YDR137W / RGP1

Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) that catalyzes nucleotide exchange on Ypt6p

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR137W / RGP1

Click on Significant Values for Screen Details ID:SGTC_22|Compound:0964-0034|FD-Score:5.27|P-value:1.44E-4 ID:SGTC_31|Compound:0508-1974|FD-Score:5.63|P-value:5.27E-5 ID:SGTC_91|Compound:0417-1751|FD-Score:4.58|P-value:8.05E-4 ID:SGTC_124|Compound:0136-0217|FD-Score:4.68|P-value:6.35E-4 ID:SGTC_278|Compound:4092-0821|FD-Score:-7.40|P-value:1.68E-7 ID:SGTC_306|Compound:1672-3436|FD-Score:4.54|P-value:8.75E-4 ID:SGTC_308|Compound:4092-1169|FD-Score:-5.11|P-value:2.14E-4 ID:SGTC_346|Compound:4513-0042|FD-Score:-7.12|P-value:4.67E-7 ID:SGTC_349|Compound:k015-0014|FD-Score:-6.66|P-value:2.21E-6 ID:SGTC_358|Compound:0075-0058|FD-Score:6.38|P-value:5.51E-6 ID:SGTC_430|Compound:0958-0115|FD-Score:4.55|P-value:8.67E-4 ID:SGTC_441|Compound:propafenone|FD-Score:-6.77|P-value:1.52E-6 ID:SGTC_445|Compound:e6 berbamine|FD-Score:7.77|P-value:4.39E-8 ID:SGTC_451|Compound:chloral hydrate|FD-Score:-6.54|P-value:3.28E-6 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-8.51|P-value:2.29E-9 ID:SGTC_455|Compound:paf C-16|FD-Score:-5.82|P-value:3.07E-5 ID:SGTC_459|Compound:nigericin|FD-Score:5.17|P-value:1.84E-4 ID:SGTC_462|Compound:ag-879|FD-Score:5.07|P-value:2.43E-4 ID:SGTC_470|Compound:aa-861|FD-Score:4.92|P-value:3.50E-4 ID:SGTC_481|Compound:bay k-8644|FD-Score:5.73|P-value:4.02E-5 ID:SGTC_515|Compound:4092-1064|FD-Score:-5.98|P-value:1.89E-5 ID:SGTC_624|Compound:k048-0052|FD-Score:6.52|P-value:3.51E-6 ID:SGTC_644|Compound:1498-1197|FD-Score:5.28|P-value:1.38E-4 ID:SGTC_646|Compound:4092-0839|FD-Score:-4.84|P-value:4.26E-4 ID:SGTC_684|Compound:1140-0066|FD-Score:5.04|P-value:2.58E-4 ID:SGTC_706|Compound:4262-0057|FD-Score:-6.45|P-value:4.39E-6 ID:SGTC_717|Compound:1532-0246|FD-Score:5.03|P-value:2.64E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:-5.88|P-value:2.52E-5 ID:SGTC_800|Compound:3448-7362|FD-Score:5.62|P-value:5.47E-5 ID:SGTC_830|Compound:4076-0286|FD-Score:6.37|P-value:5.75E-6 ID:SGTC_841|Compound:0251-0215|FD-Score:5.69|P-value:4.40E-5 ID:SGTC_865|Compound:0488-0499|FD-Score:-5.38|P-value:1.04E-4 ID:SGTC_945|Compound:3381-0768|FD-Score:-5.75|P-value:3.71E-5 ID:SGTC_954|Compound:1189-0853|FD-Score:-5.22|P-value:1.59E-4 ID:SGTC_970|Compound:1315-0089|FD-Score:8.32|P-value:5.01E-9 ID:SGTC_975|Compound:1335-0046|FD-Score:6.05|P-value:1.56E-5 ID:SGTC_1037|Compound:k284-1091|FD-Score:4.81|P-value:4.62E-4 ID:SGTC_1080|Compound:nisoldipine|FD-Score:4.58|P-value:8.05E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:5.71|P-value:4.23E-5 ID:SGTC_1165|Compound:k072-0275|FD-Score:5.13|P-value:2.05E-4 ID:SGTC_1174|Compound:0739-0097|FD-Score:5.71|P-value:4.22E-5 