YDR126W / SWF1

Palmitoyltransferase that acts on transmembrane proteins, including the SNAREs Snc1p, Syn8p, Tlg1p and likely all SNAREs; contains an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; may have a role in vacuole fusion

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR126W / SWF1

Click on Significant Values for Screen Details ID:SGTC_23|Compound:0213-0011|FD-Score:16.40|P-value:1.38E-45 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:3.77|P-value:5.17E-4 ID:SGTC_29|Compound:0299-0004|FD-Score:4.83|P-value:1.42E-5 ID:SGTC_34|Compound:0469-0683|FD-Score:22.10|P-value:3.23E-81 ID:SGTC_44|Compound:0929-0055|FD-Score:4.38|P-value:7.12E-5 ID:SGTC_70|Compound:0141-0289|FD-Score:6.32|P-value:2.32E-8 ID:SGTC_100|Compound:0086-0128|FD-Score:4.76|P-value:1.80E-5 ID:SGTC_107|Compound:0358-0022|FD-Score:24.80|P-value:1.42E-101 ID:SGTC_119|Compound:0121-0043|FD-Score:3.69|P-value:6.64E-4 ID:SGTC_124|Compound:0136-0217|FD-Score:4.94|P-value:8.98E-6 ID:SGTC_127|Compound:0180-0333|FD-Score:5.49|P-value:9.95E-7 ID:SGTC_132|Compound:0417-1715|FD-Score:4.11|P-value:1.77E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:9.92|P-value:5.54E-18 ID:SGTC_150|Compound:3970-0969|FD-Score:4.48|P-value:5.01E-5 ID:SGTC_151|Compound:3013-0144|FD-Score:4.53|P-value:4.21E-5 ID:SGTC_159|Compound:3970-0959|FD-Score:4.33|P-value:8.51E-5 ID:SGTC_168|Compound:3970-0862|FD-Score:9.29|P-value:5.32E-16 ID:SGTC_189|Compound:3970-0742|FD-Score:4.14|P-value:1.63E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:4.26|P-value:1.09E-4 ID:SGTC_214|Compound:4373-3496|FD-Score:7.46|P-value:5.86E-11 ID:SGTC_221|Compound:trifluoperazine|FD-Score:3.97|P-value:2.76E-4 ID:SGTC_315|Compound:k915-0449|FD-Score:-4.06|P-value:2.89E-4 ID:SGTC_349|Compound:k015-0014|FD-Score:-4.11|P-value:2.49E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:4.41|P-value:6.33E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.64|P-value:4.09E-5 ID:SGTC_462|Compound:ag-879|FD-Score:5.42|P-value:1.32E-6 ID:SGTC_524|Compound:r073-0010|FD-Score:3.65|P-value:7.35E-4 ID:SGTC_575|Compound:k072-0246|FD-Score:16.10|P-value:5.54E-44 ID:SGTC_589|Compound:1227-0070|FD-Score:4.45|P-value:5.55E-5 ID:SGTC_592|Compound:k241-0073|FD-Score:4.86|P-value:1.26E-5 ID:SGTC_626|Compound:0214-0009|FD-Score:5.41|P-value:1.37E-6 ID:SGTC_695|Compound:3505-6186|FD-Score:4.72|P-value:2.08E-5 ID:SGTC_764|Compound:1951-2361|FD-Score:5.73|P-value:3.48E-7 ID:SGTC_771|Compound:0250-0039|FD-Score:7.47|P-value:5.29E-11 ID:SGTC_785|Compound:1270-0111|FD-Score:4.22|P-value:1.24E-4 ID:SGTC_796|Compound:1234-0020|FD-Score:17.10|P-value:3.28E-49 ID:SGTC_800|Compound:3448-7362|FD-Score:5.23|P-value:2.92E-6 ID:SGTC_832|Compound:4083-0019|FD-Score:11.00|P-value:1.26E-21 