YDR141C / DOP1

Golgi-localized, leucine-zipper domain containing protein; involved in endosome to Golgi transport, organization of the ER, establishing cell polarity, and morphogenesis; detected in highly purified mitochondria in high-throughput studies

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDR141C / DOP1

Click on Significant Values for Screen Details ID:SGTC_206|Compound:4546-0025|FD-Score:5.12|P-value:3.42E-7 ID:SGTC_221|Compound:trifluoperazine|FD-Score:6.38|P-value:3.07E-10 ID:SGTC_286|Compound:k060-0067|FD-Score:5.06|P-value:4.54E-7 ID:SGTC_291|Compound:4130-1278|FD-Score:3.68|P-value:1.83E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:-3.86|P-value:8.49E-5 ID:SGTC_427|Compound:1354-0053|FD-Score:4.01|P-value:4.96E-5 ID:SGTC_429|Compound:1112-0049|FD-Score:7.54|P-value:1.27E-13 ID:SGTC_480|Compound:am 92016|FD-Score:-4.54|P-value:4.98E-6 ID:SGTC_504|Compound:lovastatin|FD-Score:3.28|P-value:7.32E-4 ID:SGTC_591|Compound:4299-0174|FD-Score:-3.22|P-value:8.67E-4 ID:SGTC_593|Compound:1203-0218|FD-Score:3.58|P-value:2.61E-4 ID:SGTC_603|Compound:3794-0023|FD-Score:-3.68|P-value:1.72E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:3.91|P-value:7.47E-5 ID:SGTC_969|Compound:1313-0238|FD-Score:-4.16|P-value:2.55E-5 ID:SGTC_986|Compound:1493-0483|FD-Score:3.33|P-value:6.16E-4 ID:SGTC_1164|Compound:k060-0068|FD-Score:3.26|P-value:8.03E-4 ID:SGTC_1171|Compound:0368-0077|FD-Score:4.27|P-value:1.71E-5 ID:SGTC_1265|Compound:0819-1001|FD-Score:4.91|P-value:9.75E-7 ID:SGTC_1293|Compound:1000-1278|FD-Score:3.98|P-value:5.79E-5 ID:SGTC_1433|Compound:4060-0023|FD-Score:3.49|P-value:3.63E-4 ID:SGTC_1614|Compound:st002383|FD-Score:3.46|P-value:4.02E-4 ID:SGTC_1685|Compound:st024049|FD-Score:3.97|P-value:5.93E-5 ID:SGTC_1725|Compound:st036284|FD-Score:-3.24|P-value:7.90E-4 ID:SGTC_1734|Compound:st037168|FD-Score:3.45|P-value:4.17E-4 ID:SGTC_1776|Compound:st049249|FD-Score:3.92|P-value:7.12E-5 ID:SGTC_1800|Compound:st050079|FD-Score:4.51|P-value:6.13E-6 ID:SGTC_1865|Compound:st057639|FD-Score:4.65|P-value:3.26E-6 ID:SGTC_2069|Compound:5228469|FD-Score:3.47|P-value:3.90E-4 ID:SGTC_2268|Compound:7933382|FD-Score:3.23|P-value:8.78E-4 ID:SGTC_2282|Compound:7944268|FD-Score:3.24|P-value:8.44E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:5.07|P-value:4.45E-7 ID:SGTC_2411|Compound:st077133|FD-Score:3.22|P-value:8.90E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:3.30|P-value:7.02E-4 ID:SGTC_2790|Compound:5423970|FD-Score:4.33|P-value:1.33E-5 ID:SGTC_2887|Compound:9044784|FD-Score:4.35|P-value:1.22E-5 ID:SGTC_2981|Compound:9013952|FD-Score:4.07|P-value:4.01E-5 ID:SGTC_2988|Compound:9073640|FD-Score:-5.37|P-value:8.82E-8 ID:SGTC_3011|Compound:9081274|FD-Score:3.25|P-value:8.05E-4 ID:SGTC_3031|Compound:9088762|FD-Score:3.52|P-value:3.27E-4 