YDR129C / SAC6

Fimbrin, actin-bundling protein; cooperates with Scp1p (calponin/transgelin) in the organization and maintenance of the actin cytoskeleton; relocalizes from plasma membrane to cytoplasm upon DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR129C / SAC6

Click on Significant Values for Screen Details ID:SGTC_14|Compound:0354-0009|FD-Score:6.94|P-value:1.24E-5 ID:SGTC_21|Compound:0849-0113|FD-Score:6.52|P-value:3.75E-5 ID:SGTC_22|Compound:0964-0034|FD-Score:7.23|P-value:5.48E-6 ID:SGTC_31|Compound:0508-1974|FD-Score:5.41|P-value:5.21E-4 ID:SGTC_41|Compound:0478-0632|FD-Score:5.95|P-value:1.52E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:6.36|P-value:5.60E-5 ID:SGTC_70|Compound:0141-0289|FD-Score:9.72|P-value:1.50E-9 ID:SGTC_79|Compound:0052-0007|FD-Score:6.31|P-value:6.43E-5 ID:SGTC_82|Compound:0054-0107|FD-Score:5.88|P-value:1.82E-4 ID:SGTC_98|Compound:0074-0023|FD-Score:7.43|P-value:3.08E-6 ID:SGTC_101|Compound:0490-5701|FD-Score:-5.42|P-value:3.53E-4 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:8.57|P-value:8.89E-8 ID:SGTC_103|Compound:0844-0104|FD-Score:-7.46|P-value:1.69E-6 ID:SGTC_119|Compound:0121-0043|FD-Score:6.92|P-value:1.30E-5 ID:SGTC_146|Compound:3448-8650|FD-Score:5.25|P-value:7.46E-4 ID:SGTC_172|Compound:1112-0046|FD-Score:5.45|P-value:4.80E-4 ID:SGTC_206|Compound:4546-0025|FD-Score:8.37|P-value:1.71E-7 ID:SGTC_212|Compound:3807-4682|FD-Score:6.17|P-value:8.93E-5 ID:SGTC_264|Compound:promethazine|FD-Score:6.69|P-value:2.39E-5 ID:SGTC_270|Compound:tamoxifen|FD-Score:10.40|P-value:1.11E-10 ID:SGTC_301|Compound:4119-0100|FD-Score:6.96|P-value:1.15E-5 ID:SGTC_313|Compound:3474-0040|FD-Score:5.35|P-value:6.00E-4 ID:SGTC_328|Compound:k915-0120|FD-Score:5.44|P-value:4.89E-4 ID:SGTC_459|Compound:nigericin|FD-Score:7.06|P-value:8.91E-6 ID:SGTC_481|Compound:bay k-8644|FD-Score:6.95|P-value:1.18E-5 ID:SGTC_562|Compound:3772-2733|FD-Score:7.34|P-value:3.93E-6 ID:SGTC_576|Compound:1073-0113|FD-Score:6.17|P-value:9.05E-5 ID:SGTC_581|Compound:0958-0271|FD-Score:8.48|P-value:1.19E-7 ID:SGTC_585|Compound:0kpi-0023|FD-Score:5.23|P-value:7.67E-4 ID:SGTC_600|Compound:1495-0418|FD-Score:5.42|P-value:5.15E-4 ID:SGTC_830|Compound:4076-0286|FD-Score:5.27|P-value:7.13E-4 ID:SGTC_841|Compound:0251-0215|FD-Score:6.32|P-value:6.28E-5 ID:SGTC_887|Compound:0885-0007|FD-Score:5.44|P-value:4.89E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:5.17|P-value:8.69E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:-5.78|P-value:1.51E-4 ID:SGTC_945|Compound:3381-0768|FD-Score:8.55|P-value:9.38E-8 ID:SGTC_948|Compound:3448-0295|FD-Score:7.28|P-value:4.69E-6 ID:SGTC_958|Compound:1222-0007|FD-Score:5.92|P-value:1.63E-4 ID:SGTC_1058|Compound:3448-5425|FD-Score:8.82|P-value:3.74E-8 ID:SGTC_1160|Compound:4092-0570|FD-Score:-5.64|P-value:2.10E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:-6.04|P-value:8.16E-5 