YDR136C_d / VPS61

Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 4% of ORF overlaps the verified gene RGP1; deletion causes a vacuolar protein sorting defect

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR136C / VPS61

Click on Significant Values for Screen Details ID:SGTC_31|Compound:0508-1974|FD-Score:5.68|P-value:2.16E-4 ID:SGTC_132|Compound:0417-1715|FD-Score:6.27|P-value:5.07E-5 ID:SGTC_133|Compound:0724-0033|FD-Score:7.07|P-value:5.83E-6 ID:SGTC_193|Compound:1273-0060|FD-Score:-5.10|P-value:8.07E-4 ID:SGTC_197|Compound:4544-0043|FD-Score:-6.30|P-value:4.95E-5 ID:SGTC_201|Compound:4262-0159|FD-Score:-6.34|P-value:4.41E-5 ID:SGTC_278|Compound:4092-0821|FD-Score:-6.18|P-value:6.61E-5 ID:SGTC_312|Compound:4092-0653|FD-Score:-5.42|P-value:4.07E-4 ID:SGTC_320|Compound:4092-0846|FD-Score:-6.11|P-value:7.85E-5 ID:SGTC_346|Compound:4513-0042|FD-Score:-5.80|P-value:1.70E-4 ID:SGTC_397|Compound:arbidol|FD-Score:-5.19|P-value:6.68E-4 ID:SGTC_515|Compound:4092-1064|FD-Score:-6.04|P-value:9.37E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:8.83|P-value:2.23E-8 ID:SGTC_542|Compound:3381-0244|FD-Score:-5.31|P-value:5.14E-4 ID:SGTC_643|Compound:k048-0106|FD-Score:5.13|P-value:7.36E-4 ID:SGTC_706|Compound:4262-0057|FD-Score:-6.90|P-value:9.81E-6 ID:SGTC_748|Compound:0136-0228|FD-Score:8.01|P-value:3.52E-7 ID:SGTC_788|Compound:1182-0090|FD-Score:-6.79|P-value:1.33E-5 ID:SGTC_865|Compound:0488-0499|FD-Score:-6.86|P-value:1.12E-5 ID:SGTC_871|Compound:0574-0004|FD-Score:-5.93|P-value:1.22E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:-5.14|P-value:7.49E-4 ID:SGTC_954|Compound:1189-0853|FD-Score:-11.10|P-value:3.64E-12 ID:SGTC_960|Compound:1222-0186|FD-Score:-5.64|P-value:2.44E-4 ID:SGTC_1005|Compound:4092-0690|FD-Score:-6.02|P-value:9.81E-5 ID:SGTC_1038|Compound:k292-0204|FD-Score:5.49|P-value:3.37E-4 ID:SGTC_1115|Compound:galangin|FD-Score:5.01|P-value:9.55E-4 ID:SGTC_1199|Compound:1638-0010|FD-Score:-5.65|P-value:2.36E-4 ID:SGTC_1226|Compound:3909-7979|FD-Score:-5.47|P-value:3.59E-4 ID:SGTC_1274|Compound:0865-0114|FD-Score:5.30|P-value:5.12E-4 ID:SGTC_1306|Compound:1185-0270|FD-Score:7.32|P-value:2.86E-6 ID:SGTC_1313|Compound:1220-0047|FD-Score:7.28|P-value:3.22E-6 ID:SGTC_1319|Compound:1306-0155|FD-Score:12.50|P-value:3.99E-15 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:6.31|P-value:4.55E-5 ID:SGTC_1435|Compound:4092-0789|FD-Score:-5.66|P-value:2.33E-4 ID:SGTC_1455|Compound:4262-0120|FD-Score:-5.39|P-value:4.33E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:6.00|P-value:9.96E-5 ID:SGTC_1547|Compound:harmine|FD-Score:-6.85|P-value:1.13E-5 ID:SGTC_1573|Compound:oleylamine|FD-Score:-6.90|P-value:9.87E-6 ID:SGTC_1632|Compound:st005650|FD-Score:5.11|P-value:7.74E-4 ID:SGTC_1638|Compound:st008370|FD-Score:-5.98|P-value:1.10E-4 ID:SGTC_1640|Compound:st009078|FD-Score:-5.17|P-value:6.91E-4 ID:SGTC_1649|Compound:st011737|FD-Score:-5.24|P-value:5.98E-4 