ID:SGTC_1206|Compound:3978-0017|FD-Score:-5.44|P-value:8.79E-5 ID:SGTC_1226|Compound:3909-7979|FD-Score:-5.12|P-value:2.12E-4 ID:SGTC_1233|Compound:0325-0408|FD-Score:5.38|P-value:1.07E-4 ID:SGTC_1234|Compound:0326-0494|FD-Score:4.65|P-value:6.77E-4 ID:SGTC_1240|Compound:0356-0016|FD-Score:-5.72|P-value:4.06E-5 ID:SGTC_1247|Compound:0448-0043|FD-Score:-5.72|P-value:4.10E-5 ID:SGTC_1279|Compound:0874-0590|FD-Score:4.72|P-value:5.71E-4 ID:SGTC_1306|Compound:1185-0270|FD-Score:4.91|P-value:3.63E-4 ID:SGTC_1319|Compound:1306-0155|FD-Score:5.16|P-value:1.91E-4 ID:SGTC_1362|Compound:1611-0397|FD-Score:5.66|P-value:4.81E-5 ID:SGTC_1455|Compound:4262-0120|FD-Score:-4.63|P-value:7.18E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:11.20|P-value:7.33E-15 ID:SGTC_1573|Compound:oleylamine|FD-Score:-7.62|P-value:7.69E-8 ID:SGTC_1639|Compound:Lupinine o-methylbenzoicacid ester hydrochloride|FD-Score:-5.35|P-value:1.15E-4 ID:SGTC_1672|Compound:st016598|FD-Score:-4.92|P-value:3.47E-4 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:-5.83|P-value:2.91E-5 ID:SGTC_1687|Compound:st020778|FD-Score:5.64|P-value:5.09E-5 ID:SGTC_1714|Compound:st033236|FD-Score:4.65|P-value:6.81E-4 ID:SGTC_1715|Compound:st032160|FD-Score:-6.19|P-value:9.88E-6 ID:SGTC_1718|Compound:roemerine|FD-Score:-5.21|P-value:1.66E-4 ID:SGTC_1748|Compound:st037455|FD-Score:-5.00|P-value:2.88E-4 ID:SGTC_1760|Compound:st045453|FD-Score:-5.31|P-value:1.25E-4 ID:SGTC_1773|Compound:st048542|FD-Score:-4.55|P-value:8.60E-4 ID:SGTC_1781|Compound:st038725|FD-Score:-9.64|P-value:1.52E-11 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.96|P-value:3.13E-4 ID:SGTC_1797|Compound:st048695|FD-Score:-6.61|P-value:2.65E-6 ID:SGTC_1934|Compound:st074720|FD-Score:-5.26|P-value:1.46E-4 ID:SGTC_1999|Compound:st074831|FD-Score:-4.49|P-value:9.77E-4 ID:SGTC_2006|Compound:4011487|FD-Score:-5.16|P-value:1.89E-4 ID:SGTC_2038|Compound:4100038|FD-Score:-4.73|P-value:5.58E-4 ID:SGTC_2050|Compound:5263056|FD-Score:-5.24|P-value:1.52E-4 ID:SGTC_2187|Compound:6125751|FD-Score:4.78|P-value:5.00E-4 ID:SGTC_2200|Compound:6600604|FD-Score:4.67|P-value:6.49E-4 ID:SGTC_2201|Compound:6605497|FD-Score:-7.93|P-value:2.30E-8 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:4.91|P-value:3.56E-4 ID:SGTC_2300|Compound:7976697|FD-Score:-6.33|P-value:6.51E-6 ID:SGTC_2314|Compound:7727897|FD-Score:4.66|P-value:6.66E-4 ID:SGTC_2363|Compound:9053361|FD-Score:-5.61|P-value:5.48E-5 ID:SGTC_2374|Compound:9071832|FD-Score:-5.09|P-value:2.26E-4 ID:SGTC_2380|Compound:9035439|FD-Score:-4.87|P-value:3.91E-4 ID:SGTC_2594|Compound:a-mangostin|FD-Score:-6.32|P-value:6.56E-6 ID:SGTC_2757|Compound:clomiphene|FD-Score:-4.85|P-value:4.20E-4 ID:SGTC_2790|Compound:5423970|FD-Score:-5.68|P-value:4.58E-5 ID:SGTC_2823|Compound:7987624|FD-Score:-5.08|P-value:2.32E-4 ID:SGTC_2825|Compound:7998094|FD-Score:-4.50|P-value:9.65E-4 