YDR127W / ARO1

Pentafunctional arom protein, catalyzes steps 2 through 6 in the biosynthesis of chorismate, which is a precursor to aromatic amino acids

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR127W / ARO1

Click on Significant Values for Screen Details ID:SGTC_46|Compound:0329-0187a|FD-Score:12.30|P-value:2.17E-14 ID:SGTC_59|Compound:0330-0160|FD-Score:6.53|P-value:3.43E-5 ID:SGTC_62|Compound:0180-0423|FD-Score:-5.39|P-value:3.90E-4 ID:SGTC_78|Compound:0336-0123|FD-Score:5.99|P-value:1.31E-4 ID:SGTC_79|Compound:0052-0007|FD-Score:7.14|P-value:6.68E-6 ID:SGTC_84|Compound:0443-0269|FD-Score:6.15|P-value:8.91E-5 ID:SGTC_107|Compound:0358-0022|FD-Score:6.83|P-value:1.54E-5 ID:SGTC_109|Compound:0132-0036|FD-Score:5.11|P-value:9.54E-4 ID:SGTC_110|Compound:0850-0284|FD-Score:5.96|P-value:1.43E-4 ID:SGTC_129|Compound:0088-0017|FD-Score:5.80|P-value:2.05E-4 ID:SGTC_161|Compound:4065-0411|FD-Score:11.00|P-value:8.12E-12 ID:SGTC_163|Compound:1327-0036|FD-Score:8.54|P-value:8.99E-8 ID:SGTC_207|Compound:4185-0010|FD-Score:9.36|P-value:5.17E-9 ID:SGTC_218|Compound:alverine citrate|FD-Score:6.57|P-value:3.10E-5 ID:SGTC_235|Compound:0330-0087|FD-Score:7.46|P-value:2.65E-6 ID:SGTC_239|Compound:5hr heat shock (37°C) + mitomycin C|FD-Score:5.20|P-value:7.91E-4 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:5.12|P-value:9.28E-4 ID:SGTC_253|Compound:dyclonine|FD-Score:11.00|P-value:6.77E-12 ID:SGTC_258|Compound:haloperidol|FD-Score:8.18|P-value:2.92E-7 ID:SGTC_278|Compound:4092-0821|FD-Score:8.52|P-value:9.62E-8 ID:SGTC_279|Compound:1273-0055|FD-Score:6.13|P-value:9.33E-5 ID:SGTC_298|Compound:1391-0729|FD-Score:7.82|P-value:8.85E-7 ID:SGTC_308|Compound:4092-1169|FD-Score:9.67|P-value:1.66E-9 ID:SGTC_312|Compound:4092-0653|FD-Score:5.42|P-value:4.93E-4 ID:SGTC_315|Compound:k915-0449|FD-Score:6.46|P-value:4.14E-5 ID:SGTC_337|Compound:1315-0038|FD-Score:6.94|P-value:1.14E-5 ID:SGTC_339|Compound:3091-4833|FD-Score:-4.97|P-value:9.54E-4 ID:SGTC_394|Compound:menadione|FD-Score:7.04|P-value:8.85E-6 ID:SGTC_409|Compound:arachidonic acid|FD-Score:6.18|P-value:8.27E-5 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:5.97|P-value:1.38E-4 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:7.78|P-value:1.02E-6 ID:SGTC_435|Compound:c-PAF|FD-Score:11.90|P-value:1.86E-13 ID:SGTC_444|Compound:curcumin|FD-Score:-5.58|P-value:2.53E-4 ID:SGTC_450|Compound:aminopyrene|FD-Score:6.17|P-value:8.54E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:9.36|P-value:5.26E-9 ID:SGTC_455|Compound:paf C-16|FD-Score:7.65|P-value:1.49E-6 ID:SGTC_456|Compound:gingerol|FD-Score:6.79|P-value:1.75E-5 ID:SGTC_470|Compound:aa-861|FD-Score:9.20|P-value:9.25E-9 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:15.30|P-value:2.58E-21 ID:SGTC_486|Compound:niguldipine|FD-Score:11.60|P-value:6.13E-13 ID:SGTC_505|Compound:gw-5074|FD-Score:26.60|P-value:3.78E-60 ID:SGTC_515|Compound:4092-1064|FD-Score:12.50|P-value:9.94E-15 ID:SGTC_526|Compound:4469-0568|FD-Score:6.94|P-value:1.14E-5 ID:SGTC_542|Compound:3381-0244|FD-Score:12.10|P-value:6.42E-14 ID:SGTC_543|Compound:3844-1095|FD-Score:7.88|P-value:7.57E-7 ID:SGTC_556|Compound:4058-0063|FD-Score:6.59|P-value:2.97E-5 ID:SGTC_563|Compound:tetrahydrosecaminediol|FD-Score:5.49|P-value:4.16E-4 ID:SGTC_581|Compound:0958-0271|FD-Score:15.70|P-value:2.91E-22 ID:SGTC_596|Compound:1155-0152|FD-Score:12.90|P-value:1.63E-15 ID:SGTC_601|Compound:0986-0029|FD-Score:7.80|P-value:9.65E-7 ID:SGTC_603|Compound:3794-0023|FD-Score:5.26|P-value:6.83E-4 ID:SGTC_609|Compound:0986-0026|FD-Score:7.15|P-value:6.38E-6 ID:SGTC_614|Compound:0462-0418|FD-Score:8.71|P-value:5.08E-8 ID:SGTC_637|Compound:1181-0519|FD-Score:11.70|P-value:4.75E-13 ID:SGTC_639|Compound:0833-0042|FD-Score:14.40|P-value:6.51E-19 ID:SGTC_646|Compound:4092-0839|FD-Score:9.10|P-value:1.34E-8 ID:SGTC_649|Compound:1123-0311|FD-Score:5.48|P-value:4.32E-4 ID:SGTC_651|Compound:3253-0966|FD-Score:7.67|P-value:1.41E-6 ID:SGTC_658|Compound:3253-0951|FD-Score:7.15|P-value:6.35E-6 ID:SGTC_666|Compound:0272-0154|FD-Score:6.68|P-value:2.30E-5 ID:SGTC_669|Compound:0108-0021|FD-Score:9.23|P-value:8.22E-9 