ID:SGTC_1320|Compound:1313-0481|FD-Score:5.19|P-value:8.42E-4 ID:SGTC_1333|Compound:1482-0047|FD-Score:5.45|P-value:4.79E-4 ID:SGTC_1344|Compound:1488-0097|FD-Score:5.39|P-value:5.46E-4 ID:SGTC_1352|Compound:1496-0991|FD-Score:5.54|P-value:3.95E-4 ID:SGTC_1394|Compound:3474-0001|FD-Score:10.20|P-value:2.49E-10 ID:SGTC_1414|Compound:3917-0015|FD-Score:-5.01|P-value:8.51E-4 ID:SGTC_1419|Compound:3993-2473|FD-Score:5.48|P-value:4.46E-4 ID:SGTC_1449|Compound:4112-4002|FD-Score:5.20|P-value:8.21E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:5.50|P-value:4.30E-4 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:5.53|P-value:4.05E-4 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:6.24|P-value:7.48E-5 ID:SGTC_1635|Compound:st007035|FD-Score:5.23|P-value:7.73E-4 ID:SGTC_1643|Compound:st009866|FD-Score:8.63|P-value:7.21E-8 ID:SGTC_1656|Compound:st012921|FD-Score:12.00|P-value:1.10E-13 ID:SGTC_1687|Compound:st020778|FD-Score:11.70|P-value:4.97E-13 ID:SGTC_1711|Compound:st032263|FD-Score:6.37|P-value:5.49E-5 ID:SGTC_1754|Compound:st042065|FD-Score:10.10|P-value:3.16E-10 ID:SGTC_1760|Compound:st045453|FD-Score:13.30|P-value:2.02E-16 ID:SGTC_1766|Compound:st045414|FD-Score:7.76|P-value:1.15E-6 ID:SGTC_1772|Compound:st048439|FD-Score:8.76|P-value:4.63E-8 ID:SGTC_1773|Compound:st048542|FD-Score:5.48|P-value:4.45E-4 ID:SGTC_1786|Compound:berberine|FD-Score:7.42|P-value:3.12E-6 ID:SGTC_1844|Compound:rapamycin|FD-Score:8.33|P-value:1.93E-7 ID:SGTC_1873|Compound:rapamycin|FD-Score:6.21|P-value:8.10E-5 ID:SGTC_1959|Compound:st077091|FD-Score:6.10|P-value:1.07E-4 ID:SGTC_2028|Compound:5153890|FD-Score:7.41|P-value:3.21E-6 ID:SGTC_2036|Compound:5160441|FD-Score:9.64|P-value:2.00E-9 ID:SGTC_2040|Compound:5100729|FD-Score:6.85|P-value:1.54E-5 ID:SGTC_2077|Compound:5212015|FD-Score:7.06|P-value:8.76E-6 ID:SGTC_2110|Compound:5483698|FD-Score:6.12|P-value:1.02E-4 ID:SGTC_2141|Compound:5621638|FD-Score:6.59|P-value:3.13E-5 ID:SGTC_2189|Compound:6047310|FD-Score:5.94|P-value:1.55E-4 ID:SGTC_2197|Compound:6588183|FD-Score:7.39|P-value:3.47E-6 ID:SGTC_2200|Compound:6600604|FD-Score:16.20|P-value:2.28E-23 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:5.50|P-value:4.25E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:-7.39|P-value:2.11E-6 ID:SGTC_2254|Compound:7938975|FD-Score:15.20|P-value:8.25E-21 ID:SGTC_2257|Compound:7960413|FD-Score:8.98|P-value:2.15E-8 ID:SGTC_2266|Compound:7929956|FD-Score:9.98|P-value:5.69E-10 ID:SGTC_2274|Compound:7947094|FD-Score:8.53|P-value:1.02E-7 ID:SGTC_2347|Compound:9049783|FD-Score:-7.22|P-value:3.38E-6 ID:SGTC_2355|Compound:9061122|FD-Score:9.86|P-value:9.02E-10 ID:SGTC_2356|Compound:9061756|FD-Score:9.67|P-value:1.81E-9 ID:SGTC_2357|Compound:9067248|FD-Score:17.00|P-value:9.23E-26 ID:SGTC_2359|Compound:9039622|FD-Score:10.10|P-value:3.22E-10 ID:SGTC_2396|Compound:5342950|FD-Score:7.12|P-value:7.50E-6 