ID:SGTC_2838|Compound:9002687|FD-Score:-7.89|P-value:2.69E-8 ID:SGTC_2865|Compound:9030313|FD-Score:5.60|P-value:5.69E-5 ID:SGTC_2902|Compound:5787006|FD-Score:5.02|P-value:2.73E-4 ID:SGTC_2944|Compound:9067346|FD-Score:-5.43|P-value:9.26E-5 ID:SGTC_2948|Compound:9070189|FD-Score:-9.38|P-value:5.17E-11 ID:SGTC_2991|Compound:9074669|FD-Score:-7.36|P-value:1.99E-7 ID:SGTC_2993|Compound:9054257|FD-Score:-8.46|P-value:2.78E-9 ID:SGTC_3054|Compound:9094397|FD-Score:-6.35|P-value:5.98E-6 ID:SGTC_3065|Compound:9113888|FD-Score:4.60|P-value:7.75E-4 ID:SGTC_3071|Compound:9117417|FD-Score:-5.88|P-value:2.57E-5 ID:SGTC_3077|Compound:9117319|FD-Score:4.92|P-value:3.54E-4 ID:SGTC_3081|Compound:9117243|FD-Score:-4.68|P-value:6.29E-4 ID:SGTC_3100|Compound:9120536|FD-Score:-6.28|P-value:7.48E-6 ID:SGTC_3126|Compound:9127922|FD-Score:-8.85|P-value:5.43E-10 ID:SGTC_3190|Compound:9110366|FD-Score:4.98|P-value:3.05E-4 ID:SGTC_3218|Compound:9131285|FD-Score:-7.60|P-value:8.08E-8 ID:SGTC_3269|Compound:9137823|FD-Score:4.83|P-value:4.39E-4 ID:SGTC_3278|Compound:9139605|FD-Score:5.17|P-value:1.83E-4 ID:SGTC_22|Compound:0964-0034|FD-Score:5.27|P-value:1.44E-4 ID:SGTC_31|Compound:0508-1974|FD-Score:5.63|P-value:5.27E-5 ID:SGTC_91|Compound:0417-1751|FD-Score:4.58|P-value:8.05E-4 ID:SGTC_124|Compound:0136-0217|FD-Score:4.68|P-value:6.35E-4 ID:SGTC_278|Compound:4092-0821|FD-Score:-7.40|P-value:1.68E-7 ID:SGTC_306|Compound:1672-3436|FD-Score:4.54|P-value:8.75E-4 ID:SGTC_308|Compound:4092-1169|FD-Score:-5.11|P-value:2.14E-4 ID:SGTC_346|Compound:4513-0042|FD-Score:-7.12|P-value:4.67E-7 ID:SGTC_349|Compound:k015-0014|FD-Score:-6.66|P-value:2.21E-6 ID:SGTC_358|Compound:0075-0058|FD-Score:6.38|P-value:5.51E-6 ID:SGTC_430|Compound:0958-0115|FD-Score:4.55|P-value:8.67E-4 ID:SGTC_441|Compound:propafenone|FD-Score:-6.77|P-value:1.52E-6 ID:SGTC_445|Compound:e6 berbamine|FD-Score:7.77|P-value:4.39E-8 ID:SGTC_451|Compound:chloral hydrate|FD-Score:-6.54|P-value:3.28E-6 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-8.51|P-value:2.29E-9 ID:SGTC_455|Compound:paf C-16|FD-Score:-5.82|P-value:3.07E-5 ID:SGTC_459|Compound:nigericin|FD-Score:5.17|P-value:1.84E-4 ID:SGTC_462|Compound:ag-879|FD-Score:5.07|P-value:2.43E-4 ID:SGTC_470|Compound:aa-861|FD-Score:4.92|P-value:3.50E-4 ID:SGTC_481|Compound:bay k-8644|FD-Score:5.73|P-value:4.02E-5 ID:SGTC_515|Compound:4092-1064|FD-Score:-5.98|P-value:1.89E-5 ID:SGTC_624|Compound:k048-0052|FD-Score:6.52|P-value:3.51E-6 ID:SGTC_644|Compound:1498-1197|FD-Score:5.28|P-value:1.38E-4 ID:SGTC_646|Compound:4092-0839|FD-Score:-4.84|P-value:4.26E-4 ID:SGTC_684|Compound:1140-0066|FD-Score:5.04|P-value:2.58E-4 ID:SGTC_706|Compound:4262-0057|FD-Score:-6.45|P-value:4.39E-6 ID:SGTC_717|Compound:1532-0246|FD-Score:5.03|P-value:2.64E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:-5.88|P-value:2.52E-5 