YDR131C_p

F-box protein, substrate-specific adaptor subunit that recruits substrates to a core ubiquitination complex

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR131C / YDR131C

Click on Significant Values for Screen Details ID:SGTC_543|Compound:3844-1095|FD-Score:2.91|P-value:3.13E-4 ID:SGTC_551|Compound:k048-0028|FD-Score:3.17|P-value:9.78E-5 ID:SGTC_559|Compound:1550-0661|FD-Score:3.16|P-value:1.03E-4 ID:SGTC_815|Compound:1582-0027|FD-Score:3.27|P-value:6.00E-5 ID:SGTC_876|Compound:0720-0963|FD-Score:3.32|P-value:4.77E-5 ID:SGTC_940|Compound:3232-1287|FD-Score:2.68|P-value:8.21E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:3.96|P-value:1.57E-6 ID:SGTC_1141|Compound:3253-0389|FD-Score:3.10|P-value:1.35E-4 ID:SGTC_1171|Compound:0368-0077|FD-Score:-3.05|P-value:1.54E-4 ID:SGTC_1730|Compound:st033808|FD-Score:-2.91|P-value:2.92E-4 ID:SGTC_1839|Compound:st053978|FD-Score:-2.69|P-value:7.26E-4 ID:SGTC_1996|Compound:st072960|FD-Score:3.88|P-value:2.50E-6 ID:SGTC_2092|Compound:5303694|FD-Score:-3.28|P-value:5.25E-5 ID:SGTC_2241|Compound:6772625|FD-Score:-3.33|P-value:4.27E-5 ID:SGTC_2350|Compound:9023895|FD-Score:-2.80|P-value:4.77E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:-2.74|P-value:5.93E-4 ID:SGTC_2414|Compound:st077232|FD-Score:-2.81|P-value:4.50E-4 ID:SGTC_2487|Compound:5918373|FD-Score:3.89|P-value:2.37E-6 ID:SGTC_2490|Compound:carminic acid|FD-Score:3.06|P-value:1.61E-4 ID:SGTC_2491|Compound:paeonol|FD-Score:4.15|P-value:5.45E-7 ID:SGTC_2492|Compound:derrusnin|FD-Score:4.53|P-value:4.85E-8 ID:SGTC_2493|Compound:resveratrol|FD-Score:3.79|P-value:4.11E-6 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-2.66|P-value:8.43E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:2.77|P-value:5.80E-4 ID:SGTC_2785|Compound:7756463|FD-Score:-3.08|P-value:1.35E-4 ID:SGTC_2808|Compound:7946468|FD-Score:4.08|P-value:8.03E-7 ID:SGTC_543|Compound:3844-1095|FD-Score:2.91|P-value:3.13E-4 ID:SGTC_551|Compound:k048-0028|FD-Score:3.17|P-value:9.78E-5 ID:SGTC_559|Compound:1550-0661|FD-Score:3.16|P-value:1.03E-4 ID:SGTC_815|Compound:1582-0027|FD-Score:3.27|P-value:6.00E-5 ID:SGTC_876|Compound:0720-0963|FD-Score:3.32|P-value:4.77E-5 ID:SGTC_940|Compound:3232-1287|FD-Score:2.68|P-value:8.21E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:3.96|P-value:1.57E-6 ID:SGTC_1141|Compound:3253-0389|FD-Score:3.10|P-value:1.35E-4 ID:SGTC_1171|Compound:0368-0077|FD-Score:-3.05|P-value:1.54E-4 ID:SGTC_1730|Compound:st033808|FD-Score:-2.91|P-value:2.92E-4 ID:SGTC_1839|Compound:st053978|FD-Score:-2.69|P-value:7.26E-4 ID:SGTC_1996|Compound:st072960|FD-Score:3.88|P-value:2.50E-6 ID:SGTC_2092|Compound:5303694|FD-Score:-3.28|P-value:5.25E-5 ID:SGTC_2241|Compound:6772625|FD-Score:-3.33|P-value:4.27E-5 ID:SGTC_2350|Compound:9023895|FD-Score:-2.80|P-value:4.77E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:-2.74|P-value:5.93E-4 ID:SGTC_2414|Compound:st077232|FD-Score:-2.81|P-value:4.50E-4 ID:SGTC_2487|Compound:5918373|FD-Score:3.89|P-value:2.37E-6 ID:SGTC_2490|Compound:carminic acid|FD-Score:3.06|P-value:1.61E-4 ID:SGTC_2491|Compound:paeonol|FD-Score:4.15|P-value:5.45E-7 ID:SGTC_2492|Compound:derrusnin|FD-Score:4.53|P-value:4.85E-8 ID:SGTC_2493|Compound:resveratrol|FD-Score:3.79|P-value:4.11E-6 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-2.66|P-value:8.43E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:2.77|P-value:5.80E-4 ID:SGTC_2785|Compound:7756463|FD-Score:-3.08|P-value:1.35E-4 ID:SGTC_2808|Compound:7946468|FD-Score:4.08|P-value:8.03E-7