ID:SGTC_2405|Compound:ticlatone|FD-Score:8.86|P-value:3.33E-8 ID:SGTC_2472|Compound:5377652|FD-Score:6.49|P-value:4.01E-5 ID:SGTC_2488|Compound:5268135|FD-Score:5.38|P-value:5.56E-4 ID:SGTC_2507|Compound:purpurin|FD-Score:5.71|P-value:2.66E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:10.40|P-value:1.24E-10 ID:SGTC_2526|Compound:patulin|FD-Score:8.44|P-value:1.37E-7 ID:SGTC_2533|Compound:agelasine|FD-Score:-5.90|P-value:1.13E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:6.21|P-value:8.11E-5 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:5.19|P-value:8.30E-4 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:7.80|P-value:1.03E-6 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:5.44|P-value:4.87E-4 ID:SGTC_2699|Compound:st077704|FD-Score:-5.71|P-value:1.78E-4 ID:SGTC_2737|Compound:bleomycin|FD-Score:5.54|P-value:3.96E-4 ID:SGTC_2740|Compound:felodipine|FD-Score:5.17|P-value:8.67E-4 ID:SGTC_2805|Compound:7950783|FD-Score:6.17|P-value:9.08E-5 ID:SGTC_2852|Compound:9023854|FD-Score:6.21|P-value:8.20E-5 ID:SGTC_2900|Compound:5328528|FD-Score:7.59|P-value:1.90E-6 ID:SGTC_2923|Compound:7992654|FD-Score:5.12|P-value:9.74E-4 ID:SGTC_2926|Compound:9010726|FD-Score:5.36|P-value:5.79E-4 ID:SGTC_2948|Compound:9070189|FD-Score:-5.50|P-value:2.91E-4 ID:SGTC_2954|Compound:9074818|FD-Score:5.21|P-value:8.03E-4 ID:SGTC_2960|Compound:9079389|FD-Score:5.73|P-value:2.54E-4 ID:SGTC_2980|Compound:9014342|FD-Score:5.54|P-value:3.91E-4 ID:SGTC_3000|Compound:9075062|FD-Score:5.36|P-value:5.81E-4 ID:SGTC_3019|Compound:9081971|FD-Score:5.83|P-value:2.04E-4 ID:SGTC_3119|Compound:9125183|FD-Score:5.15|P-value:9.08E-4 ID:SGTC_3120|Compound:9124077|FD-Score:7.23|P-value:5.44E-6 ID:SGTC_3126|Compound:9127922|FD-Score:-10.70|P-value:1.85E-11 ID:SGTC_3142|Compound:9086498|FD-Score:5.11|P-value:9.97E-4 ID:SGTC_3152|Compound:9099253|FD-Score:-5.05|P-value:7.88E-4 ID:SGTC_3174|Compound:9107204|FD-Score:6.98|P-value:1.09E-5 ID:SGTC_3225|Compound:9130819|FD-Score:6.40|P-value:5.06E-5 ID:SGTC_3235|Compound:9132602|FD-Score:5.86|P-value:1.90E-4 ID:SGTC_3237|Compound:9133362|FD-Score:7.54|P-value:2.21E-6 ID:SGTC_3288|Compound:9119690|FD-Score:6.33|P-value:6.02E-5 ID:SGTC_14|Compound:0354-0009|FD-Score:6.94|P-value:1.24E-5 ID:SGTC_21|Compound:0849-0113|FD-Score:6.52|P-value:3.75E-5 ID:SGTC_22|Compound:0964-0034|FD-Score:7.23|P-value:5.48E-6 ID:SGTC_31|Compound:0508-1974|FD-Score:5.41|P-value:5.21E-4 ID:SGTC_41|Compound:0478-0632|FD-Score:5.95|P-value:1.52E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:6.36|P-value:5.60E-5 ID:SGTC_70|Compound:0141-0289|FD-Score:9.72|P-value:1.50E-9 ID:SGTC_79|Compound:0052-0007|FD-Score:6.31|P-value:6.43E-5 ID:SGTC_82|Compound:0054-0107|FD-Score:5.88|P-value:1.82E-4 ID:SGTC_98|Compound:0074-0023|FD-Score:7.43|P-value:3.08E-6 ID:SGTC_101|Compound:0490-5701|FD-Score:-5.42|P-value:3.53E-4 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:8.57|P-value:8.89E-8 