ID:SGTC_842|Compound:0271-0008|FD-Score:21.60|P-value:2.18E-77 ID:SGTC_852|Compound:0418-0143|FD-Score:11.00|P-value:8.80E-22 ID:SGTC_879|Compound:0831-1030|FD-Score:3.78|P-value:4.98E-4 ID:SGTC_984|Compound:1492-0255|FD-Score:17.60|P-value:2.55E-52 ID:SGTC_1000|Compound:4048-0884|FD-Score:6.39|P-value:1.60E-8 ID:SGTC_1063|Compound:disulfiram|FD-Score:4.46|P-value:5.36E-5 ID:SGTC_1101|Compound:ebselen|FD-Score:4.71|P-value:2.17E-5 ID:SGTC_1105|Compound:epirubicin|FD-Score:3.59|P-value:8.74E-4 ID:SGTC_1142|Compound:3253-1408|FD-Score:3.69|P-value:6.66E-4 ID:SGTC_1156|Compound:4092-0367|FD-Score:-4.17|P-value:2.06E-4 ID:SGTC_1172|Compound:0370-0043|FD-Score:9.82|P-value:1.24E-17 ID:SGTC_1179|Compound:1021-1431|FD-Score:6.30|P-value:2.53E-8 ID:SGTC_1195|Compound:1502-0147|FD-Score:6.06|P-value:7.66E-8 ID:SGTC_1218|Compound:1348-1416|FD-Score:9.24|P-value:7.51E-16 ID:SGTC_1228|Compound:0124-0032|FD-Score:5.03|P-value:6.34E-6 ID:SGTC_1261|Compound:0712-0010|FD-Score:-4.52|P-value:6.24E-5 ID:SGTC_1346|Compound:1488-2224|FD-Score:5.13|P-value:4.29E-6 ID:SGTC_1424|Compound:4048-1941|FD-Score:3.86|P-value:3.89E-4 ID:SGTC_1506|Compound:4226-2149|FD-Score:3.77|P-value:5.18E-4 ID:SGTC_1552|Compound:6-methylflavone|FD-Score:3.68|P-value:6.82E-4 ID:SGTC_1607|Compound:st000305|FD-Score:3.63|P-value:7.86E-4 ID:SGTC_1611|Compound:st001856|FD-Score:3.59|P-value:8.83E-4 ID:SGTC_1696|Compound:st025591|FD-Score:24.00|P-value:8.51E-95 ID:SGTC_1762|Compound:st045503|FD-Score:6.33|P-value:2.11E-8 ID:SGTC_1773|Compound:st048542|FD-Score:3.58|P-value:9.00E-4 ID:SGTC_1823|Compound:3-hydroxy-2-naphthoic acid|FD-Score:4.83|P-value:1.40E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:6.16|P-value:4.79E-8 ID:SGTC_1873|Compound:rapamycin|FD-Score:3.62|P-value:8.22E-4 ID:SGTC_1919|Compound:st067113|FD-Score:4.44|P-value:5.70E-5 ID:SGTC_2034|Compound:5197015|FD-Score:21.50|P-value:7.92E-77 ID:SGTC_2043|Compound:5101342|FD-Score:19.50|P-value:3.17E-63 ID:SGTC_2071|Compound:5230951|FD-Score:5.17|P-value:3.75E-6 ID:SGTC_2072|Compound:5231554|FD-Score:3.57|P-value:9.42E-4 ID:SGTC_2077|Compound:5212015|FD-Score:15.40|P-value:2.49E-40 ID:SGTC_2084|Compound:5306078|FD-Score:6.77|P-value:2.36E-9 ID:SGTC_2086|Compound:5274770|FD-Score:5.69|P-value:4.10E-7 ID:SGTC_2088|Compound:5278280|FD-Score:3.88|P-value:3.74E-4 ID:SGTC_2090|Compound:5301565|FD-Score:6.47|P-value:1.10E-8 ID:SGTC_2110|Compound:5483698|FD-Score:5.88|P-value:1.80E-7 ID:SGTC_2112|Compound:5488546|FD-Score:15.10|P-value:5.67E-39 ID:SGTC_2113|Compound:5491891|FD-Score:9.29|P-value:5.39E-16 ID:SGTC_2132|Compound:5317594|FD-Score:19.80|P-value:1.31E-65 ID:SGTC_2165|Compound:5727197|FD-Score:3.71|P-value:6.12E-4 ID:SGTC_2301|Compound:7769476|FD-Score:3.76|P-value:5.40E-4 