ID:SGTC_800|Compound:3448-7362|FD-Score:5.62|P-value:5.47E-5 ID:SGTC_830|Compound:4076-0286|FD-Score:6.37|P-value:5.75E-6 ID:SGTC_841|Compound:0251-0215|FD-Score:5.69|P-value:4.40E-5 ID:SGTC_865|Compound:0488-0499|FD-Score:-5.38|P-value:1.04E-4 ID:SGTC_945|Compound:3381-0768|FD-Score:-5.75|P-value:3.71E-5 ID:SGTC_954|Compound:1189-0853|FD-Score:-5.22|P-value:1.59E-4 ID:SGTC_970|Compound:1315-0089|FD-Score:8.32|P-value:5.01E-9 ID:SGTC_975|Compound:1335-0046|FD-Score:6.05|P-value:1.56E-5 ID:SGTC_1037|Compound:k284-1091|FD-Score:4.81|P-value:4.62E-4 ID:SGTC_1080|Compound:nisoldipine|FD-Score:4.58|P-value:8.05E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:5.71|P-value:4.23E-5 ID:SGTC_1165|Compound:k072-0275|FD-Score:5.13|P-value:2.05E-4 ID:SGTC_1174|Compound:0739-0097|FD-Score:5.71|P-value:4.22E-5 ID:SGTC_1206|Compound:3978-0017|FD-Score:-5.44|P-value:8.79E-5 ID:SGTC_1226|Compound:3909-7979|FD-Score:-5.12|P-value:2.12E-4 ID:SGTC_1233|Compound:0325-0408|FD-Score:5.38|P-value:1.07E-4 ID:SGTC_1234|Compound:0326-0494|FD-Score:4.65|P-value:6.77E-4 ID:SGTC_1240|Compound:0356-0016|FD-Score:-5.72|P-value:4.06E-5 ID:SGTC_1247|Compound:0448-0043|FD-Score:-5.72|P-value:4.10E-5 ID:SGTC_1279|Compound:0874-0590|FD-Score:4.72|P-value:5.71E-4 ID:SGTC_1306|Compound:1185-0270|FD-Score:4.91|P-value:3.63E-4 ID:SGTC_1319|Compound:1306-0155|FD-Score:5.16|P-value:1.91E-4 ID:SGTC_1362|Compound:1611-0397|FD-Score:5.66|P-value:4.81E-5 ID:SGTC_1455|Compound:4262-0120|FD-Score:-4.63|P-value:7.18E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:11.20|P-value:7.33E-15 ID:SGTC_1573|Compound:oleylamine|FD-Score:-7.62|P-value:7.69E-8 ID:SGTC_1639|Compound:Lupinine o-methylbenzoicacid ester hydrochloride|FD-Score:-5.35|P-value:1.15E-4 ID:SGTC_1672|Compound:st016598|FD-Score:-4.92|P-value:3.47E-4 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:-5.83|P-value:2.91E-5 ID:SGTC_1687|Compound:st020778|FD-Score:5.64|P-value:5.09E-5 ID:SGTC_1714|Compound:st033236|FD-Score:4.65|P-value:6.81E-4 ID:SGTC_1715|Compound:st032160|FD-Score:-6.19|P-value:9.88E-6 ID:SGTC_1718|Compound:roemerine|FD-Score:-5.21|P-value:1.66E-4 ID:SGTC_1748|Compound:st037455|FD-Score:-5.00|P-value:2.88E-4 ID:SGTC_1760|Compound:st045453|FD-Score:-5.31|P-value:1.25E-4 ID:SGTC_1773|Compound:st048542|FD-Score:-4.55|P-value:8.60E-4 ID:SGTC_1781|Compound:st038725|FD-Score:-9.64|P-value:1.52E-11 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.96|P-value:3.13E-4 ID:SGTC_1797|Compound:st048695|FD-Score:-6.61|P-value:2.65E-6 ID:SGTC_1934|Compound:st074720|FD-Score:-5.26|P-value:1.46E-4 ID:SGTC_1999|Compound:st074831|FD-Score:-4.49|P-value:9.77E-4 ID:SGTC_2006|Compound:4011487|FD-Score:-5.16|P-value:1.89E-4 ID:SGTC_2038|Compound:4100038|FD-Score:-4.73|P-value:5.58E-4 