ID:SGTC_103|Compound:0844-0104|FD-Score:-7.46|P-value:1.69E-6 ID:SGTC_119|Compound:0121-0043|FD-Score:6.92|P-value:1.30E-5 ID:SGTC_146|Compound:3448-8650|FD-Score:5.25|P-value:7.46E-4 ID:SGTC_172|Compound:1112-0046|FD-Score:5.45|P-value:4.80E-4 ID:SGTC_206|Compound:4546-0025|FD-Score:8.37|P-value:1.71E-7 ID:SGTC_212|Compound:3807-4682|FD-Score:6.17|P-value:8.93E-5 ID:SGTC_264|Compound:promethazine|FD-Score:6.69|P-value:2.39E-5 ID:SGTC_270|Compound:tamoxifen|FD-Score:10.40|P-value:1.11E-10 ID:SGTC_301|Compound:4119-0100|FD-Score:6.96|P-value:1.15E-5 ID:SGTC_313|Compound:3474-0040|FD-Score:5.35|P-value:6.00E-4 ID:SGTC_328|Compound:k915-0120|FD-Score:5.44|P-value:4.89E-4 ID:SGTC_459|Compound:nigericin|FD-Score:7.06|P-value:8.91E-6 ID:SGTC_481|Compound:bay k-8644|FD-Score:6.95|P-value:1.18E-5 ID:SGTC_562|Compound:3772-2733|FD-Score:7.34|P-value:3.93E-6 ID:SGTC_576|Compound:1073-0113|FD-Score:6.17|P-value:9.05E-5 ID:SGTC_581|Compound:0958-0271|FD-Score:8.48|P-value:1.19E-7 ID:SGTC_585|Compound:0kpi-0023|FD-Score:5.23|P-value:7.67E-4 ID:SGTC_600|Compound:1495-0418|FD-Score:5.42|P-value:5.15E-4 ID:SGTC_830|Compound:4076-0286|FD-Score:5.27|P-value:7.13E-4 ID:SGTC_841|Compound:0251-0215|FD-Score:6.32|P-value:6.28E-5 ID:SGTC_887|Compound:0885-0007|FD-Score:5.44|P-value:4.89E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:5.17|P-value:8.69E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:-5.78|P-value:1.51E-4 ID:SGTC_945|Compound:3381-0768|FD-Score:8.55|P-value:9.38E-8 ID:SGTC_948|Compound:3448-0295|FD-Score:7.28|P-value:4.69E-6 ID:SGTC_958|Compound:1222-0007|FD-Score:5.92|P-value:1.63E-4 ID:SGTC_1058|Compound:3448-5425|FD-Score:8.82|P-value:3.74E-8 ID:SGTC_1160|Compound:4092-0570|FD-Score:-5.64|P-value:2.10E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:-6.04|P-value:8.16E-5 ID:SGTC_1320|Compound:1313-0481|FD-Score:5.19|P-value:8.42E-4 ID:SGTC_1333|Compound:1482-0047|FD-Score:5.45|P-value:4.79E-4 ID:SGTC_1344|Compound:1488-0097|FD-Score:5.39|P-value:5.46E-4 ID:SGTC_1352|Compound:1496-0991|FD-Score:5.54|P-value:3.95E-4 ID:SGTC_1394|Compound:3474-0001|FD-Score:10.20|P-value:2.49E-10 ID:SGTC_1414|Compound:3917-0015|FD-Score:-5.01|P-value:8.51E-4 ID:SGTC_1419|Compound:3993-2473|FD-Score:5.48|P-value:4.46E-4 ID:SGTC_1449|Compound:4112-4002|FD-Score:5.20|P-value:8.21E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:5.50|P-value:4.30E-4 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:5.53|P-value:4.05E-4 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:6.24|P-value:7.48E-5 ID:SGTC_1635|Compound:st007035|FD-Score:5.23|P-value:7.73E-4 ID:SGTC_1643|Compound:st009866|FD-Score:8.63|P-value:7.21E-8 ID:SGTC_1656|Compound:st012921|FD-Score:12.00|P-value:1.10E-13 ID:SGTC_1687|Compound:st020778|FD-Score:11.70|P-value:4.97E-13 ID:SGTC_1711|Compound:st032263|FD-Score:6.37|P-value:5.49E-5 