2.14E-6 ID:SGTC_1542|Compound:7-hydroxy-3'-methoxyflavone|FD-Score:4.34|P-value:1.55E-5 ID:SGTC_1653|Compound:st012112|FD-Score:4.10|P-value:4.19E-5 ID:SGTC_1715|Compound:st032160|FD-Score:5.49|P-value:7.00E-8 ID:SGTC_1881|Compound:5652484|FD-Score:3.49|P-value:4.13E-4 ID:SGTC_1885|Compound:st057546|FD-Score:4.10|P-value:4.19E-5 ID:SGTC_1905|Compound:st060207|FD-Score:3.79|P-value:1.40E-4 ID:SGTC_1941|Compound:st076221|FD-Score:4.92|P-value:1.20E-6 ID:SGTC_1949|Compound:st076024|FD-Score:5.49|P-value:6.98E-8 ID:SGTC_1955|Compound:wogonin|FD-Score:-3.40|P-value:5.41E-4 ID:SGTC_2283|Compound:7944793|FD-Score:-3.28|P-value:8.24E-4 ID:SGTC_2359|Compound:9039622|FD-Score:4.53|P-value:6.84E-6 ID:SGTC_2360|Compound:9040895|FD-Score:-3.95|P-value:7.54E-5 ID:SGTC_2417|Compound:cerulenin|FD-Score:7.17|P-value:3.05E-12 ID:SGTC_2427|Compound:5545055|FD-Score:5.92|P-value:6.81E-9 ID:SGTC_2430|Compound:5571206|FD-Score:3.33|P-value:6.97E-4 ID:SGTC_2560|Compound:caryophyllene|FD-Score:3.36|P-value:6.42E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:4.69|P-value:3.36E-6 ID:SGTC_2782|Compound:7736369|FD-Score:5.39|P-value:1.17E-7 ID:SGTC_2955|Compound:9076254|FD-Score:3.34|P-value:6.86E-4 ID:SGTC_2969|Compound:9091408|FD-Score:-5.26|P-value:2.16E-7 ID:SGTC_2997|Compound:9067075|FD-Score:3.79|P-value:1.40E-4 ID:SGTC_3037|Compound:9091026|FD-Score:6.82|P-value:2.96E-11 ID:SGTC_3094|Compound:9117742|FD-Score:-3.36|P-value:6.24E-4 ID:SGTC_3187|Compound:9109394|FD-Score:3.23|P-value:9.94E-4 ID:SGTC_3218|Compound:9131285|FD-Score:3.39|P-value:5.82E-4 ID:SGTC_3222|Compound:9128301|FD-Score:-3.25|P-value:9.01E-4 ID:SGTC_12|Compound:0849-0099|FD-Score:3.26|P-value:8.88E-4 ID:SGTC_15|Compound:0266-0086|FD-Score:-4.06|P-value:4.84E-5 ID:SGTC_20|Compound:0481-0013|FD-Score:-4.21|P-value:2.68E-5 ID:SGTC_103|Compound:0844-0104|FD-Score:5.37|P-value:1.29E-7 ID:SGTC_107|Compound:0358-0022|FD-Score:3.85|P-value:1.12E-4 ID:SGTC_153|Compound:4077-0274|FD-Score:3.73|P-value:1.77E-4 ID:SGTC_226|Compound:1,3-diallylurea|FD-Score:13.60|P-value:3.26E-39 ID:SGTC_266|Compound:formosanin C|FD-Score:3.62|P-value:2.60E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:3.34|P-value:6.79E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:4.08|P-value:4.49E-5 ID:SGTC_476|Compound:mead acid|FD-Score:3.96|P-value:7.24E-5 ID:SGTC_479|Compound:n-linoleoylglycine|FD-Score:-3.44|P-value:4.79E-4 ID:SGTC_488|Compound:nitrendipine|FD-Score:3.47|P-value:4.36E-4 ID:SGTC_639|Compound:0833-0042|FD-Score:5.94|P-value:5.93E-9 ID:SGTC_664|Compound:1222-0054|FD-Score:3.93|P-value:8.32E-5 ID:SGTC_772|Compound:k072-0172|FD-Score:-4.41|P-value:1.15E-5 ID:SGTC_773|Compound:4358-1457|FD-Score:-4.20|P-value:2.77E-5 ID:SGTC_852|Compound:0418-0143|FD-Score:3.41|P-value:5.46E-4 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:4.80|P-value:2.08E-6 ID:SGTC_975|Compound:1335-0046|FD-Score:3.26|P-value:9.01E-4 ID:SGTC_982|Compound:1491-0518|FD-Score:3.39|P-value:5.81E-4 ID:SGTC_1117|Compound:retinoic acid|FD-Score:-3.33|P-value:6.79E-4 ID:SGTC_1144|Compound:3486-0183|FD-Score:4.17|P-value:3.13E-5 ID:SGTC_1180|Compound:1193-0155|FD-Score:-3.25|P-value:9.00E-4 