ID:SGTC_1672|Compound:st016598|FD-Score:-7.01|P-value:7.24E-6 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:-5.24|P-value:5.94E-4 ID:SGTC_1715|Compound:st032160|FD-Score:-6.94|P-value:9.01E-6 ID:SGTC_1717|Compound:st033143|FD-Score:5.51|P-value:3.16E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-7.42|P-value:2.25E-6 ID:SGTC_1732|Compound:st034308|FD-Score:5.99|P-value:1.02E-4 ID:SGTC_1745|Compound:st081495|FD-Score:-6.57|P-value:2.42E-5 ID:SGTC_1748|Compound:st037455|FD-Score:-7.68|P-value:1.02E-6 ID:SGTC_1750|Compound:st081859|FD-Score:-8.34|P-value:1.24E-7 ID:SGTC_1773|Compound:st048542|FD-Score:-7.02|P-value:7.12E-6 ID:SGTC_1797|Compound:st048695|FD-Score:-10.60|P-value:2.48E-11 ID:SGTC_1826|Compound:st055655|FD-Score:-7.07|P-value:6.11E-6 ID:SGTC_1831|Compound:st055328|FD-Score:-5.27|P-value:5.63E-4 ID:SGTC_1880|Compound:MG-132|FD-Score:-6.40|P-value:3.81E-5 ID:SGTC_1927|Compound:st060202|FD-Score:5.67|P-value:2.22E-4 ID:SGTC_1934|Compound:st074720|FD-Score:-6.00|P-value:1.03E-4 ID:SGTC_1938|Compound:st074717|FD-Score:-5.91|P-value:1.28E-4 ID:SGTC_1949|Compound:st076024|FD-Score:-6.40|P-value:3.75E-5 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:-6.71|P-value:1.66E-5 ID:SGTC_1954|Compound:st077032|FD-Score:5.29|P-value:5.16E-4 ID:SGTC_1999|Compound:st074831|FD-Score:-6.62|P-value:2.11E-5 ID:SGTC_2006|Compound:4011487|FD-Score:-10.00|P-value:2.86E-10 ID:SGTC_2036|Compound:5160441|FD-Score:-5.02|P-value:9.67E-4 ID:SGTC_2038|Compound:4100038|FD-Score:-5.73|P-value:1.99E-4 ID:SGTC_2147|Compound:5545932|FD-Score:-5.28|P-value:5.52E-4 ID:SGTC_2155|Compound:5570423|FD-Score:-5.39|P-value:4.30E-4 ID:SGTC_2185|Compound:6113692|FD-Score:-7.15|P-value:4.87E-6 ID:SGTC_2201|Compound:6605497|FD-Score:-6.34|P-value:4.42E-5 ID:SGTC_2257|Compound:7960413|FD-Score:-6.51|P-value:2.88E-5 ID:SGTC_2347|Compound:9049783|FD-Score:-5.36|P-value:4.59E-4 ID:SGTC_2359|Compound:9039622|FD-Score:-6.20|P-value:6.29E-5 ID:SGTC_2363|Compound:9053361|FD-Score:-9.07|P-value:1.01E-8 ID:SGTC_2374|Compound:9071832|FD-Score:-7.25|P-value:3.68E-6 ID:SGTC_2377|Compound:9073351|FD-Score:-5.91|P-value:1.30E-4 ID:SGTC_2380|Compound:9035439|FD-Score:-6.19|P-value:6.43E-5 ID:SGTC_2397|Compound:5161689|FD-Score:9.52|P-value:1.82E-9 ID:SGTC_2398|Compound:5228213|FD-Score:-5.12|P-value:7.70E-4 ID:SGTC_2416|Compound:tofa|FD-Score:-5.14|P-value:7.44E-4 ID:SGTC_2421|Compound:5690543|FD-Score:-6.68|P-value:1.83E-5 ID:SGTC_2430|Compound:5571206|FD-Score:-5.32|P-value:5.02E-4 ID:SGTC_2437|Compound:5741531|FD-Score:5.30|P-value:5.12E-4 ID:SGTC_2440|Compound:5628896|FD-Score:8.51|P-value:6.71E-8 ID:SGTC_2443|Compound:5493264|FD-Score:6.54|P-value:2.49E-5 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-5.15|P-value:7.21E-4 ID:SGTC_2648|Compound:atorvastatin|FD-Score:-5.40|P-value:4.20E-4 ID:SGTC_2694|Compound:st077685|FD-Score:-5.20|P-value:6.59E-4 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:-5.76|P-value:1.84E-4 