ID:SGTC_3037|Compound:9091026|FD-Score:12.70|P-value:1.90E-35 ID:SGTC_3052|Compound:9092717|FD-Score:-6.84|P-value:1.46E-11 ID:SGTC_3076|Compound:9116187|FD-Score:4.47|P-value:7.13E-6 ID:SGTC_3173|Compound:9105693|FD-Score:3.56|P-value:2.74E-4 ID:SGTC_3306|Compound:9127676|FD-Score:3.20|P-value:9.61E-4 ID:SGTC_3341|Compound:9147222|FD-Score:-3.20|P-value:9.08E-4 ID:SGTC_206|Compound:4546-0025|FD-Score:5.12|P-value:3.42E-7 ID:SGTC_221|Compound:trifluoperazine|FD-Score:6.38|P-value:3.07E-10 ID:SGTC_286|Compound:k060-0067|FD-Score:5.06|P-value:4.54E-7 ID:SGTC_291|Compound:4130-1278|FD-Score:3.68|P-value:1.83E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:-3.86|P-value:8.49E-5 ID:SGTC_427|Compound:1354-0053|FD-Score:4.01|P-value:4.96E-5 ID:SGTC_429|Compound:1112-0049|FD-Score:7.54|P-value:1.27E-13 ID:SGTC_480|Compound:am 92016|FD-Score:-4.54|P-value:4.98E-6 ID:SGTC_504|Compound:lovastatin|FD-Score:3.28|P-value:7.32E-4 ID:SGTC_591|Compound:4299-0174|FD-Score:-3.22|P-value:8.67E-4 ID:SGTC_593|Compound:1203-0218|FD-Score:3.58|P-value:2.61E-4 ID:SGTC_603|Compound:3794-0023|FD-Score:-3.68|P-value:1.72E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:3.91|P-value:7.47E-5 ID:SGTC_969|Compound:1313-0238|FD-Score:-4.16|P-value:2.55E-5 ID:SGTC_986|Compound:1493-0483|FD-Score:3.33|P-value:6.16E-4 ID:SGTC_1164|Compound:k060-0068|FD-Score:3.26|P-value:8.03E-4 ID:SGTC_1171|Compound:0368-0077|FD-Score:4.27|P-value:1.71E-5 ID:SGTC_1265|Compound:0819-1001|FD-Score:4.91|P-value:9.75E-7 ID:SGTC_1293|Compound:1000-1278|FD-Score:3.98|P-value:5.79E-5 ID:SGTC_1433|Compound:4060-0023|FD-Score:3.49|P-value:3.63E-4 ID:SGTC_1614|Compound:st002383|FD-Score:3.46|P-value:4.02E-4 ID:SGTC_1685|Compound:st024049|FD-Score:3.97|P-value:5.93E-5 ID:SGTC_1725|Compound:st036284|FD-Score:-3.24|P-value:7.90E-4 ID:SGTC_1734|Compound:st037168|FD-Score:3.45|P-value:4.17E-4 ID:SGTC_1776|Compound:st049249|FD-Score:3.92|P-value:7.12E-5 ID:SGTC_1800|Compound:st050079|FD-Score:4.51|P-value:6.13E-6 ID:SGTC_1865|Compound:st057639|FD-Score:4.65|P-value:3.26E-6 ID:SGTC_2069|Compound:5228469|FD-Score:3.47|P-value:3.90E-4 ID:SGTC_2268|Compound:7933382|FD-Score:3.23|P-value:8.78E-4 ID:SGTC_2282|Compound:7944268|FD-Score:3.24|P-value:8.44E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:5.07|P-value:4.45E-7 ID:SGTC_2411|Compound:st077133|FD-Score:3.22|P-value:8.90E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:3.30|P-value:7.02E-4 ID:SGTC_2790|Compound:5423970|FD-Score:4.33|P-value:1.33E-5 ID:SGTC_2887|Compound:9044784|FD-Score:4.35|P-value:1.22E-5 ID:SGTC_2981|Compound:9013952|FD-Score:4.07|P-value:4.01E-5 ID:SGTC_2988|Compound:9073640|FD-Score:-5.37|P-value:8.82E-8 ID:SGTC_3011|Compound:9081274|FD-Score:3.25|P-value:8.05E-4 ID:SGTC_3031|Compound:9088762|FD-Score:3.52|P-value:3.27E-4 ID:SGTC_3037|Compound:9091026|FD-Score:12.70|P-value:1.90E-35 ID:SGTC_3052|Compound:9092717|FD-Score:-6.84|P-value:1.46E-11 ID:SGTC_3076|Compound:9116187|FD-Score:4.47|P-value:7.13E-6 ID:SGTC_3173|Compound:9105693|FD-Score:3.56|P-value:2.74E-4 ID:SGTC_3306|Compound:9127676|FD-Score:3.20|P-value:9.61E-4 ID:SGTC_3341|Compound:9147222|FD-Score:-3.20|P-value:9.08E-4