ID:SGTC_677|Compound:0929-0063|FD-Score:5.11|P-value:9.44E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:9.66|P-value:1.71E-9 ID:SGTC_710|Compound:3448-4187|FD-Score:5.33|P-value:5.88E-4 ID:SGTC_723|Compound:4182-0001|FD-Score:14.20|P-value:1.47E-18 ID:SGTC_729|Compound:4092-0585|FD-Score:5.26|P-value:6.86E-4 ID:SGTC_738|Compound:1315-0003|FD-Score:7.34|P-value:3.78E-6 ID:SGTC_739|Compound:1486-1183|FD-Score:5.83|P-value:1.91E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:8.14|P-value:3.32E-7 ID:SGTC_767|Compound:0929-0023|FD-Score:9.23|P-value:8.19E-9 ID:SGTC_768|Compound:0384-0033|FD-Score:12.60|P-value:7.18E-15 ID:SGTC_779|Compound:1360-0071|FD-Score:5.63|P-value:3.09E-4 ID:SGTC_807|Compound:1315-0151|FD-Score:10.40|P-value:8.08E-11 ID:SGTC_812|Compound:4251-0442|FD-Score:6.31|P-value:6.06E-5 ID:SGTC_819|Compound:1013-0258|FD-Score:10.40|P-value:1.01E-10 ID:SGTC_823|Compound:0417-1665|FD-Score:9.30|P-value:6.44E-9 ID:SGTC_845|Compound:0330-0138|FD-Score:11.20|P-value:3.02E-12 ID:SGTC_860|Compound:0443-0016|FD-Score:8.98|P-value:2.02E-8 ID:SGTC_872|Compound:0588-0139|FD-Score:5.26|P-value:6.85E-4 ID:SGTC_874|Compound:0599-0792|FD-Score:6.48|P-value:3.87E-5 ID:SGTC_878|Compound:0828-0289|FD-Score:14.20|P-value:1.65E-18 ID:SGTC_879|Compound:0831-1030|FD-Score:11.80|P-value:2.38E-13 ID:SGTC_890|Compound:0929-0006|FD-Score:7.83|P-value:8.71E-7 ID:SGTC_892|Compound:0929-0076|FD-Score:5.82|P-value:1.98E-4 ID:SGTC_903|Compound:1134-0042|FD-Score:8.23|P-value:2.50E-7 ID:SGTC_922|Compound:1866-0035|FD-Score:-4.96|P-value:9.93E-4 ID:SGTC_926|Compound:2268-1401|FD-Score:14.20|P-value:1.22E-18 ID:SGTC_932|Compound:2857-0803|FD-Score:5.49|P-value:4.20E-4 ID:SGTC_933|Compound:2914-0560|FD-Score:6.45|P-value:4.23E-5 ID:SGTC_960|Compound:1222-0186|FD-Score:6.79|P-value:1.74E-5 ID:SGTC_974|Compound:1326-0144|FD-Score:8.83|P-value:3.33E-8 ID:SGTC_1011|Compound:4112-3381|FD-Score:5.59|P-value:3.33E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:10.20|P-value:2.40E-10 ID:SGTC_1044|Compound:1222-0021|FD-Score:-5.87|P-value:1.29E-4 ID:SGTC_1047|Compound:2043-3044|FD-Score:6.85|P-value:1.46E-5 ID:SGTC_1058|Compound:3448-5425|FD-Score:11.20|P-value:4.13E-12 ID:SGTC_1072|Compound:oxiconazole|FD-Score:6.63|P-value:2.67E-5 ID:SGTC_1076|Compound:itraconazole|FD-Score:5.33|P-value:6.00E-4 ID:SGTC_1104|Compound:tacrolimus|FD-Score:6.63|P-value:2.64E-5 ID:SGTC_1130|Compound:3454-2858|FD-Score:9.19|P-value:9.77E-9 ID:SGTC_1160|Compound:4092-0570|FD-Score:11.90|P-value:1.52E-13 ID:SGTC_1173|Compound:0443-0020|FD-Score:10.60|P-value:3.89E-11 ID:SGTC_1181|Compound:1222-0449|FD-Score:6.12|P-value:9.53E-5 ID:SGTC_1213|Compound:1315-0166|FD-Score:8.14|P-value:3.28E-7 ID:SGTC_1219|Compound:1469-0211|FD-Score:17.10|P-value:6.05E-26 ID:SGTC_1225|Compound:1216-0074|FD-Score:9.88|P-value:7.61E-10 ID:SGTC_1226|Compound:3909-7979|FD-Score:23.10|P-value:4.72E-46 ID:SGTC_1237|Compound:0330-0133|FD-Score:10.30|P-value:1.54E-10 ID:SGTC_1240|Compound:0356-0016|FD-Score:5.56|P-value:3.56E-4 ID:SGTC_1265|Compound:0819-1001|FD-Score:-5.03|P-value:8.46E-4 ID:SGTC_1279|Compound:0874-0590|FD-Score:10.50|P-value:6.30E-11 ID:SGTC_1284|Compound:0929-0043|FD-Score:6.76|P-value:1.86E-5 ID:SGTC_1304|Compound:1165-0502|FD-Score:23.50|P-value:2.24E-47 ID:SGTC_1308|Compound:1187-1617|FD-Score:6.68|P-value:2.31E-5 ID:SGTC_1313|Compound:1220-0047|FD-Score:22.20|P-value:1.37E-42 ID:SGTC_1326|Compound:1431-2094|FD-Score:6.04|P-value:1.16E-4 ID:SGTC_1335|Compound:1486-0900|FD-Score:8.34|P-value:1.72E-7 ID:SGTC_1346|Compound:1488-2224|FD-Score:7.87|P-value:7.77E-7 ID:SGTC_1350|Compound:1495-0454|FD-Score:6.02|P-value:1.23E-4 ID:SGTC_1427|Compound:4048-4900|FD-Score:14.30|P-value:7.37E-19 ID:SGTC_1474|Compound:0330-0125|FD-Score:7.86|P-value:7.92E-7 ID:SGTC_1475|Compound:4092-1048|FD-Score:6.46|P-value:4.09E-5 ID:SGTC_1482|Compound:3346-2049|FD-Score:16.10|P-value:3.20E-23 ID:SGTC_1572|Compound:epiandrosterone|FD-Score:10.10|P-value:3.15E-10 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:7.70|P-value:1.29E-6 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:13.00|P-value:1.00E-15 ID:SGTC_1603|Compound:st002045|FD-Score:6.31|P-value:6.07E-5 