ID:SGTC_1265|Compound:0819-1001|FD-Score:4.29|P-value:1.98E-5 ID:SGTC_1310|Compound:1188-0297|FD-Score:4.28|P-value:2.06E-5 ID:SGTC_1311|Compound:1190-0148|FD-Score:4.19|P-value:2.95E-5 ID:SGTC_1452|Compound:4194-0072|FD-Score:4.79|P-value:2.14E-6 ID:SGTC_1542|Compound:7-hydroxy-3'-methoxyflavone|FD-Score:4.34|P-value:1.55E-5 ID:SGTC_1653|Compound:st012112|FD-Score:4.10|P-value:4.19E-5 ID:SGTC_1715|Compound:st032160|FD-Score:5.49|P-value:7.00E-8 ID:SGTC_1881|Compound:5652484|FD-Score:3.49|P-value:4.13E-4 ID:SGTC_1885|Compound:st057546|FD-Score:4.10|P-value:4.19E-5 ID:SGTC_1905|Compound:st060207|FD-Score:3.79|P-value:1.40E-4 ID:SGTC_1941|Compound:st076221|FD-Score:4.92|P-value:1.20E-6 ID:SGTC_1949|Compound:st076024|FD-Score:5.49|P-value:6.98E-8 ID:SGTC_1955|Compound:wogonin|FD-Score:-3.40|P-value:5.41E-4 ID:SGTC_2283|Compound:7944793|FD-Score:-3.28|P-value:8.24E-4 ID:SGTC_2359|Compound:9039622|FD-Score:4.53|P-value:6.84E-6 ID:SGTC_2360|Compound:9040895|FD-Score:-3.95|P-value:7.54E-5 ID:SGTC_2417|Compound:cerulenin|FD-Score:7.17|P-value:3.05E-12 ID:SGTC_2427|Compound:5545055|FD-Score:5.92|P-value:6.81E-9 ID:SGTC_2430|Compound:5571206|FD-Score:3.33|P-value:6.97E-4 ID:SGTC_2560|Compound:caryophyllene|FD-Score:3.36|P-value:6.42E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:4.69|P-value:3.36E-6 ID:SGTC_2782|Compound:7736369|FD-Score:5.39|P-value:1.17E-7 ID:SGTC_2955|Compound:9076254|FD-Score:3.34|P-value:6.86E-4 ID:SGTC_2969|Compound:9091408|FD-Score:-5.26|P-value:2.16E-7 ID:SGTC_2997|Compound:9067075|FD-Score:3.79|P-value:1.40E-4 ID:SGTC_3037|Compound:9091026|FD-Score:6.82|P-value:2.96E-11 ID:SGTC_3094|Compound:9117742|FD-Score:-3.36|P-value:6.24E-4 ID:SGTC_3187|Compound:9109394|FD-Score:3.23|P-value:9.94E-4 ID:SGTC_3218|Compound:9131285|FD-Score:3.39|P-value:5.82E-4 ID:SGTC_3222|Compound:9128301|FD-Score:-3.25|P-value:9.01E-4

Top fitness defect scores for YDR123C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_226 1,3-diallylurea 13.60 8.3 mM 3.26E-39 3 2.01E-42
2 SGTC_2417 cerulenin 7.17 830.0 nM 3.05E-12 5 3.76E-13
3 SGTC_3037 9091026 6.82 49.5 µM 2.96E-11 NEO1-PIK1 31 4.43E-12
4 SGTC_639 0833-0042 5.94 114.0 µM 5.93E-9 14 1.39E-9
5 SGTC_2427 5545055 5.92 42.8 µM 6.81E-9 1 1.61E-9
6 SGTC_1949 st076024 5.49 69.1 µM 6.98E-8 7 2.01E-8
7 SGTC_1715 st032160 5.49 10.2 µM 7.00E-8 19 2.01E-8
8 SGTC_2782 7736369 5.39 71.4 µM 1.17E-7 13 3.50E-8
9 SGTC_103 0844-0104 5.37 51.8 µM 1.29E-7 ERAD & cell cycle 92 3.91E-8
10 SGTC_1941 st076221 4.92 61.8 µM 1.20E-6 sphingolipid biosynthesis & PDR1 49 4.37E-7
11 SGTC_915 methyl methanesulfonate (MMS) 4.80 110.0 mM 2.08E-6 DNA damage response 18 7.94E-7
12 SGTC_1452 4194-0072 4.79 190.0 µM 2.14E-6 3 8.16E-7
13 SGTC_2596 sinensetin 4.69 100.0 µM 3.36E-6 17 1.33E-6
14 SGTC_2359 9039622 4.53 200.0 µM 6.84E-6 endomembrane recycling 13 2.88E-6
15 SGTC_1542 7-hydroxy-3'-methoxyflavone 4.34 49.7 µM 1.55E-5 8 7.00E-6
16 SGTC_1265 0819-1001 4.29 68.8 µM 1.98E-5 17 9.09E-6
17 SGTC_1310 1188-0297 4.28 994.0 nM 2.06E-5 azole & statin 27 9.50E-6
18 SGTC_1311 1190-0148 4.19 100.0 µM 2.95E-5 azole & statin 25 1.40E-5