Top fitness defect scores for YDR141C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_3037 9091026 12.70 49.5 µM 1.90E-35 NEO1-PIK1 2 1.79E-37 0.38
2 SGTC_429 1112-0049 7.54 25.5 µM 1.27E-13 DNA damage response 1 2.38E-14 2.04
3 SGTC_221 trifluoperazine 6.38 10.3 µM 3.07E-10 NEO1-PIK1 14 9.11E-11 0.33
4 SGTC_206 4546-0025 5.12 72.0 µM 3.42E-7 NEO1 8 1.54E-7 1.03
5 SGTC_2406 ethylparaben 5.07 405.7 µM 4.45E-7 4 2.03E-7 0.49
6 SGTC_286 k060-0067 5.06 22.9 µM 4.54E-7 tubulin folding & SWR complex 1 2.07E-7 0.57
7 SGTC_1265 0819-1001 4.91 68.8 µM 9.75E-7 6 4.65E-7 0.94
8 SGTC_1865 st057639 4.65 52.2 µM 3.26E-6 2 1.67E-6 0.80
9 SGTC_1800 st050079 4.51 29.1 µM 6.13E-6 NEO1-PIK1 18 3.26E-6 0.11
10 SGTC_3076 9116187 4.47 49.5 µM 7.13E-6 5 3.83E-6 0.20
11 SGTC_2887 9044784 4.35 58.4 µM 1.22E-5 fatty acid desaturase (OLE1) 16 6.73E-6 0.00
12 SGTC_2790 5423970 4.33 71.4 µM 1.33E-5 endomembrane recycling 14 7.40E-6 0.02
13 SGTC_1171 0368-0077 4.27 21.4 µM 1.71E-5 8 9.63E-6 0.14
14 SGTC_2981 9013952 4.07 39.0 µM 4.01E-5 7 2.38E-5 0.22
15 SGTC_427 1354-0053 4.01 47.3 µM 4.96E-5 2 2.98E-5 0.23
16 SGTC_1293 1000-1278 3.98 195.0 µM 5.79E-5 5 3.51E-5 0.09
17 SGTC_1685 st024049 3.97 53.1 µM 5.93E-5 TSC3-RPN4 1 3.60E-5 0.32
18 SGTC_1776 st049249 3.92 45.9 µM 7.12E-5 5 4.37E-5 0.11
19 SGTC_710 3448-4187 3.91 58.0 µM 7.47E-5 fatty acid desaturase (OLE1) 9 4.59E-5 0.09
20 SGTC_291 4130-1278 3.68 35.5 µM 1.83E-4 Golgi 8 1.18E-4 0.09

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.206 1.26E-33 YBR245C ISW1 hom ATPase subunit of imitation-switch (ISWI) class chromatin remodelers; ATPase; forms a complex with Ioc3p (Isw1a), and a complex with Ioc2p and Ioc4p (Isw1b); Isw1a and Isw1b have partially overlapping and distinct roles, Isw1a involved in repression of transcription initiation and Isw1b involved in regulation of transcription elongation; Isw1b recruited to open reading frames by H3K36 methylation and acts with Chd1p to prevent trans-histone exchange over coding regions
0.203 2.00E-32 YLL036C PRP19 het Splicing factor associated with the spliceosome; contains a U-box, a motif found in a class of ubiquitin ligases, and a WD40 domain
0.181 3.19E-26 YLR057W MNL2 hom Putative mannosidase involved in ER-associated protein degradation; localizes to the endoplasmic reticulum; sequence similarity with seven-hairpin glycosidase (GH47) family members, such as Mns1p and Mnl1p, that hydrolyze 1,2-linked alpha-D-mannose residues; non-essential gene
0.161 7.79E-21 YLR095C IOC2 hom Member of a complex (Isw1b) with Isw1p and Ioc4p that exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing, contains a PHD finger motif
0.155 1.40E-19 YPR091C NVJ2 hom Lipid-binding ER protein, enriched at nucleus-vacuolar junctions (NVJ); may be involved in sterol metabolism or signaling at the NVJ; contains a synaptotagmin-like-mitochondrial- lipid binding protein (SMP) domain; binds phosphatidylinositols and other lipids in a large-scale study; may interact with ribosomes, based on co-purification experiments
0.147 8.97E-18 YJL053W PEP8 hom Vacuolar protein component of the retromer; forms part of the multimeric membrane-associated retromer complex involved in vacuolar protein sorting along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport; interacts with Ypt7p; protein abundance increases in response to DNA replication stress
0.147 1.14E-17 YML037C_p YML037C_p hom Putative protein of unknown function with some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene
0.146 2.18E-17 YGL077C HNM1 hom Choline/ethanolamine transporter; involved in the uptake of nitrogen mustard and the uptake of glycine betaine during hypersaline stress; co-regulated with phospholipid biosynthetic genes and negatively regulated by choline and myo-inositol
0.143 8.86E-17 YJR075W HOC1 hom Alpha-1,6-mannosyltransferase involved in cell wall mannan biosynthesis; subunit of a Golgi-localized complex that also contains Anp1p, Mnn9p, Mnn11p, and Mnn10p; identified as a suppressor of a cell lysis sensitive pkc1-371 allele
0.142 1.51E-16 YOL159C-A YOL159C-A hom Protein of unknown function; overexpression affects endocytic protein trafficking; identified by sequence comparison with hemiascomycetous yeast species
0.141 1.95E-16 YAR042W SWH1 hom Protein similar to mammalian oxysterol-binding protein; contains ankyrin repeats; localizes to the Golgi and the nucleus-vacuole junction
0.139 5.96E-16 YHR012W VPS29 hom Endosomal protein that is a subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval
0.139 6.09E-16 YLR360W VPS38 hom Part of a Vps34p phosphatidylinositol 3-kinase complex that functions in carboxypeptidase Y (CPY) sorting; binds Vps30p and Vps34p to promote production of phosphatidylinositol 3-phosphate (PtdIns3P) which stimulates kinase activity; required for overflow degradation of misfolded proteins when ERAD is saturated
0.137 1.38E-15 YBR291C CTP1 hom Mitochondrial inner membrane citrate transporter, member of the mitochondrial carrier family
0.137 1.88E-15 YKR095W MLP1 hom Myosin-like protein associated with the nuclear envelope, connects the nuclear pore complex with the nuclear interior; involved with Tel1p in telomere length control; involved with Pml1p and Pml39p in nuclear retention of unspliced mRNAs