ID:SGTC_1608|Compound:st001473|FD-Score:7.14|P-value:6.69E-6 ID:SGTC_1636|Compound:st007707|FD-Score:21.00|P-value:2.67E-38 ID:SGTC_1649|Compound:st011737|FD-Score:12.10|P-value:5.84E-14 ID:SGTC_1656|Compound:st012921|FD-Score:32.50|P-value:2.48E-89 ID:SGTC_1673|Compound:st016611|FD-Score:5.34|P-value:5.77E-4 ID:SGTC_1697|Compound:st025554|FD-Score:6.85|P-value:1.47E-5 ID:SGTC_1699|Compound:st031318|FD-Score:9.05|P-value:1.55E-8 ID:SGTC_1715|Compound:st032160|FD-Score:5.28|P-value:6.57E-4 ID:SGTC_1726|Compound:st035556|FD-Score:12.80|P-value:1.89E-15 ID:SGTC_1750|Compound:st081859|FD-Score:29.20|P-value:1.62E-72 ID:SGTC_1757|Compound:st041620|FD-Score:9.94|P-value:6.06E-10 ID:SGTC_1764|Compound:st044502|FD-Score:5.31|P-value:6.14E-4 ID:SGTC_1772|Compound:st048439|FD-Score:6.97|P-value:1.07E-5 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-5.45|P-value:3.39E-4 ID:SGTC_1797|Compound:st048695|FD-Score:15.50|P-value:1.12E-21 ID:SGTC_1881|Compound:5652484|FD-Score:12.10|P-value:6.35E-14 ID:SGTC_1882|Compound:5615643|FD-Score:17.70|P-value:7.79E-28 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:22.70|P-value:1.73E-44 ID:SGTC_1909|Compound:st060837|FD-Score:8.20|P-value:2.69E-7 ID:SGTC_1921|Compound:5740136|FD-Score:6.09|P-value:1.05E-4 ID:SGTC_1933|Compound:st074711|FD-Score:5.44|P-value:4.66E-4 ID:SGTC_1937|Compound:st074714|FD-Score:7.57|P-value:1.93E-6 ID:SGTC_1952|Compound:st077036|FD-Score:5.21|P-value:7.72E-4 ID:SGTC_1975|Compound:st070967|FD-Score:6.99|P-value:1.01E-5 ID:SGTC_1982|Compound:st072467|FD-Score:5.26|P-value:6.84E-4 ID:SGTC_1999|Compound:st074831|FD-Score:11.50|P-value:7.93E-13 ID:SGTC_2003|Compound:4023581|FD-Score:5.26|P-value:6.96E-4 ID:SGTC_2024|Compound:5144227|FD-Score:11.70|P-value:3.19E-13 ID:SGTC_2036|Compound:5160441|FD-Score:15.40|P-value:1.48E-21 ID:SGTC_2038|Compound:4100038|FD-Score:23.80|P-value:1.13E-48 ID:SGTC_2050|Compound:5263056|FD-Score:8.29|P-value:2.05E-7 ID:SGTC_2056|Compound:5235370|FD-Score:19.60|P-value:1.69E-33 ID:SGTC_2077|Compound:5212015|FD-Score:6.70|P-value:2.20E-5 ID:SGTC_2086|Compound:5274770|FD-Score:7.94|P-value:6.24E-7 ID:SGTC_2106|Compound:5357045|FD-Score:6.94|P-value:1.16E-5 ID:SGTC_2122|Compound:5258151|FD-Score:5.73|P-value:2.41E-4 ID:SGTC_2132|Compound:5317594|FD-Score:23.10|P-value:6.37E-46 ID:SGTC_2137|Compound:5261020|FD-Score:6.74|P-value:2.00E-5 ID:SGTC_2197|Compound:6588183|FD-Score:6.08|P-value:1.07E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:21.50|P-value:5.88E-40 ID:SGTC_2241|Compound:6772625|FD-Score:-8.20|P-value:1.77E-7 ID:SGTC_2249|Compound:haloperidol|FD-Score:13.70|P-value:1.97E-17 ID:SGTC_2250|Compound:alverine citrate|FD-Score:7.54|P-value:2.10E-6 ID:SGTC_2254|Compound:7938975|FD-Score:29.00|P-value:4.14E-71 ID:SGTC_2255|Compound:7941087|FD-Score:5.16|P-value:8.62E-4 ID:SGTC_2271|Compound:7849410|FD-Score:7.74|P-value:1.14E-6 ID:SGTC_2296|Compound:7971656|FD-Score:6.17|P-value:8.55E-5 ID:SGTC_2300|Compound:7976697|FD-Score:6.45|P-value:4.24E-5 ID:SGTC_2301|Compound:7769476|FD-Score:8.11|P-value:3.69E-7 ID:SGTC_2312|Compound:7706453|FD-Score:10.90|P-value:1.19E-11 ID:SGTC_2322|Compound:7413319|FD-Score:17.60|P-value:2.14E-27 ID:SGTC_2332|Compound:7982454|FD-Score:5.99|P-value:1.32E-4 ID:SGTC_2384|Compound:9036245|FD-Score:15.70|P-value:2.52E-22 ID:SGTC_2437|Compound:5741531|FD-Score:15.80|P-value:1.24E-22 ID:SGTC_2445|Compound:5742597|FD-Score:12.80|P-value:2.12E-15 ID:SGTC_2447|Compound:5741742|FD-Score:7.20|P-value:5.58E-6 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:13.90|P-value:6.48E-18 ID:SGTC_2461|Compound:5755302|FD-Score:6.60|P-value:2.86E-5 ID:SGTC_2468|Compound:5987765|FD-Score:5.10|P-value:9.72E-4 ID:SGTC_2472|Compound:5377652|FD-Score:20.80|P-value:1.35E-37 ID:SGTC_2478|Compound:5763493|FD-Score:8.02|P-value:4.79E-7 ID:SGTC_2486|Compound:5283202|FD-Score:7.15|P-value:6.47E-6 ID:SGTC_2488|Compound:5268135|FD-Score:11.20|P-value:2.84E-12 ID:SGTC_2524|Compound:avocatin b|FD-Score:10.00|P-value:4.38E-10 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:11.90|P-value:1.55E-13 