ID:SGTC_2050|Compound:5263056|FD-Score:-5.24|P-value:1.52E-4 ID:SGTC_2187|Compound:6125751|FD-Score:4.78|P-value:5.00E-4 ID:SGTC_2200|Compound:6600604|FD-Score:4.67|P-value:6.49E-4 ID:SGTC_2201|Compound:6605497|FD-Score:-7.93|P-value:2.30E-8 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:4.91|P-value:3.56E-4 ID:SGTC_2300|Compound:7976697|FD-Score:-6.33|P-value:6.51E-6 ID:SGTC_2314|Compound:7727897|FD-Score:4.66|P-value:6.66E-4 ID:SGTC_2363|Compound:9053361|FD-Score:-5.61|P-value:5.48E-5 ID:SGTC_2374|Compound:9071832|FD-Score:-5.09|P-value:2.26E-4 ID:SGTC_2380|Compound:9035439|FD-Score:-4.87|P-value:3.91E-4 ID:SGTC_2594|Compound:a-mangostin|FD-Score:-6.32|P-value:6.56E-6 ID:SGTC_2757|Compound:clomiphene|FD-Score:-4.85|P-value:4.20E-4 ID:SGTC_2790|Compound:5423970|FD-Score:-5.68|P-value:4.58E-5 ID:SGTC_2823|Compound:7987624|FD-Score:-5.08|P-value:2.32E-4 ID:SGTC_2825|Compound:7998094|FD-Score:-4.50|P-value:9.65E-4 ID:SGTC_2838|Compound:9002687|FD-Score:-7.89|P-value:2.69E-8 ID:SGTC_2865|Compound:9030313|FD-Score:5.60|P-value:5.69E-5 ID:SGTC_2902|Compound:5787006|FD-Score:5.02|P-value:2.73E-4 ID:SGTC_2944|Compound:9067346|FD-Score:-5.43|P-value:9.26E-5 ID:SGTC_2948|Compound:9070189|FD-Score:-9.38|P-value:5.17E-11 ID:SGTC_2991|Compound:9074669|FD-Score:-7.36|P-value:1.99E-7 ID:SGTC_2993|Compound:9054257|FD-Score:-8.46|P-value:2.78E-9 ID:SGTC_3054|Compound:9094397|FD-Score:-6.35|P-value:5.98E-6 ID:SGTC_3065|Compound:9113888|FD-Score:4.60|P-value:7.75E-4 ID:SGTC_3071|Compound:9117417|FD-Score:-5.88|P-value:2.57E-5 ID:SGTC_3077|Compound:9117319|FD-Score:4.92|P-value:3.54E-4 ID:SGTC_3081|Compound:9117243|FD-Score:-4.68|P-value:6.29E-4 ID:SGTC_3100|Compound:9120536|FD-Score:-6.28|P-value:7.48E-6 ID:SGTC_3126|Compound:9127922|FD-Score:-8.85|P-value:5.43E-10 ID:SGTC_3190|Compound:9110366|FD-Score:4.98|P-value:3.05E-4 ID:SGTC_3218|Compound:9131285|FD-Score:-7.60|P-value:8.08E-8 ID:SGTC_3269|Compound:9137823|FD-Score:4.83|P-value:4.39E-4 ID:SGTC_3278|Compound:9139605|FD-Score:5.17|P-value:1.83E-4

Top fitness defect scores for YDR137W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1495 4469-0029 11.20 237.0 µM 7.33E-15 10 3.04E-29
2 SGTC_970 1315-0089 8.32 19.5 µM 5.01E-9 RSC & ERG11 3 4.42E-17
3 SGTC_445 e6 berbamine 7.77 66.0 µM 4.39E-8 NEO1-PIK1 13 3.99E-15
4 SGTC_624 k048-0052 6.52 28.0 µM 3.51E-6 Golgi 4 3.44E-11
5 SGTC_358 0075-0058 6.38 9.4 µM 5.51E-6 16 8.71E-11
6 SGTC_830 4076-0286 6.37 57.8 µM 5.75E-6 translation 11 9.50E-11
7 SGTC_975 1335-0046 6.05 28.5 µM 1.56E-5 RPP1 & pyrimidine depletion 7 7.40E-10
8 SGTC_481 bay k-8644 5.73 50.0 µM 4.02E-5 10 5.17E-9
9 SGTC_1174 0739-0097 5.71 51.1 µM 4.22E-5 redox potentiating 8 5.70E-9
10 SGTC_1119 parthenolide 5.71 318.5 nM 4.23E-5 TSC3-RPN4 12 5.74E-9
11 SGTC_841 0251-0215 5.69 91.2 µM 4.40E-5 40 6.23E-9
12 SGTC_1362 1611-0397 5.66 101.0 µM 4.81E-5 3 7.46E-9