ID:SGTC_1754|Compound:st042065|FD-Score:10.10|P-value:3.16E-10 ID:SGTC_1760|Compound:st045453|FD-Score:13.30|P-value:2.02E-16 ID:SGTC_1766|Compound:st045414|FD-Score:7.76|P-value:1.15E-6 ID:SGTC_1772|Compound:st048439|FD-Score:8.76|P-value:4.63E-8 ID:SGTC_1773|Compound:st048542|FD-Score:5.48|P-value:4.45E-4 ID:SGTC_1786|Compound:berberine|FD-Score:7.42|P-value:3.12E-6 ID:SGTC_1844|Compound:rapamycin|FD-Score:8.33|P-value:1.93E-7 ID:SGTC_1873|Compound:rapamycin|FD-Score:6.21|P-value:8.10E-5 ID:SGTC_1959|Compound:st077091|FD-Score:6.10|P-value:1.07E-4 ID:SGTC_2028|Compound:5153890|FD-Score:7.41|P-value:3.21E-6 ID:SGTC_2036|Compound:5160441|FD-Score:9.64|P-value:2.00E-9 ID:SGTC_2040|Compound:5100729|FD-Score:6.85|P-value:1.54E-5 ID:SGTC_2077|Compound:5212015|FD-Score:7.06|P-value:8.76E-6 ID:SGTC_2110|Compound:5483698|FD-Score:6.12|P-value:1.02E-4 ID:SGTC_2141|Compound:5621638|FD-Score:6.59|P-value:3.13E-5 ID:SGTC_2189|Compound:6047310|FD-Score:5.94|P-value:1.55E-4 ID:SGTC_2197|Compound:6588183|FD-Score:7.39|P-value:3.47E-6 ID:SGTC_2200|Compound:6600604|FD-Score:16.20|P-value:2.28E-23 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:5.50|P-value:4.25E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:-7.39|P-value:2.11E-6 ID:SGTC_2254|Compound:7938975|FD-Score:15.20|P-value:8.25E-21 ID:SGTC_2257|Compound:7960413|FD-Score:8.98|P-value:2.15E-8 ID:SGTC_2266|Compound:7929956|FD-Score:9.98|P-value:5.69E-10 ID:SGTC_2274|Compound:7947094|FD-Score:8.53|P-value:1.02E-7 ID:SGTC_2347|Compound:9049783|FD-Score:-7.22|P-value:3.38E-6 ID:SGTC_2355|Compound:9061122|FD-Score:9.86|P-value:9.02E-10 ID:SGTC_2356|Compound:9061756|FD-Score:9.67|P-value:1.81E-9 ID:SGTC_2357|Compound:9067248|FD-Score:17.00|P-value:9.23E-26 ID:SGTC_2359|Compound:9039622|FD-Score:10.10|P-value:3.22E-10 ID:SGTC_2396|Compound:5342950|FD-Score:7.12|P-value:7.50E-6 ID:SGTC_2405|Compound:ticlatone|FD-Score:8.86|P-value:3.33E-8 ID:SGTC_2472|Compound:5377652|FD-Score:6.49|P-value:4.01E-5 ID:SGTC_2488|Compound:5268135|FD-Score:5.38|P-value:5.56E-4 ID:SGTC_2507|Compound:purpurin|FD-Score:5.71|P-value:2.66E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:10.40|P-value:1.24E-10 ID:SGTC_2526|Compound:patulin|FD-Score:8.44|P-value:1.37E-7 ID:SGTC_2533|Compound:agelasine|FD-Score:-5.90|P-value:1.13E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:6.21|P-value:8.11E-5 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:5.19|P-value:8.30E-4 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:7.80|P-value:1.03E-6 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:5.44|P-value:4.87E-4 ID:SGTC_2699|Compound:st077704|FD-Score:-5.71|P-value:1.78E-4 ID:SGTC_2737|Compound:bleomycin|FD-Score:5.54|P-value:3.96E-4 ID:SGTC_2740|Compound:felodipine|FD-Score:5.17|P-value:8.67E-4 ID:SGTC_2805|Compound:7950783|FD-Score:6.17|P-value:9.08E-5 ID:SGTC_2852|Compound:9023854|FD-Score:6.21|P-value:8.20E-5 