HIPHOP chemogenomics database

YDR123C / INO2

Component of the heteromeric Ino2p/Ino4p basic helix-loop-helix transcription activator that binds inositol/choline-responsive elements (ICREs), required for derepression of phospholipid biosynthetic genes in response to inositol depletion

Zygosity: Homozygous strain

fixedexpanded
Profile for YDR123C / INO2

Click on Significant Values for Screen Details

Top fitness defect scores for YDR123C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_226	1,3-diallylurea	13.60	8.3 mM	3.26E-39		3	2.01E-42
2	SGTC_2417	cerulenin	7.17	830.0 nM	3.05E-12		5	3.76E-13
3	SGTC_3037	9091026	6.82	49.5 µM	2.96E-11	NEO1-PIK1	31	4.43E-12
4	SGTC_639	0833-0042	5.94	114.0 µM	5.93E-9		14	1.39E-9
5	SGTC_2427	5545055	5.92	42.8 µM	6.81E-9		1	1.61E-9
6	SGTC_1949	st076024	5.49	69.1 µM	6.98E-8		7	2.01E-8
7	SGTC_1715	st032160	5.49	10.2 µM	7.00E-8		19	2.01E-8
8	SGTC_2782	7736369	5.39	71.4 µM	1.17E-7		13	3.50E-8
9	SGTC_103	0844-0104	5.37	51.8 µM	1.29E-7	ERAD & cell cycle	92	3.91E-8
10	SGTC_1941	st076221	4.92	61.8 µM	1.20E-6	sphingolipid biosynthesis & PDR1	49	4.37E-7
11	SGTC_915	methyl methanesulfonate (MMS)	4.80	110.0 mM	2.08E-6	DNA damage response	18	7.94E-7
12	SGTC_1452	4194-0072	4.79	190.0 µM	2.14E-6		3	8.16E-7
13	SGTC_2596	sinensetin	4.69	100.0 µM	3.36E-6		17	1.33E-6
14	SGTC_2359	9039622	4.53	200.0 µM	6.84E-6	endomembrane recycling	13	2.88E-6
15	SGTC_1542	7-hydroxy-3'-methoxyflavone	4.34	49.7 µM	1.55E-5		8	7.00E-6
16	SGTC_1265	0819-1001	4.29	68.8 µM	1.98E-5		17	9.09E-6
17	SGTC_1310	1188-0297	4.28	994.0 nM	2.06E-5	azole & statin	27	9.50E-6
18	SGTC_1311	1190-0148	4.19	100.0 µM	2.95E-5	azole & statin	25	1.40E-5
19	SGTC_1144	3486-0183	4.17	12.5 µM	3.13E-5		21	1.50E-5
20	SGTC_1885	st057546	4.10	99.9 µM	4.19E-5		18	2.05E-5

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.355	4.51E-100	YKL182W	FAS1	het	Beta subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains acetyltransacylase, dehydratase, enoyl reductase, malonyl transacylase, and palmitoyl transacylase activities
0.190	1.62E-28	YMR222C	FSH2	hom	Putative serine hydrolase that localizes to the cytoplasm; sequence is similar to S. cerevisiae Fsh1p and Fsh3p and the human candidate tumor suppressor OVCA2
0.131	2.46E-14	YKL020C	SPT23	hom	ER membrane protein involved in regulation of OLE1 transcription, acts with homolog Mga2p; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting
0.122	1.28E-12	YDR530C	APA2	hom	Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase II; AP4A phosphorylase involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; APA2 has a paralog, APA1, that arose from the whole genome duplication
0.118	6.65E-12	YNL237W	YTP1	hom	Probable type-III integral membrane protein of unknown function, has regions of similarity to mitochondrial electron transport proteins
0.117	1.26E-11	YNL071W	LAT1	hom	Dihydrolipoamide acetyltransferase component (E2) of pyruvate dehydrogenase complex, which catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA
0.117	1.27E-11	YDR326C	YSP2	hom	Protein involved in programmed cell death; mutant shows resistance to cell death induced by amiodarone or intracellular acidification; YSP2 has a paralog, YHR080C, that arose from the whole genome duplication
0.100	6.30E-9	YOL002C	IZH2	hom	Plasma membrane protein involved in zinc homeostasis and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc
0.099	1.00E-8	YPL117C	IDI1	het	Isopentenyl diphosphate:dimethylallyl diphosphate isomerase (IPP isomerase), catalyzes an essential activation step in the isoprenoid biosynthetic pathway; required for viability
0.097	1.87E-8	YDR120C	TRM1	hom	tRNA methyltransferase; two forms of the protein are made by alternative translation starts; localizes to both the nucleus and mitochondrion to produce the modified base N2,N2-dimethylguanosine in tRNAs in both compartments
0.096	2.44E-8	YLR324W	PEX30	hom	Peroxisomal integral membrane protein, involved in negative regulation of peroxisome number; partially functionally redundant with Pex31p; genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p
0.091	1.23E-7	YOL108C	INO4	hom	Transcription factor required for derepression of inositol-choline-regulated genes involved in phospholipid synthesis; forms a complex, with Ino2p, that binds the inositol-choline-responsive element through a basic helix-loop-helix domain
0.089	2.34E-7	YNL026W	SAM50	het	Essential component of the Sorting and Assembly Machinery (SAM or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their outer membrane insertion; homologous to bacterial Omp85
0.089	2.35E-7	YMR102C_p	YMR102C_p	hom	Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene
0.087	3.92E-7	YLR204W	QRI5	hom	Mitochondrial inner membrane protein, required for accumulation of spliced COX1 mRNA; may have an additional role in translation of COX1 mRNA