ID:SGTC_2563|Compound:tomatine|FD-Score:5.62|P-value:3.14E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:5.82|P-value:1.99E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:13.20|P-value:3.01E-16 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:6.48|P-value:3.92E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:9.43|P-value:4.05E-9 ID:SGTC_2607|Compound:solasodine|FD-Score:70.60|P-value:0 ID:SGTC_2616|Compound:abietic acid|FD-Score:16.60|P-value:1.52E-24 ID:SGTC_2618|Compound:avocadyne|FD-Score:19.90|P-value:1.51E-34 ID:SGTC_2642|Compound:cholecalciferol|FD-Score:10.90|P-value:1.39E-11 ID:SGTC_2650|Compound:prasterone|FD-Score:16.00|P-value:5.63E-23 ID:SGTC_2651|Compound:1327-0036|FD-Score:13.90|P-value:7.39E-18 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.43|P-value:4.80E-4 ID:SGTC_2699|Compound:st077704|FD-Score:7.60|P-value:1.75E-6 ID:SGTC_2701|Compound:st077767|FD-Score:7.01|P-value:9.58E-6 ID:SGTC_2725|Compound:haloperidol|FD-Score:14.50|P-value:2.82E-19 ID:SGTC_2733|Compound:amorolfine|FD-Score:7.08|P-value:7.71E-6 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:5.23|P-value:7.35E-4 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:16.10|P-value:2.72E-23 ID:SGTC_2776|Compound:terbinafine|FD-Score:7.29|P-value:4.37E-6 ID:SGTC_2777|Compound:climbazole|FD-Score:7.36|P-value:3.51E-6 ID:SGTC_2778|Compound:tioconazole|FD-Score:15.00|P-value:1.97E-20 ID:SGTC_2830|Compound:7992007|FD-Score:-5.39|P-value:3.90E-4 ID:SGTC_2833|Compound:9001315|FD-Score:11.20|P-value:3.82E-12 ID:SGTC_2910|Compound:7948405|FD-Score:5.82|P-value:1.99E-4 ID:SGTC_2932|Compound:9016711|FD-Score:21.60|P-value:2.59E-40 ID:SGTC_2948|Compound:9070189|FD-Score:26.10|P-value:4.97E-58 ID:SGTC_2976|Compound:9009005|FD-Score:25.00|P-value:1.37E-53 ID:SGTC_2993|Compound:9054257|FD-Score:5.63|P-value:3.04E-4 ID:SGTC_3018|Compound:9082602|FD-Score:10.30|P-value:1.74E-10 ID:SGTC_3059|Compound:1327-0034|FD-Score:9.89|P-value:7.36E-10 ID:SGTC_3060|Compound:1327-0027|FD-Score:7.91|P-value:6.82E-7 ID:SGTC_3063|Compound:1327-0034|FD-Score:11.40|P-value:1.81E-12 ID:SGTC_3118|Compound:9124250|FD-Score:-5.73|P-value:1.78E-4 ID:SGTC_3181|Compound:9108277|FD-Score:-5.11|P-value:7.23E-4 ID:SGTC_3216|Compound:9129716|FD-Score:-5.75|P-value:1.71E-4 ID:SGTC_3237|Compound:9133362|FD-Score:7.37|P-value:3.44E-6 ID:SGTC_3267|Compound:9137951|FD-Score:5.85|P-value:1.85E-4 ID:SGTC_3292|Compound:9120825|FD-Score:5.86|P-value:1.81E-4 ID:SGTC_3303|Compound:9125618|FD-Score:6.16|P-value:8.81E-5 ID:SGTC_3308|Compound:9128332|FD-Score:19.20|P-value:1.70E-32 ID:SGTC_46|Compound:0329-0187a|FD-Score:12.30|P-value:2.17E-14 ID:SGTC_59|Compound:0330-0160|FD-Score:6.53|P-value:3.43E-5 ID:SGTC_62|Compound:0180-0423|FD-Score:-5.39|P-value:3.90E-4 ID:SGTC_78|Compound:0336-0123|FD-Score:5.99|P-value:1.31E-4 ID:SGTC_79|Compound:0052-0007|FD-Score:7.14|P-value:6.68E-6 ID:SGTC_84|Compound:0443-0269|FD-Score:6.15|P-value:8.91E-5 ID:SGTC_107|Compound:0358-0022|FD-Score:6.83|P-value:1.54E-5 ID:SGTC_109|Compound:0132-0036|FD-Score:5.11|P-value:9.54E-4 ID:SGTC_110|Compound:0850-0284|FD-Score:5.96|P-value:1.43E-4 ID:SGTC_129|Compound:0088-0017|FD-Score:5.80|P-value:2.05E-4 ID:SGTC_161|Compound:4065-0411|FD-Score:11.00|P-value:8.12E-12 ID:SGTC_163|Compound:1327-0036|FD-Score:8.54|P-value:8.99E-8 ID:SGTC_207|Compound:4185-0010|FD-Score:9.36|P-value:5.17E-9 ID:SGTC_218|Compound:alverine citrate|FD-Score:6.57|P-value:3.10E-5 ID:SGTC_235|Compound:0330-0087|FD-Score:7.46|P-value:2.65E-6 ID:SGTC_239|Compound:5hr heat shock (37°C) + mitomycin C|FD-Score:5.20|P-value:7.91E-4 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:5.12|P-value:9.28E-4 ID:SGTC_253|Compound:dyclonine|FD-Score:11.00|P-value:6.77E-12 ID:SGTC_258|Compound:haloperidol|FD-Score:8.18|P-value:2.92E-7 ID:SGTC_278|Compound:4092-0821|FD-Score:8.52|P-value:9.62E-8 ID:SGTC_279|Compound:1273-0055|FD-Score:6.13|P-value:9.33E-5 ID:SGTC_298|Compound:1391-0729|FD-Score:7.82|P-value:8.85E-7 ID:SGTC_308|Compound:4092-1169|FD-Score:9.67|P-value:1.66E-9 ID:SGTC_312|Compound:4092-0653|FD-Score:5.42|P-value:4.93E-4 ID:SGTC_315|Compound:k915-0449|FD-Score:6.46|P-value:4.14E-5 ID:SGTC_337|Compound:1315-0038|FD-Score:6.94|P-value:1.14E-5 ID:SGTC_339|Compound:3091-4833|FD-Score:-4.97|P-value:9.54E-4 