ID:SGTC_2737|Compound:bleomycin|FD-Score:5.13|P-value:7.36E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:-6.55|P-value:2.59E-5 ID:SGTC_2790|Compound:5423970|FD-Score:-8.10|P-value:2.76E-7 ID:SGTC_2816|Compound:7982706|FD-Score:-6.13|P-value:7.51E-5 ID:SGTC_2823|Compound:7987624|FD-Score:-5.43|P-value:3.91E-4 ID:SGTC_2838|Compound:9002687|FD-Score:-8.05|P-value:3.16E-7 ID:SGTC_2900|Compound:5328528|FD-Score:5.42|P-value:3.94E-4 ID:SGTC_2925|Compound:9010536|FD-Score:-6.60|P-value:2.27E-5 ID:SGTC_2948|Compound:9070189|FD-Score:-8.95|P-value:1.57E-8 ID:SGTC_2991|Compound:9074669|FD-Score:-6.98|P-value:7.96E-6 ID:SGTC_2993|Compound:9054257|FD-Score:-6.17|P-value:6.75E-5 ID:SGTC_3018|Compound:9082602|FD-Score:-5.49|P-value:3.42E-4 ID:SGTC_3033|Compound:9090887|FD-Score:-6.32|P-value:4.66E-5 ID:SGTC_3054|Compound:9094397|FD-Score:-6.30|P-value:4.91E-5 ID:SGTC_3081|Compound:9117243|FD-Score:-5.93|P-value:1.22E-4 ID:SGTC_3100|Compound:9120536|FD-Score:-8.05|P-value:3.19E-7 ID:SGTC_3126|Compound:9127922|FD-Score:-9.97|P-value:3.51E-10 ID:SGTC_3152|Compound:9099253|FD-Score:-5.07|P-value:8.62E-4 ID:SGTC_3218|Compound:9131285|FD-Score:-5.90|P-value:1.32E-4 ID:SGTC_3308|Compound:9128332|FD-Score:-5.59|P-value:2.72E-4 ID:SGTC_31|Compound:0508-1974|FD-Score:5.68|P-value:2.16E-4 ID:SGTC_132|Compound:0417-1715|FD-Score:6.27|P-value:5.07E-5 ID:SGTC_133|Compound:0724-0033|FD-Score:7.07|P-value:5.83E-6 ID:SGTC_193|Compound:1273-0060|FD-Score:-5.10|P-value:8.07E-4 ID:SGTC_197|Compound:4544-0043|FD-Score:-6.30|P-value:4.95E-5 ID:SGTC_201|Compound:4262-0159|FD-Score:-6.34|P-value:4.41E-5 ID:SGTC_278|Compound:4092-0821|FD-Score:-6.18|P-value:6.61E-5 ID:SGTC_312|Compound:4092-0653|FD-Score:-5.42|P-value:4.07E-4 ID:SGTC_320|Compound:4092-0846|FD-Score:-6.11|P-value:7.85E-5 ID:SGTC_346|Compound:4513-0042|FD-Score:-5.80|P-value:1.70E-4 ID:SGTC_397|Compound:arbidol|FD-Score:-5.19|P-value:6.68E-4 ID:SGTC_515|Compound:4092-1064|FD-Score:-6.04|P-value:9.37E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:8.83|P-value:2.23E-8 ID:SGTC_542|Compound:3381-0244|FD-Score:-5.31|P-value:5.14E-4 ID:SGTC_643|Compound:k048-0106|FD-Score:5.13|P-value:7.36E-4 ID:SGTC_706|Compound:4262-0057|FD-Score:-6.90|P-value:9.81E-6 ID:SGTC_748|Compound:0136-0228|FD-Score:8.01|P-value:3.52E-7 ID:SGTC_788|Compound:1182-0090|FD-Score:-6.79|P-value:1.33E-5 ID:SGTC_865|Compound:0488-0499|FD-Score:-6.86|P-value:1.12E-5 ID:SGTC_871|Compound:0574-0004|FD-Score:-5.93|P-value:1.22E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:-5.14|P-value:7.49E-4 ID:SGTC_954|Compound:1189-0853|FD-Score:-11.10|P-value:3.64E-12 ID:SGTC_960|Compound:1222-0186|FD-Score:-5.64|P-value:2.44E-4 ID:SGTC_1005|Compound:4092-0690|FD-Score:-6.02|P-value:9.81E-5 ID:SGTC_1038|Compound:k292-0204|FD-Score:5.49|P-value:3.37E-4 ID:SGTC_1115|Compound:galangin|FD-Score:5.01|P-value:9.55E-4 ID:SGTC_1199|Compound:1638-0010|FD-Score:-5.65|P-value:2.36E-4 