19 SGTC_1144 3486-0183 4.17 12.5 µM 3.13E-5 21 1.50E-5
20 SGTC_1885 st057546 4.10 99.9 µM 4.19E-5 18 2.05E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.355 4.51E-100 YKL182W FAS1 het Beta subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains acetyltransacylase, dehydratase, enoyl reductase, malonyl transacylase, and palmitoyl transacylase activities
0.190 1.62E-28 YMR222C FSH2 hom Putative serine hydrolase that localizes to the cytoplasm; sequence is similar to S. cerevisiae Fsh1p and Fsh3p and the human candidate tumor suppressor OVCA2
0.131 2.46E-14 YKL020C SPT23 hom ER membrane protein involved in regulation of OLE1 transcription, acts with homolog Mga2p; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting
0.122 1.28E-12 YDR530C APA2 hom Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase II; AP4A phosphorylase involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; APA2 has a paralog, APA1, that arose from the whole genome duplication
0.118 6.65E-12 YNL237W YTP1 hom Probable type-III integral membrane protein of unknown function, has regions of similarity to mitochondrial electron transport proteins
0.117 1.26E-11 YNL071W LAT1 hom Dihydrolipoamide acetyltransferase component (E2) of pyruvate dehydrogenase complex, which catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA
0.117 1.27E-11 YDR326C YSP2 hom Protein involved in programmed cell death; mutant shows resistance to cell death induced by amiodarone or intracellular acidification; YSP2 has a paralog, YHR080C, that arose from the whole genome duplication
0.100 6.30E-9 YOL002C IZH2 hom Plasma membrane protein involved in zinc homeostasis and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc
0.099 1.00E-8 YPL117C IDI1 het Isopentenyl diphosphate:dimethylallyl diphosphate isomerase (IPP isomerase), catalyzes an essential activation step in the isoprenoid biosynthetic pathway; required for viability
0.097 1.87E-8 YDR120C TRM1 hom tRNA methyltransferase; two forms of the protein are made by alternative translation starts; localizes to both the nucleus and mitochondrion to produce the modified base N2,N2-dimethylguanosine in tRNAs in both compartments
0.096 2.44E-8 YLR324W PEX30 hom Peroxisomal integral membrane protein, involved in negative regulation of peroxisome number; partially functionally redundant with Pex31p; genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p
0.091 1.23E-7 YOL108C INO4 hom Transcription factor required for derepression of inositol-choline-regulated genes involved in phospholipid synthesis; forms a complex, with Ino2p, that binds the inositol-choline-responsive element through a basic helix-loop-helix domain
0.089 2.34E-7 YNL026W SAM50 het Essential component of the Sorting and Assembly Machinery (SAM or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their outer membrane insertion; homologous to bacterial Omp85
0.089 2.35E-7 YMR102C_p YMR102C_p hom Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene
0.087 3.92E-7 YLR204W QRI5 hom Mitochondrial inner membrane protein, required for accumulation of spliced COX1 mRNA; may have an additional role in translation of COX1 mRNA