ID:SGTC_2323|Compound:6148992|FD-Score:5.89|P-value:1.71E-7 ID:SGTC_2337|Compound:9009472|FD-Score:4.25|P-value:1.11E-4 ID:SGTC_2399|Compound:5884133|FD-Score:3.85|P-value:4.07E-4 ID:SGTC_2400|Compound:5203494|FD-Score:3.89|P-value:3.54E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:18.20|P-value:1.65E-55 ID:SGTC_2433|Compound:5607874|FD-Score:3.62|P-value:8.08E-4 ID:SGTC_2438|Compound:5259590|FD-Score:6.41|P-value:1.45E-8 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:5.26|P-value:2.56E-6 ID:SGTC_2594|Compound:a-mangostin|FD-Score:-5.76|P-value:4.90E-7 ID:SGTC_2600|Compound:tangeritin|FD-Score:12.50|P-value:3.71E-27 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:3.84|P-value:4.15E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:7.06|P-value:5.08E-10 ID:SGTC_2737|Compound:bleomycin|FD-Score:10.80|P-value:4.23E-21 ID:SGTC_2743|Compound:auranofin|FD-Score:3.71|P-value:6.26E-4 ID:SGTC_2759|Compound:disulfiram|FD-Score:8.57|P-value:6.70E-14 ID:SGTC_2766|Compound:oltipraz|FD-Score:14.50|P-value:2.98E-36 ID:SGTC_2789|Compound:5281112|FD-Score:-4.11|P-value:2.47E-4 ID:SGTC_2843|Compound:9000894|FD-Score:4.52|P-value:4.37E-5 ID:SGTC_2926|Compound:9010726|FD-Score:5.20|P-value:3.32E-6 ID:SGTC_2929|Compound:9013348|FD-Score:-6.73|P-value:5.08E-9 ID:SGTC_2933|Compound:9026794|FD-Score:4.63|P-value:2.93E-5 ID:SGTC_3061|Compound:glucosamine|FD-Score:4.31|P-value:9.05E-5 ID:SGTC_3124|Compound:9127567|FD-Score:5.85|P-value:2.08E-7 ID:SGTC_3189|Compound:9110682|FD-Score:4.33|P-value:8.42E-5 ID:SGTC_3209|Compound:9113616|FD-Score:3.68|P-value:6.88E-4 ID:SGTC_3350|Compound:9150499|FD-Score:4.45|P-value:5.48E-5 ID:SGTC_23|Compound:0213-0011|FD-Score:16.40|P-value:1.38E-45 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:3.77|P-value:5.17E-4 ID:SGTC_29|Compound:0299-0004|FD-Score:4.83|P-value:1.42E-5 ID:SGTC_34|Compound:0469-0683|FD-Score:22.10|P-value:3.23E-81 ID:SGTC_44|Compound:0929-0055|FD-Score:4.38|P-value:7.12E-5 ID:SGTC_70|Compound:0141-0289|FD-Score:6.32|P-value:2.32E-8 ID:SGTC_100|Compound:0086-0128|FD-Score:4.76|P-value:1.80E-5 ID:SGTC_107|Compound:0358-0022|FD-Score:24.80|P-value:1.42E-101 ID:SGTC_119|Compound:0121-0043|FD-Score:3.69|P-value:6.64E-4 ID:SGTC_124|Compound:0136-0217|FD-Score:4.94|P-value:8.98E-6 ID:SGTC_127|Compound:0180-0333|FD-Score:5.49|P-value:9.95E-7 ID:SGTC_132|Compound:0417-1715|FD-Score:4.11|P-value:1.77E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:9.92|P-value:5.54E-18 ID:SGTC_150|Compound:3970-0969|FD-Score:4.48|P-value:5.01E-5 ID:SGTC_151|Compound:3013-0144|FD-Score:4.53|P-value:4.21E-5 ID:SGTC_159|Compound:3970-0959|FD-Score:4.33|P-value:8.51E-5 ID:SGTC_168|Compound:3970-0862|FD-Score:9.29|P-value:5.32E-16 