ID:SGTC_2900|Compound:5328528|FD-Score:7.59|P-value:1.90E-6 ID:SGTC_2923|Compound:7992654|FD-Score:5.12|P-value:9.74E-4 ID:SGTC_2926|Compound:9010726|FD-Score:5.36|P-value:5.79E-4 ID:SGTC_2948|Compound:9070189|FD-Score:-5.50|P-value:2.91E-4 ID:SGTC_2954|Compound:9074818|FD-Score:5.21|P-value:8.03E-4 ID:SGTC_2960|Compound:9079389|FD-Score:5.73|P-value:2.54E-4 ID:SGTC_2980|Compound:9014342|FD-Score:5.54|P-value:3.91E-4 ID:SGTC_3000|Compound:9075062|FD-Score:5.36|P-value:5.81E-4 ID:SGTC_3019|Compound:9081971|FD-Score:5.83|P-value:2.04E-4 ID:SGTC_3119|Compound:9125183|FD-Score:5.15|P-value:9.08E-4 ID:SGTC_3120|Compound:9124077|FD-Score:7.23|P-value:5.44E-6 ID:SGTC_3126|Compound:9127922|FD-Score:-10.70|P-value:1.85E-11 ID:SGTC_3142|Compound:9086498|FD-Score:5.11|P-value:9.97E-4 ID:SGTC_3152|Compound:9099253|FD-Score:-5.05|P-value:7.88E-4 ID:SGTC_3174|Compound:9107204|FD-Score:6.98|P-value:1.09E-5 ID:SGTC_3225|Compound:9130819|FD-Score:6.40|P-value:5.06E-5 ID:SGTC_3235|Compound:9132602|FD-Score:5.86|P-value:1.90E-4 ID:SGTC_3237|Compound:9133362|FD-Score:7.54|P-value:2.21E-6 ID:SGTC_3288|Compound:9119690|FD-Score:6.33|P-value:6.02E-5

Top fitness defect scores for YDR129C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2357 9067248 17.00 200.0 µM 9.23E-26 1 2.73E-65
2 SGTC_2200 6600604 16.20 21.9 µM 2.28E-23 tubulin folding & SWR complex 4 5.54E-59
3 SGTC_2254 7938975 15.20 95.2 µM 8.25E-21 5 3.07E-52
4 SGTC_1760 st045453 13.30 10.4 µM 2.02E-16 NEO1-PIK1 16 1.11E-40
5 SGTC_1656 st012921 12.00 11.0 µM 1.10E-13 8 1.75E-33
6 SGTC_1687 st020778 11.70 55.4 µM 4.97E-13 38 9.14E-32
7 SGTC_270 tamoxifen 10.40 5.5 µM 1.11E-10 NEO1 2 1.34E-25
8 SGTC_2514 salinomycin 10.40 42.7 µM 1.24E-10 5 1.80E-25
9 SGTC_1394 3474-0001 10.20 65.7 µM 2.49E-10 endomembrane recycling 2 1.11E-24
10 SGTC_1754 st042065 10.10 16.1 µM 3.16E-10 NEO1-PIK1 25 2.08E-24
11 SGTC_2359 9039622 10.10 200.0 µM 3.22E-10 endomembrane recycling 2 2.18E-24
12 SGTC_2266 7929956 9.98 200.0 µM 5.69E-10 1 9.75E-24
13 SGTC_2355 9061122 9.86 103.1 µM 9.02E-10 1 3.26E-23
14 SGTC_70 0141-0289 9.72 43.3 µM 1.50E-9 mitochondrial stress 20 1.23E-22
15 SGTC_2356 9061756 9.67 189.0 µM 1.81E-9 1 2.01E-22
16 SGTC_2036 5160441 9.64 105.0 µM 2.00E-9 NEO1 19 2.63E-22
17 SGTC_2257 7960413 8.98 200.0 µM 2.15E-8 NEO1-PIK1 3 1.31E-19
18 SGTC_2405 ticlatone 8.86 3.5 µM 3.33E-8 13 4.11E-19
19 SGTC_1058 3448-5425 8.82 97.3 µM 3.74E-8 6 5.55E-19
20 SGTC_1772 st048439 8.76 82.2 µM 4.63E-8 1 9.71E-19

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.320 1.76E-80 YOR035C SHE4 hom Protein containing a UCS (UNC-45/CRO1/SHE4) domain, binds to myosin motor domains to regulate myosin function; involved in endocytosis, polarization of the actin cytoskeleton, and asymmetric mRNA localization
0.311 1.03E-75 YLR370C ARC18 hom Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches
0.250 1.23E-48 YLR338W_d OPI9_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF VRP1/YLR337C