Top fitness defect scores for YDR131C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2492 derrusnin 4.53 100.0 µM 4.85E-8 2 2.89E-6
2 SGTC_2491 paeonol 4.15 100.0 µM 5.45E-7 8 1.69E-5
3 SGTC_2808 7946468 4.08 45.5 µM 8.03E-7 18 2.25E-5
4 SGTC_1134 3477-0009 3.96 42.5 µM 1.57E-6 46 3.67E-5
5 SGTC_2487 5918373 3.89 44.0 µM 2.37E-6 16 4.97E-5
6 SGTC_1996 st072960 3.88 66.8 µM 2.50E-6 14 5.16E-5
7 SGTC_2493 resveratrol 3.79 26.1 µM 4.11E-6 8 7.43E-5
8 SGTC_876 0720-0963 3.32 56.8 µM 4.77E-5 36 4.50E-4
9 SGTC_815 1582-0027 3.27 36.9 µM 6.00E-5 67 5.32E-4
10 SGTC_551 k048-0028 3.17 34.9 µM 9.78E-5 50 7.63E-4
11 SGTC_559 1550-0661 3.16 158.0 µM 1.03E-4 31 7.91E-4
12 SGTC_1141 3253-0389 3.10 52.6 µM 1.35E-4 28 9.70E-4
13 SGTC_2490 carminic acid 3.06 95.4 µM 1.61E-4 25 0.00110
14 SGTC_543 3844-1095 2.91 191.0 µM 3.13E-4 ERG2 105 0.00180
15 SGTC_2583 asiatic acid 2.77 100.0 µM 5.80E-4 88 0.00284
16 SGTC_940 3232-1287 2.68 54.8 µM 8.21E-4 NEO1 112 0.00367
17 SGTC_321 4534-3890 2.62 65.3 µM 0.00104 RPP1 & pyrimidine depletion 57 0.00439
18 SGTC_357 1325-0123 2.53 420.0 µM 0.00146 73 0.00564
19 SGTC_2410 aloe-emodin-8-o-glycoside 2.52 46.3 µM 0.00156 mitochondrial processes 132 0.00592
20 SGTC_351 caspofungin 2.52 25.0 nM 0.00157 cell wall 241 0.00595

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.234 5.34E-43 YMR322C_p SNO4_p hom Possible chaperone and cysteine protease, similar to bacterial Hsp31 and yeast Hsp31p, Hsp32p, and Hsp33p; DJ-1/ThiJ/PfpI superfamily member; predicted involvement in pyridoxine metabolism; induced by mild heat stress and copper deprivation
0.213 1.50E-35 YJR058C APS2 hom Small subunit of the clathrin-associated adaptor complex AP-2, which is involved in protein sorting at the plasma membrane; related to the sigma subunit of the mammalian plasma membrane clathrin-associated protein (AP-2) complex
0.182 1.89E-26 YGR182C_d YGR182C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF TIM13/YGR181W
0.179 1.62E-25 YOL160W_d YOL160W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.175 1.77E-24 YER109C FLO8 hom Transcription factor required for flocculation, diploid filamentous growth, and haploid invasive growth; genome reference strain S288C and most laboratory strains have a mutation in this gene
0.166 3.98E-22 YKL018C-A_p YKL018C-A_p hom Putative protein of unknown function; identified by homology; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.147 9.27E-18 YEL060C PRB1 hom Vacuolar proteinase B (yscB); serine protease of the subtilisin family; involved in protein degradation in the vacuole and required for full protein degradation during sporulation; activity inhibited by Pbi2p; protein abundance increases in response to DNA replication stress
0.144 6.57E-17 YLR066W SPC3 het Subunit of signal peptidase complex (Spc1p, Spc2p, Spc3p, Sec11p), which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC22/23
0.133 1.01E-14 YGL154C LYS5 hom Phosphopantetheinyl transferase involved in lysine biosynthesis; converts inactive apo-form of Lys2p (alpha-aminoadipate reductase) into catalytically active holo-form by posttranslational addition of phosphopantetheine
0.129 6.17E-14 YIL059C_d YIL059C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YIL060W
0.120 2.97E-12 YDR109C_p YDR109C_p hom Putative kinase
0.112 7.83E-11 YER013W PRP22 het DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase, associates with lariat intermediates before the second catalytic step of splicing; mediates ATP-dependent mRNA release from the spliceosome and unwinds RNA duplexes
0.107 4.91E-10 YLR123C_d YLR123C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR122C; contains characteristic aminoacyl-tRNA motif
0.107 5.50E-10 YOR329C SCD5 het Protein required for normal actin organization and endocytosis; targeting subunit for protein phosphatase type 1; undergoes Crm1p-dependent nuclear-cytoplasmic shuttling; multicopy suppressor of clathrin deficiency
0.106 7.14E-10 YGR072W UPF3 hom Component of the nonsense-mediated mRNA decay (NMD) pathway, along with Nam7p and Nmd2p; involved in decay of mRNA containing nonsense codons; involved in telomere maintenance