ID:SGTC_394|Compound:menadione|FD-Score:7.04|P-value:8.85E-6 ID:SGTC_409|Compound:arachidonic acid|FD-Score:6.18|P-value:8.27E-5 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:5.97|P-value:1.38E-4 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:7.78|P-value:1.02E-6 ID:SGTC_435|Compound:c-PAF|FD-Score:11.90|P-value:1.86E-13 ID:SGTC_444|Compound:curcumin|FD-Score:-5.58|P-value:2.53E-4 ID:SGTC_450|Compound:aminopyrene|FD-Score:6.17|P-value:8.54E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:9.36|P-value:5.26E-9 ID:SGTC_455|Compound:paf C-16|FD-Score:7.65|P-value:1.49E-6 ID:SGTC_456|Compound:gingerol|FD-Score:6.79|P-value:1.75E-5 ID:SGTC_470|Compound:aa-861|FD-Score:9.20|P-value:9.25E-9 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:15.30|P-value:2.58E-21 ID:SGTC_486|Compound:niguldipine|FD-Score:11.60|P-value:6.13E-13 ID:SGTC_505|Compound:gw-5074|FD-Score:26.60|P-value:3.78E-60 ID:SGTC_515|Compound:4092-1064|FD-Score:12.50|P-value:9.94E-15 ID:SGTC_526|Compound:4469-0568|FD-Score:6.94|P-value:1.14E-5 ID:SGTC_542|Compound:3381-0244|FD-Score:12.10|P-value:6.42E-14 ID:SGTC_543|Compound:3844-1095|FD-Score:7.88|P-value:7.57E-7 ID:SGTC_556|Compound:4058-0063|FD-Score:6.59|P-value:2.97E-5 ID:SGTC_563|Compound:tetrahydrosecaminediol|FD-Score:5.49|P-value:4.16E-4 ID:SGTC_581|Compound:0958-0271|FD-Score:15.70|P-value:2.91E-22 ID:SGTC_596|Compound:1155-0152|FD-Score:12.90|P-value:1.63E-15 ID:SGTC_601|Compound:0986-0029|FD-Score:7.80|P-value:9.65E-7 ID:SGTC_603|Compound:3794-0023|FD-Score:5.26|P-value:6.83E-4 ID:SGTC_609|Compound:0986-0026|FD-Score:7.15|P-value:6.38E-6 ID:SGTC_614|Compound:0462-0418|FD-Score:8.71|P-value:5.08E-8 ID:SGTC_637|Compound:1181-0519|FD-Score:11.70|P-value:4.75E-13 ID:SGTC_639|Compound:0833-0042|FD-Score:14.40|P-value:6.51E-19 ID:SGTC_646|Compound:4092-0839|FD-Score:9.10|P-value:1.34E-8 ID:SGTC_649|Compound:1123-0311|FD-Score:5.48|P-value:4.32E-4 ID:SGTC_651|Compound:3253-0966|FD-Score:7.67|P-value:1.41E-6 ID:SGTC_658|Compound:3253-0951|FD-Score:7.15|P-value:6.35E-6 ID:SGTC_666|Compound:0272-0154|FD-Score:6.68|P-value:2.30E-5 ID:SGTC_669|Compound:0108-0021|FD-Score:9.23|P-value:8.22E-9 ID:SGTC_677|Compound:0929-0063|FD-Score:5.11|P-value:9.44E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:9.66|P-value:1.71E-9 ID:SGTC_710|Compound:3448-4187|FD-Score:5.33|P-value:5.88E-4 ID:SGTC_723|Compound:4182-0001|FD-Score:14.20|P-value:1.47E-18 ID:SGTC_729|Compound:4092-0585|FD-Score:5.26|P-value:6.86E-4 ID:SGTC_738|Compound:1315-0003|FD-Score:7.34|P-value:3.78E-6 ID:SGTC_739|Compound:1486-1183|FD-Score:5.83|P-value:1.91E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:8.14|P-value:3.32E-7 ID:SGTC_767|Compound:0929-0023|FD-Score:9.23|P-value:8.19E-9 ID:SGTC_768|Compound:0384-0033|FD-Score:12.60|P-value:7.18E-15 ID:SGTC_779|Compound:1360-0071|FD-Score:5.63|P-value:3.09E-4 ID:SGTC_807|Compound:1315-0151|FD-Score:10.40|P-value:8.08E-11 ID:SGTC_812|Compound:4251-0442|FD-Score:6.31|P-value:6.06E-5 ID:SGTC_819|Compound:1013-0258|FD-Score:10.40|P-value:1.01E-10 ID:SGTC_823|Compound:0417-1665|FD-Score:9.30|P-value:6.44E-9 ID:SGTC_845|Compound:0330-0138|FD-Score:11.20|P-value:3.02E-12 ID:SGTC_860|Compound:0443-0016|FD-Score:8.98|P-value:2.02E-8 ID:SGTC_872|Compound:0588-0139|FD-Score:5.26|P-value:6.85E-4 ID:SGTC_874|Compound:0599-0792|FD-Score:6.48|P-value:3.87E-5 ID:SGTC_878|Compound:0828-0289|FD-Score:14.20|P-value:1.65E-18 ID:SGTC_879|Compound:0831-1030|FD-Score:11.80|P-value:2.38E-13 ID:SGTC_890|Compound:0929-0006|FD-Score:7.83|P-value:8.71E-7 ID:SGTC_892|Compound:0929-0076|FD-Score:5.82|P-value:1.98E-4 ID:SGTC_903|Compound:1134-0042|FD-Score:8.23|P-value:2.50E-7 ID:SGTC_922|Compound:1866-0035|FD-Score:-4.96|P-value:9.93E-4 ID:SGTC_926|Compound:2268-1401|FD-Score:14.20|P-value:1.22E-18 ID:SGTC_932|Compound:2857-0803|FD-Score:5.49|P-value:4.20E-4 ID:SGTC_933|Compound:2914-0560|FD-Score:6.45|P-value:4.23E-5 ID:SGTC_960|Compound:1222-0186|FD-Score:6.79|P-value:1.74E-5 ID:SGTC_974|Compound:1326-0144|FD-Score:8.83|P-value:3.33E-8 ID:SGTC_1011|Compound:4112-3381|FD-Score:5.59|P-value:3.33E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:10.20|P-value:2.40E-10 