YDR138W / HPR1

Subunit of THO/TREX complexes that couple transcription elongation with mitotic recombination and with mRNA metabolism and export, subunit of an RNA Pol II complex; regulates lifespan; involved in telomere maintenance; similar to Top1p

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR138W / HPR1

Click on Significant Values for Screen Details ID:SGTC_73|Compound:0327-0325|FD-Score:-4.46|P-value:1.35E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:5.25|P-value:1.46E-5 ID:SGTC_299|Compound:1273-0059|FD-Score:-4.05|P-value:4.73E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.97|P-value:5.87E-4 ID:SGTC_449|Compound:xestospongin c|FD-Score:4.86|P-value:5.51E-5 ID:SGTC_539|Compound:4859-0462|FD-Score:-4.41|P-value:1.62E-4 ID:SGTC_777|Compound:1315-0167|FD-Score:4.23|P-value:3.88E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:-4.16|P-value:3.40E-4 ID:SGTC_792|Compound:4534-1957|FD-Score:4.42|P-value:2.22E-4 ID:SGTC_826|Compound:1683-5028|FD-Score:5.75|P-value:2.27E-6 ID:SGTC_1021|Compound:4476-0760|FD-Score:5.36|P-value:9.74E-6 ID:SGTC_1039|Compound:k821-0043|FD-Score:5.06|P-value:2.87E-5 ID:SGTC_1055|Compound:3448-0672|FD-Score:4.19|P-value:4.44E-4 ID:SGTC_1157|Compound:4092-0394|FD-Score:4.00|P-value:7.55E-4 ID:SGTC_1171|Compound:0368-0077|FD-Score:-4.58|P-value:9.23E-5 ID:SGTC_1313|Compound:1220-0047|FD-Score:4.30|P-value:3.20E-4 ID:SGTC_1526|Compound:st051518|FD-Score:4.12|P-value:5.43E-4 ID:SGTC_1545|Compound:lovastatin|FD-Score:5.75|P-value:2.29E-6 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:-4.46|P-value:1.36E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:3.92|P-value:9.26E-4 ID:SGTC_1709|Compound:st033179|FD-Score:4.22|P-value:4.02E-4 ID:SGTC_1898|Compound:st060199|FD-Score:4.16|P-value:4.75E-4 ID:SGTC_2102|Compound:5377816|FD-Score:4.88|P-value:5.25E-5 ID:SGTC_2163|Compound:5671233|FD-Score:3.95|P-value:8.56E-4 ID:SGTC_2240|Compound:6690706|FD-Score:4.55|P-value:1.50E-4 ID:SGTC_2246|Compound:7293507|FD-Score:-4.33|P-value:2.01E-4 ID:SGTC_2467|Compound:5474540|FD-Score:4.74|P-value:8.26E-5 ID:SGTC_2532|Compound:xanthone|FD-Score:-4.81|P-value:4.48E-5 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:6.16|P-value:4.56E-7 ID:SGTC_2851|Compound:9015922|FD-Score:5.57|P-value:4.54E-6 ID:SGTC_2997|Compound:9067075|FD-Score:7.17|P-value:5.09E-9 ID:SGTC_3237|Compound:9133362|FD-Score:4.16|P-value:4.77E-4 ID:SGTC_3259|Compound:9138485|FD-Score:4.13|P-value:5.27E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:-4.46|P-value:1.35E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:5.25|P-value:1.46E-5 ID:SGTC_299|Compound:1273-0059|FD-Score:-4.05|P-value:4.73E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.97|P-value:5.87E-4 ID:SGTC_449|Compound:xestospongin c|FD-Score:4.86|P-value:5.51E-5 ID:SGTC_539|Compound:4859-0462|FD-Score:-4.41|P-value:1.62E-4 ID:SGTC_777|Compound:1315-0167|FD-Score:4.23|P-value:3.88E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:-4.16|P-value:3.40E-4 ID:SGTC_792|Compound:4534-1957|FD-Score:4.42|P-value:2.22E-4 ID:SGTC_826|Compound:1683-5028|FD-Score:5.75|P-value:2.27E-6 ID:SGTC_1021|Compound:4476-0760|FD-Score:5.36|P-value:9.74E-6 ID:SGTC_1039|Compound:k821-0043|FD-Score:5.06|P-value:2.87E-5 ID:SGTC_1055|Compound:3448-0672|FD-Score:4.19|P-value:4.44E-4 ID:SGTC_1157|Compound:4092-0394|FD-Score:4.00|P-value:7.55E-4 ID:SGTC_1171|Compound:0368-0077|FD-Score:-4.58|P-value:9.23E-5 ID:SGTC_1313|Compound:1220-0047|FD-Score:4.30|P-value:3.20E-4 ID:SGTC_1526|Compound:st051518|FD-Score:4.12|P-value:5.43E-4 ID:SGTC_1545|Compound:lovastatin|FD-Score:5.75|P-value:2.29E-6 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:-4.46|P-value:1.36E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:3.92|P-value:9.26E-4 ID:SGTC_1709|Compound:st033179|FD-Score:4.22|P-value:4.02E-4 ID:SGTC_1898|Compound:st060199|FD-Score:4.16|P-value:4.75E-4 ID:SGTC_2102|Compound:5377816|FD-Score:4.88|P-value:5.25E-5 ID:SGTC_2163|Compound:5671233|FD-Score:3.95|P-value:8.56E-4 ID:SGTC_2240|Compound:6690706|FD-Score:4.55|P-value:1.50E-4 ID:SGTC_2246|Compound:7293507|FD-Score:-4.33|P-value:2.01E-4 ID:SGTC_2467|Compound:5474540|FD-Score:4.74|P-value:8.26E-5 ID:SGTC_2532|Compound:xanthone|FD-Score:-4.81|P-value:4.48E-5 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:6.16|P-value:4.56E-7 ID:SGTC_2851|Compound:9015922|FD-Score:5.57|P-value:4.54E-6 ID:SGTC_2997|Compound:9067075|FD-Score:7.17|P-value:5.09E-9 ID:SGTC_3237|Compound:9133362|FD-Score:4.16|P-value:4.77E-4 ID:SGTC_3259|Compound:9138485|FD-Score:4.13|P-value:5.27E-4