ID:SGTC_189|Compound:3970-0742|FD-Score:4.14|P-value:1.63E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:4.26|P-value:1.09E-4 ID:SGTC_214|Compound:4373-3496|FD-Score:7.46|P-value:5.86E-11 ID:SGTC_221|Compound:trifluoperazine|FD-Score:3.97|P-value:2.76E-4 ID:SGTC_315|Compound:k915-0449|FD-Score:-4.06|P-value:2.89E-4 ID:SGTC_349|Compound:k015-0014|FD-Score:-4.11|P-value:2.49E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:4.41|P-value:6.33E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.64|P-value:4.09E-5 ID:SGTC_462|Compound:ag-879|FD-Score:5.42|P-value:1.32E-6 ID:SGTC_524|Compound:r073-0010|FD-Score:3.65|P-value:7.35E-4 ID:SGTC_575|Compound:k072-0246|FD-Score:16.10|P-value:5.54E-44 ID:SGTC_589|Compound:1227-0070|FD-Score:4.45|P-value:5.55E-5 ID:SGTC_592|Compound:k241-0073|FD-Score:4.86|P-value:1.26E-5 ID:SGTC_626|Compound:0214-0009|FD-Score:5.41|P-value:1.37E-6 ID:SGTC_695|Compound:3505-6186|FD-Score:4.72|P-value:2.08E-5 ID:SGTC_764|Compound:1951-2361|FD-Score:5.73|P-value:3.48E-7 ID:SGTC_771|Compound:0250-0039|FD-Score:7.47|P-value:5.29E-11 ID:SGTC_785|Compound:1270-0111|FD-Score:4.22|P-value:1.24E-4 ID:SGTC_796|Compound:1234-0020|FD-Score:17.10|P-value:3.28E-49 ID:SGTC_800|Compound:3448-7362|FD-Score:5.23|P-value:2.92E-6 ID:SGTC_832|Compound:4083-0019|FD-Score:11.00|P-value:1.26E-21 ID:SGTC_842|Compound:0271-0008|FD-Score:21.60|P-value:2.18E-77 ID:SGTC_852|Compound:0418-0143|FD-Score:11.00|P-value:8.80E-22 ID:SGTC_879|Compound:0831-1030|FD-Score:3.78|P-value:4.98E-4 ID:SGTC_984|Compound:1492-0255|FD-Score:17.60|P-value:2.55E-52 ID:SGTC_1000|Compound:4048-0884|FD-Score:6.39|P-value:1.60E-8 ID:SGTC_1063|Compound:disulfiram|FD-Score:4.46|P-value:5.36E-5 ID:SGTC_1101|Compound:ebselen|FD-Score:4.71|P-value:2.17E-5 ID:SGTC_1105|Compound:epirubicin|FD-Score:3.59|P-value:8.74E-4 ID:SGTC_1142|Compound:3253-1408|FD-Score:3.69|P-value:6.66E-4 ID:SGTC_1156|Compound:4092-0367|FD-Score:-4.17|P-value:2.06E-4 ID:SGTC_1172|Compound:0370-0043|FD-Score:9.82|P-value:1.24E-17 ID:SGTC_1179|Compound:1021-1431|FD-Score:6.30|P-value:2.53E-8 ID:SGTC_1195|Compound:1502-0147|FD-Score:6.06|P-value:7.66E-8 ID:SGTC_1218|Compound:1348-1416|FD-Score:9.24|P-value:7.51E-16 ID:SGTC_1228|Compound:0124-0032|FD-Score:5.03|P-value:6.34E-6 ID:SGTC_1261|Compound:0712-0010|FD-Score:-4.52|P-value:6.24E-5 ID:SGTC_1346|Compound:1488-2224|FD-Score:5.13|P-value:4.29E-6 ID:SGTC_1424|Compound:4048-1941|FD-Score:3.86|P-value:3.89E-4 ID:SGTC_1506|Compound:4226-2149|FD-Score:3.77|P-value:5.18E-4 ID:SGTC_1552|Compound:6-methylflavone|FD-Score:3.68|P-value:6.82E-4 ID:SGTC_1607|Compound:st000305|FD-Score:3.63|P-value:7.86E-4 ID:SGTC_1611|Compound:st001856|FD-Score:3.59|P-value:8.83E-4 ID:SGTC_1696|Compound:st025591|FD-Score:24.00|P-value:8.51E-95 ID:SGTC_1762|Compound:st045503|FD-Score:6.33|P-value:2.11E-8 ID:SGTC_1773|Compound:st048542|FD-Score:3.58|P-value:9.00E-4 ID:SGTC_1823|Compound:3-hydroxy-2-naphthoic acid|FD-Score:4.83|P-value:1.40E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:6.16|P-value:4.79E-8 ID:SGTC_1873|Compound:rapamycin|FD-Score:3.62|P-value:8.22E-4 ID:SGTC_1919|Compound:st067113|FD-Score:4.44|P-value:5.70E-5 ID:SGTC_2034|Compound:5197015|FD-Score:21.50|P-value:7.92E-77 ID:SGTC_2043|Compound:5101342|FD-Score:19.50|P-value:3.17E-63 ID:SGTC_2071|Compound:5230951|FD-Score:5.17|P-value:3.75E-6 ID:SGTC_2072|Compound:5231554|FD-Score:3.57|P-value:9.42E-4 ID:SGTC_2077|Compound:5212015|FD-Score:15.40|P-value:2.49E-40 ID:SGTC_2084|Compound:5306078|FD-Score:6.77|P-value:2.36E-9 ID:SGTC_2086|Compound:5274770|FD-Score:5.69|P-value:4.10E-7 ID:SGTC_2088|Compound:5278280|FD-Score:3.88|P-value:3.74E-4 ID:SGTC_2090|Compound:5301565|FD-Score:6.47|P-value:1.10E-8 ID:SGTC_2110|Compound:5483698|FD-Score:5.88|P-value:1.80E-7 ID:SGTC_2112|Compound:5488546|FD-Score:15.10|P-value:5.67E-39 ID:SGTC_2113|Compound:5491891|FD-Score:9.29|P-value:5.39E-16 ID:SGTC_2132|Compound:5317594|FD-Score:19.80|P-value:1.31E-65 ID:SGTC_2165|Compound:5727197|FD-Score:3.71|P-value:6.12E-4 ID:SGTC_2301|Compound:7769476|FD-Score:3.76|P-value:5.40E-4 ID:SGTC_2323|Compound:6148992|FD-Score:5.89|P-value:1.71E-7 ID:SGTC_2337|Compound:9009472|FD-Score:4.25|P-value:1.11E-4 ID:SGTC_2399|Compound:5884133|FD-Score:3.85|P-value:4.07E-4 ID:SGTC_2400|Compound:5203494|FD-Score:3.89|P-value:3.54E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:18.20|P-value:1.65E-55 ID:SGTC_2433|Compound:5607874|FD-Score:3.62|P-value:8.08E-4 ID:SGTC_2438|Compound:5259590|FD-Score:6.41|P-value:1.45E-8 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:5.26|P-value:2.56E-6 ID:SGTC_2594|Compound:a-mangostin|FD-Score:-5.76|P-value:4.90E-7 ID:SGTC_2600|Compound:tangeritin|FD-Score:12.50|P-value:3.71E-27 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:3.84|P-value:4.15E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:7.06|P-value:5.08E-10 ID:SGTC_2737|Compound:bleomycin|FD-Score:10.80|P-value:4.23E-21 ID:SGTC_2743|Compound:auranofin|FD-Score:3.71|P-value:6.26E-4 ID:SGTC_2759|Compound:disulfiram|FD-Score:8.57|P-value:6.70E-14 ID:SGTC_2766|Compound:oltipraz|FD-Score:14.50|P-value:2.98E-36 ID:SGTC_2789|Compound:5281112|FD-Score:-4.11|P-value:2.47E-4 ID:SGTC_2843|Compound:9000894|FD-Score:4.52|P-value:4.37E-5 ID:SGTC_2926|Compound:9010726|FD-Score:5.20|P-value:3.32E-6 ID:SGTC_2929|Compound:9013348|FD-Score:-6.73|P-value:5.08E-9 ID:SGTC_2933|Compound:9026794|FD-Score:4.63|P-value:2.93E-5 ID:SGTC_3061|Compound:glucosamine|FD-Score:4.31|P-value:9.05E-5 ID:SGTC_3124|Compound:9127567|FD-Score:5.85|P-value:2.08E-7 ID:SGTC_3189|Compound:9110682|FD-Score:4.33|P-value:8.42E-5 ID:SGTC_3209|Compound:9113616|FD-Score:3.68|P-value:6.88E-4 ID:SGTC_3350|Compound:9150499|FD-Score:4.45|P-value:5.48E-5

Top fitness defect scores for YDR126W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_107 0358-0022 24.80 2.7 µM 1.42E-101 SWF1 & branched chain AA biosynthesis 1 1.45E-136
2 SGTC_1696 st025591 24.00 34.8 µM 8.51E-95 SWF1 & branched chain AA biosynthesis 1 2.19E-127
3 SGTC_34 0469-0683 22.10 81.8 µM 3.23E-81 SWF1 & branched chain AA biosynthesis 1 5.36E-109
4 SGTC_842 0271-0008 21.60 11.1 µM 2.18E-77 heme biosynthesis & mitochondrial translocase 1 8.17E-104
5 SGTC_2034 5197015 21.50 53.1 µM 7.92E-77 SWF1 & branched chain AA biosynthesis 1 4.70E-103
6 SGTC_2132 5317594 19.80 122.7 µM 1.31E-65 SWF1 & branched chain AA biosynthesis 2 7.22E-88
7 SGTC_2043 5101342 19.50 149.0 µM 3.17E-63 SWF1 & branched chain AA biosynthesis 1 1.21E-84
8 SGTC_2405 ticlatone 18.20 3.5 µM 1.65E-55 3 3.34E-74
9 SGTC_984 1492-0255 17.60 2.9 µM 2.55E-52 SWF1 & branched chain AA biosynthesis 1 6.88E-70
10 SGTC_796 1234-0020 17.10 70.7 µM 3.28E-49 SWF1 & branched chain AA biosynthesis 1 1.10E-65
11 SGTC_23 0213-0011 16.40 40.0 µM 1.38E-45 copper-dependent oxidative stress 3 8.77E-61
12 SGTC_575 k072-0246 16.10 11.9 µM 5.54E-44 3 1.29E-58
13 SGTC_2077 5212015 15.40 200.0 µM 2.49E-40 3 1.12E-53
14 SGTC_2112 5488546 15.10 200.0 µM 5.67E-39 TSC3-RPN4 2 7.66E-52
15 SGTC_2766 oltipraz 14.50 83.9 µM 2.98E-36 heme requiring 2 3.63E-48
16 SGTC_2600 tangeritin 12.50 88.0 µM 3.71E-27 1 6.95E-36
17 SGTC_852 0418-0143 11.00 439.0 µM 8.80E-22 calcium & mitochondrial duress 9 1.23E-28
18 SGTC_832 4083-0019 11.00 164.0 µM 1.26E-21 translation 1 2.01E-28
19 SGTC_2737 bleomycin 10.80 30.5 nM 4.23E-21 Golgi 9 1.02E-27
20 SGTC_149 3970-0822 9.92 46.1 µM 5.54E-18 tubulin folding & SWR complex 10 1.62E-23

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.184 6.44E-27 YML034W SRC1 hom Inner nuclear membrane protein; functions in regulation of subtelomeric genes and is linked to TREX (transcription export) factors; SRC1 produces 2 splice variant proteins with different functions; alternative splicing of SRC1 pre-mRNA is promoted by Hub1p; mutant has aneuploidy tolerance
0.176 8.87E-25 YER086W ILV1 hom Threonine deaminase, catalyzes the first step in isoleucine biosynthesis; expression is under general amino acid control; ILV1 locus exhibits highly positioned nucleosomes whose organization is independent of known ILV1 regulation
0.163 3.01E-21 YOR282W_d YOR282W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps essential, verified gene PLP2/YOR281C
0.156 1.15E-19 YJL101C GSH1 hom Gamma glutamylcysteine synthetase; catalyzes the first step in glutathione (GSH) biosynthesis; expression induced by oxidants, cadmium, and mercury; protein abundance increases in response to DNA replication stress
0.154 3.30E-19 YBR058C-A TSC3 hom Protein that stimulates the activity of serine palmitoyltransferase (Lcb1p, Lcb2p) several-fold; involved in sphingolipid biosynthesis
0.152 8.75E-19 YHR025W THR1 hom Homoserine kinase, conserved protein required for threonine biosynthesis; expression is regulated by the GCN4-mediated general amino acid control pathway
0.143 6.55E-17 YPL091W GLR1 hom Cytosolic and mitochondrial glutathione oxidoreductase; converts oxidized glutathione to reduced glutathione; mitochondrial but not cytosolic form has a role in resistance to hyperoxia; protein abundance increases in response to DNA replication stress
0.142 1.93E-16 YJR139C HOM6 hom Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase), dimeric enzyme that catalyzes the third step in the common pathway for methionine and threonine biosynthesis; enzyme has nucleotide-binding, dimerization and catalytic regions
0.123 7.49E-13 YDR069C DOA4 hom Ubiquitin isopeptidase, required for recycling ubiquitin from proteasome-bound ubiquitinated intermediates, acts at the late endosome/prevacuolar compartment to recover ubiquitin from ubiquitinated membrane proteins en route to the vacuole
0.117 1.07E-11 YML073C RPL6A hom Ribosomal 60S subunit protein L6A; N-terminally acetylated; binds 5.8S rRNA; homologous to mammalian ribosomal protein L6, no bacterial homolog; RPL6A has a paralog, RPL6B, that arose from the whole genome duplication
0.114 3.76E-11 YFL033C RIM15 hom Glucose-repressible protein kinase involved in signal transduction during cell proliferation in response to nutrients, specifically the establishment of stationary phase; identified as a regulator of IME2; substrate of Pho80p-Pho85p kinase
0.113 6.56E-11 YAL024C LTE1 hom Protein similar to GDP/GTP exchange factors but without detectable GEF activity; required for asymmetric localization of Bfa1p at daughter-directed spindle pole bodies and for mitotic exit at low temperatures
0.112 7.91E-11 YOL049W GSH2 hom Glutathione synthetase, catalyzes the ATP-dependent synthesis of glutathione (GSH) from gamma-glutamylcysteine and glycine; induced by oxidative stress and heat shock
0.108 3.34E-10 YNR006W VPS27 hom Endosomal protein that forms a complex with Hse1p; required for recycling Golgi proteins, forming lumenal membranes and sorting ubiquitinated proteins destined for degradation; has Ubiquitin Interaction Motifs which bind ubiquitin (Ubi4p)
0.104 1.75E-9 YOR323C PRO2 hom Gamma-glutamyl phosphate reductase, catalyzes the second step in proline biosynthesis