ID:SGTC_1044|Compound:1222-0021|FD-Score:-5.87|P-value:1.29E-4 ID:SGTC_1047|Compound:2043-3044|FD-Score:6.85|P-value:1.46E-5 ID:SGTC_1058|Compound:3448-5425|FD-Score:11.20|P-value:4.13E-12 ID:SGTC_1072|Compound:oxiconazole|FD-Score:6.63|P-value:2.67E-5 ID:SGTC_1076|Compound:itraconazole|FD-Score:5.33|P-value:6.00E-4 ID:SGTC_1104|Compound:tacrolimus|FD-Score:6.63|P-value:2.64E-5 ID:SGTC_1130|Compound:3454-2858|FD-Score:9.19|P-value:9.77E-9 ID:SGTC_1160|Compound:4092-0570|FD-Score:11.90|P-value:1.52E-13 ID:SGTC_1173|Compound:0443-0020|FD-Score:10.60|P-value:3.89E-11 ID:SGTC_1181|Compound:1222-0449|FD-Score:6.12|P-value:9.53E-5 ID:SGTC_1213|Compound:1315-0166|FD-Score:8.14|P-value:3.28E-7 ID:SGTC_1219|Compound:1469-0211|FD-Score:17.10|P-value:6.05E-26 ID:SGTC_1225|Compound:1216-0074|FD-Score:9.88|P-value:7.61E-10 ID:SGTC_1226|Compound:3909-7979|FD-Score:23.10|P-value:4.72E-46 ID:SGTC_1237|Compound:0330-0133|FD-Score:10.30|P-value:1.54E-10 ID:SGTC_1240|Compound:0356-0016|FD-Score:5.56|P-value:3.56E-4 ID:SGTC_1265|Compound:0819-1001|FD-Score:-5.03|P-value:8.46E-4 ID:SGTC_1279|Compound:0874-0590|FD-Score:10.50|P-value:6.30E-11 ID:SGTC_1284|Compound:0929-0043|FD-Score:6.76|P-value:1.86E-5 ID:SGTC_1304|Compound:1165-0502|FD-Score:23.50|P-value:2.24E-47 ID:SGTC_1308|Compound:1187-1617|FD-Score:6.68|P-value:2.31E-5 ID:SGTC_1313|Compound:1220-0047|FD-Score:22.20|P-value:1.37E-42 ID:SGTC_1326|Compound:1431-2094|FD-Score:6.04|P-value:1.16E-4 ID:SGTC_1335|Compound:1486-0900|FD-Score:8.34|P-value:1.72E-7 ID:SGTC_1346|Compound:1488-2224|FD-Score:7.87|P-value:7.77E-7 ID:SGTC_1350|Compound:1495-0454|FD-Score:6.02|P-value:1.23E-4 ID:SGTC_1427|Compound:4048-4900|FD-Score:14.30|P-value:7.37E-19 ID:SGTC_1474|Compound:0330-0125|FD-Score:7.86|P-value:7.92E-7 ID:SGTC_1475|Compound:4092-1048|FD-Score:6.46|P-value:4.09E-5 ID:SGTC_1482|Compound:3346-2049|FD-Score:16.10|P-value:3.20E-23 ID:SGTC_1572|Compound:epiandrosterone|FD-Score:10.10|P-value:3.15E-10 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:7.70|P-value:1.29E-6 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:13.00|P-value:1.00E-15 ID:SGTC_1603|Compound:st002045|FD-Score:6.31|P-value:6.07E-5 ID:SGTC_1608|Compound:st001473|FD-Score:7.14|P-value:6.69E-6 ID:SGTC_1636|Compound:st007707|FD-Score:21.00|P-value:2.67E-38 ID:SGTC_1649|Compound:st011737|FD-Score:12.10|P-value:5.84E-14 ID:SGTC_1656|Compound:st012921|FD-Score:32.50|P-value:2.48E-89 ID:SGTC_1673|Compound:st016611|FD-Score:5.34|P-value:5.77E-4 ID:SGTC_1697|Compound:st025554|FD-Score:6.85|P-value:1.47E-5 ID:SGTC_1699|Compound:st031318|FD-Score:9.05|P-value:1.55E-8 ID:SGTC_1715|Compound:st032160|FD-Score:5.28|P-value:6.57E-4 ID:SGTC_1726|Compound:st035556|FD-Score:12.80|P-value:1.89E-15 ID:SGTC_1750|Compound:st081859|FD-Score:29.20|P-value:1.62E-72 ID:SGTC_1757|Compound:st041620|FD-Score:9.94|P-value:6.06E-10 ID:SGTC_1764|Compound:st044502|FD-Score:5.31|P-value:6.14E-4 ID:SGTC_1772|Compound:st048439|FD-Score:6.97|P-value:1.07E-5 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-5.45|P-value:3.39E-4 ID:SGTC_1797|Compound:st048695|FD-Score:15.50|P-value:1.12E-21 ID:SGTC_1881|Compound:5652484|FD-Score:12.10|P-value:6.35E-14 ID:SGTC_1882|Compound:5615643|FD-Score:17.70|P-value:7.79E-28 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:22.70|P-value:1.73E-44 ID:SGTC_1909|Compound:st060837|FD-Score:8.20|P-value:2.69E-7 ID:SGTC_1921|Compound:5740136|FD-Score:6.09|P-value:1.05E-4 ID:SGTC_1933|Compound:st074711|FD-Score:5.44|P-value:4.66E-4 ID:SGTC_1937|Compound:st074714|FD-Score:7.57|P-value:1.93E-6 ID:SGTC_1952|Compound:st077036|FD-Score:5.21|P-value:7.72E-4 ID:SGTC_1975|Compound:st070967|FD-Score:6.99|P-value:1.01E-5 ID:SGTC_1982|Compound:st072467|FD-Score:5.26|P-value:6.84E-4 ID:SGTC_1999|Compound:st074831|FD-Score:11.50|P-value:7.93E-13 ID:SGTC_2003|Compound:4023581|FD-Score:5.26|P-value:6.96E-4 ID:SGTC_2024|Compound:5144227|FD-Score:11.70|P-value:3.19E-13 ID:SGTC_2036|Compound:5160441|FD-Score:15.40|P-value:1.48E-21 ID:SGTC_2038|Compound:4100038|FD-Score:23.80|P-value:1.13E-48 ID:SGTC_2050|Compound:5263056|FD-Score:8.29|P-value:2.05E-7 