ID:SGTC_1226|Compound:3909-7979|FD-Score:-5.47|P-value:3.59E-4 ID:SGTC_1274|Compound:0865-0114|FD-Score:5.30|P-value:5.12E-4 ID:SGTC_1306|Compound:1185-0270|FD-Score:7.32|P-value:2.86E-6 ID:SGTC_1313|Compound:1220-0047|FD-Score:7.28|P-value:3.22E-6 ID:SGTC_1319|Compound:1306-0155|FD-Score:12.50|P-value:3.99E-15 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:6.31|P-value:4.55E-5 ID:SGTC_1435|Compound:4092-0789|FD-Score:-5.66|P-value:2.33E-4 ID:SGTC_1455|Compound:4262-0120|FD-Score:-5.39|P-value:4.33E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:6.00|P-value:9.96E-5 ID:SGTC_1547|Compound:harmine|FD-Score:-6.85|P-value:1.13E-5 ID:SGTC_1573|Compound:oleylamine|FD-Score:-6.90|P-value:9.87E-6 ID:SGTC_1632|Compound:st005650|FD-Score:5.11|P-value:7.74E-4 ID:SGTC_1638|Compound:st008370|FD-Score:-5.98|P-value:1.10E-4 ID:SGTC_1640|Compound:st009078|FD-Score:-5.17|P-value:6.91E-4 ID:SGTC_1649|Compound:st011737|FD-Score:-5.24|P-value:5.98E-4 ID:SGTC_1672|Compound:st016598|FD-Score:-7.01|P-value:7.24E-6 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:-5.24|P-value:5.94E-4 ID:SGTC_1715|Compound:st032160|FD-Score:-6.94|P-value:9.01E-6 ID:SGTC_1717|Compound:st033143|FD-Score:5.51|P-value:3.16E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-7.42|P-value:2.25E-6 ID:SGTC_1732|Compound:st034308|FD-Score:5.99|P-value:1.02E-4 ID:SGTC_1745|Compound:st081495|FD-Score:-6.57|P-value:2.42E-5 ID:SGTC_1748|Compound:st037455|FD-Score:-7.68|P-value:1.02E-6 ID:SGTC_1750|Compound:st081859|FD-Score:-8.34|P-value:1.24E-7 ID:SGTC_1773|Compound:st048542|FD-Score:-7.02|P-value:7.12E-6 ID:SGTC_1797|Compound:st048695|FD-Score:-10.60|P-value:2.48E-11 ID:SGTC_1826|Compound:st055655|FD-Score:-7.07|P-value:6.11E-6 ID:SGTC_1831|Compound:st055328|FD-Score:-5.27|P-value:5.63E-4 ID:SGTC_1880|Compound:MG-132|FD-Score:-6.40|P-value:3.81E-5 ID:SGTC_1927|Compound:st060202|FD-Score:5.67|P-value:2.22E-4 ID:SGTC_1934|Compound:st074720|FD-Score:-6.00|P-value:1.03E-4 ID:SGTC_1938|Compound:st074717|FD-Score:-5.91|P-value:1.28E-4 ID:SGTC_1949|Compound:st076024|FD-Score:-6.40|P-value:3.75E-5 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:-6.71|P-value:1.66E-5 ID:SGTC_1954|Compound:st077032|FD-Score:5.29|P-value:5.16E-4 ID:SGTC_1999|Compound:st074831|FD-Score:-6.62|P-value:2.11E-5 ID:SGTC_2006|Compound:4011487|FD-Score:-10.00|P-value:2.86E-10 ID:SGTC_2036|Compound:5160441|FD-Score:-5.02|P-value:9.67E-4 ID:SGTC_2038|Compound:4100038|FD-Score:-5.73|P-value:1.99E-4 ID:SGTC_2147|Compound:5545932|FD-Score:-5.28|P-value:5.52E-4 ID:SGTC_2155|Compound:5570423|FD-Score:-5.39|P-value:4.30E-4 ID:SGTC_2185|Compound:6113692|FD-Score:-7.15|P-value:4.87E-6 ID:SGTC_2201|Compound:6605497|FD-Score:-6.34|P-value:4.42E-5 ID:SGTC_2257|Compound:7960413|FD-Score:-6.51|P-value:2.88E-5 ID:SGTC_2347|Compound:9049783|FD-Score:-5.36|P-value:4.59E-4 ID:SGTC_2359|Compound:9039622|FD-Score:-6.20|P-value:6.29E-5 