Top fitness defect scores for YDR138W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2997 9067075 7.17 71.4 µM 5.09E-9 unfolded protein response 10 3.70E-13
2 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 6.16 100.0 µM 4.56E-7 3 3.73E-10
3 SGTC_826 1683-5028 5.75 118.0 µM 2.27E-6 6 4.38E-9
4 SGTC_1545 lovastatin 5.75 49.4 µM 2.29E-6 5 4.44E-9
5 SGTC_2851 9015922 5.57 71.4 µM 4.54E-6 12 1.27E-8
6 SGTC_1021 4476-0760 5.36 85.3 µM 9.74E-6 7 4.10E-8
7 SGTC_86 0417-1630 5.25 471.9 µM 1.46E-5 ubiquinone biosynthesis & proteasome 106 7.67E-8
8 SGTC_1039 k821-0043 5.06 94.0 µM 2.87E-5 Golgi 9 2.15E-7
9 SGTC_2102 5377816 4.88 72.8 µM 5.25E-5 8 5.42E-7
10 SGTC_449 xestospongin c 4.86 11.2 µM 5.51E-5 NEO1-PIK1 33 5.84E-7
11 SGTC_2467 5474540 4.74 200.0 µM 8.26E-5 5 1.08E-6
12 SGTC_2240 6690706 4.55 185.9 µM 1.50E-4 9 2.70E-6
13 SGTC_792 4534-1957 4.42 155.0 µM 2.22E-4 21 4.91E-6
14 SGTC_1313 1220-0047 4.30 237.0 µM 3.20E-4 28 8.58E-6
15 SGTC_777 1315-0167 4.23 517.0 µM 3.88E-4 Golgi 23 1.15E-5
16 SGTC_1709 st033179 4.22 39.1 µM 4.02E-4 9 1.22E-5
17 SGTC_1055 3448-0672 4.19 86.0 µM 4.44E-4 25 1.41E-5
18 SGTC_1898 st060199 4.16 18.6 µM 4.75E-4 11 1.57E-5
19 SGTC_3237 9133362 4.16 49.5 µM 4.77E-4 29 1.58E-5
20 SGTC_3259 9138485 4.13 49.5 µM 5.27E-4 10 1.84E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.122 1.28E-12 YOL072W THP1 hom Nuclear pore-associated protein; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; contains a PAM domain implicated in protein-protein binding
0.106 6.17E-10 YNL139C THO2 hom Subunit of the THO complex, which is required for efficient transcription elongation and involved in transcriptional elongation-associated recombination; required for LacZ RNA expression from certain plasmids
0.101 4.23E-9 YGL054C ERV14 hom COPII-coated vesicle protein; involved in vesicle formation and incorporation of specific secretory cargo; required for the delivery of bud-site selection protein Axl2p to cell surface; related to Drosophila cornichon; ERV14 has a paralog, ERV15, that arose from the whole genome duplication
0.093 7.25E-8 YDR159W SAC3 hom Nuclear pore-associated protein; required for biogenesis of the small ribosomal subunit; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; similar to the human germinal center-associated nuclear protein (GANP)
0.092 1.10E-7 YJR129C_p YJR129C_p hom Putative protein of unknown function; predicted S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.091 1.15E-7 YFL001W DEG1 hom tRNA:pseudouridine synthase, introduces pseudouridines at position 38 or 39 in tRNA, important for maintenance of translation efficiency and normal cell growth, localizes to both the nucleus and cytoplasm; non-essential for viability
0.091 1.31E-7 YLR315W NKP2 hom Central kinetochore protein and subunit of the Ctf19 complex; mutants have elevated rates of chromosome loss; orthologous to fission yeast kinetochore protein cnl2
0.089 2.74E-7 YDR028C REG1 hom Regulatory subunit of type 1 protein phosphatase Glc7p; involved in negative regulation of glucose-repressible genes; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p
0.088 3.17E-7 YCL014W BUD3 hom Protein involved in bud-site selection and required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding
0.086 6.02E-7 YJR063W RPA12 hom RNA polymerase I subunit A12.2; contains two zinc binding domains, and the N terminal domain is responsible for anchoring to the RNA pol I complex
0.083 1.48E-6 YDL131W LYS21 hom Homocitrate synthase isozyme; catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; LYS21 has a paralog, LYS20, that arose from the whole genome duplication
0.083 1.66E-6 YDR378C LSM6 hom Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA
0.083 1.64E-6 YLR129W DIP2 het Nucleolar protein, specifically associated with the U3 snoRNA, part of the large ribonucleoprotein complex known as the small subunit (SSU) processome, required for 18S rRNA biogenesis, part of the active pre-rRNA processing complex
0.079 4.91E-6 YGR159C NSR1 hom Nucleolar protein that binds nuclear localization sequences, required for pre-rRNA processing and ribosome biogenesis
0.077 8.92E-6 YER041W YEN1 hom Holliday junction resolvase; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p