Protein of unknown function; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress; YDR132C has a paralog, YLR108C, that arose from the whole genome duplication

Zygosity: Homozygous strain
Profile for YDR132C / YDR132C

Click on Significant Values for Screen Details

Top fitness defect scores for YDR132C deletion by condition

RankScreen IDConditionFD ScoreConc
1 SGTC_2938 9059746 6.87 27.3 µM 1.41E-13 fatty acid desaturase (OLE1) 10 3.18E-12
2 SGTC_2934 9036370 4.87 36.9 µM 1.16E-7 16 5.44E-7
3 SGTC_818 4072-2707 4.82 53.5 µM 1.59E-7 2 7.20E-7
4 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 4.03 150.0 µM 9.84E-6 Golgi 39 2.81E-5
5 SGTC_3257 9139206 4.02 33.0 µM 1.04E-5 3 2.95E-5
6 SGTC_361 000s-0510 4.02 1.4 µM 1.05E-5 30 2.97E-5
7 SGTC_1023 4482-3888 3.82 16.0 µM 2.57E-5 TSC3-RPN4 22 6.59E-5
8 SGTC_509 pifithrin 3.51 175.0 µM 1.02E-4 mitochondrial processes 10 2.24E-4
9 SGTC_1155 4088-0394 3.42 48.2 µM 1.47E-4 50 3.12E-4
10 SGTC_2343 7990716 3.32 14.8 µM 2.23E-4 38 4.51E-4
11 SGTC_1741 st038134 3.29 10.2 µM 2.55E-4 57 5.09E-4
12 SGTC_2703 st077852 3.26 53.4 µM 2.80E-4 52 5.54E-4
13 SGTC_947 3447-0010 3.25 211.0 µM 2.93E-4 38 5.76E-4
14 SGTC_743 1275-0778 3.22 158.0 µM 3.34E-4 excess fatty acid 72 6.48E-4
15 SGTC_1944 st076371 3.05 56.9 µM 6.36E-4 56 0.00115
16 SGTC_479 n-linoleoylglycine 2.98 10.0 µM 8.04E-4 34 0.00142
17 SGTC_2939 9044578 2.92 71.4 µM 0.00100 93 0.00173
18 SGTC_1241 0364-0022 2.92 50.8 µM 0.00101 ERG2 86 0.00173
19 SGTC_785 1270-0111 2.88 65.3 µM 0.00119 87 0.00201
20 SGTC_2091 4-phenylthiadiazole 2.86 200.0 µM 0.00124 58 0.00209

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.141 2.06E-16 YJR133W XPT1 hom Xanthine-guanine phosphoribosyl transferase, required for xanthine utilization and for optimal utilization of guanine
0.126 2.51E-13 YIR020C_p YIR020C_p hom Protein of unknown function; mRNA identified as translated by ribosome profiling data
0.114 4.07E-11 YJR108W ABM1 hom Protein of unknown function, required for normal microtubule organization
0.110 1.58E-10 YOR052C YOR052C hom Nuclear protein of unknown function; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner and by weak acid; transcriptionally regulated by Rpn4p along with proteasome subunit genes; putative ortholog of human AIRAP, which stimulates proteasome activity in response to arsenic; protein abundance increases in response to DNA replication stress
0.106 6.14E-10 YER085C_p YER085C_p hom Putative protein of unknown function
0.105 1.06E-9 YLL062C MHT1 hom S-methylmethionine-homocysteine methyltransferase, functions along with Sam4p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio
0.104 1.45E-9 YHL012W_p YHL012W_p hom Putative UTP glucose-1-phosphate uridylyltransferase; YHL012W has a paralog, UGP1, that arose from the whole genome duplication
0.103 2.18E-9 YOR222W ODC2 hom Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for use in lysine and glutamate biosynthesis and in lysine catabolism
0.099 8.03E-9 YOR279C RFM1 hom DNA-binding protein required for vegetative repression of middle sporulation genes; specificity factor that directs the Hst1p histone deacetylase to some of the promoters regulated by Sum1p; involved in telomere maintenance
0.098 1.20E-8 YKL063C_p YKL063C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi
0.097 2.05E-8 YML086C ALO1 hom D-Arabinono-1,4-lactone oxidase, catalyzes the final step in biosynthesis of dehydro-D-arabinono-1,4-lactone, which is protective against oxidative stress
0.095 3.87E-8 YDR479C PEX29 hom Peroxisomal integral membrane peroxin; involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p; forms ER foci upon DNA replication stress
0.090 1.82E-7 YOL105C WSC3 hom Partially redundant sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway involved in maintenance of cell wall integrity; involved in the response to heat shock and other stressors; regulates 1,3-beta-glucan synthesis
0.087 4.92E-7 YJL201W ECM25 hom Non-essential protein of unknown function; promoter contains a consensus binding sequence for factor Abf1p
0.087 5.09E-7 YDR142C PEX7 hom Peroxisomal signal receptor for the N-terminal nonapeptide signal (PTS2) of peroxisomal matrix proteins; WD repeat protein; defects in human homolog cause lethal rhizomelic chondrodysplasia punctata (RCDP)