ID:SGTC_2363|Compound:9053361|FD-Score:-9.07|P-value:1.01E-8 ID:SGTC_2374|Compound:9071832|FD-Score:-7.25|P-value:3.68E-6 ID:SGTC_2377|Compound:9073351|FD-Score:-5.91|P-value:1.30E-4 ID:SGTC_2380|Compound:9035439|FD-Score:-6.19|P-value:6.43E-5 ID:SGTC_2397|Compound:5161689|FD-Score:9.52|P-value:1.82E-9 ID:SGTC_2398|Compound:5228213|FD-Score:-5.12|P-value:7.70E-4 ID:SGTC_2416|Compound:tofa|FD-Score:-5.14|P-value:7.44E-4 ID:SGTC_2421|Compound:5690543|FD-Score:-6.68|P-value:1.83E-5 ID:SGTC_2430|Compound:5571206|FD-Score:-5.32|P-value:5.02E-4 ID:SGTC_2437|Compound:5741531|FD-Score:5.30|P-value:5.12E-4 ID:SGTC_2440|Compound:5628896|FD-Score:8.51|P-value:6.71E-8 ID:SGTC_2443|Compound:5493264|FD-Score:6.54|P-value:2.49E-5 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-5.15|P-value:7.21E-4 ID:SGTC_2648|Compound:atorvastatin|FD-Score:-5.40|P-value:4.20E-4 ID:SGTC_2694|Compound:st077685|FD-Score:-5.20|P-value:6.59E-4 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:-5.76|P-value:1.84E-4 ID:SGTC_2737|Compound:bleomycin|FD-Score:5.13|P-value:7.36E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:-6.55|P-value:2.59E-5 ID:SGTC_2790|Compound:5423970|FD-Score:-8.10|P-value:2.76E-7 ID:SGTC_2816|Compound:7982706|FD-Score:-6.13|P-value:7.51E-5 ID:SGTC_2823|Compound:7987624|FD-Score:-5.43|P-value:3.91E-4 ID:SGTC_2838|Compound:9002687|FD-Score:-8.05|P-value:3.16E-7 ID:SGTC_2900|Compound:5328528|FD-Score:5.42|P-value:3.94E-4 ID:SGTC_2925|Compound:9010536|FD-Score:-6.60|P-value:2.27E-5 ID:SGTC_2948|Compound:9070189|FD-Score:-8.95|P-value:1.57E-8 ID:SGTC_2991|Compound:9074669|FD-Score:-6.98|P-value:7.96E-6 ID:SGTC_2993|Compound:9054257|FD-Score:-6.17|P-value:6.75E-5 ID:SGTC_3018|Compound:9082602|FD-Score:-5.49|P-value:3.42E-4 ID:SGTC_3033|Compound:9090887|FD-Score:-6.32|P-value:4.66E-5 ID:SGTC_3054|Compound:9094397|FD-Score:-6.30|P-value:4.91E-5 ID:SGTC_3081|Compound:9117243|FD-Score:-5.93|P-value:1.22E-4 ID:SGTC_3100|Compound:9120536|FD-Score:-8.05|P-value:3.19E-7 ID:SGTC_3126|Compound:9127922|FD-Score:-9.97|P-value:3.51E-10 ID:SGTC_3152|Compound:9099253|FD-Score:-5.07|P-value:8.62E-4 ID:SGTC_3218|Compound:9131285|FD-Score:-5.90|P-value:1.32E-4 ID:SGTC_3308|Compound:9128332|FD-Score:-5.59|P-value:2.72E-4

Top fitness defect scores for YDR136C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1319 1306-0155 12.50 43.7 µM 3.99E-15 1 2.24E-36
2 SGTC_2397 5161689 9.52 200.0 µM 1.82E-9 2 8.46E-22
3 SGTC_528 3492-0019 8.83 172.0 µM 2.23E-8 calcium & mitochondrial duress 57 5.15E-19
4 SGTC_2440 5628896 8.51 157.8 µM 6.71E-8 2 8.68E-18
5 SGTC_748 0136-0228 8.01 77.9 µM 3.52E-7 redox potentiating 20 5.97E-16
6 SGTC_1306 1185-0270 7.32 9.0 µM 2.86E-6 Golgi 22 1.23E-13
7 SGTC_1313 1220-0047 7.28 237.0 µM 3.22E-6 9 1.67E-13
8 SGTC_133 0724-0033 7.07 378.9 µM 5.83E-6 4 7.52E-13
9 SGTC_2443 5493264 6.54 126.7 µM 2.49E-5 5 2.98E-11
10 SGTC_1349 flufenamic acid 6.31 69.0 µM 4.55E-5 3 1.36E-10
11 SGTC_132 0417-1715 6.27 25.8 µM 5.07E-5 RPP1 & pyrimidine depletion 4 1.79E-10
12 SGTC_1510 1123-0200 6.00 71.5 µM 9.96E-5 16 9.77E-10
13 SGTC_1732 st034308 5.99 51.8 µM 1.02E-4 2 1.03E-9
14 SGTC_31 0508-1974 5.68 57.2 µM 2.16E-4 2 6.79E-9
15 SGTC_1927 st060202 5.67 13.8 µM 2.22E-4 2 7.31E-9
16 SGTC_1717 st033143 5.51 58.0 µM 3.16E-4 17 1.77E-8
17 SGTC_1038 k292-0204 5.49 154.0 µM 3.37E-4 4 2.07E-8
18 SGTC_2900 5328528 5.42 85.3 µM 3.94E-4 Golgi 10 3.05E-8
19 SGTC_1274 0865-0114 5.30 173.0 µM 5.12E-4 5 5.88E-8
20 SGTC_2437 5741531 5.30 144.2 µM 5.12E-4 16 5.90E-8

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Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.545 1.18E-257 YDR137W RGP1 hom Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) that catalyzes nucleotide exchange on Ypt6p
0.497 8.94E-208 YLR262C YPT6 hom Rab family GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6
0.488 3.28E-200 YLR261C_d VPS63_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene YPT6; deletion causes a vacuolar protein sorting defect
0.445 2.10E-162 YLR039C RIC1 hom Protein involved in retrograde transport to the cis-Golgi network; forms heterodimer with Rgp1p that acts as a GTP exchange factor for Ypt6p; involved in transcription of rRNA and ribosomal protein genes
0.377 1.35E-113 YNL051W COG5 hom Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
0.344 2.43E-93 YNL041C COG6 hom Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
0.326 9.37E-84 YML071C COG8 hom Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
0.314 1.36E-77 YDR320C SWA2 hom Auxilin-like protein involved in vesicular transport; clathrin-binding protein required for uncoating of clathrin-coated vesicles
0.307 1.00E-73 YKR019C IRS4 hom EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; IRS4 has a paralog, TAX4, that arose from the whole genome duplication
0.275 7.09E-59 YGL005C COG7 hom Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
0.214 6.40E-36 YGR167W CLC1 hom Clathrin light chain; subunit of the major coat protein involved in intracellular protein transport and endocytosis; thought to regulate clathrin function; two Clathrin heavy chains (CHC1) form the clathrin triskelion structural component; YGR167W
0.197 1.17E-30 YGL223C COG1 hom Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
0.178 2.45E-25 YKR020W VPS51 hom Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; links the (VFT/GARP) complex to the SNARE Tlg1p
0.173 8.89E-24 YOL018C TLG2 hom Syntaxin-like t-SNARE that forms a complex with Tlg1p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds Vps45p, which prevents Tlg2p degradation and also facilitates t-SNARE complex formation; homologous to mammalian SNARE protein syntaxin 16 (Sx16)
0.169 8.87E-23 YJL004C SYS1 hom Integral membrane protein of the Golgi required for targeting of the Arf-like GTPase Arl3p to the Golgi; multicopy suppressor of ypt6 null mutation