ID:SGTC_2056|Compound:5235370|FD-Score:19.60|P-value:1.69E-33 ID:SGTC_2077|Compound:5212015|FD-Score:6.70|P-value:2.20E-5 ID:SGTC_2086|Compound:5274770|FD-Score:7.94|P-value:6.24E-7 ID:SGTC_2106|Compound:5357045|FD-Score:6.94|P-value:1.16E-5 ID:SGTC_2122|Compound:5258151|FD-Score:5.73|P-value:2.41E-4 ID:SGTC_2132|Compound:5317594|FD-Score:23.10|P-value:6.37E-46 ID:SGTC_2137|Compound:5261020|FD-Score:6.74|P-value:2.00E-5 ID:SGTC_2197|Compound:6588183|FD-Score:6.08|P-value:1.07E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:21.50|P-value:5.88E-40 ID:SGTC_2241|Compound:6772625|FD-Score:-8.20|P-value:1.77E-7 ID:SGTC_2249|Compound:haloperidol|FD-Score:13.70|P-value:1.97E-17 ID:SGTC_2250|Compound:alverine citrate|FD-Score:7.54|P-value:2.10E-6 ID:SGTC_2254|Compound:7938975|FD-Score:29.00|P-value:4.14E-71 ID:SGTC_2255|Compound:7941087|FD-Score:5.16|P-value:8.62E-4 ID:SGTC_2271|Compound:7849410|FD-Score:7.74|P-value:1.14E-6 ID:SGTC_2296|Compound:7971656|FD-Score:6.17|P-value:8.55E-5 ID:SGTC_2300|Compound:7976697|FD-Score:6.45|P-value:4.24E-5 ID:SGTC_2301|Compound:7769476|FD-Score:8.11|P-value:3.69E-7 ID:SGTC_2312|Compound:7706453|FD-Score:10.90|P-value:1.19E-11 ID:SGTC_2322|Compound:7413319|FD-Score:17.60|P-value:2.14E-27 ID:SGTC_2332|Compound:7982454|FD-Score:5.99|P-value:1.32E-4 ID:SGTC_2384|Compound:9036245|FD-Score:15.70|P-value:2.52E-22 ID:SGTC_2437|Compound:5741531|FD-Score:15.80|P-value:1.24E-22 ID:SGTC_2445|Compound:5742597|FD-Score:12.80|P-value:2.12E-15 ID:SGTC_2447|Compound:5741742|FD-Score:7.20|P-value:5.58E-6 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:13.90|P-value:6.48E-18 ID:SGTC_2461|Compound:5755302|FD-Score:6.60|P-value:2.86E-5 ID:SGTC_2468|Compound:5987765|FD-Score:5.10|P-value:9.72E-4 ID:SGTC_2472|Compound:5377652|FD-Score:20.80|P-value:1.35E-37 ID:SGTC_2478|Compound:5763493|FD-Score:8.02|P-value:4.79E-7 ID:SGTC_2486|Compound:5283202|FD-Score:7.15|P-value:6.47E-6 ID:SGTC_2488|Compound:5268135|FD-Score:11.20|P-value:2.84E-12 ID:SGTC_2524|Compound:avocatin b|FD-Score:10.00|P-value:4.38E-10 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:11.90|P-value:1.55E-13 ID:SGTC_2563|Compound:tomatine|FD-Score:5.62|P-value:3.14E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:5.82|P-value:1.99E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:13.20|P-value:3.01E-16 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:6.48|P-value:3.92E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:9.43|P-value:4.05E-9 ID:SGTC_2607|Compound:solasodine|FD-Score:70.60|P-value:0 ID:SGTC_2616|Compound:abietic acid|FD-Score:16.60|P-value:1.52E-24 ID:SGTC_2618|Compound:avocadyne|FD-Score:19.90|P-value:1.51E-34 ID:SGTC_2642|Compound:cholecalciferol|FD-Score:10.90|P-value:1.39E-11 ID:SGTC_2650|Compound:prasterone|FD-Score:16.00|P-value:5.63E-23 ID:SGTC_2651|Compound:1327-0036|FD-Score:13.90|P-value:7.39E-18 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.43|P-value:4.80E-4 ID:SGTC_2699|Compound:st077704|FD-Score:7.60|P-value:1.75E-6 ID:SGTC_2701|Compound:st077767|FD-Score:7.01|P-value:9.58E-6 ID:SGTC_2725|Compound:haloperidol|FD-Score:14.50|P-value:2.82E-19 ID:SGTC_2733|Compound:amorolfine|FD-Score:7.08|P-value:7.71E-6 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:5.23|P-value:7.35E-4 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:16.10|P-value:2.72E-23 ID:SGTC_2776|Compound:terbinafine|FD-Score:7.29|P-value:4.37E-6 ID:SGTC_2777|Compound:climbazole|FD-Score:7.36|P-value:3.51E-6 ID:SGTC_2778|Compound:tioconazole|FD-Score:15.00|P-value:1.97E-20 ID:SGTC_2830|Compound:7992007|FD-Score:-5.39|P-value:3.90E-4 ID:SGTC_2833|Compound:9001315|FD-Score:11.20|P-value:3.82E-12 ID:SGTC_2910|Compound:7948405|FD-Score:5.82|P-value:1.99E-4 ID:SGTC_2932|Compound:9016711|FD-Score:21.60|P-value:2.59E-40 ID:SGTC_2948|Compound:9070189|FD-Score:26.10|P-value:4.97E-58 ID:SGTC_2976|Compound:9009005|FD-Score:25.00|P-value:1.37E-53 ID:SGTC_2993|Compound:9054257|FD-Score:5.63|P-value:3.04E-4 ID:SGTC_3018|Compound:9082602|FD-Score:10.30|P-value:1.74E-10 ID:SGTC_3059|Compound:1327-0034|FD-Score:9.89|P-value:7.36E-10 ID:SGTC_3060|Compound:1327-0027|FD-Score:7.91|P-value:6.82E-7 ID:SGTC_3063|Compound:1327-0034|FD-Score:11.40|P-value:1.81E-12 ID:SGTC_3118|Compound:9124250|FD-Score:-5.73|P-value:1.78E-4 ID:SGTC_3181|Compound:9108277|FD-Score:-5.11|P-value:7.23E-4 ID:SGTC_3216|Compound:9129716|FD-Score:-5.75|P-value:1.71E-4 ID:SGTC_3237|Compound:9133362|FD-Score:7.37|P-value:3.44E-6 ID:SGTC_3267|Compound:9137951|FD-Score:5.85|P-value:1.85E-4 ID:SGTC_3292|Compound:9120825|FD-Score:5.86|P-value:1.81E-4 ID:SGTC_3303|Compound:9125618|FD-Score:6.16|P-value:8.81E-5 ID:SGTC_3308|Compound:9128332|FD-Score:19.20|P-value:1.70E-32