0.242 7.87E-46 YDR323C PEP7 hom Multivalent adaptor protein that facilitates vesicle-mediated vacuolar protein sorting by ensuring high-fidelity vesicle docking and fusion, which are essential for targeting of vesicles to the endosome; required for vacuole inheritance
0.227 2.94E-40 YGL095C VPS45 hom Protein of the Sec1p/Munc-18 family, essential for vacuolar protein sorting; required for the function of Pep12p and the early endosome/late Golgi SNARE Tlg2p; essential for fusion of Golgi-derived vesicles with the prevacuolar compartment
0.217 5.33E-37 YOR036W PEP12 hom Target membrane receptor (t-SNARE) for vesicular intermediates traveling between the Golgi apparatus and the vacuole; controls entry of biosynthetic, endocytic, and retrograde traffic into the prevacuolar compartment; syntaxin
0.216 1.65E-36 YGR167W CLC1 hom Clathrin light chain; subunit of the major coat protein involved in intracellular protein transport and endocytosis; thought to regulate clathrin function; two Clathrin heavy chains (CHC1) form the clathrin triskelion structural component; YGR167W
0.212 2.55E-35 YLR148W PEP3 hom Component of CORVET tethering complex; vacuolar peripheral membrane protein that promotes vesicular docking/fusion reactions in conjunction with SNARE proteins, required for vacuolar biogenesis
0.206 3.26E-33 YLR025W SNF7 hom One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes
0.203 2.94E-32 YML097C VPS9 hom A guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport; specifically stimulates the intrinsic guanine nucleotide exchange activity of Vps21p/Rab5: similar to mammalian ras inhibitors; binds ubiquitin
0.197 1.99E-30 YKR001C VPS1 hom Dynamin-like GTPase required for vacuolar sorting; also involved in actin cytoskeleton organization, endocytosis, late Golgi-retention of some proteins, regulation of peroxisome biogenesis
0.190 1.82E-28 YGL054C ERV14 hom COPII-coated vesicle protein; involved in vesicle formation and incorporation of specific secretory cargo; required for the delivery of bud-site selection protein Axl2p to cell surface; related to Drosophila cornichon; ERV14 has a paralog, ERV15, that arose from the whole genome duplication
0.186 1.69E-27 YPL002C SNF8 hom Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; appears to be functionally related to SNF7; involved in glucose derepression
0.181 5.37E-26 YDR495C VPS3 hom Component of CORVET tethering complex; cytoplasmic protein required for the sorting and processing of soluble vacuolar proteins, acidification of the vacuolar lumen, and assembly of the vacuolar H+-ATPase
0.178 4.44E-25 YHR108W GGA2 hom Protein that interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner to facilitate traffic through the late Golgi; binds phosphatidylinositol 4-phosphate, which plays a role in TGN localization; has homology to gamma-adaptin