13 SGTC_1687 st020778 5.64 55.4 µM 5.09E-5 116 8.37E-9
14 SGTC_31 0508-1974 5.63 57.2 µM 5.27E-5 3 8.98E-9
15 SGTC_800 3448-7362 5.62 155.0 µM 5.47E-5 translation 64 9.72E-9
16 SGTC_2865 9030313 5.60 52.0 µM 5.69E-5 5 1.05E-8
17 SGTC_1233 0325-0408 5.38 14.2 µM 1.07E-4 5 3.82E-8
18 SGTC_644 1498-1197 5.28 63.3 µM 1.38E-4 2 6.46E-8
19 SGTC_22 0964-0034 5.27 14.5 µM 1.44E-4 unfolded protein response 25 7.00E-8
20 SGTC_3278 9139605 5.17 49.5 µM 1.83E-4 2 1.14E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.545 1.18E-257 YDR136C_d VPS61_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 4% of ORF overlaps the verified gene RGP1; deletion causes a vacuolar protein sorting defect
0.508 2.94E-218 YLR262C YPT6 hom Rab family GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6
0.441 2.82E-159 YLR261C_d VPS63_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene YPT6; deletion causes a vacuolar protein sorting defect
0.401 2.94E-129 YLR039C RIC1 hom Protein involved in retrograde transport to the cis-Golgi network; forms heterodimer with Rgp1p that acts as a GTP exchange factor for Ypt6p; involved in transcription of rRNA and ribosomal protein genes
0.327 5.05E-84 YNL041C COG6 hom Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
0.322 2.35E-81 YNL051W COG5 hom Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
0.306 1.20E-73 YDR320C SWA2 hom Auxilin-like protein involved in vesicular transport; clathrin-binding protein required for uncoating of clathrin-coated vesicles
0.279 7.56E-61 YKR019C IRS4 hom EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; IRS4 has a paralog, TAX4, that arose from the whole genome duplication
0.279 5.53E-61 YML071C COG8 hom Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
0.272 1.81E-57 YGL005C COG7 hom Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
0.243 3.40E-46 YGR167W CLC1 hom Clathrin light chain; subunit of the major coat protein involved in intracellular protein transport and endocytosis; thought to regulate clathrin function; two Clathrin heavy chains (CHC1) form the clathrin triskelion structural component; YGR167W
0.203 1.56E-32 YGL223C COG1 hom Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
0.199 3.66E-31 YOL018C TLG2 hom Syntaxin-like t-SNARE that forms a complex with Tlg1p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds Vps45p, which prevents Tlg2p degradation and also facilitates t-SNARE complex formation; homologous to mammalian SNARE protein syntaxin 16 (Sx16)
0.197 1.22E-30 YKR020W VPS51 hom Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; links the (VFT/GARP) complex to the SNARE Tlg1p
0.176 1.44E-24 YJL004C SYS1 hom Integral membrane protein of the Golgi required for targeting of the Arf-like GTPase Arl3p to the Golgi; multicopy suppressor of ypt6 null mutation