Top fitness defect scores for YDR127W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2607 solasodine 70.60 47.4 µM 0 1 0
2 SGTC_1656 st012921 32.50 11.0 µM 2.48E-89 1 1.07E-232
3 SGTC_1750 st081859 29.20 2.4 µM 1.62E-72 endomembrane recycling 5 2.40E-188
4 SGTC_2254 7938975 29.00 95.2 µM 4.14E-71 2 1.24E-184
5 SGTC_505 gw-5074 26.60 63.9 µM 3.78E-60 1 9.94E-156
6 SGTC_2948 9070189 26.10 9.4 µM 4.97E-58 plasma membrane duress 1 3.85E-150
7 SGTC_2976 9009005 25.00 19.5 µM 1.37E-53 1 1.96E-138
8 SGTC_2038 4100038 23.80 31.0 µM 1.13E-48 plasma membrane duress 2 1.80E-125
9 SGTC_1304 1165-0502 23.50 251.0 µM 2.24E-47 1 4.76E-122
10 SGTC_1226 3909-7979 23.10 35.4 µM 4.72E-46 3 1.47E-118
11 SGTC_2132 5317594 23.10 122.7 µM 6.37E-46 SWF1 & branched chain AA biosynthesis 1 3.23E-118
12 SGTC_1883 5-benzylidenerhodanine 22.70 20.0 µM 1.73E-44 TRP & mitochondrial translation 2 1.94E-114
13 SGTC_1313 1220-0047 22.20 237.0 µM 1.37E-42 1 1.95E-109
14 SGTC_2932 9016711 21.60 44.5 µM 2.59E-40 2 1.97E-103
15 SGTC_2232 chlorophetanol 21.50 41.5 µM 5.88E-40 TRP & mitochondrial translation 3 1.70E-102
16 SGTC_1636 st007707 21.00 68.9 µM 2.67E-38 1 3.95E-98
17 SGTC_2472 5377652 20.80 49.4 µM 1.35E-37 TRP & mitochondrial translation 1 2.82E-96
18 SGTC_2618 avocadyne 19.90 43.4 µM 1.51E-34 6 3.07E-88
19 SGTC_2056 5235370 19.60 200.0 µM 1.69E-33 1 1.77E-85
20 SGTC_3308 9128332 19.20 17.6 µM 1.70E-32 plasma membrane duress 7 7.73E-83

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.621 0 YGL026C TRP5 hom Tryptophan synthase, catalyzes the last step of tryptophan biosynthesis; regulated by the general control system of amino acid biosynthesis
0.607 0 YDR007W TRP1 hom Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA)
0.596 3.88E-319 YDR008C_d YDR008C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.576 5.87E-294 YKL211C TRP3 hom Indole-3-glycerol-phosphate synthase; forms bifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p
0.555 3.46E-268 YDR354W TRP4 hom Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis
0.540 1.60E-251 YDR283C GCN2 hom Protein kinase, phosphorylates the alpha-subunit of translation initiation factor eIF2 (Sui2p) in response to starvation; activated by uncharged tRNAs and the Gcn1p-Gcn20p complex; contributes to DNA damage checkpoint control
0.530 2.32E-241 YKR026C GCN3 hom Alpha subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a positive regulator of GCN4 expression
0.487 7.12E-198 YER090W TRP2 hom Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p
0.484 1.38E-195 YEL009C GCN4 hom Basic leucine zipper (bZIP) transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels
0.478 7.09E-190 YGL148W ARO2 hom Bifunctional chorismate synthase and flavin reductase; catalyzes the conversion of 5-enolpyruvylshikimate 3-phosphate (EPSP) to form chorismate, which is a precursor to aromatic amino acids; protein abundance increases in response to DNA replication stress
0.394 1.23E-124 YPR060C ARO7 hom Chorismate mutase, catalyzes the conversion of chorismate to prephenate to initiate the tyrosine/phenylalanine-specific branch of aromatic amino acid biosynthesis
0.388 1.91E-120 YFR009W GCN20 hom Positive regulator of the Gcn2p kinase activity, forms a complex with Gcn1p; proposed to stimulate Gcn2p activation by an uncharged tRNA
0.369 1.82E-108 YDR035W ARO3 hom 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by phenylalanine or high concentration of tyrosine or tryptophan
0.368 1.27E-107 YGL117W_p YGL117W_p hom Putative protein of unknown function
0.256 6.23E-51 YIR023W DAL81 hom Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism